DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines

Blood

Volumn 100, Issue 12, 2002, Pages 3968-3974

  Nishihara, Hiroshi ^a   Maeda, Masae ^a   Oda, Atsushi ^a   Tsuda, Masumi ^a   Sawa, Hirofumi ^a   Nagashima, Kazuo ^a   Tanaka, Shinya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CRK LIKE PROTEIN; F ACTIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PROTEIN; PROTEIN C CRK II; PROTEIN CDM; PROTEIN DOCK2; RAC1 PROTEIN; UNCLASSIFIED DRUG; VAV PROTEIN;

ARTICLE; CONTROLLED STUDY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LEUKEMIA CELL LINE; LYMPHOCYTE MIGRATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SRC HOMOLOGY DOMAIN;

EID: 0036893185     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2001-11-0032     Document Type: Article

References (38)

1. Wu YC, Horvitz HR. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature. 1998;392:501-504.
2. Hasegawa H, Kiyokawa E, Tanaka S, et al. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol Cell Biol. 1996;16:1770-1776.
3. Erickson MR, Galletta BJ, Abmayr SM. Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization. J Cell Biol. 1997;138:589-603.
4. Kiyokawa E, Hashimoto Y, Kobayashi S, Sugimura H, Kurata T, Matsuda M. Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev. 1998;12:3331-3336.
5. Reddien PW, Horvitz HR. CED-2/CrkII and CED10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol. 2000;2: 131-136.
6. Albert ML, Kim JI, Birge RB. Alphavbeta6 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells. Nat Cell Biol. 2000;2:899-905.
7. Nagase T, Seki N, Ishikawa K, et al. Prediction of the coding sequences of unidentified human genes, VI: The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 1996;3:321-329,341-354.
8. Nishihara H, Kobayashi S, Hashimoto Y, et al. Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins. Biochim Biophys Acta. 1999;1452:179-187.
9. Fukui Y, Hashimoto O, Sanui T, et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature. 2001; 412:826-831.
10. ten Hoeve J, Morris C, Heisterkamp N, Groffen J. Isolation and chromosomal localization of CRKL, a human crk-like gene. Oncogene. 1993;8:2469-2474.
11. ten Hoeve J, Arlinghaus RB, Guo JQ. Heisterkamp N, Groffen J. Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia. Blood. 1994; 84:1731-1736.
12. Aral A, Nosaka Y, Kohsaka H, Miyasaka N, Miura O, CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G. Blood. 1999;93:3713- 3722.
13. Uemura N, Salgia R, Ewaniuk DS, Little MT, Griffin JD. Involvement of the adapter protein CRKL in integrin-mediated adhesion. Oncogene. 1999; 18:3343-3353.
14. Uemura N, Griffin JD. The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration. J Biol Chem. 1999;274: 37525-37532.
15. Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 1995;81:53-62.
16. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 1992;70:401-410.
17. Chant J, Stowers L. GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more. Cell. 1995;81:1-4.
18. Mackay DJ, Hall A. Rho GTPases. J Biol Chem. 1998;273:20685-20688.
19. Whitehead IP, Campbell S, Rossman KL, Der CJ. Dbl family proteins. Biochim Biophys Acta. 1997; 1332:F1-F23.
20. Lemmon MA, Ferguson KM, Schlessinger J. PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell. 1996;85:621-624.
21. Katzav S, Martin-Zanca D, Barbacid M. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 1989;8:2283-2290.
22. Teramoto H, Salem P, Robbins KC, Bustelo XR, Gutkind JS. Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway. J Biol Chem. 1997;272: 10751-10755.
23. Obergfell A, Judd BA, del Pozo MA, Schwartz MA, Koretzky GA, Shattil SJ. The molecular adapter SLP-76 relays signals from platelet integrin alphallbbeta3 to the actin cytoskeleton. J Biol Chem. 2001;276:5916-5923.
24. Heaney C, Kolibaba K, Bhat A, et al. Direct binding of CRKL to BCR-ABL is not required for BCRABL transformation. Blood. 1997;89:297-306.
25. Tanaka S, Hattori S, Kurata T, et al. Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells. Mol Cell Biol. 1993;13:4409-4415.
26. Oda A, Miyakawa Y, Druker BJ, et al. Crkl is constitutively tyrosine phosphorylated in platelets from chronic myelogenous leukemia patients and inducibly phosphorylated in normal platelets stimulated by thrombopoietin. Blood. 1996;88: 4304-4313.
27. Oda A, Ochs HD, Lasky LA, et al. CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk. Blood. 2001;97:2633-2639.
28. Akasaki T, Koga H, Sumimoto H. Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils. J Biol Chem. 1999;274:18055-18059.
29. del Pozo MA, Price LS, Alderson NB, Ren XD, Schwartz MA. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK. EMBO J. 2000;19:2008-2014.
30. Matsuda M, Ota S, Tanimura R, et al. Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. J Biol Chem. 1996; 271:14468-14472.
31. Felschow DM, McVeigh ML, Hoehn GT, Civin CI, Fackler MJ. The adapter protein CrkL associates with CD34. Blood. 2001;97:3768-3775.
32. Nishida M, Nagata K, Hachimori Y, et al. Novel recognition mode between Vav and Grb2 SH3 domains. EMBO J. 2001;20:2995-3007.
33. Tanaka S, Morishita T, Hashimoto Y, et al. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc Natl Acad Sci U S A. 1994;91:3443-3447.
34. Ohba Y, Ikuta K, Ogura A, et al. Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J. 2001;20:3333-3341.
35. Arrieumedou C, Randriamampita C, Bismuth G, Trautmann A, Rac is involved in early TCR signaling. J Immunol. 2000;165:3182-3189.
36. Uemura N, Griffin JD. The adapter protein Crk) links Cbl and C3g after integrin ligation and enhances cell migration. J Biol Chem. 1999;274: 37525-37532.
37. Hemmeryckx B, van Wiik A, Reichert A, et al. Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice. Cancer Res. 2001;61:1398-1405.
38. Kardinal C, Konkol B, Schulz A, et al. Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients. FASEB J. 2000;14:1529-1538.