-
1
-
-
0025022689
-
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
-
Yamano,S., Tatsuno,J. and Gonzalez,F.J. (1990) The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry, 29, 1322-1329.
-
(1990)
Biochemistry
, vol.29
, pp. 1322-1329
-
-
Yamano, S.1
Tatsuno, J.2
Gonzalez, F.J.3
-
2
-
-
8044258385
-
Role of human cytochrome P4502A6 in C-oxidation of nicotine
-
Nakajima,M., Yamamoto,T., Nunoya,K. et al. (1996) Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab. Dispos., 24, 1212-1217.
-
(1996)
Drug Metab. Dispos.
, vol.24
, pp. 1212-1217
-
-
Nakajima, M.1
Yamamoto, T.2
Nunoya, K.3
-
3
-
-
0030435329
-
(+)-cis-3,5-Dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes
-
Nunoya,K., Yokoi,T., Kimura,K. et al. (1996) (+)-cis 3,5-Dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes. J. Pharmacol. Exp. Ther., 277, 768-774.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.277
, pp. 768-774
-
-
Nunoya, K.1
Yokoi, T.2
Kimura, K.3
-
4
-
-
0033664818
-
Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes
-
Komatsu,T., Yamazaki,H., Shimada,N., Nakajima,M. and Yokoi,T. (2000) Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab. Dispos., 28, 1457-1463.
-
(2000)
Drug Metab. Dispos.
, vol.28
, pp. 1457-1463
-
-
Komatsu, T.1
Yamazaki, H.2
Shimada, N.3
Nakajima, M.4
Yokoi, T.5
-
5
-
-
0034599544
-
CYP2A6: A human coumarin 7-hydroxylase
-
Pelkonen,O., Rautio,A., Raunio,H. and Pasanen,M. (2000) CYP2A6: a human coumarin 7-hydroxylase. Toxicology, 144, 139-147.
-
(2000)
Toxicology
, vol.144
, pp. 139-147
-
-
Pelkonen, O.1
Rautio, A.2
Raunio, H.3
Pasanen, M.4
-
6
-
-
0028925110
-
Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity
-
Kharasch,E.D., Hankins,D.C. and Thummel,K.E. (1995) Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology, 82, 689-699.
-
(1995)
Anesthesiology
, vol.82
, pp. 689-699
-
-
Kharasch, E.D.1
Hankins, D.C.2
Thummel, K.E.3
-
7
-
-
0030831766
-
Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid
-
Sadeque,A.J.M., Fisher,M.B., Korzekwa,K.R., Gonzalez,F.J. and Rettie,A.E. (1997) Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid. J. Pharmacol. Exp. Ther., 283 698-703.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.283
, pp. 698-703
-
-
Sadeque, A.J.M.1
Fisher, M.B.2
Korzekwa, K.R.3
Gonzalez, F.J.4
Rettie, A.E.5
-
8
-
-
0025848338
-
A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6
-
Crespi,C.L., Penman,B.W., Gelboin,H.V. and Gonzalez,F.J. (1991) A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. Carcinogenesis, 12, 1197-1201.
-
(1991)
Carcinogenesis
, vol.12
, pp. 1197-1201
-
-
Crespi, C.L.1
Penman, B.W.2
Gelboin, H.V.3
Gonzalez, F.J.4
-
9
-
-
0035684794
-
Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase
-
Fujita,K. and Kamataki,T. (2001) Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase. Environ. Mol. Mutagen., 38, 339-346.
-
(2001)
Environ. Mol. Mutagen.
, vol.38
, pp. 339-346
-
-
Fujita, K.1
Kamataki, T.2
-
10
-
-
0026934672
-
Interindividual variability of coumarin 7-hydroxylation in healthy volunteers
-
Rautio,A., Kraul,H., Kojo,A., Salmela,E. and Pelkonen,O. (1992) Interindividual variability of coumarin 7-hydroxylation in healthy volunteers. Pharmacogenetics, 2, 227-233.
-
(1992)
Pharmacogenetics
, vol.2
, pp. 227-233
-
-
Rautio, A.1
Kraul, H.2
Kojo, A.3
Salmela, E.4
Pelkonen, O.5
-
11
-
-
0027984350
-
Interindividual variability of coumarin 7-hydroxylation in a Turkish population
-
Iscan,M., Rostami,H., Guray,T., Pelkonen,O. and Rautio,A. (1994) Interindividual variability of coumarin 7-hydroxylation in a Turkish population. Eur. J. Clin. Pharmacol., 47, 315-318.
-
(1994)
Eur. J. Clin. Pharmacol.
, vol.47
, pp. 315-318
-
-
Iscan, M.1
Rostami, H.2
Guray, T.3
Pelkonen, O.4
Rautio, A.5
-
12
-
-
9044254525
-
P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
-
Nelson,D.R., Koymans,L., Kamataki,T. et al. (1996) P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1-42.
-
(1996)
Pharmacogenetics
, vol.6
, pp. 1-42
-
-
Nelson, D.R.1
Koymans, L.2
Kamataki, T.3
-
13
-
-
0031737551
-
Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase
-
Oscarson,M., Gullsten,H., Rautio,A., Bernal,M.L., Sinues,B., Dahl,M.-L., Stengard,J.H., Pelkonen,O., Raunio,H. and Ingelman-Sundberg,M. (1998) Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase. FEBS Lett., 438, 201-205.
-
(1998)
FEBS Lett.
, vol.438
, pp. 201-205
-
-
Oscarson, M.1
Gullsten, H.2
Rautio, A.3
Bernal, M.L.4
Sinues, B.5
Dahl, M.-L.6
Stengard, J.H.7
Pelkonen, O.8
Raunio, H.9
Ingelman-Sundberg, M.10
-
14
-
-
0032698297
-
Identification and characterisation of novel polymorphisms in the CYP2A locus: Implications for nicotine metabolism
-
Oscarson,M., McLellan,R.A., Gullsten,H., Agundez,J.A.G., Benitez,J., Rautio,A., Raunio,H., Pelkonen,O. and Ingelman-Sundberg,M. (1999) Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism. FEBS Lett. 460, 321-327.
-
(1999)
FEBS Lett.
, vol.460
, pp. 321-327
-
-
Oscarson, M.1
McLellan, R.A.2
Gullsten, H.3
Agundez, J.A.G.4
Benitez, J.5
Rautio, A.6
Raunio, H.7
Pelkonen, O.8
Ingelman-Sundberg, M.9
-
15
-
-
0035947589
-
CYP2A6*6, a novel polymorphism in cytochrome P450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity
-
Kitagawa,K., Kunugita,N., Kitagawa,M. and Kawamoto,T. (2001) CYP2A6*6, a novel polymorphism in cytochrome P450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity. J. Biol. Chem., 21, 17830-17835.
-
(2001)
J. Biol. Chem.
, vol.21
, pp. 17830-17835
-
-
Kitagawa, K.1
Kunugita, N.2
Kitagawa, M.3
Kawamoto, T.4
-
16
-
-
1542264940
-
Novel mutations of the CYP2A6 gene in a Thai population with capacity of coumarin 7-hydroxylation
-
Kiyotani,K., Yamazaki,H., Fujieda,M., Daigo,S., Satarug,S., Ujjin,P. and Kamataki,T. (2002) Novel mutations of the CYP2A6 gene in a Thai population with capacity of coumarin 7-hydroxylation. Drug Metab. Pharmacokinet., 17, 161-163.
-
(2002)
Drug Metab. Pharmacokinet.
, vol.17
, pp. 161-163
-
-
Kiyotani, K.1
Yamazaki, H.2
Fujieda, M.3
Daigo, S.4
Satarug, S.5
Ujjin, P.6
Kamataki, T.7
-
17
-
-
0041361124
-
Twenty one novel single polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians
-
Kiyotani,K., Fujieda,M., Yamazaki,H., Shimada,T., Guengerich,F.P., Parkinson,A., Nakagawa,K., Ishizaki,T. and Kamataki,T. (2002) Twenty one novel single polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians. Drug Metab. Pharmacokinet., 17 453-458.
-
(2002)
Drug Metab. Pharmacokinet.
, vol.17
, pp. 453-458
-
-
Kiyotani, K.1
Fujieda, M.2
Yamazaki, H.3
Shimada, T.4
Guengerich, F.P.5
Parkinson, A.6
Nakagawa, K.7
Ishizaki, T.8
Kamataki, T.9
-
18
-
-
0036389893
-
Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity
-
Oscarson,M., McLellan,R.A., Asp,V., Ledesma,M., Ruiz,M.L., Sinues,B., Rautio,A. and Ingelman-Sundberg,M. (2002) Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity. Hum. Mutat., 20, 275-283.
-
(2002)
Hum. Mutat.
, vol.20
, pp. 275-283
-
-
Oscarson, M.1
McLellan, R.A.2
Asp, V.3
Ledesma, M.4
Ruiz, M.L.5
Sinues, B.6
Rautio, A.7
Ingelman-Sundberg, M.8
-
19
-
-
7144257874
-
A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502)
-
Nunoya,K., Yokoi,T., Kimura,K. et al. (1998) A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+ -cis 3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502). Pharmacogenetics, 8, 239-249.
-
(1998)
Pharmacogenetics
, vol.8
, pp. 239-249
-
-
Nunoya, K.1
Yokoi, T.2
Kimura, K.3
-
20
-
-
0036667958
-
Characterization of a genotype previously designated as CYP2A6 D-type: CYP2A6*4B, another entire gene deletion allele of the CYP2A6 gene in Japanese
-
Ariyoshi,N., Sekine,H., Saito,K. and Kamataki,T. (2002) Characterization of a genotype previously designated as CYP2A6 D-type: CYP2A6*4B, another entire gene deletion allele of the CYP2A6 gene in Japanese. Pharmacogenetics, 12, 501-504.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 501-504
-
-
Ariyoshi, N.1
Sekine, H.2
Saito, K.3
Kamataki, T.4
-
21
-
-
0034805710
-
A novel single nucleotide polymorphism altering stability and activity of CYP2A6
-
Ariyoshi,N., Sawamura,Y. and Kamataki,T. (2001) A novel single nucleotide polymorphism altering stability and activity of CYP2A6. Biochem. Biophys. Res. Commun., 281, 810-814.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.281
, pp. 810-814
-
-
Ariyoshi, N.1
Sawamura, Y.2
Kamataki, T.3
-
22
-
-
0036016314
-
A novel mutant allele of the CYP2A6 gene (CYP2A6*11) found in a cancer patient who showed poor metabolic phenotype towards tegafur
-
Daigo,S., Takahashi,Y., Fujieda,M. et al. (2002) A novel mutant allele of the CYP2A6 gene (CYP2A6*11) found in a cancer patient who showed poor metabolic phenotype towards tegafur. Pharmacogenetics, 12, 299-306.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 299-306
-
-
Daigo, S.1
Takahashi, Y.2
Fujieda, M.3
-
23
-
-
12144290652
-
Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9)
-
Kiyotani,K., Yamazaki,H., Fujieda,M. et al. (2003) Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9). Pharmacogenetics, 13, 689-695.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 689-695
-
-
Kiyotani, K.1
Yamazaki, H.2
Fujieda, M.3
-
24
-
-
0036299144
-
An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles
-
Xu,C., Rao,Y.S., Xu,B., Hoffman,E., Jones,J., Sellers,E.M. and Tydale,R.F. (2002) An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles. Biochem. Biophys. Res. Commun., 290, 318-324.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.290
, pp. 318-324
-
-
Xu, C.1
Rao, Y.S.2
Xu, B.3
Hoffman, E.4
Jones, J.5
Sellers, E.M.6
Tydale, R.F.7
-
26
-
-
0030686551
-
Environment and cancer: Who are susceptible?
-
Perera,F.R. (1997) Environment and cancer: who are susceptible? Science, 278, 1068-1073.
-
(1997)
Science
, vol.278
, pp. 1068-1073
-
-
Perera, F.R.1
-
27
-
-
0033550994
-
Genetic variation of CYP2A6, smoking, and risk of cancer
-
London,S.J., Idle,J.R., Daly,A.K. and Coetzee,G.A. (1999) Genetic variation of CYP2A6, smoking, and risk of cancer. Lancet, 353, 898-899.
-
(1999)
Lancet
, vol.353
, pp. 898-899
-
-
London, S.J.1
Idle, J.R.2
Daly, A.K.3
Coetzee, G.A.4
-
28
-
-
0033546744
-
CYP2A6 gene deletion reduces susceptibility to lung cancer
-
Miyamoto,M., Umetsu,Y., Dosaka-Akita,H., Sawamura,Y., Yokota,J., Kunitoh,H., Nemoto,N., Sato,K., Ariyoshi,N. and Kamataki,T. (1999) CYP2A6 gene deletion reduces susceptibility to lung cancer. Biochem. Biophys. Res. Commun., 261, 658-660.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.261
, pp. 658-660
-
-
Miyamoto, M.1
Umetsu, Y.2
Dosaka-Akita, H.3
Sawamura, Y.4
Yokota, J.5
Kunitoh, H.6
Nemoto, N.7
Sato, K.8
Ariyoshi, N.9
Kamataki, T.10
-
29
-
-
17744381734
-
Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population
-
Loriot,M-A., Rebuissou,S., Oscarson,M., Cenee,S., Miyamoto,M., Ariyoshi,N., Kamataki,T., Hemon,D., Beaune,P. and Stucker,I. (2001) Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population. Pharmacogenetics, 11, 39-44.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 39-44
-
-
Loriot, M.-A.1
Rebuissou, S.2
Oscarson, M.3
Cenee, S.4
Miyamoto, M.5
Ariyoshi, N.6
Kamataki, T.7
Hemon, D.8
Beaune, P.9
Stucker, I.10
-
30
-
-
0035916969
-
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population
-
Tan,W., Chen,G.-F., Xing,D.-Y., Song,C.-Y., Kadlubar,F.F. and Lin,D.-X. (2001) Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population. Int. J. Cancer, 95, 96-101.
-
(2001)
Int. J. Cancer
, vol.95
, pp. 96-101
-
-
Tan, W.1
Chen, G.-F.2
Xing, D.-Y.3
Song, C.-Y.4
Kadlubar, F.F.5
Lin, D.-X.6
-
31
-
-
0036716809
-
Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers. Cancer Epidemiol
-
Ariyoshi,N., Miyamoto,M., Umetsu,Y., Kunitoh,H., Dosaka-Akita,H., Sawamura,Y., Yokota,J., Nemoto,N., Sato,K. and Kamataki,T. (2002) Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers. Cancer Epidemiol. Biomarkers Prev., 11, 890-894.
-
(2002)
Biomarkers Prev.
, vol.11
, pp. 890-894
-
-
Ariyoshi, N.1
Miyamoto, M.2
Umetsu, Y.3
Kunitoh, H.4
Dosaka-Akita, H.5
Sawamura, Y.6
Yokota, J.7
Nemoto, N.8
Sato, K.9
Kamataki, T.10
-
32
-
-
0345707570
-
Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK
-
Wang,H., Tan,W., Hao,B., Miao,X., Zhou,G., He,F. and Lin,D. (2003) Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK. Cancer Res., 63, 8057-8061.
-
(2003)
Cancer Res.
, vol.63
, pp. 8057-8061
-
-
Wang, H.1
Tan, W.2
Hao, B.3
Miao, X.4
Zhou, G.5
He, F.6
Lin, D.7
-
33
-
-
0344844480
-
Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice
-
Takeuchi,H., Saoo,K., Yokohira,M., Ikeda,M., Maeta,H., Miyazaki,M., Yamazaki,H., Kamataki,T. and Imaida,K. (2003) Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. Cancer Res., 63, 7581-7583.
-
(2003)
Cancer Res.
, vol.63
, pp. 7581-7583
-
-
Takeuchi, H.1
Saoo, K.2
Yokohira, M.3
Ikeda, M.4
Maeta, H.5
Miyazaki, M.6
Yamazaki, H.7
Kamataki, T.8
Imaida, K.9
-
34
-
-
0005480504
-
Pathology: Revised classification of epithelial tumors of the lung (WHO/IASLC)
-
Hansen,H.H. (ed.), Martin Dunitz, London
-
Shimosato,Y. (2000) Pathology: revised classification of epithelial tumors of the lung (WHO/IASLC). In Hansen,H.H. (ed.), Textbook of Lung Cancer. Martin Dunitz, London, pp. 125-140.
-
(2000)
Textbook of Lung Cancer
, pp. 125-140
-
-
Shimosato, Y.1
-
35
-
-
0002440928
-
Molecular cloning
-
2nd Edn. Cold Spring Harbor Laboratory Press, New York
-
Sambrook,J., Fritsch,E.F. and Maniatis,T. (1989) Molecular cloning. In A Laboratory Manual, 2nd Edn. Cold Spring Harbor Laboratory Press, New York.
-
(1989)
A Laboratory Manual
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
36
-
-
0033659142
-
Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C
-
Ariyoshi,N., Takahashi,Y., Miyamoto,M. et al. (2000) Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C. Pharmacogenetics, 10, 687-693.
-
(2000)
Pharmacogenetics
, vol.10
, pp. 687-693
-
-
Ariyoshi, N.1
Takahashi, Y.2
Miyamoto, M.3
-
37
-
-
0027988016
-
Smoking and lung cancer: Scientific challenges and opportunities
-
Wynder,E.L. and Hoffmann,D. (1994) Smoking and lung cancer: scientific challenges and opportunities. Cancer Res., 54, 5284-5295.
-
(1994)
Cancer Res.
, vol.54
, pp. 5284-5295
-
-
Wynder, E.L.1
Hoffmann, D.2
-
38
-
-
0032211358
-
Association of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens
-
Le Marchand,L., Sivaraman,L., Pierce,L., Seifried,A., Lum,A., Wilkens,L.R. and Lau,A.F. (1998) Association of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens. Cancer Res., 58, 4858-4863.
-
(1998)
Cancer Res.
, vol.58
, pp. 4858-4863
-
-
Le Marchand, L.1
Sivaraman, L.2
Pierce, L.3
Seifried, A.4
Lum, A.5
Wilkens, L.R.6
Lau, A.F.7
-
39
-
-
0033067287
-
Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population
-
Oscarson,M., McLellan,R.A., Gullsten,H. et al. (1999) Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population. FEBS Lett., 448, 105-110.
-
(1999)
FEBS Lett.
, vol.448
, pp. 105-110
-
-
Oscarson, M.1
McLellan, R.A.2
Gullsten, H.3
-
40
-
-
0036435654
-
Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism
-
Yoshida,R., Nakajima,M., Watanabe,Y., Kwon,J.-T. and Yokoi,T. (2002) Genetic polymorphisms in human CYP2A6 gene causing impaired nicotine metabolism. Br. J. Clin. Pharmacol., 54, 511-517.
-
(2002)
Br. J. Clin. Pharmacol.
, vol.54
, pp. 511-517
-
-
Yoshida, R.1
Nakajima, M.2
Watanabe, Y.3
Kwon, J.-T.4
Yokoi, T.5
-
41
-
-
0035064372
-
Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk
-
Tyndale,R.F. and Sellers,E.M. (2001) Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk. Drug Metab. Dispos., 29, 548-552.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 548-552
-
-
Tyndale, R.F.1
Sellers, E.M.2
-
42
-
-
0036146769
-
Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior
-
Tyndale,R.F. and Sellers,E.M. (2002) Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. Ther. Drug Monit., 24, 163-171.
-
(2002)
Ther. Drug Monit.
, vol.24
, pp. 163-171
-
-
Tyndale, R.F.1
Sellers, E.M.2
-
43
-
-
0038010210
-
Decreasing smoking behaviour and risk through CYP2A6 inhibition
-
Sellers,E.M., Tyndale,R.F. and Fernandes,L.C. (2003) Decreasing smoking behaviour and risk through CYP2A6 inhibition. Drug Discov. Today, 8, 487-493.
-
(2003)
Drug Discov. Today
, vol.8
, pp. 487-493
-
-
Sellers, E.M.1
Tyndale, R.F.2
Fernandes, L.C.3
-
44
-
-
0347599059
-
The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo
-
Sellers,E.M., Ramamoorthy,Y., Zeman,M.V., Djordjevic,M.V. and Tyndale,R.F. (2003) The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo. Nicotine Tob. Res., 5, 891-899.
-
(2003)
Nicotine Tob. Res.
, vol.5
, pp. 891-899
-
-
Sellers, E.M.1
Ramamoorthy, Y.2
Zeman, M.V.3
Djordjevic, M.V.4
Tyndale, R.F.5
-
45
-
-
0029099107
-
A genetic polymorphism in coumarin 7-hydroxylation: Sequence of the human CYP2A genes and identification of variant CYP2A6 alleles
-
Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S. et al. (1995) A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Am. J. Hum. Genet., 57, 651-660.
-
(1995)
Am. J. Hum. Genet.
, vol.57
, pp. 651-660
-
-
Fernandez-Salguero, P.1
Hoffman, S.M.2
Cholerton, S.3
-
46
-
-
0032565878
-
Nicotine metabolism defect reduces smoking
-
Pianezza,M.L., Sellers,E.M. and Tyndale,R.F. (1998) Nicotine metabolism defect reduces smoking. Nature, 393, 750.
-
(1998)
Nature
, vol.393
, pp. 750
-
-
Pianezza, M.L.1
Sellers, E.M.2
Tyndale, R.F.3
-
47
-
-
0034091750
-
CYP2D6 ultrarapid metabolizer genotypes as a potential modifier of smoking behaviour
-
Saarikoski,S.T., Sata,F., Husgafvel-Pursiainen,K., Rautalahti,M., Haukka,J., Impivaara,O., Jarvisalo,J., Vainio,H. and Hirvonen,A. (2000) CYP2D6 ultrarapid metabolizer genotypes as a potential modifier of smoking behaviour. Pharmacogenetics, 10, 5-10.
-
(2000)
Pharmacogenetics
, vol.10
, pp. 5-10
-
-
Saarikoski, S.T.1
Sata, F.2
Husgafvel-Pursiainen, K.3
Rautalahti, M.4
Haukka, J.5
Impivaara, O.6
Jarvisalo, J.7
Vainio, H.8
Hirvonen, A.9
-
48
-
-
0031408864
-
Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite
-
Carmella,S.G., Borukhova,A., Desai,D. and Hecht,S.S. (1997) Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite. Carcinogenesis 18, 587-592.
-
(1997)
Carcinogenesis
, vol.18
, pp. 587-592
-
-
Carmella, S.G.1
Borukhova, A.2
Desai, D.3
Hecht, S.S.4
-
49
-
-
0026741674
-
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells
-
Smith,T.J., Guo,Z., Gonzalez,F.J., Guengerich,F.P., Stoner,G.D. and Yang,C.S. (1980) Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells. Cancer Res., 52, 1757-1763.
-
(1980)
Cancer Res.
, vol.52
, pp. 1757-1763
-
-
Smith, T.J.1
Guo, Z.2
Gonzalez, F.J.3
Guengerich, F.P.4
Stoner, G.D.5
Yang, C.S.6
-
50
-
-
0028787779
-
Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides
-
Smith,T.J., Stoner,G.D. and Yang,C.S. (1980) Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides. Cancer Res., 55, 5566-5573.
-
(1980)
Cancer Res.
, vol.55
, pp. 5566-5573
-
-
Smith, T.J.1
Stoner, G.D.2
Yang, C.S.3
-
51
-
-
84989325647
-
Eighteen novel polymorphisms of the CYP2A13 gene in Japanese
-
Fujieda,M., Yamazaki,H., Kiyotani,K., Muroi,A., Kunitoh,H., Dosaka-Akita,H., Sawamura,Y. and Kamataki,T. (2003) Eighteen novel polymorphisms of the CYP2A13 gene in Japanese. Drug Metab. Pharmacokinet., 18, 86-90.
-
(2003)
Drug Metab. Pharmacokinet.
, vol.18
, pp. 86-90
-
-
Fujieda, M.1
Yamazaki, H.2
Kiyotani, K.3
Muroi, A.4
Kunitoh, H.5
Dosaka-Akita, H.6
Sawamura, Y.7
Kamataki, T.8
-
52
-
-
0025296345
-
Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450
-
McManus,M.E., Burgess,W.M., Veronese,M.E., Huggett,A., Quattrochi,L.C. and Tukey,R.H. (1990) Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res., 50, 3367-3376.
-
(1990)
Cancer Res.
, vol.50
, pp. 3367-3376
-
-
McManus, M.E.1
Burgess, W.M.2
Veronese, M.E.3
Huggett, A.4
Quattrochi, L.C.5
Tukey, R.H.6
-
53
-
-
0027077438
-
Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens
-
Shimada,T., Yun,C.H., Yamazaki,H., Gautier,J.C., Beaune,P.H. and Guengerich,F.P. (1992) Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens. Mol. Pharmacol., 41, 856-864.
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 856-864
-
-
Shimada, T.1
Yun, C.H.2
Yamazaki, H.3
Gautier, J.C.4
Beaune, P.H.5
Guengerich, F.P.6
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