Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv

Gene Therapy

Volumn 9, Issue 4, 2002, Pages 256-262

  Arafat, W O ^a   Gomez Navarro J ^a   Buchsbaum, D J ^a   Xiang, J ^a   Wang, M ^a   Casado, E ^a   Barker, S D ^a   Mahasreshti, P J ^a   Haisma, H J ^a   Barnes, M N ^a   Siegal, G P ^a   Alvarez, R D ^a   Hemminki, A ^a   Nettelbeck, D M ^a   Curiel, D T ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Adenoviral vector; erbB 2; Gene therapy; Immunotherapy; Single chain antibody

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY DNA; ONCOPROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN BINDING; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL GROWTH; CELL SECRETION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EUKARYOTIC CELL; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GENETIC ENGINEERING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE; TARGET CELL;

ADENOVIRIDAE; ANIMALS; ANTIBODIES, MONOCLONAL; FEMALE; GENE TARGETING; GENE THERAPY; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OVARIAN NEOPLASMS; RECEPTOR, ERBB-2; TRANSFECTION; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; ANIMALIA; EUKARYOTA;

EID: 0036196127     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj/gt/3301639     Document Type: Article

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