-
1
-
-
0035524114
-
Improving the efficacy of antibody-based cancer therapies
-
Carter P. Improving the efficacy of antibody-based cancer therapies. Nat. Rev. Cancer. 1:2001;118-129.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 118-129
-
-
Carter, P.1
-
2
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 256:1975;495-497.
-
(1975)
Nature
, vol.256
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
3
-
-
0037235949
-
Engineered antibodies
-
Hudson P.J., Souriau C. Engineered antibodies. Nat. Med. 9:2003;129-134.
-
(2003)
Nat. Med.
, vol.9
, pp. 129-134
-
-
Hudson, P.J.1
Souriau, C.2
-
4
-
-
0024232289
-
Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure
-
Jain R.K., Baxter L.T. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res. 48:1988;7022-7032.
-
(1988)
Cancer Res.
, vol.48
, pp. 7022-7032
-
-
Jain, R.K.1
Baxter, L.T.2
-
5
-
-
0036382827
-
High in vivo production of a model monoclonal antibody on adenoviral gene transfer
-
Noel D., et al. High in vivo production of a model monoclonal antibody on adenoviral gene transfer. Hum. Gene Ther. 13:2002;1483-1493.
-
(2002)
Hum. Gene Ther.
, vol.13
, pp. 1483-1493
-
-
Noel, D.1
-
6
-
-
0030771777
-
In vitro and in vivo secretion of cloned antibodies by genetically modified myogenic cells
-
Noel D., et al. In vitro and in vivo secretion of cloned antibodies by genetically modified myogenic cells. Hum. Gene Ther. 8:1997;1219-1229.
-
(1997)
Hum. Gene Ther.
, vol.8
, pp. 1219-1229
-
-
Noel, D.1
-
7
-
-
0031828981
-
Recombinant adenoviral delivery for in vivo expression of scFv antibody fusion proteins
-
Whittington H.A., et al. Recombinant adenoviral delivery for in vivo expression of scFv antibody fusion proteins. Gene Ther. 5:1998;770-777.
-
(1998)
Gene Ther.
, vol.5
, pp. 770-777
-
-
Whittington, H.A.1
-
8
-
-
0036196127
-
Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv
-
Arafat W.O., et al. Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv. Gene Ther. 9:2002;256-262.
-
(2002)
Gene Ther.
, vol.9
, pp. 256-262
-
-
Arafat, W.O.1
-
9
-
-
0038265104
-
The extracellular matrix: A new turn-of-the-screw for anti-angiogenic strategies
-
Sanz L., Alvarez-Vallina L. The extracellular matrix: a new turn-of-the-screw for anti-angiogenic strategies. Trends Mol. Med. 9:2003;256-262.
-
(2003)
Trends Mol. Med.
, vol.9
, pp. 256-262
-
-
Sanz, L.1
Alvarez-Vallina, L.2
-
10
-
-
0036053161
-
Single-chain antibody-based gene therapy: Inhibition of tumor growth by in situ production of phage-derived human antibody fragments blocking functionally active sites of cell-associated matrices
-
Sanz L., et al. Single-chain antibody-based gene therapy: inhibition of tumor growth by in situ production of phage-derived human antibody fragments blocking functionally active sites of cell-associated matrices. Gene Ther. 9:2002;1049-1053.
-
(2002)
Gene Ther.
, vol.9
, pp. 1049-1053
-
-
Sanz, L.1
-
11
-
-
0141613928
-
Single-chain antibody and its derivatives directed against vascular endothelial growth factor: Application for antiangiogenic gene therapy
-
Afanasieva T.A., et al. Single-chain antibody and its derivatives directed against vascular endothelial growth factor: application for antiangiogenic gene therapy. Gene Ther. 10:2003;1850-1859.
-
(2003)
Gene Ther.
, vol.10
, pp. 1850-1859
-
-
Afanasieva, T.A.1
-
12
-
-
0032882746
-
Bispecific antibodies in cancer therapy
-
Segal D.M., et al. Bispecific antibodies in cancer therapy. Curr. Opin. Immunol. 11:1999;558-562.
-
(1999)
Curr. Opin. Immunol.
, vol.11
, pp. 558-562
-
-
Segal, D.M.1
-
13
-
-
0021997079
-
Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody
-
Perez P., et al. Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody. Nature. 316:1985;354-356.
-
(1985)
Nature
, vol.316
, pp. 354-356
-
-
Perez, P.1
-
14
-
-
0031106547
-
Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies
-
Deo Y.M., et al. Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies. Immunol. Today. 18:1997;127-135.
-
(1997)
Immunol. Today
, vol.18
, pp. 127-135
-
-
Deo, Y.M.1
-
15
-
-
0032535494
-
Immunotherapy of B-cell lymphoma with CD3x19 bispecific antibodies: Costimulation via CD28 prevents 'veto' apoptosis of antibody-targeted cytotoxic T cells
-
Daniel P.T., et al. Immunotherapy of B-cell lymphoma with CD3x19 bispecific antibodies: costimulation via CD28 prevents 'veto' apoptosis of antibody-targeted cytotoxic T cells. Blood. 92:1998;4750-4757.
-
(1998)
Blood
, vol.92
, pp. 4750-4757
-
-
Daniel, P.T.1
-
16
-
-
0024416006
-
Monoclonal antibodies that bind to distinct epitopes on FcγRI are able to trigger receptor function
-
Guyre P.M., et al. Monoclonal antibodies that bind to distinct epitopes on FcγRI are able to trigger receptor function. J. Immunol. 143:1989;1650-1655.
-
(1989)
J. Immunol.
, vol.143
, pp. 1650-1655
-
-
Guyre, P.M.1
-
17
-
-
0032519427
-
Bispecific molecules directed to the Fc receptor for IgA (FcαRI, CD89) and tumor antigens efficiently promote cell-mediated cytotoxicity of tumor targets in whole blood
-
Deo Y.M., et al. Bispecific molecules directed to the Fc receptor for IgA (FcαRI, CD89) and tumor antigens efficiently promote cell-mediated cytotoxicity of tumor targets in whole blood. J. Immunol. 160:1998;1677-1686.
-
(1998)
J. Immunol.
, vol.160
, pp. 1677-1686
-
-
Deo, Y.M.1
-
18
-
-
0027471898
-
Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors
-
Eshhar Z., et al. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors. Proc. Natl. Acad. Sci. U. S. A. 90:1993;720-724.
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 720-724
-
-
Eshhar, Z.1
-
19
-
-
0033385052
-
Bypassing immunization: Optimized design of 'designer T cells' against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA
-
Nolan K.F., et al. Bypassing immunization: optimized design of 'designer T cells' against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA. Clin. Cancer Res. 5:1999;3928-3941.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 3928-3941
-
-
Nolan, K.F.1
-
20
-
-
0029839767
-
Redirecting the complete T cell receptor/CD3 signaling machinery towards native antigen via modified T cell receptor
-
Brocker T., et al. Redirecting the complete T cell receptor/CD3 signaling machinery towards native antigen via modified T cell receptor. Eur. J. Immunol. 26:1996;1770-1774.
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 1770-1774
-
-
Brocker, T.1
-
21
-
-
0031907541
-
Harnessing Syk family tyrosine kinases as signaling domains for chimeric single chain of the variable domain receptors: Optimal design for T cell activation
-
Fitzer-Attas C.J., et al. Harnessing Syk family tyrosine kinases as signaling domains for chimeric single chain of the variable domain receptors: optimal design for T cell activation. J. Immunol. 160:1998;145-154.
-
(1998)
J. Immunol.
, vol.160
, pp. 145-154
-
-
Fitzer-Attas, C.J.1
-
22
-
-
0029841565
-
Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors
-
Álvarez-Vallina L., Hawkins R.E. Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors. Eur. J. Immunol. 26:1996;2304-2309.
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 2304-2309
-
-
Álvarez-Vallina, L.1
Hawkins, R.E.2
-
23
-
-
0032531091
-
Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
-
Finney H.M., et al. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J. Immunol. 161:1998;2791-2797.
-
(1998)
J. Immunol.
, vol.161
, pp. 2791-2797
-
-
Finney, H.M.1
-
24
-
-
0035889157
-
Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes
-
Geiger T.L., et al. Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes. Blood. 98:2001;2364-2371.
-
(2001)
Blood
, vol.98
, pp. 2364-2371
-
-
Geiger, T.L.1
-
25
-
-
0038108811
-
Induction of human T lymphocyte cytotoxicity and inhibition of tumor growth by tumor-specific diabody-based molecules secreted from gene-modified bystander cells
-
Blanco B., et al. Induction of human T lymphocyte cytotoxicity and inhibition of tumor growth by tumor-specific diabody-based molecules secreted from gene-modified bystander cells. J. Immunol. 171:2003;1070-1077.
-
(2003)
J. Immunol.
, vol.171
, pp. 1070-1077
-
-
Blanco, B.1
-
26
-
-
0028236196
-
Single-chain mono- and bispecific antibody derivatives with novel biological properties and antitumour activity from a COS cell transient expression system
-
Hayden M.S., et al. Single-chain mono- and bispecific antibody derivatives with novel biological properties and antitumour activity from a COS cell transient expression system. Ther. Immunol. 1:1994;3-15.
-
(1994)
Ther. Immunol.
, vol.1
, pp. 3-15
-
-
Hayden, M.S.1
-
27
-
-
0029148633
-
A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity
-
Mack M., et al. A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc. Natl. Acad. Sci. U. S. A. 92:1995;7021-7025.
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 7021-7025
-
-
MacK, M.1
-
28
-
-
0032146168
-
In vivo retargeting of T cell effector function by recombinant bispecific single chain Fv (anti-CD3 x anti-idiotype) induces long-term survival in the murine BCL1 lymphoma model
-
De Jonge J., et al. In vivo retargeting of T cell effector function by recombinant bispecific single chain Fv (anti-CD3 x anti-idiotype) induces long-term survival in the murine BCL1 lymphoma model. J. Immunol. 161:1998;1454-1461.
-
(1998)
J. Immunol.
, vol.161
, pp. 1454-1461
-
-
De Jonge, J.1
-
29
-
-
0032783692
-
Isolation and characterization of an anti-CD16 single-chain Fv fragment and construction of an anti-HER2/neu/anti-CD16 bispecific scFv that triggers CD16-dependent tumor cytolysis
-
McCall A.M., et al. Isolation and characterization of an anti-CD16 single-chain Fv fragment and construction of an anti-HER2/neu/anti-CD16 bispecific scFv that triggers CD16-dependent tumor cytolysis. Mol. Immunol. 36:1999;433-445.
-
(1999)
Mol. Immunol.
, vol.36
, pp. 433-445
-
-
McCall, A.M.1
-
30
-
-
0032844812
-
Enzyme recruitment and tumor cell killing in vitro by a secreted bispecific single-chain diabody
-
Brüsselbach T., et al. Enzyme recruitment and tumor cell killing in vitro by a secreted bispecific single-chain diabody. Tumor Targeting. 4:1999;115-123.
-
(1999)
Tumor Targeting
, vol.4
, pp. 115-123
-
-
Brüsselbach, T.1
-
31
-
-
0344654890
-
Novel tetravalent and bispecific IgG-like antibody molecules combining single-chain diabodies with the immunoglobulin γ1 Fc or CH3 region
-
Alt M., et al. Novel tetravalent and bispecific IgG-like antibody molecules combining single-chain diabodies with the immunoglobulin γ1 Fc or CH3 region. FEBS Lett. 454:1999;90-94.
-
(1999)
FEBS Lett.
, vol.454
, pp. 90-94
-
-
Alt, M.1
-
32
-
-
0343415665
-
A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes
-
Loffler A., et al. A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes. Blood. 95:2000;2098-2103.
-
(2000)
Blood
, vol.95
, pp. 2098-2103
-
-
Loffler, A.1
-
33
-
-
0035909785
-
Construction of a bispecific single chain antibody for recruitment of cytotoxic T cells to the tumour stroma associated antigen fibroblast activation protein
-
Wuest T., et al. Construction of a bispecific single chain antibody for recruitment of cytotoxic T cells to the tumour stroma associated antigen fibroblast activation protein. J. Biotechnol. 92:2001;159-168.
-
(2001)
J. Biotechnol.
, vol.92
, pp. 159-168
-
-
Wuest, T.1
-
34
-
-
0028841826
-
Chimaeric T-cell receptors specific to a B-lymphoma idiotype: A model for tumour immunotherapy
-
Gross G., et al. Chimaeric T-cell receptors specific to a B-lymphoma idiotype: a model for tumour immunotherapy. Biochem. Soc. Trans. 23:1995;1079-1082.
-
(1995)
Biochem. Soc. Trans.
, vol.23
, pp. 1079-1082
-
-
Gross, G.1
-
35
-
-
0037264471
-
Targeting tumours with genetically enhanced T lymphocytes
-
Sadelain M., et al. Targeting tumours with genetically enhanced T lymphocytes. Nat. Rev. Cancer. 3:2003;35-45.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 35-45
-
-
Sadelain, M.1
-
36
-
-
0031610524
-
CD20 is a molecular target for scFvFc:ζ Receptor redirected T cells: Implications for cellular immunotherapy of CD20+ malignancy
-
Jensen M., et al. CD20 is a molecular target for scFvFc:ζ receptor redirected T cells: implications for cellular immunotherapy of CD20+ malignancy. Biol. Blood Marrow Transplant. 4:1998;75-83.
-
(1998)
Biol. Blood Marrow Transplant.
, vol.4
, pp. 75-83
-
-
Jensen, M.1
-
37
-
-
0032521416
-
An anti-CD30 chimeric receptor that mediates CD3-ζ-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30
-
Hombach A., et al. An anti-CD30 chimeric receptor that mediates CD3-ζ-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30. Cancer Res. 58:1998;1116-1119.
-
(1998)
Cancer Res.
, vol.58
, pp. 1116-1119
-
-
Hombach, A.1
-
38
-
-
0029823560
-
Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44v6-specific scFv:ζ-chimera
-
Hekele A., et al. Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44v6-specific scFv:ζ-chimera. Int. J. Cancer. 68:1996;232-238.
-
(1996)
Int. J. Cancer
, vol.68
, pp. 232-238
-
-
Hekele, A.1
-
39
-
-
0036047663
-
Comparison of the TCR ζ-chain with the FcRγ-chain in chimeric TCR constructs for T cell activation and apoptosis
-
Ren-Heidenreich L., et al. Comparison of the TCR ζ-chain with the FcRγ-chain in chimeric TCR constructs for T cell activation and apoptosis. Cancer Immunol. Immunother. 51:2002;417-423.
-
(2002)
Cancer Immunol. Immunother.
, vol.51
, pp. 417-423
-
-
Ren-Heidenreich, L.1
-
40
-
-
0008911388
-
Enzyme recruitment and tumor cell killing in vitro a chimeric T-cell receptor
-
Royal R.E., et al. Enzyme recruitment and tumor cell killing in vitro a chimeric T-cell receptor. Proc. Am. Assoc. Cancer Res. 37:1996;481.
-
(1996)
Proc. Am. Assoc. Cancer Res.
, vol.37
, pp. 481
-
-
Royal, R.E.1
-
41
-
-
0027501259
-
Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors
-
Stancovski I., et al. Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors. J. Immunol. 151:1993;6577-6582.
-
(1993)
J. Immunol.
, vol.151
, pp. 6577-6582
-
-
Stancovski, I.1
-
42
-
-
0027283443
-
Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor γ chain
-
Hwu P., et al. Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor γ chain. J. Exp. Med. 178:1993;361-366.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 361-366
-
-
Hwu, P.1
-
43
-
-
0030014521
-
Single chain Ig/γ gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity
-
Weijtens M.E., et al. Single chain Ig/γ gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity. J. Immunol. 157:1996;836-843.
-
(1996)
J. Immunol.
, vol.157
, pp. 836-843
-
-
Weijtens, M.E.1
-
44
-
-
0032955712
-
Specific lysis of melanoma cells by receptor grafted T cells is enhanced by anti-idiotypic monoclonal antibodies directed to the scFv domain of the receptor
-
Reinhold U., et al. Specific lysis of melanoma cells by receptor grafted T cells is enhanced by anti-idiotypic monoclonal antibodies directed to the scFv domain of the receptor. J. Invest. Dermatol. 112:1999;744-750.
-
(1999)
J. Invest. Dermatol.
, vol.112
, pp. 744-750
-
-
Reinhold, U.1
-
45
-
-
0034634865
-
Generation of gene-modified T cells reactive against the angiogenic kinase insert domain-containing receptor (KDR) found on tumor vasculature
-
Kershaw M.H., et al. Generation of gene-modified T cells reactive against the angiogenic kinase insert domain-containing receptor (KDR) found on tumor vasculature. Hum. Gene Ther. 11:2000;2445-2452.
-
(2000)
Hum. Gene Ther.
, vol.11
, pp. 2445-2452
-
-
Kershaw, M.H.1
-
46
-
-
0033139686
-
Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen
-
Gong M.C., et al. Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen. Neoplasia. 1:1999;123-127.
-
(1999)
Neoplasia
, vol.1
, pp. 123-127
-
-
Gong, M.C.1
-
47
-
-
0030777395
-
+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope
-
+ tumor cells by a chimeric receptor with antibody-like specificity for a carbohydrate epitope. Gastroenterology. 113:1997;1163-1170.
-
(1997)
Gastroenterology
, vol.113
, pp. 1163-1170
-
-
Hombach, A.1
-
48
-
-
0034177140
-
Redirected perforin-dependent lysis of colon carcinoma by ex vivo genetically engineered CTL
-
Darcy P.M., et al. Redirected perforin-dependent lysis of colon carcinoma by ex vivo genetically engineered CTL. J. Immunol. 164:2000;3705-3712.
-
(2000)
J. Immunol.
, vol.164
, pp. 3705-3712
-
-
Darcy, P.M.1
-
49
-
-
0035502545
-
Genetic approaches for antigen-selective cell therapy
-
Álvarez-Vallina L. Genetic approaches for antigen-selective cell therapy. Curr. Gene Ther. 1:2001;385-397.
-
(2001)
Curr. Gene Ther.
, vol.1
, pp. 385-397
-
-
Álvarez-Vallina, L.1
-
50
-
-
0036570957
-
Tuning tumor-specific T-cell activation: A matter of costimulation?
-
Abken H., et al. Tuning tumor-specific T-cell activation: a matter of costimulation? Trends Immunol. 23:2002;240-245.
-
(2002)
Trends Immunol.
, vol.23
, pp. 240-245
-
-
Abken, H.1
-
51
-
-
0035251546
-
Development and applications of surface-linked single chain antibodies against T-cell antigens
-
Griffin M.D., et al. Development and applications of surface-linked single chain antibodies against T-cell antigens. J. Immunol. Methods. 248:2001;77-90.
-
(2001)
J. Immunol. Methods
, vol.248
, pp. 77-90
-
-
Griffin, M.D.1
-
52
-
-
0030300142
-
Surface expression of CD28 single chain Fv for costimulation by tumor cells
-
Winberg G., et al. Surface expression of CD28 single chain Fv for costimulation by tumor cells. Immunol. Rev. 153:1996;209-223.
-
(1996)
Immunol. Rev.
, vol.153
, pp. 209-223
-
-
Winberg, G.1
-
53
-
-
0031906785
-
Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy with the CD28 co-stimulatory pathway
-
Melero I., et al. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway. Eur. J. Immunol. 28:1998;1116-1121.
-
(1998)
Eur. J. Immunol.
, vol.28
, pp. 1116-1121
-
-
Melero, I.1
-
54
-
-
0031016269
-
Intrabodies: Turning the humoral immune system outside in for intracellular immunization
-
Marasco W.A. Intrabodies: turning the humoral immune system outside in for intracellular immunization. Gene Ther. 4:1997;11-15.
-
(1997)
Gene Ther.
, vol.4
, pp. 11-15
-
-
Marasco, W.A.1
-
55
-
-
0028839655
-
Targeted tumor killing via an intracellular antibody against erbB-2
-
Deshane J., et al. Targeted tumor killing via an intracellular antibody against erbB-2. J. Clin. Invest. 96:1995;2980-2989.
-
(1995)
J. Clin. Invest.
, vol.96
, pp. 2980-2989
-
-
Deshane, J.1
-
56
-
-
18544408628
-
A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): A phase I trial
-
Alvarez R.D., et al. A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): a phase I trial. Clin. Cancer Res. 6:2000;3081-3087.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3081-3087
-
-
Alvarez, R.D.1
-
57
-
-
0029812091
-
Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells
-
Jannot C.B., et al. Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells. Oncogene. 13:1996;275-282.
-
(1996)
Oncogene
, vol.13
, pp. 275-282
-
-
Jannot, C.B.1
-
58
-
-
0032523945
-
Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7
-
Piche A., et al. Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7. Cancer Res. 58:1998;2134-2140.
-
(1998)
Cancer Res.
, vol.58
, pp. 2134-2140
-
-
Piche, A.1
-
59
-
-
85030899583
-
-
Jendreyko, N. et al. Intra-diabodies: bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors. J. Biol. Chem. (in press)
-
Jendreyko, N. et al. Intra-diabodies: bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors. J. Biol. Chem. (in press).
-
-
-
-
60
-
-
0037434983
-
Generation and functional characterization of intracellular antibodies interacting with the kinase domain of human EGF receptor
-
Hyland S., et al. Generation and functional characterization of intracellular antibodies interacting with the kinase domain of human EGF receptor. Oncogene. 22:2003;1557-1567.
-
(2003)
Oncogene
, vol.22
, pp. 1557-1567
-
-
Hyland, S.1
-
61
-
-
0032521206
-
Intracellular expression of an antibody fragment-neutralizing p21 ras promotes tumor regression
-
Cochet O., et al. Intracellular expression of an antibody fragment-neutralizing p21 ras promotes tumor regression. Cancer Res. 58:1998;1170-1176.
-
(1998)
Cancer Res.
, vol.58
, pp. 1170-1176
-
-
Cochet, O.1
-
62
-
-
0037416179
-
Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation
-
Tanaka T., Rabbitts T.H. Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation. EMBO J. 22:2003;1025-1035.
-
(2003)
EMBO J.
, vol.22
, pp. 1025-1035
-
-
Tanaka, T.1
Rabbitts, T.H.2
-
63
-
-
0036721771
-
Intracellular single-chain variable fragments directed to the Src homology 2 domains of Syk partially inhibit Fcε RI signaling in the RBL-2H3 cell line
-
Dauvillier S., et al. Intracellular single-chain variable fragments directed to the Src homology 2 domains of Syk partially inhibit Fcε RI signaling in the RBL-2H3 cell line. J. Immunol. 169:2002;2274-2283.
-
(2002)
J. Immunol.
, vol.169
, pp. 2274-2283
-
-
Dauvillier, S.1
-
64
-
-
0036299007
-
Intracellular antibody capture technology: Application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein
-
Tse E., et al. Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein. J. Mol. Biol. 317:2002;85-94.
-
(2002)
J. Mol. Biol.
, vol.317
, pp. 85-94
-
-
Tse, E.1
-
65
-
-
0035313983
-
Overcoming multi-drug resistance using an intracellular anti-MDR1 sFv
-
Heike Y., et al. Overcoming multi-drug resistance using an intracellular anti-MDR1 sFv. Int. J. Cancer. 92:2001;115-122.
-
(2001)
Int. J. Cancer
, vol.92
, pp. 115-122
-
-
Heike, Y.1
-
66
-
-
0034710984
-
Intracellular antibody-caspase-mediated cell killing: An approach for application in cancer therapy
-
Tse E., Rabbitts T.H. Intracellular antibody-caspase-mediated cell killing: an approach for application in cancer therapy. Proc. Natl. Acad. Sci. U. S. A. 97:2000;12266-12271.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 12266-12271
-
-
Tse, E.1
Rabbitts, T.H.2
-
67
-
-
0036570976
-
Characterization of anti-cyclin e single-chain Fv antibodies and intrabodies in breast cancer cells: Enhanced intracellular stability of novel sFv-F(c) intrabodies
-
Strube R.W., Chen S.Y. Characterization of anti-cyclin E single-chain Fv antibodies and intrabodies in breast cancer cells: enhanced intracellular stability of novel sFv-F(c) intrabodies. J. Immunol. Methods. 263:2002;149-167.
-
(2002)
J. Immunol. Methods
, vol.263
, pp. 149-167
-
-
Strube, R.W.1
Chen, S.Y.2
-
68
-
-
0005382256
-
Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments
-
Caron de Fromentel C., et al. Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments. Oncogene. 18:1999;551-557.
-
(1999)
Oncogene
, vol.18
, pp. 551-557
-
-
Caron De Fromentel, C.1
-
69
-
-
0032511990
-
Characterization of a new intrabody directed against the N-terminal region of human p53
-
Cohen P.A., et al. Characterization of a new intrabody directed against the N-terminal region of human p53. Oncogene. 17:1998;2445-2456.
-
(1998)
Oncogene
, vol.17
, pp. 2445-2456
-
-
Cohen, P.A.1
-
70
-
-
0033983519
-
Tetracycline-induced expression of an anti-c-Myb single-chain antibody and its inhibitory effect on proliferation of the human leukemia cell line K562
-
Kasono K., et al. Tetracycline-induced expression of an anti-c-Myb single-chain antibody and its inhibitory effect on proliferation of the human leukemia cell line K562. Cancer Gene Ther. 7:2000;151-159.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 151-159
-
-
Kasono, K.1
-
71
-
-
0032771488
-
The selection of intracellular antibodies
-
Cattaneo A., Biocca S. The selection of intracellular antibodies. Trends Biotechnol. 17:1999;115-121.
-
(1999)
Trends Biotechnol.
, vol.17
, pp. 115-121
-
-
Cattaneo, A.1
Biocca, S.2
-
72
-
-
0036299049
-
The intracellular antibody capture technology (IACT): Towards a consensus sequence for intracellular antibodies
-
Visintin M., et al. The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies. J. Mol. Biol. 317:2002;73-83.
-
(2002)
J. Mol. Biol.
, vol.317
, pp. 73-83
-
-
Visintin, M.1
|