메뉴 건너뛰기




Volumn 144, Issue 1-3, 2000, Pages 139-147

CYP2A6: A human coumarin 7-hydroxylase

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIMETHYL 2 (3 PYRIDYL) 4 THIAZOLIDINONE; AFLATOXIN; ALCOHOL; CARCINOGEN; CLOTRIMAZOLE; COTININE; COUMARIN; COUMARIN 7 HYDROXYLASE; CYTOCHROME P 450 CYP2A6; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; ELLIPTICINE; FLAVONOID; GRISEOFULVIN; HALOTHANE; KETOCONAZOLE; LEAD; MESSENGER RNA; METHOXSALEN; METHOXYFLURANE; NICOTINE; NITROSAMINE; PHENOBARBITAL; PILOCARPINE; RIFAMPICIN; UNCLASSIFIED DRUG;

EID: 0034599544     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(99)00200-0     Document Type: Article
Times cited : (206)

References (71)
  • 1
    • 0030430033 scopus 로고    scopus 로고
    • Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes
    • Bourrie M., Meunier V., Berger Y., Fabre G. Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes. J. Pharmacol. Exp. Ther. 277:1996;321-332.
    • (1996) J. Pharmacol. Exp. Ther. , vol.277 , pp. 321-332
    • Bourrie, M.1    Meunier, V.2    Berger, Y.3    Fabre, G.4
  • 2
    • 0027270458 scopus 로고
    • High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodietylamine in mice and humans
    • Camus A.-M., Geneste O., Honkakoski P., Bereziat J.-C., Henderson C.J., Wolf C.R., Bartsch H., Lang M.A. High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodietylamine in mice and humans. Mol. Carcinog. 7:1993;268-275.
    • (1993) Mol. Carcinog. , vol.7 , pp. 268-275
    • Camus, A.-M.1    Geneste, O.2    Honkakoski, P.3    Bereziat, J.-C.4    Henderson, C.J.5    Wolf, C.R.6    Bartsch, H.7    Lang, M.A.8
  • 3
    • 0026702860 scopus 로고
    • Metabolism of nicotine by human liver microsomes: Steroselective formation of trans-nicotine N′-oxide
    • Cashman J.R., Park S.B., Yang Z.-C., Wrighton S.A., Jacob P., Benowitz N.L. Metabolism of nicotine by human liver microsomes: steroselective formation of trans-nicotine N′-oxide. Chem. Res. Toxicol. 5:1992;639-646.
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 639-646
    • Cashman, J.R.1    Park, S.B.2    Yang, Z.-C.3    Wrighton, S.A.4    Jacob, P.5    Benowitz, N.L.6
  • 6
    • 0026582870 scopus 로고
    • Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine
    • Cholerton S., Idle M.E., Vas A., Gonzalez F.J., Idle J.R. Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine. J. Chromatogr. 575:1992;325-330.
    • (1992) J. Chromatogr. , vol.575 , pp. 325-330
    • Cholerton, S.1    Idle, M.E.2    Vas, A.3    Gonzalez, F.J.4    Idle, J.R.5
  • 9
    • 0026558748 scopus 로고
    • Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes: Cross reactivity with human forms
    • Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C. Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes: cross reactivity with human forms. Eur. J. Biochem. 204:1992;641-648.
    • (1992) Eur. J. Biochem. , vol.204 , pp. 641-648
    • Dalet-Beluche, I.1    Boulenc, X.2    Fabre, G.3    Maurel, P.4    Bonfils, C.5
  • 10
    • 0029982314 scopus 로고    scopus 로고
    • Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit and human cytochromes P450
    • Ding X., Spink D.C., Bhama J.K., Sheng J.J., Vaz A.D.N., Coon M.J. Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit and human cytochromes P450. Mol. Pharmacol. 49:1996;1113-1121.
    • (1996) Mol. Pharmacol. , vol.49 , pp. 1113-1121
    • Ding, X.1    Spink, D.C.2    Bhama, J.K.3    Sheng, J.J.4    Vaz, A.D.N.5    Coon, M.J.6
  • 11
    • 0031149716 scopus 로고    scopus 로고
    • Inhibition of coumarin 7-hydroxylase activity in human liver microsomes
    • Draper A.J., Madan A., Parkinson A. Inhibition of coumarin 7-hydroxylase activity in human liver microsomes. Arch. Biochem. Biophys. 341:1997;47-61.
    • (1997) Arch. Biochem. Biophys. , vol.341 , pp. 47-61
    • Draper, A.J.1    Madan, A.2    Parkinson, A.3
  • 12
    • 0028340688 scopus 로고
    • Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: Evidence for major roles by cytochromes P450 2A6 and 2E1
    • Duescher R.J., Elfarra A.A. Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1. Arch. Biochem. Biophys. 311:1994;342-349.
    • (1994) Arch. Biochem. Biophys. , vol.311 , pp. 342-349
    • Duescher, R.J.1    Elfarra, A.A.2
  • 13
    • 0029048772 scopus 로고
    • The CYP2A gene subfamily: Species differences, regulation, catalytic activities and role in chemical carcinogenesis
    • Fernandez-Salguero P., Gonzalez F.J. The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis. Pharmacogenetics. 5:1995;S123-S128.
    • (1995) Pharmacogenetics , vol.5
    • Fernandez-Salguero, P.1    Gonzalez, F.J.2
  • 17
    • 0031810509 scopus 로고    scopus 로고
    • Developmental expression of cytochrome P450 enzymes in the human liver
    • Hakkola J., Tanaka E., Pelkonen O. Developmental expression of cytochrome P450 enzymes in the human liver. Pharmacol. Toxicol. 82:1998;209-217.
    • (1998) Pharmacol. Toxicol. , vol.82 , pp. 209-217
    • Hakkola, J.1    Tanaka, E.2    Pelkonen, O.3
  • 18
    • 0029591606 scopus 로고
    • Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19
    • Hoffman S.M.G., Fernandez-Salguero P., Gonzalez F.J., Mohrenweiser H.W. Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19. J. Mol. Evolut. 41:1995;894-900.
    • (1995) J. Mol. Evolut. , vol.41 , pp. 894-900
    • Hoffman, S.M.G.1    Fernandez-Salguero, P.2    Gonzalez, F.J.3    Mohrenweiser, H.W.4
  • 19
    • 0027984350 scopus 로고
    • A study on the interindividual variability of coumarin 7-hydroxylation in a Turkish population
    • Iscan M., Rostami H., Guray T., Pelkonen O., Rautio A. A study on the interindividual variability of coumarin 7-hydroxylation in a Turkish population. Eur. J. Clin. Pharmacol. 47:1994;315-318.
    • (1994) Eur. J. Clin. Pharmacol. , vol.47 , pp. 315-318
    • Iscan, M.1    Rostami, H.2    Guray, T.3    Pelkonen, O.4    Rautio, A.5
  • 20
    • 0028925110 scopus 로고
    • Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity
    • Kharasch E.D., Hankins D.C., Thummel K.E. Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology. 82:1995;689-699.
    • (1995) Anesthesiology , vol.82 , pp. 689-699
    • Kharasch, E.D.1    Hankins, D.C.2    Thummel, K.E.3
  • 22
    • 0028900417 scopus 로고
    • The inhibition of CYP enzymes in mouse and human liver by pilocarpine
    • Kimonen T., Juvonen R.O., Alhava E., Pasanen M. The inhibition of CYP enzymes in mouse and human liver by pilocarpine. Br. J. Pharmacol. 114:1995;832-836.
    • (1995) Br. J. Pharmacol. , vol.114 , pp. 832-836
    • Kimonen, T.1    Juvonen, R.O.2    Alhava, E.3    Pasanen, M.4
  • 23
    • 0028860852 scopus 로고
    • Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP2A5 and human CYP2A6
    • Kimonen T., Pasanen M., Gynther J., Poso A., Järvinen T., Alhava E., Juvonen R.O. Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP2A5 and human CYP2A6. Br. J. Pharmacol. 116:1995;2625-2630.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2625-2630
    • Kimonen, T.1    Pasanen, M.2    Gynther, J.3    Poso, A.4    Järvinen, T.5    Alhava, E.6    Juvonen, R.O.7
  • 24
    • 0029843690 scopus 로고    scopus 로고
    • Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis
    • Kirby G.M., Batist G., Alpert L., Lamoureux E., Cameron R.G., Alaoui-Jamali M.A. Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis. Toxicol. Pathol. 24:1996;458-467.
    • (1996) Toxicol. Pathol. , vol.24 , pp. 458-467
    • Kirby, G.M.1    Batist, G.2    Alpert, L.3    Lamoureux, E.4    Cameron, R.G.5    Alaoui-Jamali, M.A.6
  • 25
    • 0031451433 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen
    • Koenigs L.L., Peter R.M., Thompson S.J., Rettie A.E., Trager W.F. Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen. Drug Metab. Disp. 25:1997;1407-1415.
    • (1997) Drug Metab. Disp. , vol.25 , pp. 1407-1415
    • Koenigs, L.L.1    Peter, R.M.2    Thompson, S.J.3    Rettie, A.E.4    Trager, W.F.5
  • 28
    • 0025777078 scopus 로고
    • Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes
    • Maurice M., Emiliani S., Dalet-Beluche I., Derancourt J., Lange R. Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes. Eur. J. Biochem. 200:1991;511-517.
    • (1991) Eur. J. Biochem. , vol.200 , pp. 511-517
    • Maurice, M.1    Emiliani, S.2    Dalet-Beluche, I.3    Derancourt, J.4    Lange, R.5
  • 29
    • 0028218139 scopus 로고
    • Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers
    • Merkel U., Sigusch H., Hoffmann A. Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers. Eur. J. Clin. Pharmacol. 46:1994;175-177.
    • (1994) Eur. J. Clin. Pharmacol. , vol.46 , pp. 175-177
    • Merkel, U.1    Sigusch, H.2    Hoffmann, A.3
  • 30
    • 0025214234 scopus 로고
    • Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity
    • Miles J.S., McLaren A.W., Forrester L.M., Glancey M.J., Lang M.A., Wolf C.R. Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity. Biochem. J. 267:1990;365-371.
    • (1990) Biochem. J. , vol.267 , pp. 365-371
    • Miles, J.S.1    McLaren, A.W.2    Forrester, L.M.3    Glancey, M.J.4    Lang, M.A.5    Wolf, C.R.6
  • 31
    • 0028048027 scopus 로고
    • Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and healthy men
    • Mustajoki P., Mustajoki S., Rautio A., Arvela P., Pelkonen O. Effects of heme arginate on cytochrome P450-mediated metabolism of drugs in patients with variegate porphyria and healthy men. Clin. Pharmacol. Ther. 56:1994;9-13.
    • (1994) Clin. Pharmacol. Ther , vol.56 , pp. 9-13
    • Mustajoki, P.1    Mustajoki, S.2    Rautio, A.3    Arvela, P.4    Pelkonen, O.5
  • 35
    • 7144257874 scopus 로고    scopus 로고
    • A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502)
    • Nunoya K.-I., Yokoi T., Kimura K., Inoue K., Kodama T., Funayama M., Nagashima K., Funae Y., Green C., Kinoshita M., Kamataki T. A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502). Pharmacogenetics. 8:1998;239-249.
    • (1998) Pharmacogenetics , vol.8 , pp. 239-249
    • Nunoya, K.-I.1    Yokoi, T.2    Kimura, K.3    Inoue, K.4    Kodama, T.5    Funayama, M.6    Nagashima, K.7    Funae, Y.8    Green, C.9    Kinoshita, M.10    Kamataki, T.11
  • 38
    • 0026673973 scopus 로고
    • Localization of cytochrome P-450 gene expression in normal and diseased human liver by in situ hybridization of wax-embedded archival material
    • Palmer C.N.A., Coates P.J., Davies S.E., Shephard E.A., Phillips I.R. Localization of cytochrome P-450 gene expression in normal and diseased human liver by in situ hybridization of wax-embedded archival material. Hepatology. 16:1992;682-687.
    • (1992) Hepatology , vol.16 , pp. 682-687
    • Palmer, C.N.A.1    Coates, P.J.2    Davies, S.E.3    Shephard, E.A.4    Phillips, I.R.5
  • 40
    • 0026781890 scopus 로고
    • Species differences and interindividual variation in liver microsomal cytochrome P4502A enzymes: Effects on coumarin, dicumarol, and testosterone oxidation
    • Pearce R., Greenway D., Parkinson A. Species differences and interindividual variation in liver microsomal cytochrome P4502A enzymes: effects on coumarin, dicumarol, and testosterone oxidation. Arch. Biochem. Biophys. 298:1992;211-225.
    • (1992) Arch. Biochem. Biophys. , vol.298 , pp. 211-225
    • Pearce, R.1    Greenway, D.2    Parkinson, A.3
  • 41
    • 0028912706 scopus 로고
    • Individual expression of carcinogen-metabolizing enzymes: Cytochrome P4502A
    • Pelkonen O., Raunio H. Individual expression of carcinogen-metabolizing enzymes: cytochrome P4502A. J. Occup. Environ. Med. 37:1995;19-24.
    • (1995) J. Occup. Environ. Med. , vol.37 , pp. 19-24
    • Pelkonen, O.1    Raunio, H.2
  • 42
    • 0022004351 scopus 로고
    • Coumarin 7-hydroxylase activity in human liver microsomes: Properties of the enzyme and interspecies comparisons
    • Pelkonen O., Sotaniemi E.A., Ahokas J.T. Coumarin 7-hydroxylase activity in human liver microsomes: properties of the enzyme and interspecies comparisons. Br. J. Clin. Pharmacol. 19:1985;59-66.
    • (1985) Br. J. Clin. Pharmacol. , vol.19 , pp. 59-66
    • Pelkonen, O.1    Sotaniemi, E.A.2    Ahokas, J.T.3
  • 46
    • 0032565878 scopus 로고    scopus 로고
    • Nicotine metabolism defect reduces smoking
    • Pianezza M.L., Sellers E.M., Tyndale R.F. Nicotine metabolism defect reduces smoking. Nature. 393:1998;750.
    • (1998) Nature , vol.393 , pp. 750
    • Pianezza, M.L.1    Sellers, E.M.2    Tyndale, R.F.3
  • 51
    • 0026934672 scopus 로고
    • Interindividual variability of coumarin 7-hydroxylation in healthy individuals
    • Rautio A., Kraul H., Kojo A., Salmela E., Pelkonen O. Interindividual variability of coumarin 7-hydroxylation in healthy individuals. Pharmacogenetics. 2:1992;227-233.
    • (1992) Pharmacogenetics , vol.2 , pp. 227-233
    • Rautio, A.1    Kraul, H.2    Kojo, A.3    Salmela, E.4    Pelkonen, O.5
  • 54
    • 0028114740 scopus 로고
    • Use of in vitro human metabolism studies in drug development: An industrial perspective
    • Rodrigues A.D. Use of in vitro human metabolism studies in drug development: an industrial perspective. Biochem. Pharmacol. 48:1994;2147-2156.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 2147-2156
    • Rodrigues, A.D.1
  • 55
    • 0033105118 scopus 로고    scopus 로고
    • Integrated cytochrome P450 reaction phenotyping
    • Rodrigues A.D. Integrated cytochrome P450 reaction phenotyping. Biochem. Pharmacol. 57:1999;465-480.
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 465-480
    • Rodrigues, A.D.1
  • 59
    • 0029996291 scopus 로고    scopus 로고
    • Ethnic-related differences in coumarin 7-hydroxylation activity catalyzed by cytochrome P2402A6 in liver microsomes of Japanese and Caucasians populations
    • Shimada T., Yamazaki H., Guengerich F.P. Ethnic-related differences in coumarin 7-hydroxylation activity catalyzed by cytochrome P2402A6 in liver microsomes of Japanese and Caucasians populations. Xenobiotica. 26:1996;395-403.
    • (1996) Xenobiotica , vol.26 , pp. 395-403
    • Shimada, T.1    Yamazaki, H.2    Guengerich, F.P.3
  • 60
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T., Yamazaki H., Mimura M., Inui Y., Guengerich F.P. Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther. 270:1994;414-423.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 62
    • 0029809856 scopus 로고    scopus 로고
    • Human reductive halothane metabolism in vitro is catalyzed by cytochrome P4502A6 and 3A4
    • Spracklin D.K., Thummel K.E., Kharasch E.D. Human reductive halothane metabolism in vitro is catalyzed by cytochrome P4502A6 and 3A4. Drug Metab. Dispos. 24:1996;976-983.
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 976-983
    • Spracklin, D.K.1    Thummel, K.E.2    Kharasch, E.D.3
  • 63
    • 0029875880 scopus 로고    scopus 로고
    • Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: Correlation of 3-methyleneindolenine formation and protein-binding
    • Thornton-Manning J., Appleton M.L., Gonzalez F.J., Yost G.S. Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding. J. Pharmacol. Exp. Ther. 276:1996;21-29.
    • (1996) J. Pharmacol. Exp. Ther. , vol.276 , pp. 21-29
    • Thornton-Manning, J.1    Appleton, M.L.2    Gonzalez, F.J.3    Yost, G.S.4
  • 64
    • 0027219159 scopus 로고
    • Retroviral mediated expression of human cytochrome P4502A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)1-butanone (NNK)
    • Tiano H.F., Hosokawa M., Clulada P.C., Smith P.B., Wang R., Gonzalez F.J., Crespi C.L., Langenbach R. Retroviral mediated expression of human cytochrome P4502A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)1-butanone (NNK). Carcinogenesis. 14:1993;1421-1427.
    • (1993) Carcinogenesis , vol.14 , pp. 1421-1427
    • Tiano, H.F.1    Hosokawa, M.2    Clulada, P.C.3    Smith, P.B.4    Wang, R.5    Gonzalez, F.J.6    Crespi, C.L.7    Langenbach, R.8
  • 65
    • 0029813840 scopus 로고    scopus 로고
    • Stereoselective metabolism of a new anticonvulsant drug candidate, losigamone, by human liver microsomes
    • Torchin C.D., McNeilly P.J., Kapetanovic I.M., Strong J.M., Kupferberg H.J. Stereoselective metabolism of a new anticonvulsant drug candidate, losigamone, by human liver microsomes. Drug Metab. Dispos. 24:1996;1002-1008.
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 1002-1008
    • Torchin, C.D.1    McNeilly, P.J.2    Kapetanovic, I.M.3    Strong, J.M.4    Kupferberg, H.J.5
  • 67
    • 0025022689 scopus 로고
    • The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
    • Yamano S., Tatsuno J., Gonzalez F.J. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry. 29:1990;1322-1329.
    • (1990) Biochemistry , vol.29 , pp. 1322-1329
    • Yamano, S.1    Tatsuno, J.2    Gonzalez, F.J.3
  • 68
    • 0026744568 scopus 로고
    • Cytochrome P4502E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes
    • Yamazaki H., Inui Y., Yun C.-H., Guengerich F.P., Shimada T. Cytochrome P4502E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes. Carcinogenesis. 13:1992;1789-1794.
    • (1992) Carcinogenesis , vol.13 , pp. 1789-1794
    • Yamazaki, H.1    Inui, Y.2    Yun, C.-H.3    Guengerich, F.P.4    Shimada, T.5
  • 69
    • 0025841777 scopus 로고
    • Purification and characterization of human liver microsomal cytochrome P4502A6
    • Yun C.-H., Shimada T., Guengerich F.P. Purification and characterization of human liver microsomal cytochrome P4502A6. Mol. Pharmacol. 40:1991;679-685.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 679-685
    • Yun, C.-H.1    Shimada, T.2    Guengerich, F.P.3
  • 70
    • 0026540756 scopus 로고
    • Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4′-methylene-bis(2-chloroaniline)
    • Yun C.-H., Shimada T., Guengerich F.P. Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4′-methylene-bis(2-chloroaniline). Carcinogenesis. 13:1992;217-222.
    • (1992) Carcinogenesis , vol.13 , pp. 217-222
    • Yun, C.-H.1    Shimada, T.2    Guengerich, F.P.3
  • 71
    • 0033058630 scopus 로고    scopus 로고
    • Biotransformation of coumarin by rodent and human cytochromes P450: Metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice
    • Zhuo X., Gu J., Zhang Q.-Y., Spink D.C., Kaminsky L.S., Ding X. Biotransformation of coumarin by rodent and human cytochromes P450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice. J. Pharmacol. Exp. Ther. 288:1999;463-471.
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 463-471
    • Zhuo, X.1    Gu, J.2    Zhang, Q.-Y.3    Spink, D.C.4    Kaminsky, L.S.5    Ding, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.