High levels of dopamine activity in the basal ganglia of cigarette smokers

American Journal of Psychiatry

Volumn 157, Issue 4, 2000, Pages 632-634

  Salokangas, Raimo K R ^a   Vilkman, Harry ^b   Ilonen, Tuula ^b   Taiminen, Tero ^b   Bergman, Jörgen ^b   Haaparanta, Merja ^b   Solin, Olof ^b   Alanen, Anu ^b   Syvälahti, Erkka ^b   Hietala, Jarmo ^b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINE;

ADULT; ARTICLE; BASAL GANGLION; BRAIN METABOLISM; CIGARETTE SMOKING; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; DRUG UPTAKE; ENERGY METABOLISM; FRONTAL LOBE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; REINFORCEMENT;

ADULT; BASAL GANGLIA; CAUDATE NUCLEUS; CORPUS STRIATUM; DIHYDROXYPHENYLALANINE; DOPAMINE; FEMALE; FLUORINE RADIOISOTOPES; FUNCTIONAL LATERALITY; HUMANS; MALE; PUTAMEN; SMOKING; TOBACCO USE DISORDER; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 18844471225     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.157.4.632     Document Type: Article

References (14)

1. Iversen LL: Smoking harmful to the brain. Nature 1996; 382: 206-207
2. Hughes JR, Hatsukami DK, Mitchell JE, Dahlgren LA: Prevalence of smoking among psychiatric outpatients. Am J Psychiatry 1986; 143:993-997
3. Decina P, Caracci G, Sandik R, Berman W, Mukherjee S, Scapicchio P: Cigarette smoking and neuroleptic-induced parkinsonism. Biol Psychiatry 1990; 28:502-508
4. Pontieri FE, Tanda G, Orzi F, DiChiara G: Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature 1996; 382:255-257
5. Koob GF: Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 1992; 13:177-184
6. Stein EA, Pankiewicz J, Harsch HH, Cho J-K, Fuller SA, Hoffmann RG, Hawkins M, Rao SM, Bandettini PA, Bloom AS: Nicotine-induced limbic cortical activation in the human brain: a functional MRI study. Am J Psychiatry 1998; 155:1009-1015
7. Geracioti TD Jr, West SA, Baker DG, Hill KK, Ekhato NN, Wortman MD, Keck PE Jr, Norman AB: Low CSF concentration of dopamine metabolite in tobacco smokers. Am J Psychiatry 1999; 156:130-132
8. Wing JK, Babor T, Brugha T, Burke J, Cooper JE, Giel R, Jablenski A, Regier D, Sartorius N: SCAN: Schedules for Clinical Assessment in Neuropsychiatry. Arch Gen Psychiatry 1990; 47:589-593
9. 18F]-fluoride. J Labelled Compounds and Radiopharmaceuticals 1994; 35:476-477
10. Hietala J, Syvälahti E, Vilkman H, Vuorio K, Räkköläinen V, Bergman J, Haaparanta M, Solin O, Kuoppamäki M, Eronen E, Ruotsalainen U, Salokangas RKR: Domains of psychopathology and presynaptic dopamine function in vivo in neuroleptic-naive schizophrenia. Schizophr Res 1999; 35:41-50
11. Fowler JS, Volkow ND, Wang G-J, Pappas N, Logan J, Shea C, Alexoff D, MacGregor RR, Schlyer D, Zezulkova I, Wolf AP: Brain monoamine oxidase A inhibition in cigarette smokers. Proc Natl Acad Sci USA 1996; 93:14065-14069
12. Fowler JS, Volkow ND, Wang G-J, Pappas N, Logan J, MacGregor RR, Alexoff D, Shea C, Schlyer D, Wolf AP, Warner D, Zezulkova I, Cilento R: Inhibition of monoamine oxidase B in the brains of smokers. Nature 1996; 379:733-736
13. Glover V. Elsworth JD, Sandler M: Dopamine oxidation and its inhibition by (-)-depryls in man. J Neural Transm Suppl 1980; 16:163-172
14. Tiihonen J, Vilkman H, Räsänen P, Ryynänen O-P, Hakko H, Bergman J, Hämäläinen T, Laakso A, Haaparanta-Solin M. Solin O, Kuoppamäki M, Syvälahti E, Hietala J: Striatal presynaptic dopamine function in type 1 alcoholics measured with positron emission tomography. Mol Psychiatry 1998; 4: 156-161