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Volumn 58, Issue 6, 1998, Pages 1170-1176

Intracellular expression of an antibody fragment-neutralizing p21 Ras promotes tumor regression

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PROTEIN P21; RAS PROTEIN; VIRUS VECTOR;

EID: 0032521206     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (119)

References (52)
  • 1
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos, J. L. Ras oncogenes in human cancer: a review. Cancer Res., 49: 4682-4689, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 2
    • 0028958222 scopus 로고
    • Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma
    • Mills, N. E., Fishman, C. L., Rom, W. N., Dubin, N., and Jacobson, D. R. Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma. Cancer Res., 55-1444-1447, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 1444-1447
    • Mills, N.E.1    Fishman, C.L.2    Rom, W.N.3    Dubin, N.4    Jacobson, D.R.5
  • 4
    • 0023835721 scopus 로고
    • The ras oncogenes increase the intrinsic resistance of NIH3T3 cells to ionizing radiations
    • Washington DC
    • Sklar, M. D. The ras oncogenes increase the intrinsic resistance of NIH3T3 cells to ionizing radiations. Science (Washington DC), 239: 645-647, 1988.
    • (1988) Science , vol.239 , pp. 645-647
    • Sklar, M.D.1
  • 5
    • 0023901469 scopus 로고
    • Increased resistance to cis-diamminedichloroplatinum(II) in NIH3T3 cells transformed by ras oncogenes
    • Sklar, M. D. Increased resistance to cis-diamminedichloroplatinum(II) in NIH3T3 cells transformed by ras oncogenes. Cancer Res., 48: 793-797, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 793-797
    • Sklar, M.D.1
  • 6
    • 0027175360 scopus 로고
    • Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct
    • Georges, R. N., Mukhopadhyay, T., Zhang, Y., Yen, N., and Roth, J. A. Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct. Cancer Res., 53: 1743-1746, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 1743-1746
    • Georges, R.N.1    Mukhopadhyay, T.2    Zhang, Y.3    Yen, N.4    Roth, J.A.5
  • 7
    • 0027905014 scopus 로고
    • Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
    • Washington DC
    • Shirasawa, S., Furuse, M., Yokoyama, N., and Sasazuki, T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science (Washington DC), 260: 85-88, 1993.
    • (1993) Science , vol.260 , pp. 85-88
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3    Sasazuki, T.4
  • 8
    • 0027024351 scopus 로고
    • Pharmacological probes of Ras function
    • Gibbs, J. B. Pharmacological probes of Ras function. Semin. Cancer Biol., 3: 383-390, 1992.
    • (1992) Semin. Cancer Biol. , vol.3 , pp. 383-390
    • Gibbs, J.B.1
  • 9
    • 0029932755 scopus 로고    scopus 로고
    • Oncogenic Neu/ErbB-2 increases ets, AP-1 and NF-κB-dependent gene expression, and inhibiting its activation blocks Neu-mediated cellular transformation
    • Galang, C. K., Garcia-Ramirez, J. J., Solski, P. A., Westwick, J. K., Der, C. J., Neznanov, N. N., Oshima, R. G., and Hauser, C. A. Oncogenic Neu/ErbB-2 increases ets, AP-1 and NF-κB-dependent gene expression, and inhibiting its activation blocks Neu-mediated cellular transformation. J. Biol. Chem., 271: 7992-7998, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7992-7998
    • Galang, C.K.1    Garcia-Ramirez, J.J.2    Solski, P.A.3    Westwick, J.K.4    Der, C.J.5    Neznanov, N.N.6    Oshima, R.G.7    Hauser, C.A.8
  • 10
    • 0022472990 scopus 로고
    • Requirement for c-ras proteins during viral oncogene transformation
    • Smith, M. R., DeGudicibus, S. J., and Stacey, D. W. Requirement for c-ras proteins during viral oncogene transformation. Nature (Lond.), 320: 540-542, 1986.
    • (1986) Nature (Lond.) , vol.320 , pp. 540-542
    • Smith, M.R.1    DeGudicibus, S.J.2    Stacey, D.W.3
  • 11
    • 0028318136 scopus 로고
    • Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
    • Prendergast, G. C., Davide, J. P., deSolms, S. J., Giuliani, E. A., Graham, S. L., Gibbs, J. B., Oliff, A., and Kohl, N. E. Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol. Cell. Biol., 14: 4193-4202, 1994.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4193-4202
    • Prendergast, G.C.1    Davide, J.P.2    DeSolms, S.J.3    Giuliani, E.A.4    Graham, S.L.5    Gibbs, J.B.6    Oliff, A.7    Kohl, N.E.8
  • 13
    • 0028914482 scopus 로고
    • Inhibition of HIV-1 tat-mediated LTR transactivation and HIV-1 infection by anti-tat single chain intrabodies
    • Mhashilkar, A. M., Bagley, J., Chen, S. Y., Szilvay, A. M., Helland, D. G., and Marasco, W. A. Inhibition of HIV-1 tat-mediated LTR transactivation and HIV-1 infection by anti-tat single chain intrabodies. EMBO J., 14: 1542-1551, 1995.
    • (1995) EMBO J. , vol.14 , pp. 1542-1551
    • Mhashilkar, A.M.1    Bagley, J.2    Chen, S.Y.3    Szilvay, A.M.4    Helland, D.G.5    Marasco, W.A.6
  • 14
    • 0028237267 scopus 로고
    • Potent inhibition of human immunodeficiency virus type 1 replication by an intracellular anti-rev single-chain antibody
    • Duan, L., Bagasra, O., Laughlin, M. A., Aokes, J. W., and Pomerantz, R. J. Potent inhibition of human immunodeficiency virus type 1 replication by an intracellular anti-rev single-chain antibody. Proc. Natl. Acad. Sci. USA, 91: 5075-5079, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5075-5079
    • Duan, L.1    Bagasra, O.2    Laughlin, M.A.3    Aokes, J.W.4    Pomerantz, R.J.5
  • 15
    • 0019958484 scopus 로고
    • Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family
    • Furth, M. E., Davis, L. J., Fleurdelys, B. E., and Scolnick, M. Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family. J. Virol., 43: 294-304, 1982.
    • (1982) J. Virol. , vol.43 , pp. 294-304
    • Furth, M.E.1    Davis, L.J.2    Fleurdelys, B.E.3    Scolnick, M.4
  • 17
    • 0028024772 scopus 로고
    • Intracellular single chain Fv antibody inhibits ras activity in T-cell antigen receptor stimulated Jurkat cells
    • Werge, T. M., Baldari, C. T., and Telford, J. L. Intracellular single chain Fv antibody inhibits ras activity in T-cell antigen receptor stimulated Jurkat cells. FEBS Lett., 351: 393-396, 1994.
    • (1994) FEBS Lett. , vol.351 , pp. 393-396
    • Werge, T.M.1    Baldari, C.T.2    Telford, J.L.3
  • 18
  • 20
    • 0028500163 scopus 로고
    • Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines
    • Deshane, J., Loechel, F., Conry, R. M., Siegal, G. P., King, C. R., and Curiel, D. T. Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines. Gene Ther., 1: 332-337, 1994.
    • (1994) Gene Ther. , vol.1 , pp. 332-337
    • Deshane, J.1    Loechel, F.2    Conry, R.M.3    Siegal, G.P.4    King, C.R.5    Curiel, D.T.6
  • 21
    • 0028893444 scopus 로고
    • Single-chain antibody-mediated intracellular retention of ErbB-2 impairs neu differentiation factor and epidermal growth factor signaling
    • Graus-Porta, D., Beerli, R. R., and Hynes, N. E. Single-chain antibody-mediated intracellular retention of ErbB-2 impairs neu differentiation factor and epidermal growth factor signaling. Mol. Cell. Biol., 15: 1182-1191, 1995.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1182-1191
    • Graus-Porta, D.1    Beerli, R.R.2    Hynes, N.E.3
  • 22
    • 0022608757 scopus 로고
    • Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins
    • Kung, H. F., Smith, M. R., Bekesi, E., Manne, V., and Stacey, D. W. Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins. Exp Cell Res., 162: 363-371, 1986.
    • (1986) Exp Cell Res. , vol.162 , pp. 363-371
    • Kung, H.F.1    Smith, M.R.2    Bekesi, E.3    Manne, V.4    Stacey, D.W.5
  • 23
    • 0023081620 scopus 로고
    • Microinjection of transforming ras protein induces c-fos expression
    • Stacey, D. W., Watson, T., Kung, H. F., and Curran, T. Microinjection of transforming ras protein induces c-fos expression. Mol. Cell. Biol., 7: 523-527, 1987.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 523-527
    • Stacey, D.W.1    Watson, T.2    Kung, H.F.3    Curran, T.4
  • 24
    • 0023117310 scopus 로고
    • Insulin induction of Xenopus laevis oocyte maturation is inhibited by monoclonal antibody against p21 ras proteins
    • Deshpande, A. K., and Kung, H. F. Insulin induction of Xenopus laevis oocyte maturation is inhibited by monoclonal antibody against p21 ras proteins. Mol. Cell. Biol., 7: 1285-1288, 1987.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 1285-1288
    • Deshpande, A.K.1    Kung, H.F.2
  • 25
    • 0028033019 scopus 로고
    • The regulation of endothelial cell motility by p21 ras
    • Fox, P. L., Sa, G., Dobrowolski, S. F., and Stacey, D. W. The regulation of endothelial cell motility by p21 ras. Oncogene, 9: 3519-3526, 1994.
    • (1994) Oncogene , vol.9 , pp. 3519-3526
    • Fox, P.L.1    Sa, G.2    Dobrowolski, S.F.3    Stacey, D.W.4
  • 26
    • 0024461313 scopus 로고
    • Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
    • Ward, E. S., Güssow, D., Griffiths, A. D., Jones, P. T., and Winter, G. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature (Lond.), 341: 544-546, 1989.
    • (1989) Nature (Lond.) , vol.341 , pp. 544-546
    • Ward, E.S.1    Güssow, D.2    Griffiths, A.D.3    Jones, P.T.4    Winter, G.5
  • 27
    • 0029144048 scopus 로고
    • Oocyte microinjection assay for evaluation of Ras-induced signaling pathways
    • Tocqué, B., Janicot, M., and Kenigsberg, M. Oocyte microinjection assay for evaluation of Ras-induced signaling pathways. Methods Enzymol., 255: 426-435, 1995.
    • (1995) Methods Enzymol. , vol.255 , pp. 426-435
    • Tocqué, B.1    Janicot, M.2    Kenigsberg, M.3
  • 28
    • 1542698957 scopus 로고
    • Cloning immunoglobulin variable domains for expression by the polymerase chain reaction
    • Orlandi, R., Güssow, D. H., Jones, P. T., and Winter, G. Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA, 86: 3833-3837, 1989.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 3833-3837
    • Orlandi, R.1    Güssow, D.H.2    Jones, P.T.3    Winter, G.4
  • 33
    • 0021970413 scopus 로고
    • Requirement for ras proto-oncogene function during serum-stimulated growth of NIH3T3 cells
    • Mulcahy, L. S., Smith, M. R., and Stacey, D. W. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH3T3 cells. Nature (Lond.), 313: 241-243, 1985.
    • (1985) Nature (Lond.) , vol.313 , pp. 241-243
    • Mulcahy, L.S.1    Smith, M.R.2    Stacey, D.W.3
  • 34
    • 0027330107 scopus 로고
    • A common requirement for p21c-ras function in the mitogenic signaling pathways of Swiss 3T3 fibroblasts
    • Roden, R. B. S., Shachar-Hill, Y., Cosulich, S. C., Hesketh, T. R., and Metcalfe, J. C. A common requirement for p21c-ras function in the mitogenic signaling pathways of Swiss 3T3 fibroblasts. Cell Growth Differ., 4: 957-964, 1993.
    • (1993) Cell Growth Differ. , vol.4 , pp. 957-964
    • Roden, R.B.S.1    Shachar-Hill, Y.2    Cosulich, S.C.3    Hesketh, T.R.4    Metcalfe, J.C.5
  • 35
    • 0024465405 scopus 로고
    • PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes
    • Wasylyk, C., Flores, P., Gutman, A., and Wasylyk, B. PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes. EMBO J., 8: 3371-3378, 1989.
    • (1989) EMBO J. , vol.8 , pp. 3371-3378
    • Wasylyk, C.1    Flores, P.2    Gutman, A.3    Wasylyk, B.4
  • 38
    • 0026757618 scopus 로고
    • Ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiation factor 4E
    • Rinker-Schaeffer, C. W., Austin, V., Zimmer, S., and Rhoads, R. E. ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiation factor 4E. J. Biol. Chem., 267: 10659-10664, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 10659-10664
    • Rinker-Schaeffer, C.W.1    Austin, V.2    Zimmer, S.3    Rhoads, R.E.4
  • 39
    • 0029033866 scopus 로고
    • Regulation of bcl-2 expression by oncogenic ras protein in hematopoietic cells
    • Kinoshita, T., Yokota, T., Arai, K. I., and Miyajima, A. Regulation of bcl-2 expression by oncogenic ras protein in hematopoietic cells. Oncogene, 10: 2207-2212, 1995.
    • (1995) Oncogene , vol.10 , pp. 2207-2212
    • Kinoshita, T.1    Yokota, T.2    Arai, K.I.3    Miyajima, A.4
  • 42
    • 0027948205 scopus 로고
    • Induction of apoptosis by a dominant negative H-RAS mutant in K562 cells
    • Sakai, N., Ogiso, Y., Fujita, H., Watari, H., Koike, T., and Kuzumaki, N. Induction of apoptosis by a dominant negative H-RAS mutant in K562 cells. Exp. Cell Res., 215: 131-136, 1994.
    • (1994) Exp. Cell Res. , vol.215 , pp. 131-136
    • Sakai, N.1    Ogiso, Y.2    Fujita, H.3    Watari, H.4    Koike, T.5    Kuzumaki, N.6
  • 43
    • 0026555717 scopus 로고
    • Modulation of activity of the promoter of the human MDR1 gene by Ras and p53
    • Washington DC
    • Chin, K. V., Ueda, K., Pastan, I., and Gottesman, M. M. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science (Washington DC), 255: 459-462, 1992.
    • (1992) Science , vol.255 , pp. 459-462
    • Chin, K.V.1    Ueda, K.2    Pastan, I.3    Gottesman, M.M.4
  • 44
    • 0030030707 scopus 로고    scopus 로고
    • Ha-ras oncogene expression abrogates a pH-dependent endonuclease activity of apoptosis in normal rat kidney cells
    • Ostad, M., Shu, W. P., Kong, L., and Liu, B. C. S. Ha-ras oncogene expression abrogates a pH-dependent endonuclease activity of apoptosis in normal rat kidney cells. Cancer Lett., 98: 175-182, 1996.
    • (1996) Cancer Lett. , vol.98 , pp. 175-182
    • Ostad, M.1    Shu, W.P.2    Kong, L.3    Liu, B.C.S.4
  • 45
    • 0029738762 scopus 로고    scopus 로고
    • Mutant H-ras overexpression inhibits drug- and U.V.-induced apoptosis
    • Fernandes, R. S., McGowan, A. J., and Cotter, T. G. Mutant H-ras overexpression inhibits drug- and U.V.-induced apoptosis. Anticancer Res., 16: 1691-1706, 1996.
    • (1996) Anticancer Res. , vol.16 , pp. 1691-1706
    • Fernandes, R.S.1    McGowan, A.J.2    Cotter, T.G.3
  • 46
    • 0029921232 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor FTI-277 radiosensitizes H-Ras-transformed rat embryo fibroblasts
    • Bernhard, E. J., Kao, G., Cox, A. D., Sebti, S. M., Hamilton, A. D., Muschel, R. J., and McKenna, W. G. The farnesyltransferase inhibitor FTI-277 radiosensitizes H-Ras-transformed rat embryo fibroblasts. Cancer Res., 56: 1727-1730, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 1727-1730
    • Bernhard, E.J.1    Kao, G.2    Cox, A.D.3    Sebti, S.M.4    Hamilton, A.D.5    Muschel, R.J.6    McKenna, W.G.7
  • 47
    • 0027515642 scopus 로고
    • Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability
    • Arends, M. J., McGregor, A. H., Toft, N. J., Brown, E. J. H., and Wyllie, A. H. Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability. Br. J. Cancer, 68: 1127-1133, 1993.
    • (1993) Br. J. Cancer , vol.68 , pp. 1127-1133
    • Arends, M.J.1    McGregor, A.H.2    Toft, N.J.3    Brown, E.J.H.4    Wyllie, A.H.5
  • 48
    • 0029935682 scopus 로고    scopus 로고
    • Involvement of the CD95(APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells
    • Friesen, C., Herr, I., Krammer, P. H., and Debatin, K. M. Involvement of the CD95(APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med., 2: 574-577, 1996.
    • (1996) Nat. Med. , vol.2 , pp. 574-577
    • Friesen, C.1    Herr, I.2    Krammer, P.H.3    Debatin, K.M.4
  • 51
    • 0028834638 scopus 로고
    • Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH3T3 cells
    • Grugel, S., Finkenzeller, G., Weindel, K., Barleon, B., and Marmé, D. Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH3T3 cells. J. Biol. Chem., 270: 25915-25919, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25915-25919
    • Grugel, S.1    Finkenzeller, G.2    Weindel, K.3    Barleon, B.4    Marmé, D.5
  • 52
    • 0028927887 scopus 로고
    • Constitutive expression of the c-Ha-ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line
    • Nooter, K., Boersma, A. W. M., Oostrum, R. G., Jochemsen, A. G., and Stoter, G. Constitutive expression of the c-Ha-ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line. Br. J. Cancer 71: 556-561, 1995.
    • (1995) Br. J. Cancer , vol.71 , pp. 556-561
    • Nooter, K.1    Boersma, A.W.M.2    Oostrum, R.G.3    Jochemsen, A.G.4    Stoter, G.5


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