Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death

Hearing Research

Volumn 163, Issue 1-2, 2002, Pages 71-81

  Ylikoski, Jukka ^a,b   Xing Qun, Liang ^a,b   Virkkala, Jussi ^b   Pirvola, Ulla ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

c Jun N terminal kinase signalling; Cellular death; Cellular stress; Hair cell; Inner ear; Ototoxicity

Indexed keywords

CEP 1347; GENTAMICIN; STRESS ACTIVATED PROTEIN KINASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUDITORY STIMULATION; AUDITORY SYSTEM; CELL DAMAGE; CELL DEATH; CELL LOSS; COCHLEA; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM; FEMALE; GUINEA PIG; HAIR CELL; INNER EAR; INTOXICATION; NOISE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VESTIBULAR SYSTEM;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; CARBAZOLES; CELL DEATH; COCHLEA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; GENTAMICINS; GUINEA PIGS; HAIR CELLS; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEOMYCIN; VESTIBULE;

EID: 0036154388     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5955(01)00380-X     Document Type: Article

References (46)

1. Role of redox potential and reactive oxygen species in stress signalling
2. N-Methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss
3. The biochemistry of cell death by apoptosis
4. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants
5. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
6. Rapid suppression of free radical formation by NGF involves the mitogen-activated protein kinase pathway
7. Oxygen radicals and signaling
8. Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment
9. Apoptotic death of hair cells in mammalian vestibular sensory epithelia
10. Aminoglycoside antibiotics
11. Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo
12. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro
13. Intense noise-induced apoptosis in hair cells of guinea pig cochlea
14. Formation of a cytotoxic metabolite from gentamicin by liver
15. Use of poly-L-aspartic acid to inhibit aminoglycoside cochlear ototoxicity
16. Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development
17. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
18. Apoptosis
19. A radical demise; Toxins and trauma share common pathways in hair cell death
20. The stress-activated protein kinase subfamily of c-Jun kinases
21. Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear
22. Regional differences in sensitivity of the vestibular sensory epithelia to ototoxic antibiotics
23. Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases
24. The protective effect of brain-derived neurotrophic factor after gentamicin ototoxicity
25. CEP-1347/KT7515 rescues motoneurons from apoptosis and inhibits a stress activated protein kinase pathway
26. Proteasome inhibitors activate stress kinases and induce Hsp72
27. JNK and p38 stresskinases-degenerative effectors of signal-transduction-cascades in the nervous system
28. Gentamicin ototoxicity induced apoptosis of the vestibular hair cells of guinea pigs
29. Apoptosis of guinea pig cochlear hair cells following chronic aminoglycoside treatment
30. Rescue of auditory hair cells and neurons by CEP-1347/KT515, an inhibitor of c-Jun N-terminal kinase activation
31. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum
32. Formation of free radicals by gentamicin and iron and evidence for an iron-gentamicin complex
33. Social control of cell survival and cell death
34. Deciphering the mammalian stress response - A stressful task
35. Effects of BDNF and NT-3 on hair cell survival in guinea pig cochlea damaged by kanamycin treatment
36. Biochemical basis of aminoglycoside ototoxicity
37. Formation of free radicals by aminoglycoside antibiotics
38. Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo
39. Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo
40. Cell death in the inner ear associated with aging is apoptotic?
41. Amikacin intoxication induces apoptosis and cell proliferation in rat organ of Corti
42. Constitutive expression of the machinery for programmed cell death
43. Cell death: The significance of apoptosis
44. Correlative studies on the cochlear pathology and hearing loss in guinea pigs after intoxication with ototoxic antibiotics
45. Aminoglycoside ototoxicity: High affinity receptors are expressed in secretory epithelia
46. Heat stress and protection from permanent acoustic injury in mice