메뉴 건너뛰기




Volumn 22, Issue 22, 2002, Pages 8079-8087

Human Pot1 (protection of telomeres) protein: Cytolocalization, gene structure, and alternative splicing

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; NUCLEAR PROTEIN; PROTEIN POT1; SINGLE STRANDED DNA BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 0036840361     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.22.8079-8087.2002     Document Type: Article
Times cited : (145)

References (40)
  • 1
    • 0035844082 scopus 로고    scopus 로고
    • Pot1, the putative telomere end-binding protein in fission yeast and humans
    • Baumann, P., and T. R. Cech. 2001. Potl, the putative telomere end-binding protein in fission yeast and humans. Science 292:1171-1175.
    • (2001) Science , vol.292 , pp. 1171-1175
    • Baumann, P.1    Cech, T.R.2
  • 3
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn, E. H. 2001. Switching and signaling at the telomere. Cell 106: 661-673.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 4
    • 84984775429 scopus 로고    scopus 로고
    • Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
    • Broccoli, D., A. Smogorzewska, L. Chong, and T. de Lange. 1997. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 17:231-235.
    • (1997) Nat. Genet. , vol.17 , pp. 231-235
    • Broccoli, D.1    Smogorzewska, A.2    Chong, L.3    De Lange, T.4
  • 5
    • 0037087550 scopus 로고    scopus 로고
    • Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT
    • Cerezo, A., H. Kalthoff, M. Schuermann, B. Schafer, and P. Boukamp. 2002. Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT. J. Cell Sci. 115:1305-1312.
    • (2002) J. Cell Sci. , vol.115 , pp. 1305-1312
    • Cerezo, A.1    Kalthoff, H.2    Schuermann, M.3    Schafer, B.4    Boukamp, P.5
  • 6
    • 0034352944 scopus 로고    scopus 로고
    • The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity
    • Colgin, L. M., C. Wilkinson, A. Englezou, A. Kilian, M. O. Robinson, and R. R. Reddel. 2000. The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity. Neoplasia 2:426-432.
    • (2000) Neoplasia , vol.2 , pp. 426-432
    • Colgin, L.M.1    Wilkinson, C.2    Englezou, A.3    Kilian, A.4    Robinson, M.O.5    Reddel, R.R.6
  • 7
    • 0033214013 scopus 로고    scopus 로고
    • Est1 and Cdc13 as comediators of telomerase access
    • Evans, S. K., and V. Lundblad, 1999. Est1 and Cdc13 as comediators of telomerase access. Science 286:117-120.
    • (1999) Science , vol.286 , pp. 117-120
    • Evans, S.K.1    Lundblad, V.2
  • 8
    • 0027163938 scopus 로고
    • Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits
    • Fang, G., and T. R. Cech. 1993. Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits. Proc. Natl. Acad. Sci. USA 90:6056-6060.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6056-6060
    • Fang, G.1    Cech, T.R.2
  • 9
    • 0027168268 scopus 로고
    • Oxytricha telomere-binding protein: Separable DNA-binding and dimerization domains of the alpha-subunit
    • Fang, G., J. T. Gray, and T. R. Cech. 1993. Oxytricha telomere-binding protein: Separable DNA-binding and dimerization domains of the alpha-subunit. Genes Dev. 7:870-882.
    • (1993) Genes Dev. , vol.7 , pp. 870-882
    • Fang, G.1    Gray, J.T.2    Cech, T.R.3
  • 10
    • 0026091685 scopus 로고
    • Molecular cloning of telomere-binding protein genes from Stylonychia mytilis
    • Fang, G., and T. R. Cech. 1991. Molecular cloning of telomere-binding protein genes from Stylonychia mytilis. Nucleic Acids Res. 19:5515-5518.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 5515-5518
    • Fang, G.1    Cech, T.R.2
  • 11
    • 0028822203 scopus 로고
    • Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
    • Garvik, B., M. Carson, and L. Hartwell. 1995. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell. Biol. 15:6128-6138.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6128-6138
    • Garvik, B.1    Carson, M.2    Hartwell, L.3
  • 12
    • 0023037564 scopus 로고
    • Telomere proteins: Specific recognition and protection of the natural termini of Oxytricha macronuclear DNA
    • Gottschling, D. E., and V. A. Zakian. 1986. Telomere proteins: Specific recognition and protection of the natural termini of Oxytricha macronuclear DNA. Cell 47:195-205.
    • (1986) Cell , vol.47 , pp. 195-205
    • Gottschling, D.E.1    Zakian, V.A.2
  • 13
    • 0025984268 scopus 로고
    • Cloning and expression of genes for the Oxytricha telomere-binding protein: Specific subunit interactions in the telomeric complex
    • Gray, J. T., D. W. Celander, C. M. Price, and T. R. Cech. 1991. Cloning and expression of genes for the Oxytricha telomere-binding protein: Specific subunit interactions in the telomeric complex. Cell 67:807-814.
    • (1991) Cell , vol.67 , pp. 807-814
    • Gray, J.T.1    Celander, D.W.2    Price, C.M.3    Cech, T.R.4
  • 14
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
    • Greider, C. W., and E. H. Blackburn. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337:331-337.
    • (1989) Nature , vol.337 , pp. 331-337
    • Greider, C.W.1    Blackburn, E.H.2
  • 16
    • 0032431057 scopus 로고    scopus 로고
    • Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA
    • Horvath, M. P., V. L. Schweiker, J. M. Bevilacqua, J. A. Ruggles, and S. C. Schultz. 1998. Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA. Cell 95:963-974.
    • (1998) Cell , vol.95 , pp. 963-974
    • Horvath, M.P.1    Schweiker, V.L.2    Bevilacqua, J.M.3    Ruggles, J.A.4    Schultz, S.C.5
  • 18
    • 0019568388 scopus 로고
    • All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′ terminus
    • Klobutcher, L. A., M. T. Swanton, P. Donini, and D. M. Prescott. 1981. All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′ terminus. Proc. Natl. Acad. Sci. USA 78:3015-3019.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 3015-3019
    • Klobutcher, L.A.1    Swanton, M.T.2    Donini, P.3    Prescott, D.M.4
  • 19
    • 0023665902 scopus 로고
    • An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
    • Kozak, M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125-8148.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 8125-8148
    • Kozak, M.1
  • 20
    • 0034716904 scopus 로고    scopus 로고
    • Identification of human Rap1: Implications for telomere evolution
    • Li, B., S. Oestreich, and T. de Lange. 2000. Identification of human Rap1: Implications for telomere evolution. Cell 101:471-483.
    • (2000) Cell , vol.101 , pp. 471-483
    • Li, B.1    Oestreich, S.2    De Lange, T.3
  • 22
    • 0031000884 scopus 로고    scopus 로고
    • Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    • Makarov, V. L., Y. Hirose, and J. P. Langmore. 1997. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88:657-666.
    • (1997) Cell , vol.88 , pp. 657-666
    • Makarov, V.L.1    Hirose, Y.2    Langmore, J.P.3
  • 23
    • 0030982721 scopus 로고    scopus 로고
    • The terminal DNA structure of mammalian chromosomes
    • McElligott, R., and R. J. Wellinger. 1997. The terminal DNA structure of mammalian chromosomes. EMBO J. 16:3705-3714.
    • (1997) EMBO J. , vol.16 , pp. 3705-3714
    • McElligott, R.1    Wellinger, R.J.2
  • 25
    • 0036337915 scopus 로고    scopus 로고
    • A genomic view of alternative splicing
    • Modrek, B., and C. Lee. 2002. A genomic view of alternative splicing. Nat. Genet. 30:13-19.
    • (2002) Nat. Genet. , vol.30 , pp. 13-19
    • Modrek, B.1    Lee, C.2
  • 27
    • 0033406877 scopus 로고    scopus 로고
    • Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops
    • Murti, K. G., and D. M. Prescott. 1999. Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops. Proc. Natl. Acad. Sci. USA 96:14436-14439.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14436-14439
    • Murti, K.G.1    Prescott, D.M.2
  • 28
    • 0027479161 scopus 로고
    • OB (oligonucleotide/oligosaccharide binding)-fold: Common structural and functional solution for non-homologous sequences
    • Murzin, A. G. 1993. OB (oligonucleotide/oligosaccharide binding)-fold: Common structural and functional solution for non-homologous sequences. EMBO J. 12:861-867.
    • (1993) EMBO J. , vol.12 , pp. 861-867
    • Murzin, A.G.1
  • 29
    • 0036176232 scopus 로고    scopus 로고
    • Dimeric structure of the Oxytricha nova telomere end-binding protein alpha-subunit bound to ssDNA
    • Peersen, O. B., J. A. Ruggles, and S. C. Schultz. 2002. Dimeric structure of the Oxytricha nova telomere end-binding protein alpha-subunit bound to ssDNA. Nat. Struct. Biol. 9:182-187.
    • (2002) Nat. Struct. Biol. , vol.9 , pp. 182-187
    • Peersen, O.B.1    Ruggles, J.A.2    Schultz, S.C.3
  • 30
    • 0035830494 scopus 로고    scopus 로고
    • Cdc13 delivers separate complexes to the telomere for end protection and replication
    • Pennock, A., K. Buckley, and V. Lundblad. 2001. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104:387-396.
    • (2001) Cell , vol.104 , pp. 387-396
    • Pennock, A.1    Buckley, K.2    Lundblad, V.3
  • 31
    • 0027476057 scopus 로고
    • Telomeric structure in cells with chromosome end associations
    • Saltman, D., R. Morgan, M. L. Cleary, and T. de Lange. 1993. Telomeric structure in cells with chromosome end associations. Chromosoma 102:121-128.
    • (1993) Chromosoma , vol.102 , pp. 121-128
    • Saltman, D.1    Morgan, R.2    Cleary, M.L.3    De Lange, T.4
  • 32
    • 0034687248 scopus 로고    scopus 로고
    • Tankyrase promotes telomere elongation in human cells
    • Smith, S., and T. de Lange. 2000. Tankyrase promotes telomere elongation in human cells. Curr. Biol. 10:1299-1302.
    • (2000) Curr. Biol. , vol.10 , pp. 1299-1302
    • Smith, S.1    De Lange, T.2
  • 34
    • 0037047643 scopus 로고    scopus 로고
    • Estlp as a cell cycle-regulated activator of telomere-bound telomerase
    • Taggart, A., S. Teng, and V. Zakian. 2002. Estlp as a cell cycle-regulated activator of telomere-bound telomerase. Science 297:1023-1026.
    • (2002) Science , vol.297 , pp. 1023-1026
    • Taggart, A.1    Teng, S.2    Zakian, V.3
  • 35
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B., A. Smogorzewska, and T. de Lange. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 36
    • 0027104087 scopus 로고
    • Euplotes crassus has genes encoding telomere-binding proteins and telomere-binding protein homologs
    • Wang, W., R. Skopp, M. Scofield, and C. Price. 1992. Euplotes crassus has genes encoding telomere-binding proteins and telomere-binding protein homologs. Nucleic Acids Res. 20:6621-6629.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 6621-6629
    • Wang, W.1    Skopp, R.2    Scofield, M.3    Price, C.4
  • 37
    • 0027509950 scopus 로고
    • Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase
    • Wellinger, R. J., A. J. Wolf, and V. A. Zakian. 1993. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell 72:51-60.
    • (1993) Cell , vol.72 , pp. 51-60
    • Wellinger, R.J.1    Wolf, A.J.2    Zakian, V.A.3
  • 38
    • 0033577876 scopus 로고    scopus 로고
    • Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
    • Wick, M., D. Zubov, and G. Hagen. 1999. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene 232:97-106.
    • (1999) Gene , vol.232 , pp. 97-106
    • Wick, M.1    Zubov, D.2    Hagen, G.3
  • 39
    • 0030731928 scopus 로고    scopus 로고
    • Normal human chromosomes have long G-rich telomeric overhangs at one end
    • Wright, W. E., V. M. Tesmer, K. E. Huffman, S. D. Levene, and J. W. Shay. 1997. Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11:2801-2809.
    • (1997) Genes Dev. , vol.11 , pp. 2801-2809
    • Wright, W.E.1    Tesmer, V.M.2    Huffman, K.E.3    Levene, S.D.4    Shay, J.W.5
  • 40
    • 0034523665 scopus 로고    scopus 로고
    • An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity
    • Yi, X., D. M. White, D. L. Aisner, J. A. Baur, W. E. Wright, and J. W. Shay. 2000. An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia 2:433-440.
    • (2000) Neoplasia , vol.2 , pp. 433-440
    • Yi, X.1    White, D.M.2    Aisner, D.L.3    Baur, J.A.4    Wright, W.E.5    Shay, J.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.