Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

Human Molecular Genetics

Volumn 14, Issue 5, 2005, Pages 679-691

  Bowman, Aaron B ^a   Yoo, Seung Yun ^a,c   Dantuma, Nico P ^b   Zoghbi, Huda Y ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 7; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; POLYGLUTAMINE; PROTEASOME; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS INCLUSION BODY; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; ENZYME DEFECT; FEMALE; IN VITRO STUDY; MALE; MOUSE; NERVE CELL; NEUROPATHY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REPORTER GENE; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; GENES, REPORTER; INTRANUCLEAR INCLUSION BODIES; MICE; NERVE TISSUE PROTEINS; NEURONS; PEPTIDES; PHOTORECEPTORS; PROTEASOME ENDOPEPTIDASE COMPLEX; RNA, MESSENGER; SPINOCEREBELLAR ATAXIAS; UBIQUITIN;

EID: 14644419638     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddi064     Document Type: Article

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