Structure-activity relationships within a series of caspase inhibitors: Effect of leaving group modifications

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 20, 2003, Pages 3623-3626

  Ullman, Brett R ^a   Aja, Teresa ^a   Deckwerth, Thomas L ^a   Diaz, Jose Luis ^a   Herrmann, Julia ^a   Kalish, Vincent J ^a   Karanewsky, Donald S ^a   Meduna, Steven P ^a   Nalley, Kip ^a   Robinson, Edward D ^a   Roggo, Silvio P ^b   Sayers, Robert O ^a   Schmitz, Albert ^b   Ternansky, Robert J ^a   Tomaselli, Kevin J ^a   Wu, Joe C ^a  

^a PFIZER INC   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CASPASE 3; CASPASE 6; CASPASE 8; CASPASE INHIBITOR; INTERLEUKIN 1BETA CONVERTING ENZYME;

ARTICLE; CELL DAMAGE; CELL DEATH; DRUG DEVELOPMENT; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

EID: 10744229934     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00755-8     Document Type: Article

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