Role of Rho-family GTPase Cdc42 in polarized expression of lymphocyte appendages

Journal of Leukocyte Biology

Volumn 73, Issue 6, 2003, Pages 830-840

  Ratner, Stuart ^a,b   Piechocki, Marie P ^a   Galy, Anne ^a  

^a KARMANOS CANCER INSTITUTE   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemotaxis; Cytoskeleton; Human; Leukemia; Motility; T cell

Indexed keywords

LYMPHOCYTE ANTIGEN; PROTEIN CDC42; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ARTICLE; CELL ULTRASTRUCTURE; CHEMOREACTIVITY; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LAMELLIPODIUM; LEUKEMIA CELL; LYMPHOCYTE MIGRATION; NEUTROPHIL CHEMOTAXIS; POLARIZATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN INDUCTION; RANDOMIZATION; CELL CULTURE; CELL MOTION; CELL POLARITY; CYTOLOGY; ENZYMOLOGY; GENE VECTOR; GENETICS; IMMUNOLOGY; KINETICS; LYMPHOCYTE ACTIVATION; MUTATION; PHYSIOLOGY; PSEUDOPODIUM; RETROVIRUS; T LYMPHOCYTE; ULTRASTRUCTURE;

UROPODA;

CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; CELL POLARITY; CELLS, CULTURED; GENETIC VECTORS; HUMANS; KINETICS; LYMPHOCYTE ACTIVATION; MUTATION; PSEUDOPODIA; RETROVIRIDAE; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0038341887     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1001894     Document Type: Article

References (42)

1. del Pozo, M. A., Vicente-Manzanares, M., Tejedor, R., Serrador, J. M., Sanchez-Madrid, F. (1999) Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes. Eur. J. Immunol. 29, 3609-3620.
2. Friedl, P., Brocker, E. B., Zanker, K. S. (1998) Integrins, cell matrix interactions and cell migration strategies: fundamental differences in leukocytes and tumor cells. Cell Adhes. Commun. 6, 225-236.
3. von Andrian, U. H., Mackay, C. R. (2000) T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 343, 1020-1034.
4. Haston, W. S., Shields, J. M. (1984) Contraction waves in lymphocyte locomotion. J. Cell Sci. 68, 227-241.
5. Sanchez-Madrid, F., del Pozo, M. (1999) Leukocyte polarization in cell migration and immune interactions. EMBO J. 18, 501-511.
6. Brown, M. J., Hallam, J. A., Liu, Y., Yamada, K. M., Shaw, S. (2001) Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin. J. Immunol. 167, 641-645.
7. Ratner, S., Sherrod, W. S., Lichlyter, D. L. (1997) Microtubule retraction into the uropod and its role in T cell polarization and motility. J. Immunol. 159, 1063-1067.
8. Serrador, J. M., Nieto, M., Sanchez-Madrid, F. (1999) Cytoskeletal rearrangement during migration and activation of T lymphocytes. Trends Cell Biol. 9, 228-233.
9. Wang, X. Y., Ostberg, J. R., Repasky, E. A. (1999) Effect of fever-like whole-body hyperthermia on lymphocyte spectrin distribution, protein kinase C activity, and uropod formation. J. Immunol. 162, 3378-3387.
10. del Pozo, M. A., Sanchez-Mateos, P., Sanchez-Madrid, F. (1996) Cellular polarization induced by chemokines: a mechanism for leukocyte recruitment? Immunol. Today 17, 127-131.
11. Brown, M. J., Hallam, J. A., Colucci-Guyon, E., Shaw, S. (2001) Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments. J. Immunol. 166, 6640-6646.
12. Allen, W. E., Zicha, D., Ridley, A. J., Jones, G. E. (1998) A role for Cdc42 in macrophage chemotaxis. J. Cell Biol. 141, 1147-1157.
13. Haddad, E., Zugaza, J. L., Louache, F., Debili, N., Crouin, C., Schwarz, K., Fischer, A., Vainchenker, W., Bertoglio, J. (2001) The interaction between Cdc42 and WASP is required for SDF-1-induced T lymphocyte chemotaxis. Blood 97, 33-38.
14. Wilkinson, P. C. (1986) The locomotor capacity of human lymphocytes and its enhancement by cell growth. Immunology 57, 281-289.
15. Ridley, A. J., Hall, A. (1992) The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
16. Sander, E. E., van Delft, S., ten Klooster, J. P., Reid, T., van der Kammen, R. A., Michiels, F., Collard, J. G. (1998) Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J. Cell Biol. 143, 1385-1398.
17. Stowers, L., Yelon, D., Berg, L. J., Chant, J. (1995) Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl. Acad. Sci. USA 92, 5027-5031.
18. Burbelo, P. D., Drechsel, D., Hall, A. (1995) A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem. 270, 29071-29074.
19. Qiu, R. G., Abo, A., McCormick, F., Symons, M. (1997) Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol. Cell. Biol. 17, 3449-3458.
20. Feig, L. A. (1999) Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases. Nat. Cell Biol. 1, E25-E27.
21. D'Souza-Schorey, C., Boettner, B., Van Aelst, A. L. (1998) Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes. Mol. Cell. Biol. 18, 3936-3946.
22. Stam, J. C., Michiels, F., van der Kammen, R. A., Moolenaar, W. H., Collard, J. G. (1998) Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. EMBO J. 17, 4066-4074.
23. Soede, R. D., Zeelenberg, I. S., Wijnands, Y. M., Kamp, M., Roos, E. (2001) Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42. J. Immunol. 166, 4293-4301.
24. Woodside, D. G., Wooten, D. K., McIntyre, B. W. (1998) Adenosine diphosphate (ADP)-ribosylation of the guanosine triphosphatase (GTPase) Rho in resting peripheral blood human T lymphocytes results in pseudopodial extension and the inhibition of T cell activation. J. Exp. Med. 188, 1211-1221.
25. Verschueren, H., De, B. P., De, B. J., Dewit, J., Aktories, K., Just, I. (1997) ADP-ribosylation of Rho-proteins with botulinum C3 exoenzyme inhibits invasion and shape changes of T-lymphoma cells. Eur. J. Cell Biol. 73, 182-187.
26. Tominaga, T., Sugie, K., Hirata, M., Morii, N., Fukata, J. (1993) Inhibition of PMA-induced LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP-binding protein, Rho. J. Cell Biol. 120, 1529-1537.
27. Krawczyk, C., Penninger, J. M. (2001) Molecular motors involved in T cell receptor clusterings. J. Leukoc. Biol. 69, 317-330.
28. Yoshida, H., Tomiyama, Y., Ishikawa, J., Oritani, K., Matsumura, I., Shiraga, M., Yokota, T., Okajima, Y., Ogawa, M., Miyagawa, J., Nishiura, T. Matsuzawa, Y. (2000) Integrin-associated protein/CD47 regulates motile activity in human B-cell lines through CDC42. Blood 96, 234-241.
29. Schmitz, A. A., Govek, E. E., Bottner, B., Van Aelst, L. (2000) Rho GTPases: signaling, migration, and invasion. Exp. Cell Res. 261, 1-12.
30. Chen, X. Q., Tan, I., Leung, T., Lim, L. (1999) The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells. J. Biol. Chem. 274, 19901-19905.
31. Edwards, D. C., Sanders, L. C., Bokoch, G. M., Gill, G. N. (1999) Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell Biol. 1, 253-259.
32. Osman, M. A., Cerione, R. A. (1998) Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates cdc42p effects on the actin cytoskeleton. J. Cell Biol. 142, 443-455.
33. Qiu, R. G., Abo, A., Martin, G. S. (2000) A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKC zeta signaling and cell transformation. Curr. Biol. 10, 697-707.
34. Etienne-Manneville, S., Hall, A. (2001) Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell 106, 489-498.
35. Wang, F., Herzmark, P., Weiner, O. D., Srinivasan, S., Servant, G., Bourne, H. R. (2002) Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat. Cell Biol. 4, 513-518.
36. Fukata, M., Watanabe, T., Noritake, J., Nakagawa, M., Yamaga, M., Kuroda, S., Matsuura, Y., Iwamatsu, A., Perez, F., Kaibuchi, K. (2002) Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell 109, 873-885.
37. Kroschewski, R., Hall, A., Mellman, I. (1999) Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells. Nat. Cell Biol. 1, 8-13.
38. Wu, W. J., Erickson, J. W., Lin, R., Cerione, R. A. (2000) The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation. Nature 405, 800-804.
39. Friedl, P., Zanker, K. S., Brocker, E. B. (1998) Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin function. Microsc. Res. Tech. 43, 369-378.
40. Arthur, W. T., Petch, L. A., Burridge, K. (2000) Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism. Curr. Biol. 10, 719-722.
41. Worthylake, R. A., Lemoine, S., Watson, J. M., Burridge, K. (2001) RhoA is required for monocyte tail retraction during transendothelial migration. J. Cell Biol. 154, 147-160.
42. Nobes, C. D., Hall, A. (1999) Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144, 1235-1244.