Mechanism of antiandrogen action: Key role of hsp90 in conformational change and transcriptional activity of the androgen receptor

Biochemistry

Volumn 41, Issue 39, 2002, Pages 11824-11831

  Georget, Virginie ^a,b   Térouanne, Béatrice ^a   Nicolas, Jean Claude ^a   Sultan, Charles ^a,c  

^a INSERM   (France)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c LAPEYRONIE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND BINDING;

ASSAYS; CELLS; CONFORMATIONS; HORMONES; PROTEINS;

BIOCHEMISTRY;

ANDROGEN RECEPTOR; ANSAMYCIN DERIVATIVE; ANTIANDROGEN; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HYBRID PROTEIN;

ANIMAL CELL; ARTICLE; CELL NUCLEUS TRANSPLANTATION; CELL STRAIN COS7; CONFORMATIONAL TRANSITION; DRUG MECHANISM; GENE EXPRESSION REGULATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; TRANSCRIPTION REGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANDROGEN ANTAGONISTS; ANIMALS; BENZOQUINONES; CELL LINE; CELL NUCLEUS; COS CELLS; ENDOPEPTIDASES; GREEN FLUORESCENT PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYDROLYSIS; KINETICS; LACTAMS, MACROCYCLIC; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; PLASMIDS; PROTEIN CONFORMATION; QUINONES; RECEPTORS, ANDROGEN; TRANS-ACTIVATORS; TRANSFECTION;

ANIMALIA;

EID: 0036786205     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0259150     Document Type: Article

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