Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation

EMBO Journal

Volumn 22, Issue 5, 2003, Pages 1025-1035

  Tanaka, Tomoyuki ^a   Rabbitts, Terence H ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Cancer therapy; CDR; Framework; Intrabody; Oncogene

Indexed keywords

PROTEIN ANTIBODY; RAS PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CANCER CELL; CANCER INHIBITION; CELL STRAIN 3T3; COMPLEMENTARITY DETERMINING REGION; CONSENSUS SEQUENCE; CYTOPLASM; DISULFIDE BOND; EMBRYO; GENE MUTATION; GENETIC TRANSFORMATION; IN VIVO STUDY; MALIGNANT TRANSFORMATION; MAMMAL CELL; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; SOLUBILITY;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; CELL TRANSFORMATION, NEOPLASTIC; COS CELLS; CYSTEINE; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOSORBENT TECHNIQUES; MICE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RAS PROTEINS; SEQUENCE ALIGNMENT; SURFACE PLASMON RESONANCE;

ANIMALIA; MAMMALIA;

EID: 0037416179     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg106     Document Type: Article

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