Apoptosis resistance in peripheral blood lymphocytes of alopecia areata patients

Journal of Autoimmunity

Volumn 23, Issue 3, 2004, Pages 241-256

  Zöller, Margot ^a,b   McElwee, Kevin J ^c   Vitacolonna, Mario ^a   Hoffmann, Rolf ^c  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF KARLSRUHE   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Apoptosis; Autoimmunity; Cell surface molecules; Human; T lymphocytes

Indexed keywords

CD4 ANTIGEN; CD40 LIGAND; CD44V ANTIGEN; FAS ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; PROTEIN SUBUNIT;

ADOLESCENT; ADULT; ALOPECIA AREATA; APOPTOSIS; ARTICLE; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION;

EID: 14244250952     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaut.2004.08.002     Document Type: Article

References (77)

1. K.H. Safavi, S.A. Muller, V.J. Suman, A.N. Moshell, and L.J. Melton 3rd Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989 Mayo Clin Proc 70 1995 628 633
2. K. McElwee, P. Freyschmidt-Paul, A. Ziegler, R. Happle, and R. Hoffmann Genetic susceptibility and severity of alopecia areata in human and animal models Eur J Dermatol 11 2001 11 16
3. S.A. Muller, and R.K. Winkelmann Alopecia areata. An evaluation of 736 patients Arch Dermatol 88 1963 290 297
4. F.B. De Waard-van der Spek, A.P. Oranje, D.M. De Raeymaecker, and J.D. Peereboom-Wynia Juvenile versus maturity-onset alopecia areata - a comparative retrospective clinical study Clin Exp Dermatol 14 1989 429 433
5. A.T. Gulec, N. Tanriverdi, C. Duru, Y. Saray, and C. Akcali The role of psychological factors in alopecia areata and the impact of the disease on the quality of life Int J Dermatol 43 2004 352 356
6. R.A. Schwartz, and C.K. Janniger Alopecia areata Cutis 59 1997 238 241
7. A. Tosti, R. Morelli, F. Bardazzi, and A.M. Peluso Prevalence of nail abnormalities in children with alopecia areata Pediatr Dermatol 11 1994 112 115
8. A. Tosti, S. Colombati, G.M. Caponeri, C. Ciliberti, G. Tosti, and M. Bosi Ocular abnormalities occurring with alopecia areata Dermatologica 170 1985 69 73
9. C. Perret, L. Wiesner-Menzel, and R. Happle Immunohistochemical analysis of T-cell subsets in the peribulbar and intrabulbar infiltrates of alopecia areata Acta Derm Venereol 64 1984 26 30
10. D.J. Tobin Characterization of hair follicle antigens targeted by the anti-hair follicle immune response J Invest Dermatol Symp Proc 8 2003 176 181
11. R.S. Kalish, and A. Gilhar Alopecia areata: autoimmunity - the evidence is compelling J Invest Dermatol Symp Proc 8 2003 164 167
12. P. Freyschmidt-Paul, R. Happle, K.J. McElwee, and R. Hoffmann Alopecia areata: treatment of today and tomorrow J Invest Dermatol Symp Proc 8 2003 12 17
13. A.J. McDonagh, and R. Tazi-Ahnini Epidemiology and genetics of alopecia areata Clin Exp Dermatol 27 2002 405 409
14. R. Paus, A. Slominski, and B.M. Czarnetzki Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb? Yale J Biol Med 66 1993 541 554
15. K.J. McElwee, R. Hoffmann, P. Freyschmidt-Paul, E. Wenzel, S. Kissling, and J.P. Sundberg Resistance to alopecia areata in C3H/HeJ mice is associated with increased expression of regulatory cytokines and a failure to recruit CD4+ and CD8+ cells J Invest Dermatol 119 2002 1426 1433
16. M. Zöller, K.J. McElwee, P. Engel, and R. Hoffmann Transient CD44 variant isoform expression and reduction in CD4(+)/CD25(+) regulatory T cells in C3H/HeJ mice with alopecia areata J Invest Dermatol 118 2002 983 992
17. M. Zöller, K.J. McElwee, M. Vitacolonna, and R. Hoffmann The progressive state, in contrast to the stable or regressive state of alopecia areata, is reflected in peripheral blood mononuclear cells Exp Dermatol 13 2004 435 444
18. E. Suri Payer, A.Z. Amar, A.M. Thornton, and E.M. Shevach CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells J Immunol 160 1998 1212 1218
19. D. Dieckmann, H. Plottner, S. Berchtold, T. Berger, and G. Schuler Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood J Exp Med 193 2001 1303 1310
20. H. Jonuleit, E. Schmitt, M. Stassen, A. Tuettenberg, J. Knop, and A.H. Enk Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood J Exp Med 193 2001 1285 1294
21. M.K. Levings, R. Sangregorio, and M.G. Roncarolo Human CD25(+)CD4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function J Exp Med 193 2001 1295 1302
22. E.M. Shevach Certified professionals: CD4+CD25+ suppressor T cells J Exp Med 193 2001 41 45
23. M. Asano, M. Toda, N. Sakaguchi, and S. Sakaguchi Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation J Exp Med 184 1996 387 396
24. S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains CD25. Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol 155 1995 1151 1164
25. B. Singh, S. Read, C. Asseman, V. Malmstrom, C. Mottet, and L.A. Stephens Control of intestinal inflammation by regulatory T cells Immunol Rev 182 2001 190 200
26. R.S. McHugh, and E.M. Shevach Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease J Immunol 168 2002 5979 5983
27. A. Saoudi, B. Seddon, D. Fowell, and D. Mason The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients J Exp Med 184 1996 2393 2398
28. M.S. Jordan, A. Boesteanu, A.J. Reed, A.L. Petrone, A.E. Holenbeck, and M.A. Lerman Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide Nat Immunol 2 2001 301 306
29. D.Y. Wu, and I. Goldschneider Tolerance to cyclosporin A-induced autologous graft-versus-host disease is mediated by a CD4+CD25+ subset of recent thymic emigrants J Immunol 166 2001 7158 7164
30. R. Pacholczyk, P. Kraj, and L. Ignatowicz Peptide specificity of thymic selection of CD4+CD25+ T cells J Immunol 168 2002 613 620
31. W.F. Ng, P.J. Duggan, F. Ponchel, G. Matarese, G. Lombardi, and A.D. Edwards Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells Blood 98 2001 2736 2744
32. E. Chiffoleau, G. Beriou, P. Dutartre, C. Usal, J.P. Soulillou, and M.C. Cuturi Role for thymic and splenic regulatory CD4+ T cells induced by donor dendritic cells in allograft tolerance by LF15-0195 treatment J Immunol 168 2002 5058 5069
33. L.S. Taams, M. Vukmanovic-Stejic, J. Smith, P.J. Dunne, J.M. Fletcher, and F.J. Plunkett Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells Eur J Immunol 32 2002 1621 1630
34. C. Baecher-Allan, J.A. Brown, G.J. Freeman, and D.A. Hafler CD4+CD25 high regulatory cells in human peripheral blood J Immunol 167 2001 1245 1253
35. B. Salomon, D.J. Lenschow, L. Rhee, N. Ashourian, B. Singh, and A. Sharpe B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes Immunity 12 2000 431 440
36. T. Takahashi, T. Tagami, S. Yamazaki, T. Uede, J. Shimizu, and N. Sakaguchi Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4 J Exp Med 192 2000 303 310
37. A.M. Thornton, and E.M. Shevach CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production J Exp Med 188 1998 287 296
38. L.A. Stephens, C. Mottet, D. Mason, and F. Powrie Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro Eur J Immunol 31 2001 1247 1254
39. D. Dieckmann, C.H. Bruett, H. Plöttner, M.B. Lutz, and G. Schuler Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells J Exp Med 196 2002 247 253
40. H. Jonuleit, E. Schmitt, H. Kakirman, M. Stassen, J. Knop, and A.H. Enk Infectious tolerance: human CD25+ regulatory T cell convey suppressor activity on conventional CD4+ T helper cells J Exp Med 196 2002 255 260
41. J.A. Williams, S.O. Sharrow, A.J. Adams, and R.J. Hodes CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes J Immunol 168 2002 2759 2765
42. A. Kumanogoh, X. Wang, I. Lee, C. Watanabe, M. Kamanaka, and W. Shi Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development J Immunol 166 2001 353 360
43. N. Föger, R. Marhaba, and M. Zöller CD44 supports T cell proliferation and apoptosis by apposition of protein kinases Eur J Immunol 30 2000 2888 2899
44. Y. Ohtani, X.Y. Zhou, K. Toyo-Oka, X.G. Tai, C.S. Park, and T. Hamaoka Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts J Immunol 164 2000 1251 1259
45. D.G. Jackson, J.I. Bell, R. Dickinson, J. Timans, J. Shields, and N. Whittle Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon J Cell Biol 128 1995 673 685
46. H.C. DeGrendele, P. Estess, and M.H. Siegelman Requirement for CD44 in activated T cell extravasation into an inflammatory site Science 278 1997 672 675
47. S.N. Wagner, C. Wagner, U. Reinhold, R. Funk, M. Zöller, and M. Goos Predominant expression of CD44 splice variant v10 in malignant and reactive human skin lymphocytes J Invest Dermatol 111 1998 464 471
48. S. Seiter, P. Engel, N. Föhr, and M. Zöller Mitigation of delayed-type hypersensitivity reactions by a CD44 variant isoform v3-specific antibody: blockade of leukocyte egress J Invest Dermatol 113 1999 11 21
49. K.L. Bennett, D.G. Jackson, J.C. Simon, E. Tanczos, R. Peach, and B. Modrell CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor J Cell Biol 128 1999 687 698
50. G.F. Weber, S. Ashkar, M.J. Glimcher, and H. Cantor Receptor-ligand interaction between CD44 and osteopontin Eta-1 Science 271 1996 509 512
51. H.U. Grimme, C.C. Termeer, K.L. Bennett, J.M. Weiss, E. Schopf, and A. Aruffo Colocalization of basic fibroblast growth factor and CD44 isoforms containing the variably spliced exon v3 CD44v3; in normal skin and in epidermal skin cancers Br J Dermatol 141 1999 824 832
52. Y.U. Katagiri, J. Sleeman, H. Fujii, P. Herrlich, H. Hotta, and K. Tanaka CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis Cancer Res 59 1999 219 226
53. R. van der Voort, T.E. Taher, V.J. Wielenga, M. Spaargaren, R. Prevo, and L. Smit Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met J Biol Chem 274 1999 6499 6506
54. S. Seiter, D.S. Schmidt, and M. Zöller The CD44 variant isoforms CD44v6 and CD44v7 are expressed by distinct leukocyte subpopulations and exert non-overlapping functional activities Int Immunol 12 2000 37 49
55. S. Seiter, D. Schadendorf, W. Tilgen, and M. Zöller CD44 variant isoform expression in a variety of skin-associated autoimmune diseases Clin Immunol Immunopathol 89 1998 79 93
56. B. Wittig, S. Seiter, D.S. Schmidt, M. Zuber, M. Neurath, and M. Zöller CD44 variant isoforms on blood leukocytes in chronic inflammatory bowel disease and other systemic autoimmune diseases Lab Invest 79 1999 747 759
57. B. Wittig, C. Schwärzler, N. Föhr, U. Günthert, and M. Zöller Curative treatment of an experimentally induced colitis by a CD44 variant V7-specific antibody J Immunol 161 1998 1069 1073
58. B.M. Wittig, B. Johansson, M. Zöller, C. Schwärzler, and U. Günthert Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 CD44v7 J Exp Med 191 2000 2053 2064
59. J.D. Mountz, T. Zhou, X. Su, J. Cheng, M. Pierson, and H. Bluethmann Autoimmune disease results from multiple interactive defects in apoptosis induction molecules and signaling pathways Behring Inst Mitt 97 1996 200 219
60. L. van Parijs, V.L. Perez, and A.K. Abbas Mechanisms of peripheral T cell tolerance Novartis Found Symp 215 1998 5 14
61. R. Marhaba, M. Bourouba, and M. Zöller Chronic inflammatory bowel disease as a consequence of CD44v7-mediated upregulation of anti-apoptotic gene expression J Leukoc Biol 74 2003 135 148
62. E. Olsen, M. Hordinsky, S. McDonald-Hull, M. Price, J. Roberts, and J. Shapiro Alopecia areata investigational assessment guidelines Natl Alopecia Areata Found J Am Acad Dermatol 40 1999 242
63. C. Cotellessa, K. Peris, E. Caracciolo, C. Mordenti, and S. Chimenti The use of topical diphenylcyclopropenone for the treatment of extensive alopecia areata J Am Acad Dermatol 44 2001 73 76
64. L.J. Wysocki, and V.L. Sato "Panning" for lymphocytes: a method for cell selection Proc Natl Acad Sci U S A 75 1978 2844 2848
65. S. Seiter, W. Tilgen, K. Herrmann, D. Schadendorf, E. Patzelt, and P. Möller Expression of CD44 splice variants in human skin and epidermal tumours Virchows Arch 428 1996 141 149
66. I. Vermes, C. Haanen, H. Steffens-Naken, and C. Reutelinsperger A novel assay for apoptosis. Flow cytometric detection of phosphatitylserine expression on early apoptotic cells using fluorescein labelled Annexin V J Immunol Methods 184 1995 39 51
67. L.S.K. Walker, and A.K. Abbas The enemy within: keeping self-reactive T cells at bay in the periphery Nature Rev Immunol 2 2002 11 19
68. E.Y. Woo, H. Yeh, C.S. Chu, K. Schlienger, R.G. Carroll, and J.L. Riley Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation J Immunol 168 2002 4272 4276
69. A. Bhandoola, K. Yui, R.M. Siegel, L. Zerva, and M.I. Greene Gld and lpr mice: single gene mutant models for failed self tolerance Int Rev Immunol 11 1994 231 244
70. L.A. O'Reilly, and A. Strasser Apoptosis and autoimmune disease Inflamm Res 48 1999 5 21
71. L. Ricci-Vitiani, C. Conticello, A. Zeuner, and R. De Maria CD95/CD95L interactions and their role in autoimmunity Apoptosis 5 2000 419 424
72. D.A. Hildeman, Y. Zhu, T.C. Mitchell, J. Kappler, and P. Marrack Molecular mechanisms of activated T cell death in vivo Curr Opin Immunol 14 2002 354 359
73. O. Seidi, and M. Sharief The expression of apoptosis-regulatory proteins in B lymphocytes from patients with multiple sclerosis J Neuroimmunol 130 2002 202 210
74. M.K. Sharief, M. Douglas, M. Noori, and Y.K. Semra The expression of pro- and anti-apoptosis Bcl-2 family proteins in lymphocytes from patients with multiple sclerosis J Neuroimmunol 125 2002 155 162
75. C. Bodemer, M. Peuchmaur, S. Fraitaig, L. Chatenoud, N. Brousse, and Y. deProst Role of cytotoxic T cells in chronic alopecia areata J Invest Dermatol 114 2000 112 116
76. lpr mice are not susceptible to alopecia areata after grafting of alopecia areata-affected skin from C3H/HeJ mice J Invest Dermatol Symp Proc 8 2003 104 108
77. O.D. Perez, S. Kinoshita, Y. Hitoshi, D.G. Payan, T. Kitamura, and G.P. Nolan Activation of the PKB/AKT pathway by ICAM 2 Immunity 16 2002 51 65