Inhibition of the c-Jun N-terminal kinase signaling pathway influences neurite outgrowth of spiral ganglion neurons in vitro

Laryngoscope

Volumn 112, Issue 11, 2002, Pages 2057-2061

  Bodmer, Daniel ^a   Gloddek, Bertrand ^a   Ryan, Allen F ^a   Huverstuhl, Jochen ^a   Brors, Dominik ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

C Jun N terminal kinase; Neurite; Rat; Spiral ganglion neurons

Indexed keywords

NEUROTROPHIN 3; STRESS ACTIVATED PROTEIN KINASE;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; ENZYME INHIBITION; EXPLANT; NERVE CELL CULTURE; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPIRAL GANGLION;

ANALYSIS OF VARIANCE; ANIMALS; CELL CULTURE TECHNIQUES; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEURITES; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPIRAL GANGLION;

EID: 0036844412     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200211000-00028     Document Type: Article

References (23)

1. Pirvola U, Xing-Qun L, Virkkala J, et al. Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 2000;20:43-50.
2. Ylikoski J, Xing-Qun L, Virkkala J, Pirvola U. Blockade of c e-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death. Hear Res 2002;163:71-81.
3. Ernfors P, Duan ML, El Shamy WM, Canlon B. Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3. Nat Med 1996;2:463-467.
4. Lefebvre PP, Van de Water TR, Staecker H, et al. Nerve growth factor stimulates neurite regeneration but not survival of adult auditory neurons in vitro. Acta Otolaryngol 1992;112:288-293.
5. Dazert S, Kim D, Luo L, et al. Focal delivery of fibroblast growth factor-1 by transfected cells induces spiral ganglion neurite targeting in vitro. J Cell Physiol 1998;177:123-129.
6. Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000;10:381-391.
7. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001;410:37-40.
8. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995;270:1326-1331.
9. Dragunow M, Young D, Hughes P, et al. Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain: Injury? Brain Res Mol Brain Res 1993;18:347-352.
10. Yao R, Yoshihara M, Osada H. Specific activation of a c-Jun NH2-terminal kinase isoform and induction of neurite outgrowth in PC-12 cells by staurosporine. J Biol Chem 1997;272:18261-18266.
11. Dragunow M, Xu R, Walton M, et al. c-Jun promotes neurite outgrowth and survival in PC12 cells. Brain Res Mol Brain Res 2000;83:20-23.
12. Van de Water TR, Ruben RJ. Organ culture of the mammalian inner ear. Acta Otolaryngol 1971;71:303-312.
13. Murakata C, Kaneko M, Gessner G, et al. Mixed lineage kinase activity of indolocarbazole analogues. Bioorg Med Chem Lett 2002;12:147-150.
14. Aletsee C, Beros A, Mullen L, et al. Ras/MEK but not p38 signaling mediates NT-3-induced neurite extension from spiral ganglion neurons. J Assoc Res Otolaryngol 2001;2:377-387.
15. Ding DL, Wang J, Salvi R, et al. Selective loss of inner hair cells and type-I ganglion neurons in carboplatin-treated chinchillas: Mechanisms of damage and protection. Ann N Y Acad Sci 1999;884:152-170.
16. Shulman A. The cochleovestibular system/ototoxicity/clinical issues. Ann N Y Acad Sci 1999;884:433-436.
17. Schacht J. Antioxidant therapy attenuates aminoglycoside-induced hearing loss. Ann N Y Acad Sci 1999;884:125-130.
18. Sha SH, Taylor R, Forge A, Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 2001;155:1-8.
19. Huang T, Cheng AG, Stupak H, et al. Oxidative stress-induced apoptosis of cochlear sensory cells: Otoprotective strategies. Int J Dev Neurosci 2000;18:259-270.
20. Farinas I, Jones KR, Backus C, Wang XY, Reichardt LF. Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature 1994;369:658-661.
21. Maroney AC, Finn JP, Bozyczko-Coyne D, et al. CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults. J Neurochem 1999;73:1901-1912.
22. Meyer D, Liu A, Margolis B. Interaction of c-Jun aminoterminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. J Biol Chem 1999;274:35113-35118.
23. Mainiero F, Murgia C, Wary KK, et al. The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J 1997;16:2365-2375.