Brain atrophy and neuronal loss in alcoholism: A role for DNA damage?

Neurochemistry International

Volumn 37, Issue 5-6, 2000, Pages 403-412

  Brooks, P J ^a  

^a Sect Clin and Exp Neuropsychol   (United States)

Author keywords

Acetaldehyde; DNA repair; Lipid peroxidation; Neurodegeneration; Oxidative damage

Indexed keywords

ACETALDEHYDE; ALCOHOL; REACTIVE OXYGEN METABOLITE; RNA POLYMERASE II;

ALCOHOL ABUSE; ALCOHOLISM; APOPTOSIS; BRAIN ATROPHY; CELL LOSS; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; GENE EXPRESSION; GENETIC DISORDER; GRAY MATTER; HUMAN; HYPOTHESIS; LIPID PEROXIDATION; LONG TERM EXPOSURE; MODEL; NERVE CELL LESION; NERVE DEGENERATION; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NEURORADIOLOGY; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; WHITE MATTER; XERODERMA PIGMENTOSUM;

EID: 0034335375     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(00)00051-6     Document Type: Article

References (87)

1. Andrews A.D., Barrett S.F., Robbins J.H. Xeroderma pigmentosum neurological abnormalities correlate with colony-forming ability after ultraviolet radiation. Proceedings of the National Academy of Sciences, U.S.A. 75:1978;1984-1988.
2. Aragon C., Stotland L., Amit Z. Studies on ethanol-brain catalase interaction: evidence for central ethanol oxidation. Alcoholism: Clinical and Experimental Research. 15:1991;165-169.
3. Arendt T., Bruckner M.K., Pagliusi S., Krell T. Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury. Part I: degeneration and plastic response of basal forebrain neurons. Neuroscience. 65:1995;633-645.
4. Arendt T., Bruckner M.K., Big V., Marcova L. Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. Part II: ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease. Journal of Comparative Neurology. 351:1995;189-222.
5. Badsberg-Jensen G., Pakkenberg B. Do alcoholics drink their neurons away. Lancet. 342:1993;1201-1204.
6. Bartolomei M., Tilghman S. Genomic imprinting in mammals. Annual Review of Genetics. 31:1997;493-525.
7. Brash D.E., Rudolph J.A., Simon J.A., Lin A., McKenna G.J., Baden H.P., Halperin A.J., Ponten J. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proceedings of the National Academy of Sciences, U.S.A. 88:1991;10124-10128.
8. Breese G.R., Morrow A.L., Simson P.E., Criswell H.E., McCown T.J., Duncan G.E., Keir W.J. The neuroanatomical specificity of ethanol action on ligand-gated ion channels: a hypothesis. Alcohol Alcoholism Supplement. 2:1993;309-313.
9. Brooks P. DNA damage, DNA repair, and alcohol toxicity. Alcoholism: Clinical and Experimental Research. 21:1997;1073-1082.
10. Brookes, P.J., Wise, D.S., Berry, D.A., Kosmoski, J.V., Smerdon, M.J., Somers, R.L., Mackie, H., Spoonde, A.Y., Ackerman, E.J., Coleman, K., Tarone, R.E., Robbins, J.H., 2000. The oxidative DNA lesion 8,5′-cyclo-2′-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells. Journal of Biological Chemistry (in press).
11. Cai Q., Tian L., Wei H. Age-dependent increase of indigenous DNA adducts in rat brain is associated with a lipid peroxidation product. Experimental Gerontology. 31:1996;373-385.
12. Charness M.E. Brain lesions in alcoholics. Alcoholism: Clinical and Experimental Research. 17:1993;2-11.
13. Cleaver J., Kraemer K. Xeroderma pigmentosum and Cockayne syndrome. Scriver C., Beaudet A., Sly W., Valle D. The Metabolic and Molecular Basis of Inherited Disease. 1995;4393-4419 McGraw-Hill, New York.
14. Dai Y. Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates. Biochemistry. 32:1993;6928-6937.
15. de Laat W.L., Jaspers N.G., Hoeijmakers J.H. Molecular mechanism of nucleotide excision repair. Genes and Development. 13:1999;768-785.
16. De Sanctis C., Cacchione A. L'Idiozia xerodermica. Riv. Sper. Freniat. 56:1932;269-292. (cited in Yano, 1950).
17. Dodd P.R., Kril J.J., Thomas G.J., Watson W.E., Johnston G.A., Harper C.G. Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy. Brain Research. 710:1996;215-228.
18. Friedberg E., Walker G., Siede W. DNA Repair and Mutagenesis. 1995;ASM Press, Washington, DC.
19. Grossman L. Epidemiology of ultraviolet-DNA repair capacity and human cancer. Environmental Health Perspectives. 105:(Supplement 4):1997;927-930.
20. Hanamura A., Caceres J.F., Mayeda A., Franza B.R., Krainer A.R. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA. 4:1988;430-444.
21. Handa J., Nakano Y., Aiguchi I. Cranial computerized tomography findings in xeroderma pigmentosum with neurologic manifestations. Journal of Computer Assisted Tomography. 2:1985;456-459.
22. Hansson T., Tindberg N., Ingelman-Sundberg M., Kohler C. Regional distribution of ethanol-inducible cytopchrome P450 IIE1 in rat central nervous system. Neuroscience. 34:1990;451-463.
23. Harper C. The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? Journal of Neuropathology and Experimental Neurology. 57:1998;101-110.
24. Harper C., Kril J. If you drink your brain will shrink. Neuropathological considerations. Alcohol and Alcoholism Supplement. 1:1991;375-380.
25. Harper C., Kril J., Daly J. Are we drinking our neurones away? British Medical Journal (Clinical Research Edition). 294:1987;534-536.
26. Harper C., Sheedy D., Halliday G., Double K., Dodd P., Lewohl J., Kril J. Neuropathological studies: the relationship between alcohol and aging. Gomberg M., Hegedus A., Zucker R. Alcohol Problems and Aging. NIAAA Research Monograph 33. 1998;117-134 Bethesda, MD, USPHS.
27. Iorio K., Tabakoff B., Hoffman P. Gltamate-induced neurotoxicity is increased in cerebellar granule cells exposed chronically to ethanol. European Journal of Pharmacology. 248:1993;209-212.
28. Itoh M., Hayashi M., Shioda K., Minagawa M., Isa F., Tamagawa K., Morimatsu Y., Oda M. Neurodegeneration in hereditary nucleotide repair disorders. Brain and Development. 21:1999;326-333.
29. Jones G.D., Dickinson L., Lunec J., Routledge M.N. SVPD-post-labeling detection of oxidative damage negates the problem of adventitious oxidative effects during 32P-labeling. Carcinogenesis. 20:1999;503-507.
30. Koumenis C., Giaccia A. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Molecular Cell Biology. 17:1997;7306-7316.
31. Kril J.J., Halliday G.M. Brain shrinkage in alcoholics: a decade on and what have we learned? Progress in Neurobiology. 58:1999;381-387.
32. Kril J.J., Halliday G.M., Svoboda M.D., Cartwright H. The cerebral cortex is damaged in chronic alcoholics. Neuroscience. 79:1997;983-998.
33. Kril J.J., Harper C.G. Neuronal counts from four cortical regions of alcoholic brains. Acta Neuropathologica (Berlin). 79:1989;200-204.
34. Langlais P., Anderson G., Gou S., Bondy S. Increased free radical production during thiamine deficiency. Metabolic Brain Disease. 12:1997;137-143.
35. Lewohl J.M., Crane D.I., Dodd P.R. Expression of the alpha 1, alpha 2 and alpha 3 isoforms of the GABA-A receptor in human alcoholic brain. Brain Research. 751:1997;102-112.
36. Lewohl J.M., Crane D.I., Dodd P.R. Zolpidem binding sites on the GABA(A) receptor in brain from human cirrhotic and non-cirrhotic alcoholics. European Journal of Pharmacology. 326:1997;265-272.
37. Lewohl J.M., Crane D.I., Dodd P.R. Alcohol, alcoholic brain damage, and GABAA receptor isoform gene expression. Neurochemistry International. 29:1996;677-684.
38. Ley R., Applegate L. Ultraviolet radiation-induced histopathologic changes in the skin of the marsupial Monodelphis domestica. II. Quantitative studies of the photoreactivation of induced hyperplasia and sunburn cell formation. Journal of Investigative Dermatology. 85:1985;365-367.
39. Lindahl T. Instability and decay of the primary structure of DNA. Nature. 362:1993;709-714.
40. Ljungman M., Zhang F., Chen F., Rainbow A.J., McKay B.C. Inhibition of RNA polymerase II as a trigger for the p53 response. Oncogene. 18:1999;583-592.
41. Ljungman M., Zhang F. Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis. Oncogene. 13:1996;823-831.
42. Lyon M. X chromosome inactivation. Current Biology. 9:1999;235-237.
43. Maeda T., Sato K., Minami H., Taguchi H., Yoshikawa K. Chronological difference in walking impairment among Japanese group A xeroderma pigmentosum (XP-A) patients with various combinations of mutation sites. Clinical Genetics. 48:1995;225-231.
44. Maeda T., Sato K., Minami H., Taguchi H., Yoshikawa K. PCR-RFLP analysis as an aid to genetic counseling of families of Japanese patients with group A xeroderma pigmentosum. Journal of Investigative Dermatology. 109:1997;306-309.
45. Maezawa Y., Yamauchi M., Searashi Y., Takeda K., Mizuhara Y., Kimura T., Toda G., Suzuki H., Sakurai S. Association of restriction fragment-length polymorphisms in the alcohol dehydrogenase 2 gene with alcoholic brain atrophy. Alcoholism: Clinical and Experimental Research. 20:1996;29A-32A.
46. Marnett L.J. Lipid peroxidation-DNA damage by malondialdehyde. Mutation Research. 424:1999;83-95.
47. Masutani C., Kusumoto R., Yamada A., Dohmae N., Yokoi M., Yuasa M., Araki M., Iwai S., Takio K., Hanaoka F. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature. 399:1999;700-704.
48. Mayeda A., Krainer A.R. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell. 68:1992;365-375.
49. Mimaki T., Itoh N., Abe J., Tagawa T., Sato K., Yabuuchi H., Takebe H. Neurological manifestations in Xeroderma Pigmentosum. Annals of Neurology. 20:1986;70-75.
50. Mohrenweiser H.W., Jones I.M. Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation? Mutation Research. 400:1998;15-24.
51. Pfefferbaum A., Lim K.O., Zipursky R.B., Mathalon D.H., Rosenbloom M.J., Lane B., Ha C.N., Sullivan E.V. Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcoholism: Clinical and Experimental Research. 16:1992;1078-1089.
52. Pfefferbaum A., Sullivan E.V., Mathalon D.H., Lim K.O. Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcoholism: Clinical and Experimental Research. 21:1997;521-529.
53. Pfefferbaum A., Sullivan E.V., Mathalon D.H., Shear P.K., Rosenbloom M.J., Lim K.O. Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcoholism: Clinical and Experimental Research. 19:1995;1177-1191.
54. Pfefferbaum A., Sullivan E.V., Rosenbloom M.J., Mathalon D.H., Lim K.O. A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval. Archives of General Psychiatry. 55:1998;905-912.
55. Pfefferbaum A., Sullivan E.V., Rosenbloom M.J., Shear P.K., Mathalon D.H., Lim K.O. Increase in brain cerebrospinal fluid volume is greater in older than in younger alcoholic patients: a replication study and CT/MRI comparison. Psychiatry Research. 50:1993;257-274.
56. Phillips D.H., Castegnaro M. Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols. Mutagenesis. 14:1999;301-315.
57. Ploskonosova I., Baranov V.I., Gaziev A.I. PCR assay of DNA damage and repair at the gene level in brain and spleen of gamma-irradiated young and old rats. Mutation Research. 434:1999;109-117.
58. Randerath K., Randerath E., Smith C.V., Chang J. Structural origins of bulky oxidative DNA adducts (type II I-compounds) as deduced by oxidation of oligonucleotides of known sequence. Chemical Research in Toxicology. 9:1996;247-254.
59. Randerath K., Randerath E., Zhou G.D., Li D. Bulky endogenous DNA modifications (I-compounds)-possible structural origins and functional implications. Mutation Research. 424:1999;183-194.
60. Rapic Otrin V., Kuraoka I., Nardo T., McLenigan M., Eker A.P., Stefanini M., Levine A.S., Wood R.D. Relationship of the xeroderma pigmentosum group E DNA repair defect to the chromatin and DNA binding proteins UV-DDB and replication protein A. Molecular and Cellular Biology. 18:1998;3182-3190.
61. Reynolds I., Hastings T. Glutamate Induces the formation of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. Journal of Neuroscience. 15:1995;3318-3327.
62. Robbins J. Xeroderma pigmentosum. Defective DNA repair causes skin cancer and neurodegeration. Journal of the American Medical Association. 260:1988;384-388.
63. Robbins J.H., Brumback R.A., Mendiones M., Barrett S.F., Carl J.R., Cho S., Denckla M.B., Ganges M.B., Gerber L.H., Guthrie R.A. Neurological disease in xeroderma pigmentosum. Documentation of a late onset type of the juvenile onset form. Brain. 114:1991;1335-1361.
64. Robbins J.H., Brumback R.A., Moshell A.N. Clinically asymptomatic xeroderma pigmentosum neurological disease in an adult: evidence for a neurodegeneration in later life caused by defective DNA repair. European Neurology. 33:1993;188-190.
65. Robbins J.H., Polinsky R.J., Moshell A.N. Evidence that lack of deoxyribonucleic acid repair causes death of neurons in xeroderma pigmentosum. Annals of Neurology. 13:1983;682-684.
66. Roberts B., Shoaf S., Jeong K.-S., Song B. Induction of cytochrome p4502E1(CYP2E1) in liver, kidney, brain, and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochemical and Biophysical Research Communications. 205:1994;1064-1071.
67. Roytta M., Antitnen A. Xeroderma pigmentosum and neurological abnormalities. A clinical and neuropathological study. Acta Neurologica. Scandinavica. 73:1986;191-199.
68. Sancar A. DNA excision repair. Annual Review of Biochemistry. 65:1996;43-81.
69. Satoh M., Jones C., Wood R., Lindahl T. DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical induced base lesions. Proceedings of the National Academy of Sciences, U.S.A. 90:1993;6335-6339.
70. Schmitz C., Axmacher B., Zunker U., Korr H. Age-related changes of DNA repair and mitochondrial DNA synthesis in the mouse brain. Acta Neuropathologica (Berlin). 97:1999;71-81.
71. Shen M.R., Jones I.M., Mohrenweiser H. Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Research. 58:1998;604-608.
72. Steinberg J.J., Oliver G.W. Jr, Cajigas A. The formation and measurement of DNA neuroadduction in alcoholism. Case report. American Journal of Forensic Medicine and Pathology. 18:1997;84-91.
73. Sugasawa K., Ng J.M., Masutani C., Iwai S., van der Spek P.J., Eker A.P., Hanaoka F., Bootsma D., Hoeijmakers J.H. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Molecular Cell. 2:1998;223-232.
74. Tornaletti S., Hanawalt P.C. Effect of DNA lesions on transcription elongation. Biochimie. 81:1999;139-146.
75. Tsai G., Gastfriend D.R., Coyle J.T. The glutamatergic basis of human alcoholism. American Journal of Psychiatry. 152:1995;332-340.
76. Tsai G., Ragan P., Chang R., Chen S., Linnoila V.M.I., Coyle J.T. Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal. American Journal of Psychaitry. 155:1998;726-732.
77. Tsai G., Coyle J.T. The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annual Review of Medicine. 49:1998;173-184.
78. Victor M. Alcoholic dementia. Canadian Journal of Neurological Sciences. 21:1994;88-99.
79. Wakasugi M., Sancar A. Order of assembly of human DNA repair excsion nuclease. Journal of Biological Chemistry. 274:1999;18759-18768.
80. Wang J., Takagaki Y., Manley J. Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. Genes and Development. 10:1996;2588-2599.
81. Warner M., Gustaffson J.-A. Effect of ethanol on cytochrome P450 in the rat brain. Proceedings of the National Academy of Sciences, U.S.A. 91:1994;1019-1023.
82. Wei Q. Effect of aging on DNA repair and skin carcinogenesis: a minireview of population-based studies. Journal of Investigative Dermatology: Symposium Proceedings. 3:1998;19-22.
83. Wood R.D. DNA damage recognition during nucleotide excision repair in mammalian cells. Biochimie. 81:1999;39-44.
84. Yano K. Xeroderma pigmentosum with disturbance of the central nervous system: a Histopathological investigation. Folia Psychiatry and Neurology, Japan. 4:1950;143-175. Translated.
85. Zhang S.X., Weilersbacher G.S., Henderson S.W., Corso T., Olney J.W., Langlais P.J. Excitotoxic cytopathology, progression, and reversibility of thiamine deficiency-induced diencephalic lesions. Journal of Neuropathology and Experimental Neurology. 54:1995;255-267.
86. Ziegler A., Jonason A.S., Leffell D.J., Simon J.A., Sharma H.W., Kimmelman J., Remington L., Jacks T., Brash D.E. Sunburn and p53 in the onset of skin cancer. Nature. 372:1994;773-776.
87. Zimatkin S.M., Liopo A.V., Deitrich R.A. Distribution and kinetics of ethanol metabolism in rat brain. Alcoholism: Clinical and Experimental Research. 22:1998;1623-1627.