P53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin

International Journal of Oncology

Volumn 14, Issue 1, 1999, Pages 5-14

  Meng Py, Raymond D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apoptosis; Chemosensitivity; E2F 1; P53; Rb

Indexed keywords

CARRIER PROTEIN; CELL CYCLE PROTEIN; CYCLOHEXIMIDE; DNA; DNA BINDING PROTEIN; DOXORUBICIN; E2F1 PROTEIN, HUMAN; E2F1 PROTEIN, MOUSE; ETOPOSIDE; PROTEIN P53; RETINOBLASTOMA BINDING PROTEIN 1; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1;

ANIMAL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL CULTURE; DNA DAMAGE; DRUG EFFECT; DRUG RESISTANCE; HUMAN; MOUSE; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CYCLOHEXIMIDE; DNA; DNA DAMAGE; DNA-BINDING PROTEINS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; ETOPOSIDE; HUMANS; MICE; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032622050     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Adams PD and Kaelin WG Jr: Transcriptional control by E2F. Semin Cancer Biol 6: 99-108,1995.
2. La Thangue NB: DP and E2F proteins: components of a hetcrodimeric transcription factor implicated in cell cycle control. Curr Opin Cell Biol 443-450, 1994.
3. Ohtani K, De Grcgori J and Nevins JR: Regulation of the cyclin E gene by transcription factor E2F1. Proc NatI Acad Sci USA 92: 12146-12150, 1995.
4. Botz J, Zcrfass-Thome K, Spitkovsky D, Delius H, Vogt B, Eilers M, Hatzgeorgiou A and Janssen-Durr P: Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol Cell Biol 16: 3401-3409, 1996.