Morpholino and phosphorothioate antisense oligomers compared in cell-free and in-cell systems

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 2, 1997, Pages 63-70

  Summerton, James ^a,b   Stein, David ^a   Huang, Sung Ben ^a   Matthews, Paula ^a   Weller, Dwight ^a   Partridge, Michael ^a  

^a Antivirals Inc   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DNA; GLOBIN; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ARTICLE; CELL FREE SYSTEM; COMPARATIVE STUDY; CONTROLLED STUDY; DNA SEQUENCE; GENE TARGETING; GLOBIN GENE; HELA CELL; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA TRANSLATION; TRANSLATION REGULATION;

EID: 0030969949     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.63     Document Type: Article

References (5)

1. BELIKOVA, A., ZARYTOVA, V., and GRINEVA, N. (1967). Synthesis of ribonucleosides and diribonucleoside phosphates containing 2-chloro-ethylamine and nitrogen mustard residues. Tetrahedron Lett. 5, 3557-3562.
2. CAZENAVE, C., STEIN, C., LOREAU, N., THUONG, N., NECKERS, L., SUBASINGHE, C., HELENE, C., COHEN, J., and TOULME, J. (1989). Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides. Nucleic Acids Res. 17, 4255-4274.
3. CROOKE, S., and LEBLEU, B., eds. (1993). Antisense Research and Applications. (CRC Press, Inc., Boca Raton, FL).
4. YASWEN, P., STAMPFER, M., GHOSH, K., and COHEN, J. (1993). Effects of sequence of thioated oligonucleotides on cultured human mammary epithelial cells. Antisense Res. Dev. 3, 67-77.
5. ZAMECNIK, P., and STEPHENSON, M. (1978). Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. USA 76, 280-284.