CD44 variants but not CD44s cooperate with β1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine- aspartic acid, thereby stimulating cell motility and chemotaxis

Cancer Research

Volumn 59, Issue 1, 1999, Pages 219-226

  Katagiri, Yohko U ^a   Sleeman, Jonathan ^b   Fujii, Hideki ^c   Herrlich, Peter ^b   Hotta, Hiroshi ^a   Tanaka, Kumiko ^a   Chikuma, Shunsuke ^a   Yagita, Hideo ^d   Okumura, Ko ^d   Murakami, Masaaki ^a   Saiki, Ikuo ^c   Chambers, Ann F ^e   Uede, Toshimitsu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF TOYAMA   (Japan)

^d JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; INTEGRIN; OSTEOPONTIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; CELL SPREADING; CHEMOTAXIS; FLOW CYTOMETRY; METASTASIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIGENS, CD29; ANTIGENS, CD44; ARGININE; ASPARTIC ACID; BINDING SITES; CHEMOTAXIS; GLYCINE; OSTEOPONTIN; PROTEIN BINDING; RATS; SIALOGLYCOPROTEINS; TUMOR CELLS, CULTURED;

EID: 0032926684     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Denhardt, D. T., and Guo, X. Osteopontin: a protein with diverse functions. FASEB J., 7: 1475-1482, 1993.
2. Behrend, E. I., Craig, A. M., Wilson, S. M., Denhardt, D., and Chambers, A. F. Reduced malignancy of ras-transformed NIH 3T3 cells expressing antisense osteopontin RNA. Cancer Res., 54: 832-837, 1994.
3. Patarca, R., Saavedra, R. A., and Cantor, H. Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/ osteopontin gene. Crit. Rev. Immunol., 13: 225-246, 1993.
4. Oates, A. J., Barraclough, R., and Rudland, P. S. The role of osteopontin in tumorigenesis and metastasis. Invasion Metastasis, 17: 1-15, 1997.
5. Singhal, H., Bautista, D. S., Tonkin, K. S., O'Malley, F. P., Tuck, A. B., Chambers, A. F., and Harris, J. F. Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival. Clin. Cancer Res., 3: 605-611, 1997.
6. Tuck, A. B., O'Malley, F. P., Singhal, H., Tonkin, K. S., Harris, J. F., Bautista, D., and Chambers, A. F. Osteopontin (OPN) and p53 expression are associated with tumor progression in a case of synthronous, bilateral, invasive mammary carcinomas. Arch. Pathol. Lab. Med., 121: 578-584, 1997.
7. Helfrich, M. H., Nesbitt, S. A., Dorey, E. L., and Horton, M. A. Rat osteoblasts adhere to a wide range of RGD (Arg-Gly-Asp) peptide-containing proteins, including the bone sialoproteins and fibronectin, via a β 3 integrin. J. Bone Miner. Res., 7: 335-343, 1994.
8. Hu, D. D., Lin, E. C. K., Kovach, N. L., Hoyer, J. R., and Smith, J. W. A biochemical characterization of the binding of osteopontin to integrin αvβ3, αvβ1 and αvβ5. J. Biol. Chem., 270: 2632-2638, 1995.
9. Liaw, L., Skinner, M. P., Ranies, E. W., Ross, R., Cheresh, D. A., Schwartz, S. M., and Giachelli, C. M. The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins: role of αvβ3 in smooth muscle migration to osteopontin in vitro. J. Clin. Invest., 95: 713-724, 1995.
10. Smith, L. L., Cheung, H-K., Ling, L. E., Chen, J., Sheppard, D., Pytela, R., and Giachelli, C. M. Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by α9β1 integrin. J. Biol. Chem., 271: 28485-28491, 1996.
11. Katagiri, Y., Murakami, M., Mori, K., Iizuka, J., Hara, T., Tanaka, K., Jia, W-J., Chambers, A. F., and Uede, T. 1996. Non-RGD domains of osteopontin promote cell adhesion without involving αv integrins. J. Cell. Biochem., 62: 123-131, 1996.
12. Weber, G. F., Ashkar, S., Glimcher, M. J., and Cantor, H. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science (Washington DC), 271: 509-512, 1996.
13. Herrlich, P., Zoller, M., Pals, S. T., and Ponta, H. CD44 splice variants: metastasis meet lymphocytes. Immunol. Today, 14: 395-399, 1993.
14. Knudson, C. B., and Knudson, W. Hyaluronan-binding protein in development, tissue homeostasis, and disease FASEB J., 7: 1233-1241, 1993.
15. Lesley, J., Hyman, R., and Kincade, P. W. CD44 and its interaction with the cellular matrix. Adv. Immunol., 54: 271-335, 1993.
16. Screaton, G. R., Bell, M. V., Jackson, D. G., Cornelis, F. B., Gerth, U., and Bell, J. I. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc. Natl. Acad. Sci. USA, 89: 12160-12164, 1992.
17. Naot, D., Sionov, R. V., and Ish-Scalom, D. CD44: structure, function and association with the malignant process. Adv. Cancer Res., 71: 241-319, 1997.
18. Sleeman, J. P., Arming, S., Moll, J. F., Hekele, A., Rudy, W., Sherman, L. S., Kreil, G., Ponta, H., and Herrlich, P. Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells. Cancer Res., 56: 3134-3141, 1996.
19. Sleeman, J. P., Ruddy, W., Hofmann, M., Moll, J., Herrlich, P., and Ponta, H. Regulated clustering of variant CD44 proteins increases their hyaluonate binding capacity. J. Cell Biol., 135: 1139-1150, 1996.
20. Sleeman, J. P., Kondo, K., Moll, J., Ponta, H., and Herrlich, P. Variant exons v6 and v7 together expand the repertoire of glycosamino glycans bound by CD44. J. Biol. Chem., 272: 31837-31844, 1997.
21. Gille, J., and Swerlick, R. A. Integrins: role in cell adhesion and communication. Ann. NY Acad. Sci., 797: 93-106, 1996.
22. Imhof, B. A., Piali, L., Gisler, R. H., and Dunon, D. 1996 Involvement of α 6 and α v integrins in metastasis. Curr. Top. Microbiol. Immunol., 213: 195-203, 1996.
23. Varner, J. A., and Cheresh, D. A. Integrins and cancer. Curr. Opin. Cell Biol., 8: 724-730, 1996.
24. Dedhar, S., and Hannigan, G. E. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr. Opin. Cell Biol., 8: 657-669, 1996.
25. Humphreis, M. J. Integrin activation: the link between ligand binding and signal transduction. Curr. Opin. Cell Biol., 8: 632-640, 1996.
26. Matsku, S., Wenzel, A., Liu, S., and Zoller, A. Antigenic differences between metastatic and nonmetastatic BSp73 rat tumor variants characterized by monoclonal antibodies. Cancer Res., 49: 1294-1299, 1989.
27. Weiss, J. M., Sleeman, J. P., Renkl, A. C., Dittmar, H., Termeer, C. C., Taxis, S., Howells, N., Hofmann, M., Kohler, G., Schopf, E., Ponta, H., Herrlich, P., and Simon, J. C. An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell function. J. Cell Biol., 5: 1137-1147, 1997.
28. Noto, K., Kato, K., Okumura, K., and Yagita, H. Identification and functional characterization of mouse CD29 with a mAb. Int. Immunol., 7: 835-842, 1995.
29. Yasuda, M., Hsunuma, Y., Adachi, H., Sekino, C., Sakanishi, T., Hashimoto, H., Ra, C., Yagita, H., and Okumura, K. Expression and function of fibronectin binding integrins on rat mast cells. Int. Immunol., 7: 251-258, 1995.
30. Hudson, D. L., Sleeman, J. P., and Watt, F. M. CD44 is the major peanut lectin-binding glycoprotein of human epidermal keratinocytes and plays a role in intercellular adhesion. J. Cell Sci., 108: 1959-1970, 1995.
31. Rudy, W., Hofmann, M., Schwartz-Albiez, R., Zoller, M., Heider, K. H., Ponta, H., and Herrlich, P. The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior. Cancer Res., 53: 1262-1268, 1993.
32. Seiter, S., Arch, R., Reber, S., Komitowski, D., Hofmann, M., Ponta, H., Herrlich, P., Matzku, S., and Zoller, M. Prevention of tumor metastasis formation by anti-variant CD44. J. Exp. Med., 177: 1443-1445, 1993.
33. Matsumoto, Y., Saiki, I., Murota, J., Okuyama, H., Tamura, M., and Azuma, I. Recombinant human granulocyte colony-stimulating factor inhibits the metastasis of hematogenous and non-hematogenous tumors in mice. Int. J. Cancer, 49: 444-449, 1991.
34. Craij, A. M., Smith, J. H., and Denhardt, D. T. Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-0-tetradecanoylphorbol 13 acetate in mouse epidermis. J. Biol. Chem., 264: 9682-9689, 1989.
35. Staar, L., and Quaranta, V. An efficient and reliable method for cloning PCR-amplification products: a survey of point mutations in integrin cDNA. Biotechniques, 13: 612-618, 1992.
36. Smith, D. B., and Johnson, K. S. Single step purification of polypeptides expressed in Escherichia coli as fusions with glutalhione S-transferase. Gene, 67: 31-40, 1988.
37. Xuan, J-W., Hota, C., Shigeyama, Y., D'Errico, J. A., Somerman, M. J., and Chambers, A. F. Site-directed mutagenesis of the arginine-glycine-aspartic acid sequence in osteopontin destroys cell adhesion and migration functions. J. Cell. Biochem., 56: 1-11, 1994.
38. Guan, J. L., and Hynes, R. O. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β7. Cell, 60: 53-61, 1990.
39. Yamaki, T., Uede, T., Shijubo, N., and Kikuchi, K. Functional analysis of mononuclear cells infiltrating into tumors. III. Soluble factors involved in the regulation of T lymphocyte infiltration into tumors. J. Immunol., 140: 4388-4396, 1988.
40. Gunthert, U., Hottmann, M., Rudy, W., Reber, S., Zoller, M., Haussmann, I., Mastzku, S., Wenzel, A., Ponta, H., and Herrlich, P. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell, 65: 13-24, 1991.
41. Perschl, A., Lesley, J., English, N., Trowbridge, I., and Hyman, R. Role of CD44 cytoplasmic domain in hyaluronan binding. Eur. J. Immunol., 25: 495-501, 1995.