Neuronal apoptosis after CNS injury: The roles of glutamate and calcium

Journal of Neurotrauma

Volumn 17, Issue 10, 2000, Pages 857-869

  Zipfel, G J ^a   Babcock, D J ^a   Lee, J M ^a   Choi, D W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Excitotoxicity; Hypoxia; Ischemia; Neuroprotection; Stroke; Trauma

Indexed keywords

CALCIUM; CYCLOHEXIMIDE; GLUTAMIC ACID;

APOPTOSIS; CALCIUM CELL LEVEL; CALCIUM CURRENT; HUMAN; NERVE CELL NECROSIS; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NEUROTOXICITY; PATHOGENESIS; PATHOPHYSIOLOGY; REVIEW;

EID: 0033782480     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2000.17.857     Document Type: Review

References (158)

1. Diffuse axonal injury in head injury: Definition, diagnosis and grading
2. Combined mechanical trauma and metabolic impairment in vitro induces NMDA receptor-dependent neuronal cell death and caspase-3-dependent apoptosis
3. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
4. Permeability of the post-synaptic membrane of an excitatory glutamate synapse to sodium and potassium
5. Death receptors: Signaling and modulation
6. N-Methyl-D-aspartate promotes the survival of cerebellar granule cells in culture
7. A review of current evidence for apoptosis after spinal cord injury
8. Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy
9. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
10. + efflux in the activation of apoptosis
11. The role of glutamate antagonists for the treatment of CNS injury
12. AMPA neurotoxicity in cultured cerebellar granule neurons: Mode of cell death
13. Apaf1 and the apoptotic machinery
14. A cautionary note on the use of the TUNEL stain to determine apoptosis
15. Bcl-2 is expressed in neurons that survive focal ischemia in the rat
16. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia
17. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
18. Extracellular calcium deprivation in astrocytes: Regulation of mRNA expression and apoptosis
19. Calcium: Still center-stage in hypoxicischemic neuronal death
20. Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage
21. Ionic dependence of glutamate neurotoxicity in cortical cell culture
22. Ischemia-induced neuronal apoptosis
23. Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases
24. Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia
25. A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome
26. Induction of mitosis in mature neurons in central nervous system by sustained depolarization
27. 2+ signaling in CA1 neurons after brief ischemia in gerbils
28. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
29. + channels in human T lymphocytes: A role in mitogenesis?
30. Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat
31. Pathobiology of ischaemic stroke: An integrated view
32. Neuronal survival and calcium influx induced by basic fibroblast growth factor in chick ciliary ganglion neurons
33. Role of calcium in glucocorticosteroid-induced apoptosis of thymocytes and lymphoma cells: Resurrection of old theories by new findings
34. Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases
35. Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected to transient focal cerebral ischemia
36. Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons
37. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
38. Calcium in the mitochondria following brief ischemia of gerbil brain
39. β-Amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation
40. Caspase pathways, neuronal apoptosis and CNS injury
41. The role of excitatory amino acids and NMDA receptors in traumatic brain injury
42. Both apoptosis and necrosis occur following intrastriatal administration of excitotoxins
43. 45Ca autoradiographic study
44. Neuroprotective action of cycloheximide involves induction of Bcl-2 and antioxident pathways
45. Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: The involvement of intracellular calcium and RNA synthesis
46. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture
47. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
48. Interferon alpha and intracytoplasmic free calcium in hairy cell leukemia cells
49. Effects of cycloheximide on delayed neuronal death in rat hippocampus
50. Caspase inhibition selectively reduces the apoptotic component of oxygen-glucose deprivation-induced cortical neuronal cell death
51. Bcl-2 family gene products in cerebral ischemia and traumatic brain injury
52. Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death
53. Calcium ionophores can induce either apoptosis or necrosis in cultured cortical neurons
54. Slowly triggered excitotoxicity occurs by necrosis in cortical cultures
55. Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro
56. Inhibition of interleukin lbeta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
57. Programmed cell death in Caenorhabditis elegans
58. Lactic acidosis and recovery of mitochondrial function following forebrain ischemia in the rat
59. Correlation of glutamate-induced apoptosis with caspase activities in cultured rat cerebral cortical neurons
60. WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation
61. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
62. Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain
63. Molecular mechanisms of developmental neuronal death
64. Bax directly induces release of cytochrome c from isolated mitochondria
65. Thapsigargin-induced persistent intracellular calcium pool depletion and apoptosis in human hepatoma cells
66. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
67. Amelioration of hippocampal neuronal damage after global ischemia by neuronal overexpression of BCL-2 in transgenic mice
68. Non-NMDA receptor-mediated neurotoxicity in cortical culture
69. Programmed cell death: Its possible contribution to neurotoxicity mediated by calcium channel antagonists
70. 2+ determine nerve growth factor dependence of sympathetic ganglion cells
71. 2+
72. Up-regulation of bax protein levels in neurons following cerebral ischemia
73. Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis
74. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress
75. Effect of glucocorticosteroid treatment on intracellular calcium homeostasis in mouse lymphoma cells
76. 2+ influx
77. Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons
78. The changing landscape of ischaemic brain injury mechanisms
79. Opposing effects of thapsigargin on the survival of developing cerebellar granule neurons in culture
80. p53-Immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats
81. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats
82. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia
83. Kainic acid-induced limbic seizures: Metabolic, behavioral, electroencephalographic and neuropathological correlates
84. Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice
85. Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain
86. Apoptosis following experimental stroke: Fact or fashion
87. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis
88. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
89. The role of calcium in the regulation of apoptosis
90. Excitatory amino acid antagonists and their potential for the treatment of ischaemic brain damage in man
91. Susceptibility to apoptosis is enhanced in immature cortical neurons
92. Alterations of extracellular calcium elicit selective modes of cell death and protease activation in SH-SY5Y human neuroblastoma cells
93. Multisite phosphorylation and the integration of stress signals at p53
94. Protection against hypoxic/ischaemic brain damage with excitatory amino acid antagonist
95. Bcl-2 gene family in the nervous system
96. 2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion
97. The rationale for glutamate antagonists in the treatment of traumatic brain injury
98. Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy
99. Overexpression of Bcl-2 is neuroprotective after experimental brain injury in transgenic mice
100. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia
101. Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy
102. Caspase structure, proteolytic substrates, and function during apoptotic cell death
103. The role of calcium in apoptosis
104. Caspases: The proteases of the apoptotic pathway
105. Acute dendrotoxic changes in the hippocampus of kainate treated rats
106. Nitric oxide induces cultured cortical neuron apoptosis
107. N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain
108. Kainate-induced apoptotic cell death in hippocampal neurons
109. Effects of alterations in calcium homeostasis on apoptosis during neoplastic progression
110. Stimulation of N-methyl-D-aspartate receptors induces apoptosis in rat brain
111. BCL-2 overexpression attenuates cortical cell loss after traumatic brain injury in transgenic mice
112. Apoptosis following traumatic brain injury
113. Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione
114. Clinical trials in head injury
115. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
116. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat
117. Serum deprivation-induced apoptosis in cultured hippocampi is prevented by kainate
118. Glutamate and the pathophysiology of hypoxic-iscchemic brain injury
119. The role of interleukin 1 in acute neurodegeneration and stroke: Pathophysiological and therapeutic implications
120. The molecular mechanisms of neuronal apoptosis
121. Apoptosis: Definition, mechanisms, and relevance to disease
122. Seizure activity and lesions after intrahippocampal quinolinic acid injection
123. Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat brain
124. Programmed cell death, apoptosis and killer genes
125. Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study
126. Accumulation of calcium in the brain following head trauma
127. Apoptosis in vasculature of spontaneously hypertensive rats: Effect of an angiotensin converting enzyme inhibitor and a calcium channel antagonist
128. Reduction of delayed neuronal death by inhibition of protein synthesis
129. 2+] in hypoxia and ischemia in rat brain in vivo
130. Kainic acid induces apoptosis in neurons
131. Depressed intracellular calcium transients and contraction in myocytes from hypertrophied and failing guinea pig hearts
132. Serial killers: Ordering caspase activation events in apoptosis
133. Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons
134. Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by phosphatidylinositol-3 kinase- and MAPK-independent pathways
135. Kainic acid-induced seizures: Neurochemical and histopathological changes
136. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
137. Apoptotic cell death and caspase-3 activation induced by N-methyl-D-aspartate receptor antagonists and their prevention by insulin-like growth factor I
138. 2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons
139. The stimulation of ion fluxes in brain slices by glutamate and other excitatory amino acids
140. Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons
141. Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons
142. Endonuclease activation following focal ischemic injury in the rat brain
143. Intracellular calcium levels influence apoptosis in mature sensory neurons after trophic factor deprivation
144. Death by suicide: One way to go in mammalian cellular development?
145. Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat
146. NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain
147. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein-labelled Annexin V
148. Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores
149. Expression of calbindin-D28k in C6 glial cells stabilizes intracellular calcium levels and protects against apoptosis induced by calcium ionophore and amyloid beta-peptide
150. Cell death: The significance of apoptosis
151. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury
152. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury
153. Diphenylhydantoin induces apoptotic cell death of cultured rat cerebellar granule neurons
154. Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons
155. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
156. Transient elevation of intracellular calcium ion levels as an early event in T-2 toxin-induced apoptosis in human promyelotic cell line HL-60
157. + efflux and neuronal apoptosis
158. Mediation of neuronal apoptosis by enhancement of outward potassium current