Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine α-hydroxylation by human liver microsomes

Carcinogenesis

Volumn 18, Issue 8, 1997, Pages 1623-1630

  Patten, Christopher J ^a,c,d   Smith, Teresa J ^b   Friesen, Mark J ^a   Tynes, Ronald E ^a   Yang, C S ^b   Murphy, Sharon E ^c,d  

^a Sandoz Pharma Ltd   (Switzerland)

^b RUTGERS UNIVERSITY   (United States)

^c AMERICAN HEALTH FOUNDATION   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; COUMARIN; CYTOCHROME P450; NITROSONORNICOTINE; TROLEANDOMYCIN;

ARTICLE; CARCINOGENESIS; CATALYST; CHO CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROXYLATION; LIVER MICROSOME; METABOLIC ACTIVATION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; CRICETINAE; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROXYLATION; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; NITROSAMINES; NITROSO COMPOUNDS;

EID: 0031419535     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.8.1623     Document Type: Article

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