Cutting edge: Curative treatment of an experimentally induced colitis by a CD44 variant V7-specific antibody

Journal of Immunology

Volumn 161, Issue 3, 1998, Pages 1069-1073

  Wittig, Bianca ^a   Schwärzler, Christoph ^b   Föhr, Nicole ^a   Günthert, Ursula ^b   Zöller, Margot ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; CD44V ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MONOCLONAL ANTIBODY; OVALBUMIN; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; HERMES ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELPER CELL; INTERFERON PRODUCTION; INTRAVENOUS DRUG ADMINISTRATION; LAMINA PROPRIA; LYMPH NODE CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; RECTAL DRUG ADMINISTRATION; SUBCUTANEOUS DRUG ADMINISTRATION; ANIMAL; ANTIBODY SPECIFICITY; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; ENTERITIS; IMMUNOLOGY; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; TH1 CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, CD44; COLITIS; CYTOKINES; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MICE; MICE, INBRED BALB C; TH1 CELLS; TRINITROBENZENESULFONIC ACID;

EID: 0032134179     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Willenbucher, R. F. 1996. Inflammatory bowel disease. Semin. Gastrointest. Dis. 7:94.
2. Lofberg, R. 1997. Medical treatment for inflammatory bowel disease: refinements and new modalities. J. Int. Med. 241:1.
3. Elson, C. O. 1996. The basis of current and future therapy for inflammatory bowel disease. Am. J. Med. 100:656.
4. MacDonald, T. T. 1994. Gastrointestinal inflammation. Inflammatory bowel disease in knockout mice. Curr. Biol. 4:261.
5. Powrie, F., and M. W. Leach. 1995. Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation. Ther. Immunol. 2:115.
6. Bhatti, M. A., and H. J. Hodgson. 1995. Animal models of inflammatory bowel disease. Int. J. Exp. Pathol. 76: 309.
7. Elson, C. O., R. B. Sartor, G. S. Tennyson, and R. H. Riddell. 1995. Experimental models of inflammatory bowel disease. Gastroenterology 109:1344.
8. Strober, W., B. Kelsall, I. Fuss, T. Marth, B. Ludviksson, R. Ehrhardt, and M. Neurath. 1997. Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation. Immunol. Today 18:61.
9. + T cells. Immunity 1:553.
10. Neurath, M. F., I. Fuss, B. L. Kelsall, E. Stuber, and W. Strober. 1995. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281.
11. Van Deventer, S. J. 1997. Tumour necrosis factor and Crohn's disease. Gut 40: 443.
12. Arch, R., K. Wirth, M. Hofmann, H. Ponta, S. Matzku, P. Herrlich, and M. Zöller. 1992. Participation in normal immune responses of a metastasis-inducing splice variant of CD44. Science 257:682.
13. Guo, Y., Y. Wu, S. Shinde, M. S. Sy, A. Aruffo, and Y. Liu. 1996. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J. Exp. Med. 184:955.
14. lck in T lymphocytes. J. Biol. Chem. 271:2863.
15. Wittig, B., S. Seiter, N. Föger, C. Schwärzler, U. Günthert, and M. Zöller. 1996. Functional activity of murine CD44 variant isoforms in allergic and delayed type hypersensitivity. Immunol. Lett. 57:217.
16. Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
17. Fitch, F. W., M. D. McKisic, D. W. Lancki, and T. F. Gajewski. 1993. Differential regulation of murine T lymphocyte subsets. Annu. Rev. Immunol. 11:29.
18. Segal, B. M., D. K. Dwyer, and E. M. Shevach. 1998. An interleukin (IL)-10/ IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187:537.
19. Grewal, I. S., and R. A. Flavell. 1996. The role of CD40 ligand in costimulation and T-cell activation. Immunol. Rev. 153:85.
20. + T cells via CD40 ligand. Proc. Natl. Acad. Sci. USA 94:599.
21. Stuber, E., W. Strober, and M. Neurath. 1996. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J. Exp. Med. 183:693.