메뉴 건너뛰기




Volumn 77, Issue 3, 2005, Pages 145-158

Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2A6; NICOTINE;

EID: 13944284575     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2004.10.011     Document Type: Review
Times cited : (240)

References (139)
  • 1
    • 0021816453 scopus 로고
    • Abuse liability and pharmacodynamic characteristics of intravenous and inhaled nicotine
    • J.E. Henningfield, K. Miyasato, D.R. Jasinski Abuse liability and pharmacodynamic characteristics of intravenous and inhaled nicotine J Pharmacol Exp Ther 234 1985 1 12
    • (1985) J Pharmacol Exp Ther , vol.234 , pp. 1-12
    • Henningfield, J.E.1    Miyasato, K.2    Jasinski, D.R.3
  • 2
    • 0028966054 scopus 로고
    • The scientific case that nicotine is addictive
    • I.P. Stolerman, M.J. Jarvis The scientific case that nicotine is addictive Psychopharmacology (Berl) 117 1995 2 10, discussion 14-20
    • (1995) Psychopharmacology (Berl) , vol.117 , pp. 2-10
    • Stolerman, I.P.1    Jarvis, M.J.2
  • 3
    • 0031470773 scopus 로고    scopus 로고
    • Nicotine activates and desensitizes midbrain dopamine neurons
    • V.I. Pidoplichko, M. DeBiasi, J.T. Williams, J.A. Dani Nicotine activates and desensitizes midbrain dopamine neurons Nature 390 1997 401 404
    • (1997) Nature , vol.390 , pp. 401-404
    • Pidoplichko, V.I.1    Debiasi, M.2    Williams, J.T.3    Dani, J.A.4
  • 4
    • 0029943635 scopus 로고    scopus 로고
    • Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
    • F.E. Pontieri, G. Tanda, F. Orzi, G. Di Chiara Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs Nature 382 1996 255 257
    • (1996) Nature , vol.382 , pp. 255-257
    • Pontieri, F.E.1    Tanda, G.2    Orzi, F.3    Di Chiara, G.4
  • 6
    • 0037275136 scopus 로고    scopus 로고
    • Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area
    • S.R. Laviolette, D. van der Kooy Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area Mol Psychiatry 8 2003 50 59
    • (2003) Mol Psychiatry , vol.8 , pp. 50-59
    • Laviolette, S.R.1    Van Der Kooy, D.2
  • 8
    • 0033913561 scopus 로고    scopus 로고
    • Neurobiology of addiction: Toward the development of new therapies
    • G.F. Koob Neurobiology of addiction Toward the development of new therapies Ann N Y Acad Sci 909 2000 170 185
    • (2000) Ann N Y Acad Sci , vol.909 , pp. 170-185
    • Koob, G.F.1
  • 10
    • 0036499938 scopus 로고    scopus 로고
    • Nicotine addiction: The possible role of functional upregulation
    • B. Buisson, D. Bertrand Nicotine addiction: the possible role of functional upregulation Trends Pharmacol Sci 23 2002 130 136
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 130-136
    • Buisson, B.1    Bertrand, D.2
  • 11
    • 1842366036 scopus 로고    scopus 로고
    • Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration
    • C.M. Flores, M.I. Davila-Garcia, Y.M. Ulrich, K.J. Kellar Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration J Neurochem 69 1997 2216 2219
    • (1997) J Neurochem , vol.69 , pp. 2216-2219
    • Flores, C.M.1    Davila-Garcia, M.I.2    Ulrich, Y.M.3    Kellar, K.J.4
  • 12
    • 0344258434 scopus 로고    scopus 로고
    • Increased nicotinic receptors in brains from smokers: Membrane binding and autoradiography studies
    • D.C. Perry, M.I. Davila-Garcia, C.A. Stockmeier, K.J. Kellar Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies J Pharmacol Exp Ther 289 1999 1545 1552
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1545-1552
    • Perry, D.C.1    Davila-Garcia, M.I.2    Stockmeier, C.A.3    Kellar, K.J.4
  • 13
    • 0032492857 scopus 로고    scopus 로고
    • Dramatic decreases in brain reward function during nicotine withdrawal
    • M.P. Epping-Jordan, S.S. Watkins, G.F. Koob, A. Markou Dramatic decreases in brain reward function during nicotine withdrawal Nature 393 1998 76 79
    • (1998) Nature , vol.393 , pp. 76-79
    • Epping-Jordan, M.P.1    Watkins, S.S.2    Koob, G.F.3    Markou, A.4
  • 15
    • 0029979162 scopus 로고    scopus 로고
    • Pharmacology of nicotine: Addiction and therapeutics
    • N.L. Benowitz Pharmacology of nicotine: addiction and therapeutics Annu Rev Pharmacol Toxicol 36 1996 597 613
    • (1996) Annu Rev Pharmacol Toxicol , vol.36 , pp. 597-613
    • Benowitz, N.L.1
  • 16
    • 0842286066 scopus 로고    scopus 로고
    • Why people smoke
    • M.J. Jarvis Why people smoke BMJ 328 2004 277 279
    • (2004) BMJ , vol.328 , pp. 277-279
    • Jarvis, M.J.1
  • 17
    • 0041377930 scopus 로고    scopus 로고
    • Nicotine as a modulator of behavior: Beyond the inverted U
    • M.R. Picciotto Nicotine as a modulator of behavior: beyond the inverted U Trends Pharmacol Sci 24 2003 493 499
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 493-499
    • Picciotto, M.R.1
  • 18
    • 0034042225 scopus 로고    scopus 로고
    • Stages in the development of adolescent smoking
    • K.P. Mayhew, B.R. Flay, J.A. Mott Stages in the development of adolescent smoking Drug Alcohol Depend 59 Suppl 1 2000 S61 S81
    • (2000) Drug Alcohol Depend , vol.59 , Issue.1 SUPPL.
    • Mayhew, K.P.1    Flay, B.R.2    Mott, J.A.3
  • 19
    • 0038417109 scopus 로고    scopus 로고
    • Elucidating the role of genetic factors in smoking behavior and nicotine dependence
    • C. Lerman, W. Berrettini Elucidating the role of genetic factors in smoking behavior and nicotine dependence Am J Med Genet 118B 2003 48 54
    • (2003) Am J Med Genet , vol.118 , pp. 48-54
    • Lerman, C.1    Berrettini, W.2
  • 20
    • 0033301678 scopus 로고    scopus 로고
    • The genetic epidemiology of smoking
    • P.F. Sullivan, K.S. Kendler The genetic epidemiology of smoking Nicotine Tob Res 1 Suppl 2 1999 S51 S57, discussion S69-70
    • (1999) Nicotine Tob Res , vol.1 , Issue.2 SUPPL.
    • Sullivan, P.F.1    Kendler, K.S.2
  • 21
    • 0037764979 scopus 로고    scopus 로고
    • Genetics of alcohol and tobacco use in humans
    • R.F. Tyndale Genetics of alcohol and tobacco use in humans Ann Med 35 2003 94 121
    • (2003) Ann Med , vol.35 , pp. 94-121
    • Tyndale, R.F.1
  • 22
    • 0033505607 scopus 로고    scopus 로고
    • Genetic and social determinants of initiation and age at onset of smoking in Australian twins
    • A.C. Heath, K.M. Kirk, J.M. Meyer, N.G. Martin Genetic and social determinants of initiation and age at onset of smoking in Australian twins Behav Genet 29 1999 395 407
    • (1999) Behav Genet , vol.29 , pp. 395-407
    • Heath, A.C.1    Kirk, K.M.2    Meyer, J.M.3    Martin, N.G.4
  • 23
    • 0033499297 scopus 로고    scopus 로고
    • The genetics of smoking initiation and quantity smoked in Dutch adolescent and young adult twins
    • J.R. Koopmans, W.S. Slutske, A.C. Heath, M.C. Neale, D.I. Boomsma The genetics of smoking initiation and quantity smoked in Dutch adolescent and young adult twins Behav Genet 29 1999 383 393
    • (1999) Behav Genet , vol.29 , pp. 383-393
    • Koopmans, J.R.1    Slutske, W.S.2    Heath, A.C.3    Neale, M.C.4    Boomsma, D.I.5
  • 26
    • 3242813711 scopus 로고    scopus 로고
    • Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients
    • V. De Luca, A.H. Wong, D.J. Muller, G.W. Wong, R.F. Tyndale, J.L. Kennedy Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients Neuropsychopharmacology 29 2004 1522 1526
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1522-1526
    • De Luca, V.1    Wong, A.H.2    Muller, D.J.3    Wong, G.W.4    Tyndale, R.F.5    Kennedy, J.L.6
  • 28
    • 0026472046 scopus 로고
    • Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics
    • L.E. Adler, L.J. Hoffer, J. Griffith, M.C. Waldo, R. Freedman Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics Biol Psychiatry 32 1992 607 616
    • (1992) Biol Psychiatry , vol.32 , pp. 607-616
    • Adler, L.E.1    Hoffer, L.J.2    Griffith, J.3    Waldo, M.C.4    Freedman, R.5
  • 30
    • 0035209299 scopus 로고    scopus 로고
    • Polysubstance abuse-vulnerability genes: Genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms
    • G.R. Uhl, Q.R. Liu, D. Walther, J. Hess, D. Naiman Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms Am J Hum Genet 69 2001 1290 1300
    • (2001) Am J Hum Genet , vol.69 , pp. 1290-1300
    • Uhl, G.R.1    Liu, Q.R.2    Walther, D.3    Hess, J.4    Naiman, D.5
  • 31
    • 84872249295 scopus 로고    scopus 로고
    • A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population
    • M.D. Li, J.Z. Ma, R. Cheng, R.T. Dupont, N.J. Williams, K.M. Crews A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population BMC Genet 4 Suppl 1 2003 S103 S107
    • (2003) BMC Genet , vol.4 , Issue.1 SUPPL.
    • Li, M.D.1    Ma, J.Z.2    Cheng, R.3    Dupont, R.T.4    Williams, N.J.5    Crews, K.M.6
  • 34
    • 0034589734 scopus 로고    scopus 로고
    • Reward deficiency syndrome: Genetic aspects of behavioral disorders
    • D.E. Comings, K. Blum Reward deficiency syndrome: genetic aspects of behavioral disorders Prog Brain Res 126 2000 325 341
    • (2000) Prog Brain Res , vol.126 , pp. 325-341
    • Comings, D.E.1    Blum, K.2
  • 36
    • 0034723044 scopus 로고    scopus 로고
    • Polymorphisms in genes involved in neurotransmission in relation to smoking
    • T. Arinami, H. Ishiguro, E.S. Onaivi Polymorphisms in genes involved in neurotransmission in relation to smoking Eur J Pharmacol 410 2000 215 226
    • (2000) Eur J Pharmacol , vol.410 , pp. 215-226
    • Arinami, T.1    Ishiguro, H.2    Onaivi, E.S.3
  • 38
    • 0037152634 scopus 로고    scopus 로고
    • Applying genetic approaches to the treatment of nicotine dependence
    • C. Lerman, R. Niaura Applying genetic approaches to the treatment of nicotine dependence Oncogene 21 2002 7412 7420
    • (2002) Oncogene , vol.21 , pp. 7412-7420
    • Lerman, C.1    Niaura, R.2
  • 39
    • 0032253783 scopus 로고    scopus 로고
    • Suppression of nicotine intake during ad libitum cigarette smoking by high-dose transdermal nicotine
    • N.L. Benowitz, S. Zevin, P. Jacob III Suppression of nicotine intake during ad libitum cigarette smoking by high-dose transdermal nicotine J Pharmacol Exp Ther 287 1998 958 962
    • (1998) J Pharmacol Exp Ther , vol.287 , pp. 958-962
    • Benowitz, N.L.1    Zevin, S.2    Jacob III, P.3
  • 40
    • 0031030483 scopus 로고    scopus 로고
    • Nicotine self-administration in animals and humans: Similarities and differences
    • J.E. Rose, W.A. Corrigall Nicotine self-administration in animals and humans: similarities and differences Psychopharmacology (Berl) 130 1997 28 40
    • (1997) Psychopharmacology (Berl) , vol.130 , pp. 28-40
    • Rose, J.E.1    Corrigall, W.A.2
  • 41
    • 0035282788 scopus 로고    scopus 로고
    • Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei
    • R. Klink, A. de Kerchove d'Exaerde, M. Zoli, J.P. Changeux Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei J Neurosci 21 2001 1452 1463
    • (2001) J Neurosci , vol.21 , pp. 1452-1463
    • Klink, R.1    De Kerchove D'Exaerde, A.2    Zoli, M.3    Changeux, J.P.4
  • 42
    • 0345599247 scopus 로고    scopus 로고
    • Subtype-selective up-regulation by chronic nicotine of high-affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography
    • H.N. Nguyen, B.A. Rasmussen, D.C. Perry Subtype-selective up-regulation by chronic nicotine of high-affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography J Pharmacol Exp Ther 307 2003 1090 1097
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 1090-1097
    • Nguyen, H.N.1    Rasmussen, B.A.2    Perry, D.C.3
  • 43
    • 0032495515 scopus 로고    scopus 로고
    • Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine
    • M.R. Picciotto, M. Zoli, R. Rimondini, C. Lena, L.M. Marubio, E.M. Pich Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine Nature 391 1998 173 177
    • (1998) Nature , vol.391 , pp. 173-177
    • Picciotto, M.R.1    Zoli, M.2    Rimondini, R.3    Lena, C.4    Marubio, L.M.5    Pich, E.M.6
  • 44
    • 0038367987 scopus 로고    scopus 로고
    • Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors
    • L.M. Marubio, A.M. Gardier, S. Durier, D. David, R. Klink, M.M. Arroyo-Jimenez Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors Eur J Neurosci 17 2003 1329 1337
    • (2003) Eur J Neurosci , vol.17 , pp. 1329-1337
    • Marubio, L.M.1    Gardier, A.M.2    Durier, S.3    David, D.4    Klink, R.5    Arroyo-Jimenez, M.M.6
  • 45
    • 0032144990 scopus 로고    scopus 로고
    • Nicotine and food induced dopamine release in the nucleus accumbens of the rat: Putative role of alpha7 nicotinic receptors in the ventral tegmental area
    • B. Schilstrom, H.M. Svensson, T.H. Svensson, G.G. Nomikos Nicotine and food induced dopamine release in the nucleus accumbens of the rat: putative role of alpha7 nicotinic receptors in the ventral tegmental area Neuroscience 85 1998 1005 1009
    • (1998) Neuroscience , vol.85 , pp. 1005-1009
    • Schilstrom, B.1    Svensson, H.M.2    Svensson, T.H.3    Nomikos, G.G.4
  • 46
    • 0033577176 scopus 로고    scopus 로고
    • Nicotine withdrawal in the rat: Role of alpha7 nicotinic receptors in the ventral tegmental area
    • G.G. Nomikos, B.E. Hildebrand, G. Panagis, T.H. Svensson Nicotine withdrawal in the rat: role of alpha7 nicotinic receptors in the ventral tegmental area Neuroreport 10 1999 697 702
    • (1999) Neuroreport , vol.10 , pp. 697-702
    • Nomikos, G.G.1    Hildebrand, B.E.2    Panagis, G.3    Svensson, T.H.4
  • 47
    • 3042635325 scopus 로고    scopus 로고
    • A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men
    • Y. Feng, T. Niu, H. Xing, X. Xu, C. Chen, S. Peng A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men Am J Hum Genet 75 2004 112 121
    • (2004) Am J Hum Genet , vol.75 , pp. 112-121
    • Feng, Y.1    Niu, T.2    Xing, H.3    Xu, X.4    Chen, C.5    Peng, S.6
  • 48
    • 0036000064 scopus 로고    scopus 로고
    • Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)
    • K.K. Lueders, S. Hu, L. McHugh, M.V. Myakishev, L.A. Sirota, D.H. Hamer Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2) Nicotine Tob Res 4 2002 115 125
    • (2002) Nicotine Tob Res , vol.4 , pp. 115-125
    • Lueders, K.K.1    Hu, S.2    McHugh, L.3    Myakishev, M.V.4    Sirota, L.A.5    Hamer, D.H.6
  • 49
    • 0020725604 scopus 로고
    • Nicotine's role in smoking: An analysis of nicotine regulation
    • M.J. McMorrow, R.M. Foxx Nicotine's role in smoking: an analysis of nicotine regulation Psychol Bull 93 1983 302 327
    • (1983) Psychol Bull , vol.93 , pp. 302-327
    • McMorrow, M.J.1    Foxx, R.M.2
  • 50
    • 0021882484 scopus 로고
    • Nicotine renal excretion rate influences nicotine intake during cigarette smoking
    • N.L. Benowitz, P. Jacob III Nicotine renal excretion rate influences nicotine intake during cigarette smoking J Pharmacol Exp Ther 234 1985 153 155
    • (1985) J Pharmacol Exp Ther , vol.234 , pp. 153-155
    • Benowitz, N.L.1    Jacob III, P.2
  • 52
    • 0027987497 scopus 로고
    • Metabolism of nicotine to cotinine studied by a dual stable isotope method
    • N.L. Benowitz, P. Jacob III Metabolism of nicotine to cotinine studied by a dual stable isotope method Clin Pharmacol Ther 56 1994 483 493
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 483-493
    • Benowitz, N.L.1    Jacob III, P.2
  • 53
    • 0030885491 scopus 로고    scopus 로고
    • A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes
    • E.S. Messina, R.F. Tyndale, E.M. Sellers A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes J Pharmacol Exp Ther 282 1997 1608 1614
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 1608-1614
    • Messina, E.S.1    Tyndale, R.F.2    Sellers, E.M.3
  • 56
    • 5544281923 scopus 로고    scopus 로고
    • Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes
    • M. Nakajima, T. Yamamoto, K. Nunoya, T. Yokoi, K. Nagashima, K. Inoue Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes J Pharmacol Exp Ther 277 1996 1010 1015
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1010-1015
    • Nakajima, M.1    Yamamoto, T.2    Nunoya, K.3    Yokoi, T.4    Nagashima, K.5    Inoue, K.6
  • 59
    • 0031875570 scopus 로고    scopus 로고
    • Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6
    • H. Hadidi, Y. Irshaid, C.B. Vagbo, A. Brunsvik, S. Cholerton, K. Zahlsen Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6 Eur J Clin Pharmacol 54 1998 437 441
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 437-441
    • Hadidi, H.1    Irshaid, Y.2    Vagbo, C.B.3    Brunsvik, A.4    Cholerton, S.5    Zahlsen, K.6
  • 61
    • 0026934672 scopus 로고
    • Interindividual variability of coumarin 7-hydroxylation in healthy volunteers
    • A. Rautio, H. Kraul, A. Kojo, E. Salmela, O. Pelkonen Interindividual variability of coumarin 7-hydroxylation in healthy volunteers Pharmacogenetics 2 1992 227 233
    • (1992) Pharmacogenetics , vol.2 , pp. 227-233
    • Rautio, A.1    Kraul, H.2    Kojo, A.3    Salmela, E.4    Pelkonen, O.5
  • 62
    • 0034746463 scopus 로고    scopus 로고
    • Trans-3'-hydroxycotinine: Disposition kinetics, effects and plasma levels during cigarette smoking
    • N.L. Benowitz, P. Jacob III Trans-3'-hydroxycotinine: disposition kinetics, effects and plasma levels during cigarette smoking Br J Clin Pharmacol 51 2001 53 59
    • (2001) Br J Clin Pharmacol , vol.51 , pp. 53-59
    • Benowitz, N.L.1    Jacob III, P.2
  • 63
    • 0029996291 scopus 로고    scopus 로고
    • Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian populations
    • T. Shimada, H. Yamazaki, F.P. Guengerich Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian populations Xenobiotica 26 1996 395 403
    • (1996) Xenobiotica , vol.26 , pp. 395-403
    • Shimada, T.1    Yamazaki, H.2    Guengerich, F.P.3
  • 65
    • 0035138840 scopus 로고    scopus 로고
    • Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans
    • M. Nakajima, J.T. Kwon, N. Tanaka, T. Zenta, Y. Yamamoto, H. Yamamoto Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans Clin Pharmacol Ther 69 2001 72 78
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 72-78
    • Nakajima, M.1    Kwon, J.T.2    Tanaka, N.3    Zenta, T.4    Yamamoto, Y.5    Yamamoto, H.6
  • 66
    • 0033965729 scopus 로고    scopus 로고
    • Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans
    • M. Nakajima, S. Yamagishi, H. Yamamoto, T. Yamamoto, Y. Kuroiwa, T. Yokoi Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans Clin Pharmacol Ther 67 2000 57 69
    • (2000) Clin Pharmacol Ther , vol.67 , pp. 57-69
    • Nakajima, M.1    Yamagishi, S.2    Yamamoto, H.3    Yamamoto, T.4    Kuroiwa, Y.5    Yokoi, T.6
  • 68
    • 4644255903 scopus 로고    scopus 로고
    • Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians
    • K. Schoedel, E. Hoffmann, Y. Rao, E. Sellers, R.F. Tyndale Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians Pharmacogenetics 14 2004 615 626
    • (2004) Pharmacogenetics , vol.14 , pp. 615-626
    • Schoedel, K.1    Hoffmann, E.2    Rao, Y.3    Sellers, E.4    Tyndale, R.F.5
  • 69
    • 0346338138 scopus 로고    scopus 로고
    • The meanings of smoking among Chinese American and Taiwanese American college students
    • F.N. Hsia, D. Spruijt-Metz The meanings of smoking among Chinese American and Taiwanese American college students Nicotine Tob Res 5 2003 837 850
    • (2003) Nicotine Tob Res , vol.5 , pp. 837-850
    • Hsia, F.N.1    Spruijt-Metz, D.2
  • 71
    • 10344238546 scopus 로고    scopus 로고
    • Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers
    • M. Fujieda, H. Yamazaki, T. Saito, K. Kiyotani, M.A. Gyamfi, M. Sakurai Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers Carcinogenesis 25 2004 2451 2458
    • (2004) Carcinogenesis , vol.25 , pp. 2451-2458
    • Fujieda, M.1    Yamazaki, H.2    Saito, T.3    Kiyotani, K.4    Gyamfi, M.A.5    Sakurai, M.6
  • 72
    • 0023694465 scopus 로고
    • Cigarette brand-switching: Effects on smoke exposure and smoking behavior
    • J.P. Zacny, M.L. Stitzer Cigarette brand-switching: effects on smoke exposure and smoking behavior J Pharmacol Exp Ther 246 1988 619 627
    • (1988) J Pharmacol Exp Ther , vol.246 , pp. 619-627
    • Zacny, J.P.1    Stitzer, M.L.2
  • 74
    • 0033807421 scopus 로고    scopus 로고
    • Duplications and defects in the CYP2A6 gene: Identification, genotyping, and in vivo effects on smoking
    • Y. Rao, E. Hoffmann, M. Zia, L. Bodin, M. Zeman, E.M. Sellers Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking Mol Pharmacol 58 2000 747 755
    • (2000) Mol Pharmacol , vol.58 , pp. 747-755
    • Rao, Y.1    Hoffmann, E.2    Zia, M.3    Bodin, L.4    Zeman, M.5    Sellers, E.M.6
  • 75
    • 0032565878 scopus 로고    scopus 로고
    • Nicotine metabolism defect reduces smoking
    • M.L. Pianezza, E.M. Sellers, R.F. Tyndale Nicotine metabolism defect reduces smoking Nature 393 1998 750
    • (1998) Nature , vol.393 , pp. 750
    • Pianezza, M.L.1    Sellers, E.M.2    Tyndale, R.F.3
  • 76
    • 0035064372 scopus 로고    scopus 로고
    • Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk
    • R.F. Tyndale, E.M. Sellers Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk Drug Metab Dispos 29 2001 548 552
    • (2001) Drug Metab Dispos , vol.29 , pp. 548-552
    • Tyndale, R.F.1    Sellers, E.M.2
  • 77
    • 0028923773 scopus 로고
    • Individual differences in sensitivity to nicotine: Implications for genetic research on nicotine dependence
    • O.F. Pomerleau Individual differences in sensitivity to nicotine: implications for genetic research on nicotine dependence Behav Genet 25 1995 161 177
    • (1995) Behav Genet , vol.25 , pp. 161-177
    • Pomerleau, O.F.1
  • 79
    • 0031955969 scopus 로고    scopus 로고
    • Early experiences with tobacco among women smokers, ex-smokers, and never-smokers
    • O.F. Pomerleau, C.S. Pomerleau, R.J. Namenek Early experiences with tobacco among women smokers, ex-smokers, and never-smokers Addiction 93 1998 595 599
    • (1998) Addiction , vol.93 , pp. 595-599
    • Pomerleau, O.F.1    Pomerleau, C.S.2    Namenek, R.J.3
  • 81
    • 0038348799 scopus 로고    scopus 로고
    • Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults
    • M. Ando, N. Hamajima, N. Ariyoshi, T. Kamataki, K. Matsuo, Y. Ohno Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults J Epidemiol 13 2003 176 181
    • (2003) J Epidemiol , vol.13 , pp. 176-181
    • Ando, M.1    Hamajima, N.2    Ariyoshi, N.3    Kamataki, T.4    Matsuo, K.5    Ohno, Y.6
  • 83
    • 1342269739 scopus 로고    scopus 로고
    • Whole deletion of CYP2A6 gene (CYP2A6*4C) and smoking behavior
    • K. Iwahashi, C. Waga, T. Takimoto Whole deletion of CYP2A6 gene (CYP2A6*4C) and smoking behavior Neuropsychobiology 49 2004 101 104
    • (2004) Neuropsychobiology , vol.49 , pp. 101-104
    • Iwahashi, K.1    Waga, C.2    Takimoto, T.3
  • 84
    • 0037677439 scopus 로고    scopus 로고
    • Association of CYP2A6 deletion polymorphism with smoking habit and development of pulmonary emphysema
    • N. Minematsu, H. Nakamura, M. Iwata, H. Tateno, T. Nakajima, S. Takahashi Association of CYP2A6 deletion polymorphism with smoking habit and development of pulmonary emphysema Thorax 58 2003 623 628
    • (2003) Thorax , vol.58 , pp. 623-628
    • Minematsu, N.1    Nakamura, H.2    Iwata, M.3    Tateno, H.4    Nakajima, T.5    Takahashi, S.6
  • 85
    • 0033550994 scopus 로고    scopus 로고
    • Genetic variation of CYP2A6, smoking, and risk of cancer
    • S.J. London, J.R. Idle, A.K. Daly, G.A. Coetzee Genetic variation of CYP2A6, smoking, and risk of cancer Lancet 353 1999 898 899
    • (1999) Lancet , vol.353 , pp. 898-899
    • London, S.J.1    Idle, J.R.2    Daly, A.K.3    Coetzee, G.A.4
  • 86
    • 17744381734 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population
    • M.A. Loriot, S. Rebuissou, M. Oscarson, S. Cenee, M. Miyamoto, N. Ariyoshi Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population Pharmacogenetics 11 2001 39 44
    • (2001) Pharmacogenetics , vol.11 , pp. 39-44
    • Loriot, M.A.1    Rebuissou, S.2    Oscarson, M.3    Cenee, S.4    Miyamoto, M.5    Ariyoshi, N.6
  • 87
    • 13944249744 scopus 로고    scopus 로고
    • An improved assay shows no association between the CYP2A6 gene and cigarette smoking behavior
    • S.Z. Sabol, D.H. Hamer An improved assay shows no association between the CYP2A6 gene and cigarette smoking behavior Behav Genet 157 1999 632 634
    • (1999) Behav Genet , vol.157 , pp. 632-634
    • Sabol, S.Z.1    Hamer, D.H.2
  • 88
    • 2542503580 scopus 로고    scopus 로고
    • A meta-analytic review of the CYP2A6 genotype and smoking behavior
    • B. Carter, T. Long, P. Cinciripini A meta-analytic review of the CYP2A6 genotype and smoking behavior Nicotine Tob Res 6 2004 221 227
    • (2004) Nicotine Tob Res , vol.6 , pp. 221-227
    • Carter, B.1    Long, T.2    Cinciripini, P.3
  • 90
    • 0034534428 scopus 로고    scopus 로고
    • The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit
    • D.F. Gu, L.J. Hinks, N.E. Morton, I.N. Day The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit Ann Hum Genet 64 2000 383 390
    • (2000) Ann Hum Genet , vol.64 , pp. 383-390
    • Gu, D.F.1    Hinks, L.J.2    Morton, N.E.3    Day, I.N.4
  • 91
    • 10444269359 scopus 로고    scopus 로고
    • Genetically decreased CYP2A6 and the risk of tobacco dependence: A prospective study in novice smokers
    • J. O'Laughlin, G. Paradis, W. Kim, J.R. DiFranza, G. Meshefedijan, E. McMillan Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study in novice smokers Tob Control 13 2004 422 428
    • (2004) Tob Control , vol.13 , pp. 422-428
    • O'Laughlin, J.1    Paradis, G.2    Kim, W.3    Difranza, J.R.4    Meshefedijan, G.5    McMillan, E.6
  • 93
    • 0142132207 scopus 로고    scopus 로고
    • Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: Critical periods, patterns of exposure, dose thresholds
    • Y. Abreu-Villaca, F.J. Seidler, D. Qiao, C.A. Tate, M.M. Cousins, I. Thillai Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: critical periods, patterns of exposure, dose thresholds Neuropsychopharmacology 28 2003 1935 1949
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1935-1949
    • Abreu-Villaca, Y.1    Seidler, F.J.2    Qiao, D.3    Tate, C.A.4    Cousins, M.M.5    Thillai, I.6
  • 94
    • 0038456229 scopus 로고    scopus 로고
    • Evidence for enhanced neurobehavioral vulnerability to nicotine during periadolescence in rats
    • W. Adriani, S. Spijker, V. Deroche-Gamonet, G. Laviola, M. Le Moal, A.B. Smit Evidence for enhanced neurobehavioral vulnerability to nicotine during periadolescence in rats J Neurosci 23 2003 4712 4716
    • (2003) J Neurosci , vol.23 , pp. 4712-4716
    • Adriani, W.1    Spijker, S.2    Deroche-Gamonet, V.3    Laviola, G.4    Le Moal, M.5    Smit, A.B.6
  • 95
    • 3042858854 scopus 로고    scopus 로고
    • Age-dependent effects of nicotine on locomotor activity and conditioned place preference in rats
    • J.D. Belluzzi, A.G. Lee, H.S. Oliff, F.M. Leslie Age-dependent effects of nicotine on locomotor activity and conditioned place preference in rats Psychopharmacology (Berl) 174 2004 389 395
    • (2004) Psychopharmacology (Berl) , vol.174 , pp. 389-395
    • Belluzzi, J.D.1    Lee, A.G.2    Oliff, H.S.3    Leslie, F.M.4
  • 97
    • 0036711037 scopus 로고    scopus 로고
    • Nicotine-induced conditioned place preference in adolescent and adult rats
    • B.J. Vastola, L.A. Douglas, E.I. Varlinskaya, L.P. Spear Nicotine-induced conditioned place preference in adolescent and adult rats Physiol Behav 77 2002 107 114
    • (2002) Physiol Behav , vol.77 , pp. 107-114
    • Vastola, B.J.1    Douglas, L.A.2    Varlinskaya, E.I.3    Spear, L.P.4
  • 98
    • 0033947883 scopus 로고    scopus 로고
    • Predicting smoking cessation and major depression in nicotine-dependent smokers
    • N. Breslau, E.O. Johnson Predicting smoking cessation and major depression in nicotine-dependent smokers Am J Public Health 90 2000 1122 1127
    • (2000) Am J Public Health , vol.90 , pp. 1122-1127
    • Breslau, N.1    Johnson, E.O.2
  • 100
    • 0141741729 scopus 로고    scopus 로고
    • Estimates of global mortality attributable to smoking in 2000
    • M. Ezzati, A.D. Lopez Estimates of global mortality attributable to smoking in 2000 Lancet 362 2003 847 852
    • (2003) Lancet , vol.362 , pp. 847-852
    • Ezzati, M.1    Lopez, A.D.2
  • 101
    • 0026583615 scopus 로고
    • The health consequences of smoking: Cardiovascular diseases
    • P.E. McBride The health consequences of smoking Cardiovascular diseases Med Clin North Am 76 1992 333 353
    • (1992) Med Clin North Am , vol.76 , pp. 333-353
    • McBride, P.E.1
  • 102
    • 0034609239 scopus 로고    scopus 로고
    • Smoking, smoking cessation, and lung cancer in the UK since 1950: Combination of national statistics with two case-control studies
    • R. Peto, S. Darby, H. Deo, P. Silcocks, E. Whitley, R. Doll Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies BMJ 321 2000 323 329
    • (2000) BMJ , vol.321 , pp. 323-329
    • Peto, R.1    Darby, S.2    Deo, H.3    Silcocks, P.4    Whitley, E.5    Doll, R.6
  • 103
    • 0038010210 scopus 로고    scopus 로고
    • Decreasing smoking behaviour and risk through CYP2A6 inhibition
    • E.M. Sellers, R.F. Tyndale, L.C. Fernandes Decreasing smoking behaviour and risk through CYP2A6 inhibition Drug Discov Today 8 2003 487 493
    • (2003) Drug Discov Today , vol.8 , pp. 487-493
    • Sellers, E.M.1    Tyndale, R.F.2    Fernandes, L.C.3
  • 105
    • 0028233466 scopus 로고
    • The effectiveness of the nicotine patch for smoking cessation: A meta-analysis
    • M.C. Fiore, S.S. Smith, D.E. Jorenby, T.B. Baker The effectiveness of the nicotine patch for smoking cessation A meta-analysis JAMA 271 1994 1940 1947
    • (1994) JAMA , vol.271 , pp. 1940-1947
    • Fiore, M.C.1    Smith, S.S.2    Jorenby, D.E.3    Baker, T.B.4
  • 106
    • 0344765490 scopus 로고    scopus 로고
    • Evidence for metabolic activation of N'-nitrosonornicotine and N-nitrosobenzylmethylamine by a rat nasal coumarin hydroxylase
    • C.J. Patten, L.A. Peterson, S.E. Murphy Evidence for metabolic activation of N'-nitrosonornicotine and N-nitrosobenzylmethylamine by a rat nasal coumarin hydroxylase Drug Metab Dispos 26 1998 177 180
    • (1998) Drug Metab Dispos , vol.26 , pp. 177-180
    • Patten, C.J.1    Peterson, L.A.2    Murphy, S.E.3
  • 107
    • 0031419535 scopus 로고    scopus 로고
    • Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes
    • C.J. Patten, T.J. Smith, M.J. Friesen, R.E. Tynes, C.S. Yang, S.E. Murphy Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes Carcinogenesis 18 1997 1623 1630
    • (1997) Carcinogenesis , vol.18 , pp. 1623-1630
    • Patten, C.J.1    Smith, T.J.2    Friesen, M.J.3    Tynes, R.E.4    Yang, C.S.5    Murphy, S.E.6
  • 108
    • 0041856534 scopus 로고    scopus 로고
    • Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes
    • G.B. Smith, J.R. Bend, L.L. Bedard, K.R. Reid, D. Petsikas, T.E. Massey Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes Drug Metab Dispos 31 2003 1134 1141
    • (2003) Drug Metab Dispos , vol.31 , pp. 1134-1141
    • Smith, G.B.1    Bend, J.R.2    Bedard, L.L.3    Reid, K.R.4    Petsikas, D.5    Massey, T.E.6
  • 109
    • 0026744568 scopus 로고
    • Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes
    • H. Yamazaki, Y. Inui, C.H. Yun, F.P. Guengerich, T. Shimada Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes Carcinogenesis 13 1992 1789 1794
    • (1992) Carcinogenesis , vol.13 , pp. 1789-1794
    • Yamazaki, H.1    Inui, Y.2    Yun, C.H.3    Guengerich, F.P.4    Shimada, T.5
  • 110
    • 0030917238 scopus 로고    scopus 로고
    • The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer
    • M.R. Law, J.K. Morris, H.C. Watt, N.J. Wald The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer Br J Cancer 75 1997 1690 1693
    • (1997) Br J Cancer , vol.75 , pp. 1690-1693
    • Law, M.R.1    Morris, J.K.2    Watt, H.C.3    Wald, N.J.4
  • 113
    • 0345707570 scopus 로고    scopus 로고
    • Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK
    • H. Wang, W. Tan, B. Hao, X. Miao, G. Zhou, F. He Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK Cancer Res 63 2003 8057 8061
    • (2003) Cancer Res , vol.63 , pp. 8057-8061
    • Wang, H.1    Tan, W.2    Hao, B.3    Miao, X.4    Zhou, G.5    He, F.6
  • 114
    • 0035916969 scopus 로고    scopus 로고
    • Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population
    • W. Tan, G.F. Chen, D.Y. Xing, C.Y. Song, F.F. Kadlubar, D.X. Lin Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population Int J Cancer 95 2001 96 101
    • (2001) Int J Cancer , vol.95 , pp. 96-101
    • Tan, W.1    Chen, G.F.2    Xing, D.Y.3    Song, C.Y.4    Kadlubar, F.F.5    Lin, D.X.6
  • 115
    • 0347599059 scopus 로고    scopus 로고
    • The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK) metabolism in vivo
    • E.M. Sellers, Y. Ramamoorthy, M.V. Zeman, M.V. Djordjevic, R.F. Tyndale The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) metabolism in vivo Nicotine Tob Res 5 2003 891 899
    • (2003) Nicotine Tob Res , vol.5 , pp. 891-899
    • Sellers, E.M.1    Ramamoorthy, Y.2    Zeman, M.V.3    Djordjevic, M.V.4    Tyndale, R.F.5
  • 116
    • 0033960956 scopus 로고    scopus 로고
    • Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity
    • E.D. Kharasch, D.C. Hankins, J.K. Taraday Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity Drug Metab Dispos 28 2000 28 33
    • (2000) Drug Metab Dispos , vol.28 , pp. 28-33
    • Kharasch, E.D.1    Hankins, D.C.2    Taraday, J.K.3
  • 117
    • 0031451433 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen
    • L.L. Koenigs, R.M. Peter, S.J. Thompson, A.E. Rettie, W.F. Trager Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen Drug Metab Dispos 25 1997 1407 1415
    • (1997) Drug Metab Dispos , vol.25 , pp. 1407-1415
    • Koenigs, L.L.1    Peter, R.M.2    Thompson, S.J.3    Rettie, A.E.4    Trager, W.F.5
  • 118
    • 0033940293 scopus 로고    scopus 로고
    • Mimicking gene defects to treat drug dependence
    • E.M. Sellers, R.F. Tyndale Mimicking gene defects to treat drug dependence Ann N Y Acad Sci 909 2000 233 246
    • (2000) Ann N Y Acad Sci , vol.909 , pp. 233-246
    • Sellers, E.M.1    Tyndale, R.F.2
  • 119
    • 0344844480 scopus 로고    scopus 로고
    • Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone in female A/J mice
    • H. Takeuchi, K. Saoo, M. Yokohira, M. Ikeda, H. Maeta, M. Miyazaki Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone in female A/J mice Cancer Res 63 2003 7581 7583
    • (2003) Cancer Res , vol.63 , pp. 7581-7583
    • Takeuchi, H.1    Saoo, K.2    Yokohira, M.3    Ikeda, M.4    Maeta, H.5    Miyazaki, M.6
  • 120
    • 0033866924 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking
    • E.M. Sellers, H.L. Kaplan, R.F. Tyndale Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking Clin Pharmacol Ther 68 2000 35 43
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 35-43
    • Sellers, E.M.1    Kaplan, H.L.2    Tyndale, R.F.3
  • 121
    • 0034805710 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism altering stability and activity of CYP2a6
    • N. Ariyoshi, Y. Sawamura, T. Kamataki A novel single nucleotide polymorphism altering stability and activity of CYP2a6 Biochem Biophys Res Commun 281 2001 810 814
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 810-814
    • Ariyoshi, N.1    Sawamura, Y.2    Kamataki, T.3
  • 124
    • 0030697098 scopus 로고    scopus 로고
    • A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin
    • H. Hadidi, K. Zahlsen, J.R. Idle, S. Cholerton A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin Food Chem Toxicol 35 1997 903 907
    • (1997) Food Chem Toxicol , vol.35 , pp. 903-907
    • Hadidi, H.1    Zahlsen, K.2    Idle, J.R.3    Cholerton, S.4
  • 126
    • 0033659142 scopus 로고    scopus 로고
    • Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C
    • N. Ariyoshi, Y. Takahashi, M. Miyamoto, Y. Umetsu, S. Daigo, T. Tateishi Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C Pharmacogenetics 10 2000 687 693
    • (2000) Pharmacogenetics , vol.10 , pp. 687-693
    • Ariyoshi, N.1    Takahashi, Y.2    Miyamoto, M.3    Umetsu, Y.4    Daigo, S.5    Tateishi, T.6
  • 127
    • 0032945691 scopus 로고    scopus 로고
    • A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans
    • K.I. Nunoya, T. Yokoi, K. Kimura, T. Kainuma, K. Satoh, M. Kinoshita A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans J Pharmacol Exp Ther 289 1999 437 442
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 437-442
    • Nunoya, K.I.1    Yokoi, T.2    Kimura, K.3    Kainuma, T.4    Satoh, K.5    Kinoshita, M.6
  • 128
    • 0033067287 scopus 로고    scopus 로고
    • Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population
    • M. Oscarson, R.A. McLellan, H. Gullsten, Q.Y. Yue, M.A. Lang, M.L. Bernal Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population FEBS Lett 448 1999 105 110
    • (1999) FEBS Lett , vol.448 , pp. 105-110
    • Oscarson, M.1    McLellan, R.A.2    Gullsten, H.3    Yue, Q.Y.4    Lang, M.A.5    Bernal, M.L.6
  • 129
    • 7144257874 scopus 로고    scopus 로고
    • A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502)
    • K. Nunoya, T. Yokoi, K. Kimura, K. Inoue, T. Kodama, M. Funayama A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5- dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) Pharmacogenetics 8 1998 239 249
    • (1998) Pharmacogenetics , vol.8 , pp. 239-249
    • Nunoya, K.1    Yokoi, T.2    Kimura, K.3    Inoue, K.4    Kodama, T.5    Funayama, M.6
  • 130
    • 0032698297 scopus 로고    scopus 로고
    • Identification and characterisation of novel polymorphisms in the CYP2A locus: Implications for nicotine metabolism
    • M. Oscarson, R.A. McLellan, H. Gullsten, J.A. Agundez, J. Benitez, A. Rautio Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism FEBS Lett 460 1999 321 327
    • (1999) FEBS Lett , vol.460 , pp. 321-327
    • Oscarson, M.1    McLellan, R.A.2    Gullsten, H.3    Agundez, J.A.4    Benitez, J.5    Rautio, A.6
  • 131
    • 0035947589 scopus 로고    scopus 로고
    • CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity
    • K. Kitagawa, N. Kunugita, M. Kitagawa, T. Kawamoto CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity J Biol Chem 276 2001 17830 17835
    • (2001) J Biol Chem , vol.276 , pp. 17830-17835
    • Kitagawa, K.1    Kunugita, N.2    Kitagawa, M.3    Kawamoto, T.4
  • 132
    • 0036435654 scopus 로고    scopus 로고
    • Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism
    • R. Yoshida, M. Nakajima, Y. Watanabe, J.T. Kwon, T. Yokoi Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism Br J Clin Pharmacol 54 2002 511 517
    • (2002) Br J Clin Pharmacol , vol.54 , pp. 511-517
    • Yoshida, R.1    Nakajima, M.2    Watanabe, Y.3    Kwon, J.T.4    Yokoi, T.5
  • 133
    • 0036016314 scopus 로고    scopus 로고
    • A novel mutant allele of the CYP2A6 gene (CYP2A6*11) found in a cancer patient who showed poor metabolic phenotype towards tegafur
    • S. Daigo, Y. Takahashi, M. Fujieda, N. Ariyoshi, H. Yamazaki, W. Koizumi A novel mutant allele of the CYP2A6 gene (CYP2A6*11) found in a cancer patient who showed poor metabolic phenotype towards tegafur Pharmacogenetics 12 2002 299 306
    • (2002) Pharmacogenetics , vol.12 , pp. 299-306
    • Daigo, S.1    Takahashi, Y.2    Fujieda, M.3    Ariyoshi, N.4    Yamazaki, H.5    Koizumi, W.6
  • 134
    • 0036389893 scopus 로고    scopus 로고
    • Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity
    • M. Oscarson, R.A. McLellan, V. Asp, M. Ledesma, M.L. Ruiz, B. Sinues Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity Hum Mutat 20 2002 275 283
    • (2002) Hum Mutat , vol.20 , pp. 275-283
    • Oscarson, M.1    McLellan, R.A.2    Asp, V.3    Ledesma, M.4    Ruiz, M.L.5    Sinues, B.6
  • 135
    • 12144290652 scopus 로고    scopus 로고
    • Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9)
    • K. Kiyotani, H. Yamazaki, M. Fujieda, S. Iwano, K. Matsumura, S. Satarug Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9) Pharmacogenetics 13 2003 689 695
    • (2003) Pharmacogenetics , vol.13 , pp. 689-695
    • Kiyotani, K.1    Yamazaki, H.2    Fujieda, M.3    Iwano, S.4    Matsumura, K.5    Satarug, S.6
  • 136
    • 0034816629 scopus 로고    scopus 로고
    • Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: Impairment of its promoter activity
    • M. Pitarque, O. von Richter, B. Oke, H. Berkkan, M. Oscarson, M. Ingelman-Sundberg Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity Biochem Biophys Res Commun 284 2001 455 460
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 455-460
    • Pitarque, M.1    Von Richter, O.2    Oke, B.3    Berkkan, H.4    Oscarson, M.5    Ingelman-Sundberg, M.6
  • 137
    • 0037757965 scopus 로고    scopus 로고
    • Effects of polymorphism in promoter region of human CYP2A6 gene (CYP2A6*9) on expression level of messenger ribonucleic acid and enzymatic activity in vivo and in vitro
    • R. Yoshida, M. Nakajima, K. Nishimura, S. Tokudome, J.T. Kwon, T. Yokoi Effects of polymorphism in promoter region of human CYP2A6 gene (CYP2A6*9) on expression level of messenger ribonucleic acid and enzymatic activity in vivo and in vitro Clin Pharmacol Ther 74 2003 69 76
    • (2003) Clin Pharmacol Ther , vol.74 , pp. 69-76
    • Yoshida, R.1    Nakajima, M.2    Nishimura, K.3    Tokudome, S.4    Kwon, J.T.5    Yokoi, T.6
  • 138
    • 0035976390 scopus 로고    scopus 로고
    • Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method
    • T. Paschke, M. Riefler, A. Schuler-Metz, L. Wolz, G. Scherer, C.M. McBride Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method Toxicology 168 2001 259 268
    • (2001) Toxicology , vol.168 , pp. 259-268
    • Paschke, T.1    Riefler, M.2    Schuler-Metz, A.3    Wolz, L.4    Scherer, G.5    McBride, C.M.6
  • 139
    • 0032805514 scopus 로고    scopus 로고
    • Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method
    • G.F. Chen, Y.M. Tang, B. Green, D.X. Lin, F.P. Guengerich, A.K. Daly Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method Pharmacogenetics 9 1999 327 332
    • (1999) Pharmacogenetics , vol.9 , pp. 327-332
    • Chen, G.F.1    Tang, Y.M.2    Green, B.3    Lin, D.X.4    Guengerich, F.P.5    Daly, A.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.