Effect of geldanamycin on androgen receptor function and stability

Cell Stress and Chaperones

Volumn 7, Issue 1, 2002, Pages 55-64

  Vanaja, Donkena Krishna ^a   Mitchell, Susan H ^a   Toft, David O ^a   Young, Charles Y F ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; BUFFER; GELDANAMYCIN; IMMUNOPHILIN; LACTACYSTIN; MIBOLERONE; PROSTATE SPECIFIC ANTIGEN; SULFUR 35; TRITON X 114;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HORMONE BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; REPORTER GENE; TRANSACTIVATION;

ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; CELL DIVISION; GENE EXPRESSION; HUMANS; LACTAMS, MACROCYCLIC; LIGANDS; MALE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; QUINONES; RECEPTORS, ANDROGEN; RNA, MESSENGER; TACROLIMUS BINDING PROTEINS; TUMOR CELLS, CULTURED;

EID: 0036461583     PISSN: 13558145     EISSN: None     Source Type: Journal    
DOI: 10.1379/1466-1268(2002)007<0055:EOGOAR>2.0.CO;2     Document Type: Article

References (52)

1. Bagatell R, Khan O, Paine-Murrieta G, Taylor CW, Akinaga S, Whitesell L. 2001. Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer. Clin Cancer Res 7: 2076-2084.
2. Bamberger CM, Wald M, Bamberger AM, Schulte HM. 1997. Inhibition of mineralocorticoid and glucocorticoid receptor function by the heat shock protein 90-binding agent geldanamycin. Mol Cell Endocrinol 131: 233-240.
3. Bender AT, Demady DR, Osawa Y. 2000. Ubiquitination of neuronal nitric-oxide synthase in vivo and in vitro. J Biol Chem 275: 17407-17411.
4. Bresnick EH, Dalman F, Sanchez ER, Pratt WB. 1989. Evidence that the 90-kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor. J Biol Chem 264: 4992-4997.
5. Buchner J. 1999. Hsp90 and Co. - a holding for folding. Trends Biochem Sci 24: 136-141.
6. Caplan AJ. 1999. Hsp90's secrets unfold: new insights from structural and functional studies. Trends Cell Biol 9: 262-268.
7. Chung BH, Mitchell SH, Zhang JS, Young CYF. 2001. Effects of docosahexaenoic acid and eicosapentaenoic acid on androgen-mediated cell growth and gene expression in LNCaP prostate cancer cells. Carcinogenesis 22: 1201-1206.
8. Cory AH, Owen TC, Barltrop JA, Cory JG. 1991. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun 3: 207-212.
9. Dasgupta G, Momand J. 1997. Geldanamycin prevents nuclear translocation of mutant p53. Exp Cell Res 237: 29-37.
10. Denny WB, Valentine DL, Reynolds PD, Smith DF, Scammell JG. 2000. Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding. Endocrinology 141: 4107-4113.
11. Doucet-Brutin S, Renoir M, LeGallic L, Vincent S, Marty L, Fort P. 1995. Growth regulated expression of FKBP-59 immunophilin in normal and transformed fibroblastic cells. Exp Cell Res 220: 152-160.
12. Duina AA, Chang HCJ, Marsh JA, Lindquist S, Gaber RF. 1996. A cyclophilin function in Hsp90-dependent signal transduction. Science 274: 1713-1715.
13. Evans RM. 1988. The steroid and thyroid hormone receptor superfamily. Science 240: 889-895.
14. Fang Y, Floss AE, Robins DM, Caplan AJ. 1996. Hsp90 regulates androgen receptor hormone binding affinity in vivo. J Biol Chem 271: 28697-28702.
15. Grenert JP, Sullivan WP, Fadden P, et al. 1997. The amino-terminal domain of heat shock protein 90 (Hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates Hsp90 conformation. J Biol Chem 272: 23843-23850.
16. Haendler B, Schuttke I, Schleuning WD. 2001. Androgen receptor signalling: comparative analysis of androgen response elements and implication of heat-shock protein 90 and 14-3-3n. Mol Cell Endocrinol 173: 63-73.
17. Hynes NE, Stern DF. 1994. The biology of erb-B-2/neu/HER-2 and its role in cancer. Biochem Biophys Acta 1198: 165-184.
18. Johnson JL, Toft DO. 1995. Binding of p23 and Hsp90 during assembly with the progesterone receptor. Mol Endocrinol 6: 670-678.
19. Kester HA, Vander Leede BM, Vander Saag PT, Vander Burg B. 1997. Novel progesterone targets identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation. J Biol Chem 272: 16637-16643.
20. Krongard A, Wilson CM, Wilson JD, Allman DR, McPhaul MJ. 1991. Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells. Mol Endocrinol 7: 924-936.
21. Liu J, DeFranco B. 1999. Chromatin recycling of glucocorticoid receptors: implications for multiple roles of heat shock protein 90. Mol Endocrinol 13: 355-365.
22. Milad M, Sullivan W, Diehl E, Altmann M, Nordeen S, Edwards DP, Toft DO. 1995. Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. Mol Endocrinol 9: 838-847.
23. Miller P, DiOrio C, Moyer M, Schnur RC, Bruskin A, Cullen W, Moyer JD. 1994. Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins. Cancer Res 54: 2724-2730.
24. Mimnaugh EG, Chavany C, Neckers L. 1996. Polyubiquitination and proteasomal degradation of the p185c-erB-2 receptor proteintyrosine kinase induced by geldanamycin. J Biol Chem 271: 22796-22801.
25. Mitchell SH, Murtha PE, Zhang S, Zhu W, Young CYE 2000. An androgen response element mediates LNCaP cell dependent androgen induction of the hK2 gene. Mol Cell Endocrinol 168: 89-99.
26. Mukherjee A, Kirkovsky LI, Kimura Y, Marvel MM, Miller DD, Dalton JT. 1999. Affinity labeling of the androgen receptor with nonsteroidal chemoaffinity ligands. Biochem Pharmacol 58: 1259-1267.
27. Nemoto T, Ohara-Nemoto Y, Ota M. 1992. Association of the 90-kDa heat shock protein does not affect the ligand-binding ability of androgen receptor. J Steroid Biochem Mol Biol 42: 803-812.
28. Ohara-Nemoto Y, Nemoto T, Ota M. 1991. The Mr 90,000 heat shock protein-free androgen receptor has a high affinity for steroid, in contrast to the glucocorticoid receptor. J Biochem (Tokyo) 109: 113-119.
29. Pratt WB. 1997. The role of heat-shock proteins in regulating the function, folding and trafficking of the glucocorticoid receptor. J Biol Chem 268: 21455-21458.
30. Pratt WB. 1998. The Hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors. Proc Exp Biol Med 217: 420-434.
31. Pratt WB, Silverstein AM, Galigniana MD. 1999. A model for the cytoplasmic trafficking of signalling proteins involving the Hsp90-binding immunophilins and p50cdc37. Cell Signal 11: 839-851.
32. Pratt WB, Toft DO. 1997. Steroid receptor interactions with heatshock protein and immunophilin chaperones. Endocrinol Rev 18: 1-55.
33. Quarmby VE, Yarbrough WG, Lubahn DB, French FS, Wilson EM. 1990. Autologous down-regulation of androgen receptor messenger ribonucleic acid. Mol Endocrinol 4: 22-28.
34. Schmid FX. 1993. Prolyl isomerase: enzymatic analysis of slow protein folding reactions. Annu Rev Biomol Struct 22: 123-143.
35. Schulte TW, An WG, Neckers LM. 1997. Geldanamycin-induced destabilization of Raf-1 involves the proteasome. Biochem Biophy Res Commun 239: 655-659.
36. Segnitz B, Gehring U. 1997. The function of steroid hormone receptor is inhibited by the Hsp90-specific compound geldanamycin. J Biol Chem 272: 18694-18701.
37. Sepp-Lorenzino L, Ma Z, Ledwohl DE, Vinitsky A, Rosen N. 1995. Herbimycm A induces the 20S proteasome and ubiquitin-dependent degradation of receptor tyrosine kinases. J Biol Chem 270: 16580-16587.
38. Smith DF. 1993. Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes. Mol Endocrinol 7: 1418-1429.
39. Smith DF, Whitesell L, Nair SC, Chen S, Prapapanich V, Rimerman RA. 1995. Progesterone receptor structure and function altered by geldanamycin an Hsp90-binding agent. Mol Cell Biol 15: 6804-6812.
40. Stenoien DL, Cummings CJ, Adams HP, Manini KP, DeMartino GN, Marcelli M, Weigel NL, Manchini MA. 1999. Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone. Hum Mol Genet 8: 731-741.
41. Syms JA, Norris JS, Panko WB, Smith RG. 1985. Mechanism of androgen-receptor augmentation. J Biol Chem 260: 455-461.
42. Tan JA, Joseph DR, Quarmby VE, Lubahn DB, Sar M, French FS, Wilson EM. 1988. The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid, and immunocytochemical localization of the receptor protein. Mol Endocrinol 2: 1276-1285.
43. Uehara Y, Hori M, Takeuchi T, Umezawa H. 1986. Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus. Mol Cell Biol 6: 2198-2206.
44. Vasilevskaya IA, O'Dwyer PJ. 1999. Effects of geldanamycin on signaling through activator-protein 1 in hypoxia HT29 human colon adenocarcinoma cells. Cancer Res 59: 3935-3940.
45. Veldscholte J, Berrevoets CA, Zegers ND, van der Kwast TH, Grootegoed JA, Mulder E. 1992. Hormone-induced dissociation of the androgen receptor-heat shock protein complex: use of a new monoclonal antibody to distinguish transformed from nontransformed receptors. Biochemistry 31: 7422-7430.
46. Ward BK, Mark PJ, Ingram DM, Minchin RF, Ratajczak T. 2000. Expression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52 in breast cancer. Breast Cancer Res Treat 58: 267-280.
47. Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. 1994. Inhibition of heat shock protein Hsp90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 91: 8324-8328.
48. Whitesell L, Sutphin P, An WG, Schulte T, Blagosklonny MV, Neckers L. 1997. Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo. Oncogene 14: 2809-2816.
49. Xie YB, Sui YP, Shan LX, Palvimo JJ, Phillips DM, Janne OA. 1992. Expression of androgen receptor in insect cells. Purification of the receptor and renaturation of its steroid and DNA binding functions. J Biol Chem 267: 4939-4948.
50. Yamaji H, Nakajiam M, Seimiya H, Saya H, Sugita M, Tsuruo T. 1995. Inhibition of the association with nuclear matrix of pRB, p70 and p40 proteins along with the specific suppression of c-MYC expression by geldanamycin, an inhibitor of Src tyrosine kinase. J Antibiot 48: 1021-1026.
51. Yeh WC, Li TK, Bierer BE, McKnight SL. 1995. Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation. Proc Natl Acad Sci U S A 92: 11081-11085.
52. Zhu W, Smith A, Young CYE 1999. A nonsteroidal anti-inflammatory drug flufenamic acid inhibits the expression of the androgen receptor in LNCaP cells. Endocrinology 140: 5451-5454.