The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis

Blood

Volumn 97, Issue 1, 2001, Pages 33-38

  Haddad, Elie ^b   Zugaza, José L ^b   Louache, Fawzia ^b   Debili, Najet ^b   Crouin, Catherine ^b   Schwarz, Klaus ^b   Fischer, Alain ^b   Vainchenker, William ^b   Bertoglio, Jacques ^a  

^a INSERM   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; GUANOSINE TRIPHOSPHATASE; PROTEIN CDC42; PROTEIN CRIB; RAC PROTEIN; RECOMBINANT PROTEIN; STROMAL CELL DERIVED FACTOR 1; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPATHOGENESIS; IMMUNOPRECIPITATION; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; T LYMPHOCYTE ACTIVATION; WISKOTT ALDRICH SYNDROME;

EID: 0035174959     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.1.33     Document Type: Article

References (46)

1. The Wiskott-Aldrich syndrome
2. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases
3. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome
4. Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42
5. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
6. Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization
7. Regulation of actin polymerization by Arp2/3 complex and WASP/Scar proteins
8. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex
9. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
10. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
11. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
12. Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine
13. Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome
14. Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome
15. The thrombocytopenia of Wiskott Aldrich syndrome is not related to a defect in proplatelet formation
16. Abnormalities of lymphocyte locomotion in immunodeficiency disease
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19. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
20. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
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24. Characterization of a monoclonal antibody specific for the Ras-related GTP-binding protein Rho A
25. Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts
26. The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation
27. Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK
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29. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor (SDF-1)
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32. Is Wiskott-Aldrich syndrome a cell trafficking disorder?
33. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
34. Actin cytoskeletal function is spared, but apoptosis is increased, in WAS patient hematopoietic cells
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36. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
37. The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways
38. Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis
39. Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: Roles of phosphoinositide-3 kinase and protein kinase C
40. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
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43. Rho GTPases control polarity, protrusion, and adhesion during cell movement
44. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42
45. The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes
46. Spontaneous apoptosis in lymphocytes from patients with Wiskott-Aldrich syndrome: Correlation of accelerated cell death and attenuated bcl-2 expression