Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex

Nature

Volumn 410, Issue 6827, 2001, Pages 494-497

  Xu, Guozhou ^a   Cirilli, Maurizio ^a,b   Huang, Yihua ^c   Rich, Rebecca L ^d   Myszka, David G ^d   Wu, Hao ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b CNR   (Italy)

^c Weill Cornell Graduate School of Biomedical Sciences   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; PROTEIN P35;

APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME INHIBITION; GEL ELECTROPHORESIS; HUMAN; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; REGULATORY MECHANISM; STRUCTURE ANALYSIS;

BINDING SITES; CASPASE 8; CASPASE 9; CASPASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; VIRAL PROTEINS;

EID: 0035932465     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35068604     Document Type: Article

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