A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)- cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502)

Pharmacogenetics

Volumn 8, Issue 3, 1998, Pages 239-249

  Nunoya, Ken ichi ^a   Yokoi, Tsuyoshi ^a   Kimura, Kanzo ^b   Inoue, Kazuaki ^c   Kodama, Takao ^d   Funayama, Masato ^e   Nagashima, Kazuo ^f   Funae, Yoshihiko ^g   Green, Carol ^h   Kinoshita, Moritoshi ⁱ   Kamataki, Tetsuya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

^d Hokkaido Assoc Med Serv Workers   (Japan)

^e SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f HOKKAIDO UNIVERSITY   (Japan)

^g OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h SRI INTERNATIONAL   (United States)

ⁱ OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Gene deletion; Genetic polymorphism; Poor metabolizer; Restriction fragment length polymorphism

Indexed keywords

3,5 DIMETHYL 2 (3 PYRIDYL) 4 THIAZOLIDINONE; COUMARIN;

ARTICLE; DRUG HYDROXYLATION; DRUG OXIDATION; ENZYME ACTIVITY; GENE DELETION; HUMAN; HUMAN EXPERIMENT; LIVER MICROSOME METABOLISM; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 7144257874     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-199806000-00006     Document Type: Article

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