Targeting the JNK pathway as a therapeutic protective strategy for nervous system diseases

Reviews in the Neurosciences

Volumn 16, Issue 1, 2005, Pages 57-67

  Bonny, Christophe ^a   Borsello, Tiziana ^a,b   Zine, Azel ^c,d  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c UNIV MONTPELLIER   (France)

^d Montpellier University Medical Center   (France)

Author keywords

Apoptosis; c Jun N terminal kinase (JNK); D JNKI 1 peptide; Hearing loss; Ischemic damage; JNK inhibition; Signaling pathways

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; APTIGANEL; CEP 1347; CISPLATIN; CLOMETHIAZOLE; EBSELEN; GENTAMICIN; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEOMYCIN; NEUROPROTECTIVE AGENT; PROTEIN C JUN; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; AUDITORY NERVOUS SYSTEM; BRAIN ISCHEMIA; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; HAIR CELL; HEARING LOSS; MOUSE; NERVE CELL DEGENERATION; NEUROPROTECTION; NOISE INJURY; NONHUMAN; OTOTOXICITY; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 15944378127     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVNEURO.2005.16.1.57     Document Type: Review

References (59)

1. Asoh S, Ohsawa I, Mori T, Katsura KI, Hiraide T, Katayama Y, Kimura M, Ozaki D, Yamagata K, Ohta S. Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci USA 2002; 99: 17107-17112.
2. Barr RK, Kendrick TS, Bogoyevitch MA. Identification of the critical features of a small peptide inhibitor of JNK activity. J Biol Chem 2002; 277: 10987-10997.
3. Behrens A, Sibilia M, Wagner EF. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet 1999; 21: 326-329.
4. Bhalla, US, Iyengar, R. Emergent properties of networks of biological signaling pathways. Science 1999; 283: 381-387.
5. Bodmer D, Gloddek B, Ryan AF, Huverstuhl J, Brors D. Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro. Laryngoscope 2002; 112: 2057-2061.
6. Borsello T, Bonny C. Use of cell-permeable peptides to prevent neuronal degeneration. Trends Mol Med 2004; 10: 239-244.
7. Borsello T, Clarke PGH, Hirt L, Vercelli A, Repici M, Schorderet DF, Bogousslavsky J, Bonny C. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nature Med 2003; 9: 1180-1186.
8. Borsello T, Croquelois K, Hornung JP, Clarke PG. N-Methyl-D-aspartate- triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c-Jun N-terminal kinase pathway. Eur J Neurosci 2003; 18: 473-485.
9. 2-terminal protein kinase inhibitor with neuroprotective properties. J Pharmacol Exp Ther 2004; 310: 25-32.
10. Conlon BJ, Aran JM, Erre JP, Smith DW. Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid. Hear Res 1999; 128: 40-44.
11. Finkel T. Oxygen radicals and signaling. Curr Opin Cell Biol 1998; 10: 248-253.
12. Forge A. Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment. Hear Res 1985; 19: 171-182.
13. Forge A, Li L. Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear Res 2000; 139: 97-115.
14. Gallo KA, Johnson GL. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol 2002; 3: 663-672.
15. Gupta S, Campbell D, Derijard B, Davis RJ. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 1995; 267: 389-393.
16. Halazonetis D, Georgopoulos K, Greenberg, ME, Leder P. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 1998; 55: 917-924.
17. Harris CA, Deshmukh M, Tsui-Pierchala B, Maroney A, Johnson EM Jr. Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons J Neurosci 2002; 22: 103-113.
18. Hu BH, Henderson D, Nicotera TM. Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise. Hear Res 2002; 166: 62-71.
19. Huang T, Cheng AG, Stupak H, Liu W, Kim A, Staecker H, Lefebvre PP, Malgrange B, Kopke RD, Moonen G, Van De Water TR. Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategies. Int J Dev Neurosci 2000; 18: 259-270.
20. Ip T, Davis RJ. Signal transduction by the c-Jun N-terminal kinase (JNK) from inflammation to development. Curr Opin Cell Biol 1998; 10: 205-219.
21. Jacono AA, Hu B, Kopke RD, Henderson D, Van De Water T, Steinman HM. Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla. Hear Res 1998; 117: 31-38.
22. Kelkar N, Gupta S, Dickens M, Davis RJ. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol Cell Biol 2000; 20: 1030-1043.
23. Kim HS, Park CH, Cha SH, Lee JH, Lee S, Kim Y, Rah JC, Jeong SJ, Suh YH, et al. Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity. FASEB J 2000; 14: 1508-1517.
24. 2+-mediated activation of c-Jun N-terminal kinase and nuclear factor kappa B by NMDA in cortical cell cultures. J Neurochem 1998; 71: 1390-1395.
25. Kopke R, Allen KA, Henderson D, Hoffer M, Frenz D, Van De Water TR. A radical demise. Toxins and trauma share common pathways in hair cell death. Ann NY Acad Sci 1999; 884: 171-191.
26. Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 1999; 22: 667-676.
27. Lefebvre PP, Malgrange B, Lallemend F, Staecker H, Moonen G, Van De Water TR. Mechanisms of cell death in the injured auditory system: otoprotective strategies. Audiol Neuro Otol 2002; 3: 165-170.
28. Legos JJ, Tuma RF, Barone FC. Pharmacological interventions for stroke: failures and future. Expert Opin Invest Drugs 2002; 11: 603-614.
29. 2-terminal kinases. J Biol Chem 1996; 271: 15703-15707.
30. Lynch ED, Gu R, Pierce C, Kil J. Ebselen-mediated protection from single and repeated noise exposure in rat. Laryngoscope 2004; 114: 333-337.
31. Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, Vaught JL. CEP-1347 (KT7515), a semi-synthetic inhibitor of the mixed lineage kinase family. J Biol Chem 2001; 276: 25302-25308.
32. Maroney AC, Glicksman MA, Basma AN, Walton KM, Knight EJR, Murphy CA, Bartlett BA, Finn JP, Angeles T, Matsuda Y, Neff NT, Dionne CA. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J Neurosci 1998; 18: 104-111.
33. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995; 80: 179-185.
34. May MJ, D'Acquisto F, Madge LA, Glockner J, Pober JS, Ghosh S. Selective inhibition of NF-κB activation by a peptide that blocks the interaction of NEMO with the KB kinase complex. Science 2000; 289: 1550-1554.
35. Meloche S, Seuwen K, Pagés G, Pouysségur J. Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. Mol Endocrinol 1992; 6: 845-854.
36. Ogita K, Matsunobu T, Schacht J. Acoustic trauma enhances DNA binding of transcription factor AP-1 in the guinea pig inner ear. NeuroReport 2000; 20: 859-862.
37. Olney JW, Labruyere J, Price MT. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 1989; 244: 1360-1362.
38. Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, Walton KM. Ylikoski J. Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 2000; 20: 43-50.
39. Priuska EM, Schacht J. Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol 1995; 50: 1749-1752.
40. Saporito MS, Brown EM, Miller MS, Carswell S. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo. J Pharmacol Exp Ther 1999; 288: 421-427.
41. Savinainen A, Garcia EP, Dorow D, Marshall J, Liu YF. Kainate receptor-activation induces mixed lineage kinase-mediated cellular signaling via post-synaptic density protein 95. J Biol Chem 2001; 276: 11382-11386.
42. Scarpidis U, Madnani D, Shoemaker C, Fletcher C, Kojima K, Eshraghi AA Staecker H, Lefebvre PP, Malgrange B, Balkany TJ, Van De Water TR. Arrest of apoptosis in auditory neurons: implications for sensorineural preservation in cochlear implantation. Otol Neurotol 2003; 24: 409-417.
43. Schauwecker PE. Seizure-induced neuronal death is associated with induction of c-Jun N-terminal kinase and is dependent on genetic background. Brain Res 2000; 884: 116-128.
44. Shizuki K, Ogawa K, Matsunobu T, Kanzaki J, Ogita K. Expression of c-Fos after noise-induced temporary threshold shift in the guinea pig cochlea. Neurosci Lett 2002; 320: 73-76.
45. Steinberg GK, Panahian N, Perez-Pinzon MA, Sun GH, Modi MW, Sepinwall J. Narrow temporal therapeutic window for NMDA antagonist protection against focal cerebral ischaemia. Neurobiol Dis 1995; 2: 109-118.
46. Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000; 288: 870-874.
47. Traverse S, Seedorf, K, Paterson H, Marshall CJ, Cohen P, Ullrich A. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol 1994; 4: 694-701.
48. Vago P, Humbert G, Lenoir M. Amikacin intoxication induces apoptosis and cell proliferation in rat organ of Corti. NeuroReport 1998; 9: 431-436.
49. Wang J, Van De Water TR, Bonny C, de Ribaupierre F, Puel JL, Zine A. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci 2003; 23: 8596-8607.
50. Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis RJ. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 1998; 281: 1671-1674.
51. Wu DC, Ye W, Che XM, Yang GY. Activation of mitogen-activated protein kinases after permanent cerebral artery occlusion in mouse brain. J Cereb Blood Flow Metab 2000; 20: 1320-1330.
52. Xu Z, Kukekov NV, Greene LA. POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J 2003; 22: 252-261.
53. Yamasoba T, Nuttall AL, Harris C, Raphael Y, Miller JM. Role of glutathione in protection against noise-induced hearing loss. Brain Res 1998; 784: 82-90.
54. Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic P, Flavell RA. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997; 389: 865-870.
55. Ylikoski J, Xing-Qun L, Virkkala J, Pirvola U. Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death. Hear Res 2002; 163: 71-81.
56. Yoshizumi M, Fujita Y, Izawa Y, Suzaki Y, Kyaw M, Ali N, Tsuchiya K, Kagami S, Yano S, Sone S, Tamaki T. Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells. Exp Cell Res 2004; 292: 1-10.
57. Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H, Smith MA. Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem 2001; 76: 435-441.
58. Zipfel GJ, Babcock DJ, Lee JM, Choi DW. Neuronal apoptosis after CNS injury: the roles of glutamate and calcium. J Neurotrauma 2000; 17: 857-869.
59. Zivin JA. Current status of new drug development for ischemic stroke. In: Hsu CY, ed. Ischemic Stroke: From Basic Mechanisms to New Drug Development. Monographs in Clinical Science, Vol. 16. Basel: Karger, 1998; 128-138.