Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes

Blood

Volumn 98, Issue 8, 2001, Pages 2364-2371

  Geiger, Terrenes L ^a,b,c,d,e   Nguyen, Phuong ^a,b,c,d,e   Leitenberg, David ^a,b,c,d,e   Flavell, Richard A ^a,b,c,d  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^c GEORGE WASHINGTON UNIVERSITY   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CHIMERIC PROTEIN; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN; T LYMPHOCYTE RECEPTOR; TYROSINE KINASE RECEPTOR;

ADOPTIVE IMMUNOTHERAPY; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0035889157     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.8.2364     Document Type: Article

References (32)

1. Bordignon C, Carlo-Stella C, Colombo MP, et al. Cell therapy: achievements and perspectives. Haematologica. 1999;84:1110-1149.
2. Dazzi F, Goldman J. Donor lymphocyte infusions. Curr Opin Hematol. 1999;6:394-399.
3. Riddell SR, Greenberg PD. Principles for adoptive T cell therapy of human viral diseases. Ann Rev Immunol. 1995;13:545-586.
4. Mitsuyasu RT, Anton PA, Deeks SG, et al. Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects. Blood. 2000;96:785-793.
5. Eshhar Z. Tumor-specific T-bodies: towards clinical application. Cancer Immunol Immunother. 1997;45:131-136.
6. Abken H, Hombach A, Reinhold U, Ferrone S. Can combined T-cell and antibody-based immunotherapy outsmart tumor cells? Immunol Today. 1998;19:2-5.
7. Abken H, Hombach A, Heuser C, Sircar R, Pohl C, Reinhold U. Chimeric T-cell receptors: highly specific tools to target cytotoxic T-lymphocytes to tumour cells. Cancer Treat Rev. 1997;23:97-112.
8. Bitton N, Gorochov G, Debre P, Eshhar Z. Gene therapy approaches to HIV-infection: immunological strategies: use of T bodies and universal receptors to redirect cytolytic T-cells. Front Biosci. 1999;4:D386-D393.
9. Willemsen RA, Weijtens ME, Ronteltap C, et al. Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR. Gene Ther. 2000;7:1369-1377.
10. Brocker T. Chimeric Fv-zeta or Fv-epsilon receptors are not sufficient to induce activation or cytokine production in peripheral T cells. Blood. 2000;96:1999-2001.
11. Clevers H, Alarcon B, Wileman T, Terhorst C. The T cell receptor/CD3 complex: a dynamic protein ensemble. Ann Rev Immunol. 1988;6:629-662.
12. Weiss A. T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein tyrosine kinases. Cell. 1993;73:209-212.
13. Janeway CJ. The T cell receptor as a multicomponent signalling machine. Ann Rev Immunol. 1992;10:645-676.
14. Anderson SJ, Levin SD, Perlmutter RM. Involvement of the protein tyrosine kinase p56Ick in T cell signaling and thymocyte development. Adv Immunol. 1994;56:151-178.
15. Geiger T, Leitenberg D, Flavell R. The T-cellreceptor ζ chain is sufficient for the activation and maturation of primary T lymphocytes. J Immunol. 1999;162:5931-5939.
16. Finney HM, Lawson AD, Bebbington CR, Weir AN. Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol. 1998;161:2791- 2797.
17. Ausubel FM, Brent R, Kingston RE, et al. Current Protocols in Molecular Biology. New York: John Wiley and Sons; 1989.
18. Wolff C, Hong S, vonGrafenstein H, Janeway C. TCR-CD4 and TCR-TCR interactions as distinctive mechanisms for the induction of increased intracellular calcium in T-cell signaling. J Immunol. 1993;151:1337-1345.
19. Hong SC, Sant'Angelo DB, Dittel BN, et al. The orientation of a T cell receptor to its MHC class II: peptide ligands. J Immunol. 1997;159:4395-4402.
20. Liu H, Vignali DA. Differential CD3 zeta phosphorylation is not required for the induction of T cell antagonism by altered peptide ligands. J Immunol. 1999;163:599-602.
21. Woodland D, Happ MP, Bill J, Pa mer E. Requirement for cotolerogenic gene procucts in the clonal deletion of I-E reactive T cells. Science. 1990;247:964-967.
22. Bachmann MF, Gallimore A, Linkert S, et al. Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells. J Exp Med. 1999;189:1521-1530.
23. Carey KD, Dillon TJ, Schmitt JM, et al. CD28 and the tyrosine kinase Ick stimulate mitogen-activated protein kinase activity in T cells via inhibi- tion of the small G protein Rap1. Mol Cell Biol. 2000;20:8409-8419.
24. Holdorf AD, Green JM, Levin SD, et al. Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation. J Exp Med. 1999; 190:375-384.
25. Alam SM, Davies GM, Lin CM, et al. Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. Immunity. 1999;10:227-237.
26. Germain RN, Stefanova I. The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annu Rev Immunol. 1999;17:467-522.
27. Molina TJ, Kishihara K, Siderovski DP, et al. Profound block in thymocyte development in mice lacking p56Ick [see comments]. Nature. 1992;357:161-164.
28. Mannie MD, Rosser JM, White GA. Autologous rat myelin basic protein is a partial agonist that is converted into a full antagonist upon blockade of CD4. Evidence for the integration of efficacious and nonefficacious signals during T cell antigen recognition. J Immunol. 1995;154:2642-2654.
29. Vidal K, Daniel C, Hill M, Littman DR, Allen PM. Differential requirements for CD4 in TCR-ligand interactions. J Immunol. 1999;163:4811-4818.
30. Kersh EN, Kersh GJ, Allen PM. Partially phosphorylated T cell receptor zeta molecules can inhibit T cell activation, J Exp Med. 1999;190:1627-1636.
31. Chambers C, Allison J. Co-stimulation in T cell repsonses. Curr Opin Immunol. 1997;9:396-404.
32. Rutledge T, Cosson P, Manolios N, Bonifacino J, Klausner R. Transmembrane helical interactions: zeta chain dimerization and functional association with the T cell receptor. EMBO J. 1992;11:3245-3254.