-
1
-
-
0026702860
-
Metabolism of nicotine by human liver microsomes: Stereoselective formation of trans-nicotine N′-oxide
-
CASHMAN, J. R., PARK, S. B., YANG, Z. C., WHIGHTON, S. A., JACOB, P., and BENOWITZ, N. L. 1992, Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N′-oxide. Chemical Research in Toxicologv, 5, 639-646.
-
(1992)
Chemical Research in Toxicologv
, vol.5
, pp. 639-646
-
-
Cashman, J.R.1
Park, S.B.2
Yang, Z.C.3
Whighton, S.A.4
Jacob, P.5
Benowitz, N.L.6
-
2
-
-
0026582870
-
Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine
-
CHOLERTON, S., IDLE, M. E., VAS, A., GONZALEZ, F. J., and IDLE, J. R., 1992, Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine. Journal of Chromatography, 575, 325-330.
-
(1992)
Journal of Chromatography
, vol.575
, pp. 325-330
-
-
Cholerton, S.1
Idle, M.E.2
Vas, A.3
Gonzalez, F.J.4
Idle, J.R.5
-
3
-
-
0025179176
-
Human cytochrome P450IIA3: CDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1
-
CRESIM, C. L., PENMAN, B. W., LEAKEY, J., ARLOTTO, M. P., STARK, A., PARKINSON, A., TURNER, T., STEIMEL, D. T., RUDO, K., DAVIES, R. L., and LANGENBACH, R., 1990, Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1. Carcinogenesis, 11, 1293-1300.
-
(1990)
Carcinogenesis
, vol.11
, pp. 1293-1300
-
-
Cresim, C.L.1
Penman, B.W.2
Leakey, J.3
Arlotto, M.P.4
Stark, A.5
Parkinson, A.6
Turner, T.7
Steimel, D.T.8
Rudo, K.9
Davies, R.L.10
Langenbach, R.11
-
4
-
-
0028340688
-
Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: Evidence for major roles by cytochromes P450 2A6 and 2E1
-
DUESCHER, R. J., and ELFARRA, A. A., 1994, Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1. Archives of Biochemistry and Biophysics, 311, 342-349.
-
(1994)
Archives of Biochemistry and Biophysics
, vol.311
, pp. 342-349
-
-
Duescher, R.J.1
Elfarra, A.A.2
-
5
-
-
0024236331
-
The molecular biology of cytochrome P450s
-
GONZALEZ, F. J., 1989, The molecular biology of cytochrome P450s. Pharmacological Reviews, 40, 243-288.
-
(1989)
Pharmacological Reviews
, vol.40
, pp. 243-288
-
-
Gonzalez, F.J.1
-
6
-
-
0026651273
-
Human cytochromes P450: Problems and prospects
-
GONZALEZ, F. J., 1992, Human cytochromes P450: problems and prospects. Trends in Pharmacological Sciences, 13, 346-352.
-
(1992)
Trends in Pharmacological Sciences
, vol.13
, pp. 346-352
-
-
Gonzalez, F.J.1
-
7
-
-
0026082836
-
DNA-expressed human cytochrome P450s: A new age of molecular toxicology and human risk assessment
-
GONZALEZ, F. J., CRESPI, C. L., and GELBOIN, H. V., 1991, cDNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment. Mutation Research, 247, 113-127.
-
(1991)
Mutation Research
, vol.247
, pp. 113-127
-
-
Gonzalez, F.J.1
Crespi, C.L.2
Gelboin, H.V.3
-
9
-
-
0002254766
-
Analysis and characterization of enzymes
-
edited by A. W. Haves (New York: Raven)
-
GUENGERICH, F. P., 1994, Analysis and characterization of enzymes. In Principles and Methods of Toxicology, 3rd edn, edited by A. W. Haves (New York: Raven), pp. 1259-1313.
-
(1994)
Principles and Methods of Toxicology, 3rd Edn
, pp. 1259-1313
-
-
Guengerich, F.P.1
-
10
-
-
0020028678
-
Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis
-
GUENGERICH, F. P., WANG, P., and DAVIDSON, N. K., 1982, Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Biochemistry, 21, 1698-1706.
-
(1982)
Biochemistry
, vol.21
, pp. 1698-1706
-
-
Guengerich, F.P.1
Wang, P.2
Davidson, N.K.3
-
11
-
-
0024520452
-
Point mutation at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (ω-1)-hydroxylase and testosterone 16α-hydroxylase)
-
IMAI, Y. and XAKAMURA, M., 1989, Point mutation at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (ω-1)-hydroxylase and testosterone 16α-hydroxylase). Biochemical and Biophysical Research Communications, 158, 717-722.
-
(1989)
Biochemical and Biophysical Research Communications
, vol.158
, pp. 717-722
-
-
Imai, Y.1
Xakamura, M.2
-
12
-
-
0027984350
-
Interindividual variability of coumarin 7-hydroxylation in a Turkish population
-
ISCAN, M., ROSTAMI, H., GURAY, T., PELKONEN, O., and RAUTIO, A., 1994, Interindividual variability of coumarin 7-hydroxylation in a Turkish population. European Journal of Clinical Pharmacology, 47, 315-318.
-
(1994)
European Journal of Clinical Pharmacology
, vol.47
, pp. 315-318
-
-
Iscan, M.1
Rostami, H.2
Guray, T.3
Pelkonen, O.4
Rautio, A.5
-
13
-
-
0019741894
-
Production and application of antibodies to rat liver cytochrome P-450
-
KAMINSKY, L. S., FASCO, M. J., and GUENGERICH, F. P., 1981, Production and application of antibodies to rat liver cytochrome P-450. Methods in Enzymology, 74, 262-272.
-
(1981)
Methods in Enzymology
, vol.74
, pp. 262-272
-
-
Kaminsky, L.S.1
Fasco, M.J.2
Guengerich, F.P.3
-
14
-
-
0024976419
-
Alteration of mouse cytochrome P45()coh substrate specificity by mutation of a single amino-acid residue
-
LINDBERG, R., and NEGISHI, M., 1989, Alteration of mouse cytochrome P45()coh substrate specificity by mutation of a single amino-acid residue. Nature, 339, 632-634.
-
(1989)
Nature
, vol.339
, pp. 632-634
-
-
Lindberg, R.1
Negishi, M.2
-
15
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L., and RANDALL, R. L., 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265-275.
-
(1951)
Journal of Biological Chemistry
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.L.4
-
16
-
-
0025777078
-
Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes
-
MAURICE, M., EMILIANI, S., DALET-BELUCHE, I., DERANCOURT, J., and LANGE, R., 1991, Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes. European Journal of Biochemistry, 200, 511-517.
-
(1991)
European Journal of Biochemistry
, vol.200
, pp. 511-517
-
-
Maurice, M.1
Emiliani, S.2
Dalet-Beluche, I.3
Derancourt, J.4
Lange, R.5
-
17
-
-
0027519429
-
Characterization of cytochrome P450 2B6 in human liver microsomes
-
MIMURA, M., BABA, T., YAMAZAKI, H., OHMORI, S., INUI, Y., GONZALEZ, F. J., GUENGERICH, F. P., and SHIMADA, T., 1993, Characterization of cytochrome P450 2B6 in human liver microsomes. Drug Metabolism and Disposition, 21, 1048-1056.
-
(1993)
Drug Metabolism and Disposition
, vol.21
, pp. 1048-1056
-
-
Mimura, M.1
Baba, T.2
Yamazaki, H.3
Ohmori, S.4
Inui, Y.5
Gonzalez, F.J.6
Guengerich, F.P.7
Shimada, T.8
-
19
-
-
0027446505
-
The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature
-
NELSON, D. R., KAMATAKI, T., WAXMAN, D. J., GUENGERICH, F. P., ESTABROOK, R. W., FEYEREISEN, R., GONZALEZ, F. J., COON, M. J., GUNSALUS, I. C., GOTOH, O., OKUDA, K., and NEBERT, D. W., 1993, The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA and Cell Biology, 12, 1-51.
-
(1993)
DNA and Cell Biology
, vol.12
, pp. 1-51
-
-
Nelson, D.R.1
Kamataki, T.2
Waxman, D.J.3
Guengerich, F.P.4
Estabrook, R.W.5
Feyereisen, R.6
Gonzalez, F.J.7
Coon, M.J.8
Gunsalus, I.C.9
Gotoh, O.10
Okuda, K.11
Nebert, D.W.12
-
20
-
-
78651165715
-
The carbon monoxide-bin ding pigment of liver microsomes. I. Evidence for its hemoprotein nature
-
OMURA, T. and SATO, R., 1964, The carbon monoxide-bin ding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry, 239, 2370-2378.
-
(1964)
Journal of Biological Chemistry
, vol.239
, pp. 2370-2378
-
-
Omura, T.1
Sato, R.2
-
21
-
-
0026781890
-
Species difference and interindividual variation in liver microsomal cytochrome P450 2A enzymes: Effects on coumarin, dicumarol, and testosterone oxidation
-
PEARCE, R., GREENWAY, D., and PARKINSON, A., 1992, Species difference and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation. Archives of Biochemistry and Biophysics, 298, 211-225.
-
(1992)
Archives of Biochemistry and Biophysics
, vol.298
, pp. 211-225
-
-
Pearce, R.1
Greenway, D.2
Parkinson, A.3
-
22
-
-
0026934672
-
Interindividual variability of coumarin 7-hydroxylation in healthy volunteers
-
RAUTIO, A., KRAUL, H., KOJO, A., SALMELA, E., and PELKONEN, O., 1992, Interindividual variability of coumarin 7-hydroxylation in healthy volunteers. Pharmacogenetics, 2, 227-233.
-
(1992)
Pharmacogenetics
, vol.2
, pp. 227-233
-
-
Rautio, A.1
Kraul, H.2
Kojo, A.3
Salmela, E.4
Pelkonen, O.5
-
23
-
-
0023733220
-
Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse
-
RAUNIO, H., SYNGELMA, T., PASANEN, M., JUVONEN, R., HONKAKOSKI, P., KAIRALUOMA, M. A., SOTANIEMI, E., LANG, M. A., and PELKONEN, O., 1988, Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse. Biochemical Pharmacology, 37, 3889-3895.
-
(1988)
Biochemical Pharmacology
, vol.37
, pp. 3889-3895
-
-
Raunio, H.1
Syngelma, T.2
Pasanen, M.3
Juvonen, R.4
Honkakoski, P.5
Kairaluoma, M.A.6
Sotaniemi, E.7
Lang, M.A.8
Pelkonen, O.9
-
24
-
-
0023276802
-
Cytochrome P-450-mediated activation of procarcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK1002
-
SHIMADA, T., and NAKAMURA, S., 1987, Cytochrome P-450-mediated activation of procarcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK1002. Biochemical Pharmacology, 36, 1979-1987.
-
(1987)
Biochemical Pharmacology
, vol.36
, pp. 1979-1987
-
-
Shimada, T.1
Nakamura, S.2
-
25
-
-
0028237729
-
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
-
SHIMADA, T., YAMAZAKI, H., MIMURA, M., INUI, Y., and GUENGERICH, F. P., 1994, Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of Pharmacology and Experimental Therapeutics, 270, 414-423.
-
(1994)
Journal of Pharmacology and Experimental Therapeutics
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Inui, Y.4
Guengerich, F.P.5
-
26
-
-
0018795341
-
Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles
-
TANIGUCHI, H., IMAI, Y., IYANAGI, T., and SATO, R., 1979, Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles. Biochimica et Biophysica Acta, 550, 341-356.
-
(1979)
Biochimica et Biophysica Acta
, vol.550
, pp. 341-356
-
-
Taniguchi, H.1
Imai, Y.2
Iyanagi, T.3
Sato, R.4
-
27
-
-
0026750647
-
The human hepatic cytochromes P450 involved in drug metabolism
-
WRIGHTON, S. A., and STEVENS, J. C., 1992, The human hepatic cytochromes P450 involved in drug metabolism. Critical Reviews in Toxicology, 22, 1-21.
-
(1992)
Critical Reviews in Toxicology
, vol.22
, pp. 1-21
-
-
Wrighton, S.A.1
Stevens, J.C.2
-
28
-
-
0025022689
-
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
-
YAMANO, S., TATSUNO, J., and GONZALEZ, F. J., 1990, The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry, 29, 1322-1329.
-
(1990)
Biochemistry
, vol.29
, pp. 1322-1329
-
-
Yamano, S.1
Tatsuno, J.2
Gonzalez, F.J.3
-
29
-
-
0027990736
-
Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes
-
YAMAZAKI, H., GUO, Z., PERSMARK, M., MIMURA, M., INOTE, K., GUENGERICH, F. P., and SHIMADA, T., 1994a, Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Molecular Pharmacology, 46, 568-577.
-
(1994)
Molecular Pharmacology
, vol.46
, pp. 568-577
-
-
Yamazaki, H.1
Guo, Z.2
Persmark, M.3
Mimura, M.4
Inote, K.5
Guengerich, F.P.6
Shimada, T.7
-
30
-
-
0026744568
-
Cytochrome P450 2F1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes
-
YAMAZAKI, H., INUI, Y., YUN, C. H., GUENGERICH, F. P., and SHIMADA, T., 1992, Cytochrome P450 2F1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes. Carcinogenesis, 13, 1789-1794.
-
(1992)
Carcinogenesis
, vol.13
, pp. 1789-1794
-
-
Yamazaki, H.1
Inui, Y.2
Yun, C.H.3
Guengerich, F.P.4
Shimada, T.5
-
31
-
-
0028075688
-
Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7α- and coumarin 7-hydroxylations
-
YAMAZAKI, H., MIMURA, M., SUGAHARA, C., and SHIMADA, T., 1994b, Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7α- and coumarin 7-hydroxylations. Biochemical Pharmacology, 48, 1524-1527.
-
(1994)
Biochemical Pharmacology
, vol.48
, pp. 1524-1527
-
-
Yamazaki, H.1
Mimura, M.2
Sugahara, C.3
Shimada, T.4
-
32
-
-
0017088267
-
Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography
-
YASUKOCHI, Y., and MASTERS, B., 1976, Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography. Journal of Biological Chemistry, 251, 5337-5344.
-
(1976)
Journal of Biological Chemistry
, vol.251
, pp. 5337-5344
-
-
Yasukochi, Y.1
Masters, B.2
-
33
-
-
0027744044
-
Cytochrome P450 mediated metabolism of diazepam in human and rat: Involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner
-
YASUMORI, T., NAGATA, K., YANG, S. K., CHEN, L. S., MTRAYAMA, N., YAMAZOE, Y., and KATO, R., 1993, Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner. Pharmacogenetics, 3, 291-301.
-
(1993)
Pharmacogenetics
, vol.3
, pp. 291-301
-
-
Yasumori, T.1
Nagata, K.2
Yang, S.K.3
Chen, L.S.4
Mtrayama, N.5
Yamazoe, Y.6
Kato, R.7
-
34
-
-
0025841777
-
Purification and characterization of human liver microsomal cytochrome P-450 2A6
-
YUN, C. H., SHIMADA, T., and GUENGERICH, F. P., 1991, Purification and characterization of human liver microsomal cytochrome P-450 2A6. Molecular Pharmacology, 40, 679-685.
-
(1991)
Molecular Pharmacology
, vol.40
, pp. 679-685
-
-
Yun, C.H.1
Shimada, T.2
Guengerich, F.P.3
|