CD44 variant isoform expression in a variety of skin-associated autoimmune diseases

Clinical Immunology and Immunopathology

Volumn 89, Issue 1, 1998, Pages 79-93

  Seiter, Simone ^a,b   Schadendorf, Dirk ^b   Tilgen, Wolfgang ^a   Zöller, Margot ^b,c  

^a SAARLAND UNIVERSITY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Autoimmunity; CD44 variant exons; Dermatology; Immunohistology

Indexed keywords

CD4 ANTIGEN; CD44V ANTIGEN; CD8 ANTIGEN; CHEMOKINE; CYTOKINE; HERMES ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; LEUKOCYTE; LYMPHOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; MORPHEA; PEMPHIGOID; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; SKIN BIOPSY; SKIN DISEASE; SKIN LUPUS ERYTHEMATOSUS; T LYMPHOCYTE SUBPOPULATION; VASCULAR ENDOTHELIUM; VASCULITIS;

EID: 0032190256     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1998.4565     Document Type: Article

References (76)

1. Griffiths C. E., Boffa M. J., Gallatin W. M., Martin S. Elevated levels of circulating intercellular adhesion molecule-3 (cICAM-3) in psoriasis. Acta Derm. Venereol. 76:1996;2-5.
2. Nousari H. C., Anhalt G. J. Bullous skin diseases. Curr. Opin. Immunol. 7:1995;844-852.
3. Yang X. D., Michie S. A., Mebius R. E., Tisch R., Weissman I., McDevitt H. O. The role of cell adhesion molecules in the development of IDDM. Implications for pathogenesis and therapy. Diabetes. 45:1996;705-710.
4. Aziz K. E., Wakefield D. In vivo and in vitro expression of adhesion molecules by peripheral blood lymphocytes from patients with primary Sjögren's syndrome: Culture-associated enhancement of LECAM-1 and CD44. Rheumatol. Int. 15:1995;69-74.
5. Raine C. S., Cannella B., Duijvestijn A. M., Cross A. H. Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Lab. Invest. 63:1990;476-489.
6. Wenisch C., Myskiw D., Gessl A., Graninger W. Circulating selectins, intercellual adhesion molecule-1, and vascular cell adhesion molecule-1 in hyperthyroidism. J. Clin. Endocrinol. Metab. 80:1995;2122-2126.
7. Mikecz K., Brennan F. R., Kim J. H., Glant T. T. The role of adhesion molecules in the development of autoimmune arthritis. Scand. J. Rheumatol. Suppl. 101:1995;99-106.
8. Mrowka C., Sieberth H. G. Circulating adhesion molecules ICAM-1, VCAM-1 and E-selectin in systemic vasculitis: Marked differences between Wegener's granulomatosis and systemic lupus erythematosus. Clin. Invest. 72:1994;762-768.
9. Roep B., Heidenthal E., de-Vries R. R., Kolb H., Martin S. Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus. Lancet. 343:1994;1590-1593.
10. Hill S., Milla P. J., Ciampolillo A., Napolitano G., Bottazzo G. F., Mirakian R. LFA-1 and ICAM-1 molecule expression in jejunal mucosa from children with autoimmune enteropathy. Autoimmunity. 13:1992;233-241.
11. Burge S. M., Schomberg K. H. Adhesion molecules and related proteins in Darier's disease and Hailey-Hailey disease. Br. J. Dermatol. 127:1992;335-343.
12. Cannella B., Cross A. H., Raine C. S. Relapsing autoimmune demyelination: a role for vascular addressins. J. Neuroimmunol. 35:1991;295-300.
13. Breedveld F. C., van der Lubbe P. A. Monoclonal antibody therapy of inflammatory rheumatic diseases. Br. Med. Bull. 51:1995;493-502.
14. Uchio E., Kijima M., Tanaka S., Ohno S. Suppression of experimental uveitis with monoclonal antibodies to ICAM-1 and LFA-1. Invest. Ophthalmol. Visual Sci. 35:1994;2626-2631.
15. Archelos J. J., Maurer M., Jung S., Toyka K. V., Hartung H. P. Suppression of experimental allergic neuritis by an antibody to the intracellular adhesion molecule ICAM-1. Brain. 116:1993;1043-1058.
16. Archelos J. J., Jung S., Maurer M., Schmied M., Lassmann H., Tamatani T., Miyasaka M., Toyka K. V., Hartung H. P. Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1. Ann. Neurol. 34:1993;145-154.
17. Harning R., Pelletier J., Van G., Takei F., Merluzzi V. J. Monoclonal antibody to MALA-2 (ICAM-1) reduces acute autoimmune nephritis in kdkd mice. Clin. Immunol. Immunopathol. 64:1992;129-134.
18. Hayashi Y., Haneji N., Yanagi K., Higashiyama H., Yagita H., Hamano H. Prevention of adoptive transfer of murine Sjögren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). Clin. Exp. Immunol. 102:1995;360-367.
19. Baron J. L., Reich E. P., Visintin I., Janeway C. A. Jr. The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1. J. Clin. Invest. 93:1994;1700-1708.
20. Benz P. S., Fan X., Wuthrich R. P. Enhanced tubular epithelial CD44 expression in MRL-lpr lupus nephritis. Kidney Int. 50:1996;156-163.
21. Hayashi Y., Haneji N., Hamano H., Yanagi K., Takanashi M., Ishimaru N. Effector mechanism of experimental autoimmune sialadenitis in the mouse model for primary Sjögren's syndrome. Cell. Immunol. 171:1996;217-225.
22. Verdrengh M., Holmdahl R., Tarkowski A. Administration of antibodies to hyaluronanreceptor (CD44) delays the start and ameliorates the severity of collagen II arthritis. Scand. J. Immunol. 42:1995;353-358.
23. Engelhardt B., Conley F. K., Kilshaw P. J., Butcher E. C. Lymphocytes infiltrating the CNS during inflammation display a distinctive phenotype and bind to VCAM-1 but not to MAdCAM-1. Int. Immunol. 7:1995;481-491.
24. Nishikawa K., Andres G., Bhan A. K., McCluskey R. T., Collins A. B., Stow J. L., Stamenkovic I. Hyaluronate is a component of crescents in rat autoimmune glomerulonephritis. Lab. Invest. 68:1993;146-153.
25. Haegel H., Tolg C., Hofmann M., Ceredig R. Activated mouse astrocytes and T cells express similar CD44 variants. Role of CD44 in astrocyte/T cell binding. J. Cell Biol. 122:1993;1067-1077.
26. Wang W., Kobayashi S., Uede T. Dysregulated expression of cellular adhesion molecules in autoimmune-prone mice. J. Dermatol. 19:1992;831-835.
27. Zeine R., Owens T. Direct demonstration of the infiltration of murine central nervous system by Pgp-1/CD44high CD45RB(low) CD4+ T cells that induce experimental allergic encephalomyelitis. J. Neuroimmunol. 40:1992;57-69.
28. Budd R. C., Schumacher J. H., Winslow G., Mosmann T. R. Elevated production of interferon-gamma and interleukin 4 by mature T cells from autoimmune lpr mice correlates with Pgp-1 (CD44) expression. Eur. J. Immunol. 21:1991;1081-1084.
29. Milde K. F., Alonso M., Kong S. S., Alejandro R., Mintz D. H., Pastori R. L. Expression of a specific subset of CD44 variant transcripts in NOD pancreatic islets. Diabetes. 45:1996;718-724.
30. Gunthert U. CD44: A multitude of isoforms with diverse functions. Curr. Top. Microbiol. Immunol. 184:1993;47-63.
31. Rosenberg W. M., Prince C., Kaklamanis L., Fox S. B., Jackson D. G., Simmons D. L., Chapman R. W., Trowell J. M., Jewell D. P., Bell J. I. Increased expression of CD44v6 and CD44v3 in ulcerative colitis but not colonic Crohn's disease. Lancet. 345:1995;1205-1209.
32. Wittig B., Schwärzler C., Föhr N., Günthert U., Zöller M. Curative treatment of an experimentally induced colitis by a CD44 variant exon v7 specific antibody. J. Immunol. 161:1998;1069-1073.
33. Rösel M., Seiter S., Zöller M. CD44v10 expression in the mouse and functional activity in delayed type hypersensitivity. J. Cell. Physiol. 171:1997;305-317.
34. Wittig B., Seiter S., Föger N., Schwärzler C., Günthert U., Zöller M. Functional activity of murine CD44 variant isoforms in allergic and delayed type hypersentivity. Immunol. Lett. 57:1997;217-223.
35. Huet S., Groux H., Caillou B., Valentin H., Prieur A. M., Bernard A. CD44 contributes to T cell activation. J. Immunol. 143:1989;798-801.
36. Shimizu Y., van Seventer G. A., Siraganian R., Wahl L., Shaw S. Dual role of the CD44 molecule in T-cell adhesion and activation. J. Immunol. 143:1989;2457-2463.
37. Denning S. M., Le P. T., Singer K. H., Haynes B. F. Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation. J. Immunol. 144:1990;7-15.
38. Pierres A., Lipcey C., Mawas C., Olive D. A unique CD44 monoclonal antibody identifies a new T cell activation pathway. Eur. J. Immunol. 22:1992;413-417.
39. Galandrini R., Albi N., Tripodi G., Zarcone D., Terenzi A., Moretta A., Grossi C. E., Velardi A. Antibodies to CD44 trigger effector functions of human T cell clones. J. Immunol. 150:1993;4225-4231.
40. Conrad P., Rothman B. L., Kelley K. A., Blue M. L. Mechanism of peripheral T cell activation by coengagement of CD44 and CD2. J. Immunol. 149:1992;1833-1839.
41. Naujokas M. F., Morin M., Anderson M. S., Peterson M., Miller J. The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44. Cell. 74:1993;257-268.
42. Sommer F., Huber M., Röllinghoff M., Lohoff M. CD44 plays a co-stimulatory role in murine T cell activation: ligation of CD44 selectively co-stimulates IL-2 production, but not proliferation in TCR-stimulated murine Th1 cells. Int. Immunol. 7:1995;1779-1786.
43. Guo Y., Wu Y., Shinde S., Sy M. S., Aruffo A., Lia Y. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J. Exp. Med. 184:1996;955-961.
44. Arch R., Wirth K., Hofmann M., Ponta H., Matzku S., Herrlich P., Zöller M. Participation of a metastasis-inducing splice variant of CD44 in normal immune response. Science. 257:1992;682-685.
45. Koopman G., Heider K. H., Horst E., Adolf G. R., van den Berg F., Ponta H., Herrlich P., Pals S. T. Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44. J. Exp. Med. 177:1993;897-904.
46. Levesque M. C., Haynes B. F. In vitro culture of human peripheral blood monocytes induces hyaluronan binding and up-regulates monocyte variant CD44 isoform expression. J. Immunol. 156:1996;1557-1565.
47. Kugelman, L. C. Ganguly, S. Haggerty, J. G. Weissman, S. M. Milstone, L. M. The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44, J. Invest. Dermatol. 99, 381, 385.
48. Brown T. A., Bouchard T., StJohn T., Wayner E., Carter W. G. Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons. J. Cell Biol. 113:1991;207-221.
49. Jackson D. G., Bell J. I., Dickinson R., Timans J., Shields J., Whittle N. Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. J. Cell Biol. 128:1995;673-685.
50. Weber G. F., Ashkar S., Glimcher M. J., Cantor H. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science. 271:1996;509-512.
51. Bennett K. L., Jackson D. G., Simon J. C., Tanczos E., Peach R., Modrell B., Stamenkovic I., Plowman G., Aruffo A. CD44 isoforms containing exon v3 are responsible for the presentation of heparin-binding growth factor. J. Cell Biol. 128:1995;687-698.
52. Tanaka A. S., Adams D. H., Hubscher S., Hirano H., Siebenlist U., Shaw S. T cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β Nature. 361:1993;79-82.
53. Rusnati M., Presta M. Interaction of angiogenic basic fibroblast growth factor with endothelial cell heparan sulfate proteoglycans. Biological implications in neovascularization. Int. J. Clin. Lab. Res. 26:1996;15-23.
54. Ihrcke N. S., Platt J. L. Shedding of heparan sulfate proteoglycan by stimulated endothelial cells: Evidence for proteolysis of cell-surface molecules. J. Cell. Physiol. 168:1996;625-637.
55. Henke C. A., Roongta U., Mickelson D. J., Knutson J. R., McCarthy J. B. CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix. J. Clin. Invest. 97:1996;2541-2552.
56. Heider K. H., Hofmann M., Horst E., van den Berg F., Ponta H., Herrlich P., Pals S. T. A human homologue of the rat metastasis-associated variant of CD44 is expressed in colo-rectal carcinomas and adenomatous polyps. J. Cell Biol. 120:1993;227-233.
57. Seiter S., Schadendorf D., Herrmann K., Schneider M., Rösel M., Arch R., Tilgen W., Zöller M. Expression of splice variants of CD44 during melanoma progression. Clin. Cancer Res. 2:1996;447-456.
58. Cattoretti G., Berti E., Schiró R., D'Amato L., Valeggio C., Rilke F. Improved avidin-biotin-peroxidase complex (ABC) staining. Histochem. J. 20:1988;75-80.
59. Seiter S., Herrmann K., Möller P., Patzelt E., Tilgen W., Zöller M. Expression of splice variant of CD44 on human skin and epidermal tumours. Virchow's Arch. Pathol. 428:1996;141-149.
60. Soukka T., Salmi M., Joensuu H., Hakkinen L., Sointu P., Koulu L., Kalimo K., Klemi P., Grenman R., Jalkanen S. Regulation of CD44v6-containing isoforms during proliferation of normal and malignant epithelial cells. Cancer Res. 57:1997;2281-2289.
61. Leigh C. J., Palechek P. L., Knutson J. R., McCarthy J. B., Cohen M. B., Argenyi Z. B. CD44 expression in benign and malignant nevomelanocytic lesions. Hum. Pathol. 27:1996;1288-1294.
62. Springer T. A. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell. 76:1994;301-314.
63. DeGrendele H. C., Estess O., Siegelman M. H. Requirement for CD44 in activated T cell extravasation into an inflammatory site. Science. 278:1997;672-675.
64. Salmon J. K., Armstrong C. A., Ansel J. C. The skin as an immune organ. West. J. Med. 160:1994;146-152.
65. Hogan A. D., Burks A. W. Epidermal Langerhans' cells and their function in the skin immune system. Ann. Allergy Asthma Immunol. 75:1995;5-10.
66. Singer K. H., Le P. T., Denning S. M., Whichard L. P., Haynes B. F. The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. J. Invest. Dermatol. 94:1990;85-90.
67. Nickoloff B. J., Griffiths C. E., Barker J. N. The role of adhesion molecules, chemotactic factors, and cytokines in inflammatory and neoplastic skin disease - 1990 update. J. Invest. Dermatol. 94:1990;151-157.
68. Luger, T. A. Schwarz, T. Evidence for an epidermal cytokine network, J. Invest. Dermatol. 95, 100, 104.
69. Leung D. Y. Atopic dermatitis: The skin as a window into the pathogenesis of chronic allergic diseases. J. Allergy Clin. Immunol. 96:1995;302-318.
70. Sarris A. H., Esgleyes Ribot T., Crow M., Broxmeyer H. E., Karasavvas N., Pugh W., Grossman D., Deisseroth A., Duvic M. Cytokine loops involving interferon-gamma and IP-10, a cytokine chemotactic for CD4+ lymphocytes: An explanation for the epidermotropism of cutaneous T-cell lymphoma? Blood. 86:1995;651-658.
71. Heald P. W., Yan S. L., Edelson R. L., Tigelaar R., Picker L. J. Skin-selective lymphocyte homing mechanisms in the pathogenesis of leukemic cutaneous T-cell lymphoma. J. Invest. Dermatol. 101:1993;222-226.
72. Picker L. J., Martin R. J., Trumble A., Newman L. S., Collins P. A., Bergstresser P. R., Leung D. Y. Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites. Eur. J. Immunol. 24:1994;1269-1277.
73. Santamaria Babi L. F., Picker L. J., Perez Soler M. T., Drzimalla K., Flohr P., Blaser K., Hauser C. Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen. J. Exp. Med. 181:1995;1935-1940.
74. Koszik F., Strunk D., Simonitsch I., Picker L. J., Stingl G., Payer E. Expression of monoclonal antibody HECA-452-defined E-selectin ligands on Langerhans cells in normal and diseased skin. J. Invest. Dermatol. 102:1994;773-780.
75. Wagner, S. N. Bertsch, H. P. Wagner, C. Nußbaum, G. Zöller, M. Goos, M. Malignant and reactive cutaneous lymphoid cell infiltrates exhibit a unique pattern of CD44 splice variants, J. Invest. Dermatol.
76. Cooper D. L., Dougherty G., Harn H. J., Jackson S., Baptist E. W., Byers J., Datta A., Phillips G., Isola N. R. The complex CD44 transcriptional unit: Alternative splicing of three internal exons generates the epithelial form of CD44. Biochem. Biophys. Res. Commun. 182:1992;569-578.