The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint

Experimental Cell Research

Volumn 304, Issue 1, 2005, Pages 1-15

  Ho, Chui Chui ^a   Siu, Wai Yi ^a   Chow, Jeremy P H ^a   Lau, Anita ^a   Arooz, Talha ^a   Tong, Hoi Yee ^a   Ng, Irene O L ^b   Poon, Randy Y C ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Adriamycin; Cell cycle; Checkpoint; DNA damage; DNA replication

Indexed keywords

BLASTICIDIN S; CAFFEINE; CDC25A PHOSPHATASE; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE 1; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ETOPOSIDE; HISTONE H3; HYDROXYUREA; NOCODAZOLE; POISON; PROTEIN TYROSINE PHOSPHATASE; PUROMYCIN; SHORT HAIRPIN RNA; THYMIDINE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; KNOCKOUT GENE; LIVER CELL CARCINOMA; MOUSE; MUTANT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; UPREGULATION;

EID: 13544251546     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2004.10.016     Document Type: Article

References (50)

1. D.O. Morgan Cyclin-dependent kinases: engines, clocks, and microprocessors Annu. Rev. Cell Dev. Biol. 13 1997 261 291
2. R.Y.C. Poon Cell cycle control J.R. Bertino Encyclopedia of Cancer 2002 Academic Press San Diego
3. B.B. Zhou, and S.J. Elledge The DNA damage response: putting checkpoints in perspective Nature 408 2000 433 439
4. Y. Shiloh ATM and related protein kinases: safeguarding genome integrity Nat. Rev., Cancer 3 2003 155 168
5. J. Bartek, and J. Lukas Chk1 and Chk2 kinases in checkpoint control and cancer Cancer Cell 3 2003 421 429
6. A. Blasina, I.V. de Weyer, M.C. Laus, W.H. Luyten, A.E. Parker, and C.H. McGowan A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase Curr. Biol. 9 1999 1 10
7. A. Lopez-Girona, J. Kanoh, and P. Russell Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast Curr. Biol. 11 2001 50 54
8. N. Mailand, A.V. Podtelejnikov, A. Groth, M. Mann, J. Bartek, and J. Lukas Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability EMBO J. 21 2002 5911 5920
9. J. Falck, N. Mailand, R.G. Syljuasen, J. Bartek, and J. Lukas The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis Nature 410 2001 842 847
10. Y. Shiloh ATM and ATR: networking cellular responses to DNA damage Curr. Opin. Genet. Dev. 11 2001 71 77
11. R.T. Abraham Cell cycle checkpoint signaling through the ATM and ATR kinases Genes Dev. 15 2001 2177 2196
12. Q. Liu, S. Guntuku, X.S. Cui, S. Matsuoka, D. Cortez, K. Tamai, G. Luo, S. Carattini-Rivera, F. DeMayo, A. Bradley, L.A. Donehower, and S.J. Elledge Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint Genes Dev. 14 2000 1448 1459
13. H. Zhao, and H. Piwnica-Worms ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 Mol. Cell. Biol. 21 2001 4129 4139
14. H. Takai, K. Tominaga, N. Motoyama, Y.A. Minamishima, H. Nagahama, T. Tsukiyama, K. Ikeda, K. Nakayama, and M. Nakanishi Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice Genes Dev. 14 2000 1439 1447
15. H. Takai, K. Naka, Y. Okada, M. Watanabe, N. Harada, S. Saito, C.W. Anderson, E. Appella, M. Nakanishi, H. Suzuki, K. Nagashima, H. Sawa, K. Ikeda, and N. Motoyama Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription EMBO J. 21 2002 5195 5205
16. A. Hirao, A. Cheung, G. Duncan, P.M. Girard, A.J. Elia, A. Wakeham, H. Okada, T. Sarkissian, J.A. Wong, T. Sakai, E. De Stanchina, R.G. Bristow, T. Suda, S.W. Lowe, P.A. Jeggo, S.J. Elledge, and T.W. Mak Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner Mol. Cell. Biol. 22 2002 6521 6532
17. C.P. Ng, H.C. Lee, C.W. Ho, T. Arooz, W.Y. Siu, A. Lau, and R.Y.C. Poon Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains J. Biol. Chem. 279 2004 8808 8819
18. Y. Sanchez, C. Wong, R.S. Thoma, R. Richman, Z. Wu, H. Piwnica-Worms, and S.J. Elledge Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 Science 277 1997 1497 1501
19. C.Y. Peng, P.R. Graves, R.S. Thoma, Z. Wu, A.S. Shaw, and H. Piwnica-Worms Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216 Science 277 1997 1501 1505
20. B. Furnari, N. Rhind, and P. Russell Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase Science 277 1997 1495 1497
21. Z. Guo, A. Kumagai, S.X. Wang, and W.G. Dunphy Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts Genes Dev. 14 2000 2745 2756
22. W.A. Cliby, C.J. Roberts, K.A. Cimprich, C.M. Stringer, J.R. Lamb, S.L. Schreiber, and S.H. Friend Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints EMBO J. 17 1998 159 169
23. E.J. Brown, and D. Baltimore Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance Genes Dev. 17 2003 615 628
24. G. Zachos, M.D. Rainey, and D.A. Gillespie Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects EMBO J. 22 2003 713 723
25. M. Gatei, K. Sloper, C. Sorensen, R. Syljuasen, J. Falck, K. Hobson, K. Savage, J. Lukas, B.B. Zhou, J. Bartek, and K.K. Khanna Ataxia-telangiectasia- mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation J. Biol. Chem. 278 2003 14806 14811
26. X. Wang, J. Khadpe, B. Hu, G. Iliakis, and Y. Wang An over-activated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells J. Biol. Chem. 278 2003 30869 30874
27. H. Zhao, J.L. Watkins, and H. Piwnica-Worms Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints Proc. Natl. Acad. Sci. U. S. A. 99 2002 14795 14800
28. R.C. Bast, D.W. Kufe, R.E. Pollock, R.R. Weichselbaum, J.F. Holland, E. Frei, and T.S. Gansler Cancer Medicine Fifth ed. 2000 B.C. Decker Inc. Ontario
29. W.Y. Siu, A. Lau, T. Arooz, J.P. Chow, H.T. Ho, and R.Y.C. Poon Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms Mol. Cancer Ther. 3 2004 621 632
30. J.Y. Yu, S.L. DeRuiter, and D.L. Turner RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells Proc. Natl. Acad. Sci. U. S. A. 99 2002 6047 6052
31. C.H. Yam, R.W. Ng, W.Y. Siu, A.W. Lau, and R.Y.C. Poon Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2 Mol. Cell. Biol. 19 1999 635 645
32. R.M. Horton, and L.R. Pease Recombination and mutagenesis of DNA sequences using PCR M.J. McPherson Directed Mutagenesis 1991 IRL Press at OUP Oxford
33. J.P.H. Chow, W.Y. Siu, H.T.B. Ho, K.H.T. Ma, C.C. Ho, and R.Y.C. Poon Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints J. Biol. Chem. 278 2003 40815 40828
34. C.H. Yam, W.Y. Siu, A. Lau, and R.Y.C. Poon Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2 J. Biol. Chem. 275 2000 3158 3167
35. A. Hirao, Y.Y. Kong, S. Matsuoka, A. Wakeham, J. Ruland, H. Yoshida, D. Liu, S.J. Elledge, and T.W. Mak DNA damage-induced activation of p53 by the checkpoint kinase Chk2 Science 287 2000 1824 1827
36. F. Ausubel, R. Brent, R. Kingston, D. Moore, J. Seidman, J. Smith, and K. Struhl Current Protocols in Molecular Biology 1991 John Wiley & Sons New York
37. R.Y.C. Poon, H. Toyoshima, and T. Hunter Redistribution of the CDK inhibitor p27 between different cyclin. CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation Mol. Biol. Cell 6 1995 1197 1213
38. W.Y. Siu, T. Arooz, and R.Y.C. Poon Differential responses of proliferating versus quiescent cells to Adriamycin Exp. Cell Res. 250 1999 131 141
39. K.K.W. Li, I.O.L. Ng, S.T. Fan, J.H. Albrecht, K. Yamashita, and R.Y.C. Poon Activation of cyclin-dependent kinases CDC2 and CDK2 in hepatocellular carcinoma Liver 22 2002 259 268
40. 160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin Science 270 1995 90 93
41. J.P.H. Chow, W.I. Siu, T.K. Fung, W.M. Chan, A. Lau, T. Arooz, C.-P. Ng, K. Yamashita, and R.Y.C. Poon DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase Mol. Biol. Cell 14 2003 3189 4002
42. T.K. Fung, W.Y. Siu, C.H. Yam, A. Lau, and R.Y.C. Poon Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins J. Biol. Chem. 277 2002 35140 35149
43. Y.J. Shann, and M.T. Hsu Cloning and characterization of liver-specific isoform of Chk1 gene from rat J. Biol. Chem. 276 2001 48863 48870
44. R.Y.C. Poon, M.S. Chau, K. Yamashita, and T. Hunter The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells Cancer Res. 57 1997 5168 5178
45. D.M. Dykxhoorn, C.D. Novina, and P.A. Sharp Killing the messenger: short RNAs that silence gene expression Nat. Rev., Mol. Cell Biol. 4 2003 457 467
46. M. Scheffner, K. Munger, J.C. Byrne, and P.M. Howley The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines Proc. Natl. Acad. Sci. U. S. A. 88 1991 5523 5527
47. M.J. Hendzel, Y. Wei, M.A. Mancini, A. Van Hooser, T. Ranalli, B.R. Brinkley, D.P. Bazett-Jones, and C.D. Allis Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation Chromosoma 106 1997 348 360
48. I. Oishi, K. Iwai, Y. Kagohashi, H. Fujimoto, K. Kariya, T. Kataoka, H. Sawa, H. Okano, H. Otani, H. Yamamura, and Y. Minami Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination Mol. Cell. Biol. 21 2001 1329 1335
49. A. Higashitani, H. Aoki, A. Mori, Y. Sasagawa, T. Takanami, and H. Takahashi Caenorhabditis elegans Chk2-like gene is essential for meiosis but dispensable for DNA repair FEBS Lett. 485 2000 35 39
50. P.J. Johnson Are there indications for chemotherapy in hepatocellular carcinoma? Surg. Oncol. Clin. N. Am. 12 2003 127 134