DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase

Molecular Biology of the Cell

Volumn 14, Issue 10, 2003, Pages 3989-4002

  Chow, Jeremy P H ^a   Siu, Wai Yi ^a   Fung, Tsz Kan ^a   Chan, Wan Mui ^a   Lau, Anita ^a   Arooz, Talha ^a   Ng, Chuen Pei ^a   Yamashita, Katsumi ^b   Poon, Randy Y C ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ATM PROTEIN; CASPASE 3; CYCLIN A; CYCLIN B1; CYCLINE; DNA FRAGMENT; HISTONE H2A; HISTONE H3; PROTEIN CDC25A; PROTEIN KINASE; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL DEATH; CELL VIABILITY; CHROMOSOME CONDENSATION; COMET ASSAY; COMPLEX FORMATION; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; ENZYME INACTIVATION; HUMAN; HUMAN CELL; INTERPHASE; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; SPINDLE CELL;

ANIMALS; CASPASE 3; CASPASES; CDC2-CDC28 KINASES; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL DEATH; CELLS, CULTURED; CHROMOSOMES; CLONING, MOLECULAR; CYCLIN A; CYCLIN B; DNA DAMAGE; DNA TOPOISOMERASES; DNA-BINDING PROTEINS; G1 PHASE; G2 PHASE; HELA CELLS; HISTONES; HUMANS; MICE; MITOTIC SPINDLE APPARATUS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0141541760     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E03-03-0168     Document Type: Article

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