Composition and conservation of the telomeric complex

Cellular and Molecular Life Sciences

Volumn 60, Issue 11, 2003, Pages 2295-2302

  Kanoh, J ^a   Ishikawa, F ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Ku; Myb motif; Pot1; Rap1; TRF

Indexed keywords

DNA; PROTEIN;

CHROMOSOME; DNA BINDING; EUKARYOTE EVOLUTION; HUMAN; NONHUMAN; NUCLEOTIDE REPEAT; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN INTERACTION; REVIEW; TELOMERE; YEAST;

HUMANS; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES POMBE PROTEINS; TELOMERE; TELOMERE-BINDING PROTEINS; TELOMERIC REPEAT BINDING PROTEIN 1; TELOMERIC REPEAT BINDING PROTEIN 2; TRANSCRIPTION FACTORS;

EUKARYOTA; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 0345687981     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-003-3245-y     Document Type: Review

References (92)

1. Shampay J., Szostak J. W. and Blackburn E. H. (1984) DNA sequences of telomeres maintained in yeast. Nature 310: 154-157
2. Sugawara N. and Szostak J. W. (1986) Telomeres of Schizosaccaromyces pombe. Yeast (Suppl.) 2: S373
3. McKnight T. D., Fitzgerald M. S. and Shippen D. E. (1997) Plant telomeres and telomerases. Biochemistry 62: 1224-1231
4. Moyzis R. K., Buckingham J. M., Cram L. S., Dani M., Deaven L. L., Jones M. D. et al. (1988) A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA 85: 6622-6626
5. Chikashige Y., Ding D. Q., Funabiki H., Haraguchi T., Mashiko S., Yanagida M. et al. (1994) Telomere-led premeiotic chromosome movement in fission yeast. Science 264: 270-273
6. Scherthan H., Bahler J. and Kohli J. (1994) Dynamics of chromosome organization and pairing during meiotic prophase in fission yeast. J. Cell Biol. 127: 273-285
7. Dernburg A. F., Sedat J. W., Cande W. Z. and Bass H. W. (1995) Cytology of Telomeres. In Telomeres. Edited by Blackburn, EH. and Greider, CW. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 295-338
8. Trelles-Sticken E., Loidl J. and Scherthan H. (1999) Bouquet formation in budding yeast: initiation of recombination is not required for meiotic telomere clustering. J. Cell Sci. 112: 651-658
9. Niwa O., Shimanuki M. and Miki F. (2000) Telomere-led bouquet formation facilitates homologous chromosome pairing and restricts ectopic interaction in fission yeast meiosis. EMBO J. 19: 3831-3840
10. Huet J., Cottrell P., Cool M., Vignais M. L., Thiele D., Marck C. et al. (1985) A general upstream binding factor for genes of the yeast translational apparatus. EMBO J. 4: 3539-3547
11. Buchman A. R., Lue N. F. and Kornberg R. D. (1988) Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein. Mol. Cell. Biol. 8: 5086-5099
12. Shore D. and Nasmyth K. (1987) Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Cell 51: 721-732
13. Conrad M. N., Wright J. H., Wolf A. J. and Zakian V. A. (1990) RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell 63: 739-750
14. Lustig A. J., Kurtz S. and Shore D. (1990) Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length. Science 250: 549-553
15. Hardy C. F., Balderes D. and Shore D. (1992) Dissection of a carboxy-terminal region of the yeast regulatory protein RAP1 with effects on both transcriptional activation and silencing. Mol. Cell. Biol. 12: 1209-1217
16. Kyrion G., Boakye K. A. and Lustig A. J. (1992) C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol. Cell. Biol. 12: 5159-5173
17. Kyrion G., Liu K., Liu C. and Lustig A. J. (1993) RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes Dev. 7: 1146-1159
18. Hardy C. F. J., Sussel L. and Shore D. (1992) A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev. 6: 801-814
19. Wotton D. and Shore D. (1997) A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev. 11: 748-760
20. Marcand S., Gilson E. and Shore D. (1997) A protein-counting mechanism for telomere length regulation in yeast. Science 275: 986-990
21. Moretti P., Freeman K., Coodly L. and Shore D. (1994) Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev. 8: 2257-2269
22. Cockell M., Palladino F., Laroche T., Kyrion G., Liu C., Lustig A. J. et al. (1995) The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J. Cell Biol. 129: 909-924
23. Strahl-Bolsinger S., Hecht A., Luo K. and Grunstein M. (1997) SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast. Genes Dev. 11: 83-93
24. Hecht A., Laroche T., Strahl-Bolsinger S., Gasser S. M. and Grunstein M. (1995) Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell 80: 583-592
25. Hoppe G. J., Tanny J. C., Rudner A. D., Gerber S. A., Danaie S., Gygi S. et al. (2002) Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacerylation. Mol. Cell. Biol. 22: 4167-4180
26. Tsukamoto Y., Kato J. and Ikeda H. (1998) Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature 388: 900-903
27. Boulton S. J. and Jackson S. P. (1998) Components of the Kudependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17: 1819-1828
28. Shou W., Seol J. H., Shevchenko A., Baskerville C., Moazed D., Chen Z. W. et al. (1999) Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97: 233-244
29. Straight A. F., Shou W., Dowd G. J., Turck C. W., Deshaies R. J., Johnson A. D. et al. (1999) Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 97: 245-256
30. Singer M. S. and Gottschling D. E. (1994) TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 266: 404-409
31. Nugent C. I., Hughes T. R., Lue N. F. and Lundblad V. (1996) Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274: 249-252
32. 1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc. Natl. Acad. Sci. USA 93: 13760-13765
33. Evans S. K. and Lundblad V. (1999) Est1 and Cdc13 as comediators of telomerase access. Science 286: 117-120
34. Qi H. and Zakian V. A. (2000) The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase α and the telomerase-associated Est1 protein. Genes Dev. 14: 1777-1788
35. Zhou J., Hidaka K. and Futcher B. (2000) The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA. Mol. Cell. Biol. 20: 1947-1955
36. Grandin N., Reed S. I. and Charbonneau M. (1997) Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev. 11: 512-527
37. Grandin N., Damon C. and Charbonneau M. (2000) Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment. Mol. Cell. Biol. 20: 8397-8408
38. Grandin N., Damon C. and Charbonneau M. (2001) Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J. 20: 1173-1183
39. Pennock E., Buckley K. and Lundblad V. (2001) Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104: 387-396
40. Laroche T., Martin S. G., Gotta M., Gorham H. C., Pryde F. E., Louis E. J. et al. (1998) Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. Curr. Biol. 8: 653-656
41. Gravel S., Larrivee M., Labrecque P. and Wellinger R. J. (1998) Yeast Ku as a regulator of chromosomal DNA end structure. Science 280: 741-744
42. Polotnianka R. M., Li J. and Lustig A. J. (1998) The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr. Biol. 8: 831-834
43. Galy V., Olivo-Marin J. C., Scherthan H., Doye V., Rascalou N. and Nehrbass U. (2000) Nuclear pore complexes in the organization of silent telomeric chromatin. Nature 403: 108-112
44. Peterson S. E., Stellwagen A. E., Diede S. J., Singer M. S., Haimberger Z. W., Johnson C. O. et al. (2001) The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. Nat. Genet. 27: 64-67
45. Feuerbach F., Galy V., Trelles-Sticken E., Fromont-Racine M., Jacquier A., Gilson E. et al. (2002) Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast. Nat. Cell Biol. 4: 214-221
46. Hediger F., Neumann R., Van Houwe G., Dubrana K. and Gasser S. M. (2002) Live imaging of telomeres: yKu and Sir proteins define redundant telomere-anchoring pathways in yeast. Curr. Biol. 12: 2076-2089
47. Cooper J. P., Nimmo E. R., Allshire R. C. and Cech T. R. (1997) Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385: 744-747
48. Nimmo E. R., Pidoux A. L., Perry P. E. and Allshire R. C. (1998) Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe. Nature 392: 825-828
49. Chikashige Y. and Hiraoka Y. (2001) Telomere binding of the Rap1 protein is required for meiosis in fission yeast. Curr. Biol. 11: 1618-1623
50. Kanoh J. and Ishikawa F. (2001) spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr. Biol. 11: 1624-1630
51. Perrod S., Cockell M. M., Laroche T., Renauld H., Ducrest A. L., Bonnard C. et al. (2001) A cytosolic NAD-dependent deacerylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast. EMBO J. 20: 197-209
52. Aasland R. and Stewart A. F. (1995) The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1. Nucleic Acids Res. 23: 3168-3174
53. Platero J. S., Hartnett T. and Eissenberg J. C. (1995) Functional analysis of the chromo domain of HP1. EMBO J. 14: 3977-3986
54. Ekwall K., Javerzat J. P., Lorentz A., Schmidt H., Cranston G. and Allshire R. (1995) The chromodomain protein Swi6: a key component at fission yeast centromeres. Science 269: 1429-1431
55. Partridge J. F., Borgstrom B. and Allshire R. C. (2000) Distinct protein interation domains and protein spreading in a complex centromere. Genes Dev. 14: 783-791
56. Bernard P., Maure J. F., Partridge J. F., Genier S., Javerzat J. P. and Allshire R. C. (2001) Requirement of heterochromatin for cohesion at centromeres. Science 294: 2539-2542
57. Nonaka N., Kitajima T., Yokobayashi S., Xiao G., Yamamoto M., Grewal S. I. et al. (2002) Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast. Nat. Cell Biol. 4: 89-93
58. Lorentz A., Ostermann K., Fleck O. and Schmidt H. (1994) Switching gene swi6, involved in repression of silent mating-type loci in fission yeast, encodes a homologue of chromatin-associated proteins from Drosophila and mammals. Gene 143: 139-143
59. Grewal S. I. and Klar A. J. (1997) A recombinationally repressed region between mat2 and mat3 loci shares homology to centromeric repeats and regulates directionality of mating-type switching in fission yeast. Genetics 146: 1221-1238
60. Nakayama J., Klar A. J. and Grewal S. I. (2000) A chromodomain protein, Swi6, performs imprinting functions in fission yeast during mitosis and meiosis. Cell 101: 307-317
61. Ekwall K., Nimmo E. R., Javerzat J. P., Borgstrom B., Egel R., Cranston G. et al. (1996) Mutations in the fission yeast silencing factors clr4+ and rik1+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function. J. Cell Sci. 109: 2637-2648
62. Thon G. and Verhein-Hansen J. (2000) Four chromo-domain proteins of Schizosaccharomyces pombe differentially repress transcription at various chromosomal locations. Genetics 155: 551-568
63. Baumann P. and Cech T. R. (2000) Protection of telomeres by the Ku protein in fission yeast. Mol. Biol. Cell 11: 3265-3275
64. Manolis K. G., Nimmo E. R., Hartsuiker E., Carr A. M., Jeggo P. A. and Allshire R. C. (2001) Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe. EMBO J. 20: 210-221
65. Nakamura T. M., Moser B. A. and Russell P. (2002) Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161: 1437-1452
66. Miyoshi T., Sadaie M., Kanoh J. and Ishikawa F. (2003) Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast. J. Biol. Chem. 278: 1924-1931
67. Sugawara N. (1989) DNA sequences at telomeres of fission yeast S. pombe. Ph.D. thesis. Harvard University, Cambridge, MA.
68. Ferreira M. G. and Cooper J. P. (2001) The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions. Mol. Cell 7: 55-63
69. Baumann P. and Cech T. R. (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292: 1171-1175
70. Chong L., van Steensel B., Broccoli D., Erdjument-Bromage H., Hanish J., Tempst P. et al. (1995) A human telomeric protein. Science 270: 1663-1667
71. Bilaud T., Brun C., Ancelin K., Koering C. E., Laroche T. and Gilson E. (1997) Telomeric localization of TRF2, a novel human telobox protein. Nat. Genet. 17: 236-239
72. Broccoli D., Smogorzewska A., Chong L. and de Lange T. (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 17: 231-235
73. Bianchi A., Smith S., Chong L., Elias P. and de Lange T. (1997) TRF1 is a dimer and bends telomeric DNA. EMBO J. 16: 1785-1794
74. Spink K. G., Evans R. J. and Chambers A. (2000) Sequence-specific binding of Taz1p dimers to fission yeast telomeric DNA. Nucleic Acids Res. 28: 527-533
75. van Steensel B. and de Lange T. (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385: 740-743
76. Smogorzewska A., van Steensel B., Bianchi A., Oelmann S., Schaefer M. R., Schnapp G. et al. (2000) Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20: 1659-1668
77. van Steensel B., Smogorzewska A. and de Lange T. (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413
78. Smogorzewska A., Karlseder J., Holtgreve-Grez H., Jauch A. and de Lange T. (2002) DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr. Biol. 12: 1635-1644
79. Griffith J. D., Comeau L., Rosenfield S., Stansel R. M., Bianchi A., Moss H. et al. (1999) Mammalian telomeres end in a large duplex loop. Cell 97: 503-514
80. Stansel R. M., de Lange T. and Griffith J. D. (2001) T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J. 20: 5532-5540
81. Smith S., Giriat I., Schmitt A. and de Lange T. (1998) Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282: 1484-1487
82. Kim S., Kaminker P. and Campisi J. (1999) TIN2, a new regulator of telomere length in human cells. Nat. Genet. 23: 405-412
83. Smith S. and de Lange T. (2000) Tankyrase promotes telomere elongation in human cells. Curr. Biol. 10: 1299-1302
84. Li B., Oestreich S. and de Lange T. (2000) Identification of human Rap1: Implications for telomere evolution. Cell 101: 471-483
85. Ogata K., Hojo H., Aimoto S., Nakai T., Nakamura H., Sarai A. et al. (1992) Solution structure of a DNA-binding unit of Myb: A helix-turn-helix- related motif with conserved tryptophans forming a hydrophobic core. Proc. Natl. Acad. Sci. USA 89: 6428-6432
86. Baumann P., Podell E. and Cech T. R. (2002) Human Pot1 (Protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. Mol. Cell. Biol. 22: 8079-8087
87. Hsu H. L., Gilley D., Galande S. A., Hande M. P., Allen B., Kim S. H. et al. (2000) Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev. 14: 2807-2812
88. Song K., Jung D., Jung Y., Lee S. G. and Lee I. (2000) Interaction of human Ku70 with TRF2. FEBS Lett. 481: 81-85
89. Bianchi A. and de Lange T. (1999) Ku binds telomeric DNA in vitro. J. Biol. Chem. 274: 21223-21227
90. Walker J. R., Corpina R. A. and Goldberg J. (2001) Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412: 607-614
91. Song K., Jung Y., Jung D. and Lee I. (2001) Human Ku70 interacts with heterochromatin protein 1α. J. Biol. Chem. 276: 8321-8327
92. Baur J. A., Zou Y., Shay J. W. and Wright W. E. (2001) Telomere position effect in human cells. Science 292: 2075-2077