Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment

Molecular and Cellular Biology

Volumn 20, Issue 22, 2000, Pages 8397-8408

  Grandin, N ^a   Damon, C ^a   Charbonneau, M ^a  

^a UNIVERSITÉ DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; HYBRID PROTEIN; TELOMERASE;

ALLELE; ARTICLE; DNA REPAIR; ENZYME ANALYSIS; FUNGAL GENETICS; FUNGUS MUTANT; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; SACCHAROMYCES CEREVISIAE; TELOMERE; YEAST;

ANTIGENS, NUCLEAR; CHROMOSOMAL PROTEINS, NON-HISTONE; CYCLIN B; DNA HELICASES; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ANALYSIS, DNA; TELOMERASE;

EID: 0033766666     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.22.8397-8408.2000     Document Type: Article

References (61)

1. Extension of life-span by introduction of telomerase into normal human cells
2. Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance
3. Components of the Ku-dependent nonhomologous end-joining pathways are involved in telomeric length maintenance and telomeric silencing
4. Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo
5. Proteins that bind to double-stranded regions of telomeric DNA
6. DNA end-joining: From yeast to man
7. Variability at the telomeres of the human X/Y pseudoautosomal region
8. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases α and δ
9. Est1 and Cdc13 as comediators of telomerase access
10. A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae
11. HDF2, the second subunit of the Ku homologue from Saccharomyces cerevisiae
12. Subtelomeric repeat amplification is associated with growth at elevated temperature in yku70 mutants of Saccharomyces cerevisiae
13. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
14. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
15. The Cdc14 phosphatase interacts with Dbf2 kinase activity during exit from mitosis in Saccharomyces cerevisiae
16. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13
17. Yeast Ku as a regulator of chromosomal DNA end structure
18. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
19. Molecular model for telomeric heterochromatin in yeast
20. The many interfaces of Mre11
21. Sir-Ku-itous routes to make ends meet
22. A RAP1-interacting protein involved in silencing and telomere length regulation
23. Ku is associated with the telomere in mammals
24. The Est3 protein is a subunit of yeast telomerase
25. Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein
26. Genomic stability: Silencing and DNA repair connect
27. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae
28. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
29. 1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo
30. Telomerase and chromosome end maintenance
31. Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity
32. - senescence
33. A mutant with a defect in telomere elongation leads to senescence in yeast
34. Identification of yeast mutants with altered telomere structure
35. A protein-counting mechanism for telomere length regulation in yeast
36. Relocalization of telomeric Ku and Sir proteins in response to DNA strand breaks in yeast
37. Runaway telomere elongation caused by telomerase RNA gene mutations
38. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
39. Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by Rif proteins
40. Cell cycle and genetic requirement of two pathways of nonhomologous end-joining repair of double-strand breaks in S. cerevisiae
41. Reversing time: Origin of telomerase
42. The telomerase reverse transcriptase: Components and regulation
43. Telomere maintenance is dependent on activities required for end repair of double-strand breaks
44. Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
45. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities
46. The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae
47. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase α and the telomerase-associated Est1 protein
48. Varying the number of telomere-bound proteins does not alter telomere length in tel1Δ cell
49. Loss of a yeast telomere: Arrest, recovery, and chromosome loss
50. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
51. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
52. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
53. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
54. Est1 has the properties of a single-stranded telomere end-binding protein
55. Telomeres: Moonlighting by DNA repair proteins
56. 1-3 tails late in S phase
57. Evidence for a new step in telomere maintenance
58. A novel Rap1-interacting factor, Rif2p, cooperates with Rif1 to regulate telomere length in Saccharomyces cerevisiae
59. Structure, function, and replication of Saccharomyces cerevisiae telomeres
60. The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA