메뉴 건너뛰기




Volumn 2, Issue 6, 2003, Pages 350-364

Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders

Author keywords

BDNF; Complex genetics; DAT; Endopheno types; Knockout mice; MAO; NET; Serotonin transporter

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; SEROTONIN 1B RECEPTOR; SEROTONIN TRANSPORTER;

EID: 0345305851     PISSN: 16011848     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1601-1848.2003.00049.x     Document Type: Review
Times cited : (113)

References (136)
  • 3
    • 0041346384 scopus 로고    scopus 로고
    • A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter. I. Affective disorders
    • Anguelova, M., Benkelfat, C. & Turecki, G. (2003) A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter. I. Affective disorders. Mol Psychiatry 8, 574-591.
    • (2003) Mol Psychiatry , vol.8 , pp. 574-591
    • Anguelova, M.1    Benkelfat, C.2    Turecki, G.3
  • 4
    • 0034989269 scopus 로고    scopus 로고
    • Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock
    • Bae, K., Jin, X., Maywood, E.S., Hastings, M.H., Reppert, S.M. & Weaver, D.R. (2001) Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30, 525-536.
    • (2001) Neuron , vol.30 , pp. 525-536
    • Bae, K.1    Jin, X.2    Maywood, E.S.3    Hastings, M.H.4    Reppert, S.M.5    Weaver, D.R.6
  • 5
    • 0035313575 scopus 로고    scopus 로고
    • CNS region-specific oxytocin receptor expression: Importance in regulation of anxiety and sex behavior
    • Bale, T.L., Davis, A.M., Auger, A.P., Dorsa, D.M. & McCarthy, M.M. (2001) CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J Neurosci 21, 2546-2552.
    • (2001) J Neurosci , vol.21 , pp. 2546-2552
    • Bale, T.L.1    Davis, A.M.2    Auger, A.P.3    Dorsa, D.M.4    McCarthy, M.M.5
  • 6
    • 0036137946 scopus 로고    scopus 로고
    • Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior
    • Bale, T.L., Picetti, R., Contarino, A., Koob, G.F., Vale, W.W. & Lee, K.F. (2002) Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. J Neurosci 22, 193-199.
    • (2002) J Neurosci , vol.22 , pp. 193-199
    • Bale, T.L.1    Picetti, R.2    Contarino, A.3    Koob, G.F.4    Vale, W.W.5    Lee, K.F.6
  • 7
    • 0038701684 scopus 로고    scopus 로고
    • Huntingtin aggregation and toxicity in Huntington's disease
    • Bates, G. (2003) Huntingtin aggregation and toxicity in Huntington's disease. Lancet 361, 1642-1644.
    • (2003) Lancet , vol.361 , pp. 1642-1644
    • Bates, G.1
  • 10
  • 11
    • 0031978809 scopus 로고    scopus 로고
    • Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4- methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter-deficient mice
    • Bengel, D., Murphy, D.L., Andrews, A.M., Wichems, C.H., Feltner, D., Heils, A., Mossner, R., Westphal, H. & Lesch, K.P. (1998) Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4- methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter-deficient mice. Mol Pharmacol 53, 649-655.
    • (1998) Mol Pharmacol , vol.53 , pp. 649-655
    • Bengel, D.1    Murphy, D.L.2    Andrews, A.M.3    Wichems, C.H.4    Feltner, D.5    Heils, A.6    Mossner, R.7    Westphal, H.8    Lesch, K.P.9
  • 12
    • 0029057784 scopus 로고
    • The expression of additive and nonadditive genetic variation under stress
    • Blows, M.W. & Sokolowski, M.B. (1995) The expression of additive and nonadditive genetic variation under stress. Genetics 140, 1149-1159.
    • (1995) Genetics , vol.140 , pp. 1149-1159
    • Blows, M.W.1    Sokolowski, M.B.2
  • 14
    • 0027442475 scopus 로고
    • Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
    • Brunner, H.G., Nelen, M., Breakefield, X.O., Ropers, H.H. & van Oost, B.A. (1993) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262, 578-580.
    • (1993) Science , vol.262 , pp. 578-580
    • Brunner, H.G.1    Nelen, M.2    Breakefield, X.O.3    Ropers, H.H.4    Van Oost, B.A.5
  • 15
    • 0036255542 scopus 로고    scopus 로고
    • The mouse: Genetics meets behaviour
    • Bucan, M. & Abel, T. (2002) The mouse: genetics meets behaviour. Nat Rev Genet 3, 114-123.
    • (2002) Nat Rev Genet , vol.3 , pp. 114-123
    • Bucan, M.1    Abel, T.2
  • 16
    • 0035479022 scopus 로고    scopus 로고
    • Knockout models resulting in the development of obesity
    • Butler, A.A. & Cone, R.D. (2001) Knockout models resulting in the development of obesity. Trends Genet 17, S50-S54.
    • (2001) Trends Genet , vol.17
    • Butler, A.A.1    Cone, R.D.2
  • 17
    • 0030058732 scopus 로고    scopus 로고
    • Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: Role of a serotonin excess during the critical period
    • Cases, O., Vitalis, T., Seif, I., De Maeyer, E., Sotelo, C. & Gaspar, P. (1996) Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period. Neuron 16, 297-307.
    • (1996) Neuron , vol.16 , pp. 297-307
    • Cases, O.1    Vitalis, T.2    Seif, I.3    De Maeyer, E.4    Sotelo, C.5    Gaspar, P.6
  • 21
    • 0035882382 scopus 로고    scopus 로고
    • Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter. Abnormal intestinal motility and the expression of cation transporters
    • Chen, J.J., Li, Z., Pan, H., Murphy, D.L., Tamir, H., Koepsell, H. & Gershon, M.D. (2001) Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter. Abnormal intestinal motility and the expression of cation transporters. J Neurosci 21, 6348-6361.
    • (2001) J Neurosci , vol.21 , pp. 6348-6361
    • Chen, J.J.1    Li, Z.2    Pan, H.3    Murphy, D.L.4    Tamir, H.5    Koepsell, H.6    Gershon, M.D.7
  • 22
    • 0028909487 scopus 로고
    • Epistasis and its contribution to genetic variance components
    • Cheverud, J.M. & Routman, E.J. (1995) Epistasis and its contribution to genetic variance components. Genetics 139, 1455-1461.
    • (1995) Genetics , vol.139 , pp. 1455-1461
    • Cheverud, J.M.1    Routman, E.J.2
  • 23
    • 0026508778 scopus 로고
    • Clinical, biochemical, and neuropsychiatric evaluation of a patient with a contiguous gene syndrome due to a microdeletion Xp11.3 including the Norrie disease locus and monoamine oxidase (MAOA and MAOB) genes
    • Collins, F.A., Murphy, D.L., Reiss, A.L., Sims, K.B., Lewis, J.G., Freund, L., Karoum, F., Zhu, D., Maumenee, I.H. & Antonarakis, S.E. (1992) Clinical, biochemical, and neuropsychiatric evaluation of a patient with a contiguous gene syndrome due to a microdeletion Xp11.3 including the Norrie disease locus and monoamine oxidase (MAOA and MAOB) genes. Am J Med Genet 42, 127-134.
    • (1992) Am J Med Genet , vol.42 , pp. 127-134
    • Collins, F.A.1    Murphy, D.L.2    Reiss, A.L.3    Sims, K.B.4    Lewis, J.G.5    Freund, L.6    Karoum, F.7    Zhu, D.8    Maumenee, I.H.9    Antonarakis, S.E.10
  • 24
    • 0036797562 scopus 로고    scopus 로고
    • Epistasis: What it means, what it doesn't mean, and statistical methods to detect it in humans
    • Cordell, H.J. (2002) Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet 11, 2463-2468.
    • (2002) Hum Mol Genet , vol.11 , pp. 2463-2468
    • Cordell, H.J.1
  • 26
    • 0020312284 scopus 로고
    • Endogenous serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) levels in large regions and in discrete brain areas of C57BL and BALBc mice at three times of the day
    • Daszuta, A. & Barrit, M.C. (1982) Endogenous serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) levels in large regions and in discrete brain areas of C57BL and BALBc mice at three times of the day. Brain Res Bull 8, 477-482.
    • (1982) Brain Res Bull , vol.8 , pp. 477-482
    • Daszuta, A.1    Barrit, M.C.2
  • 29
    • 0034948210 scopus 로고    scopus 로고
    • Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice
    • Dluzen, D.E., Gao, X., Story, G.M., Anderson, L.I., Kucera, J. & Walro, J.M. (2001) Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice. Exp Neurol 170, 121-128.
    • (2001) Exp Neurol , vol.170 , pp. 121-128
    • Dluzen, D.E.1    Gao, X.2    Story, G.M.3    Anderson, L.I.4    Kucera, J.5    Walro, J.M.6
  • 30
    • 0032763829 scopus 로고    scopus 로고
    • Alterations in nigrostriatal dopaminergic function within BDNF mutant mice
    • Dluzen, D.E., Story, G.M., Xu, K., Kucera, J. & Walro, J.M. (1999) Alterations in nigrostriatal dopaminergic function within BDNF mutant mice. Exp Neurol 160, 500-507.
    • (1999) Exp Neurol , vol.160 , pp. 500-507
    • Dluzen, D.E.1    Story, G.M.2    Xu, K.3    Kucera, J.4    Walro, J.M.5
  • 31
    • 0029061838 scopus 로고
    • Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent
    • Dupuis, J., Brown, P.O. & Siegmund, D. (1995) Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent. Genetics 140, 843-856.
    • (1995) Genetics , vol.140 , pp. 843-856
    • Dupuis, J.1    Brown, P.O.2    Siegmund, D.3
  • 32
    • 0029119322 scopus 로고
    • Developmental regulation of early serotonergic neuronal differentiation: The role of brain-derived neurotrophic factor and membrane depolarization
    • Eaton, M.J., Staley, J.K., Globus, M.Y. & Whittemore, S.R. (1995) Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization. Dev Biol 170, 169-182.
    • (1995) Dev Biol , vol.170 , pp. 169-182
    • Eaton, M.J.1    Staley, J.K.2    Globus, M.Y.3    Whittemore, S.R.4
  • 34
    • 0028274040 scopus 로고
    • Mice lacking brain-derived neurotrophic factor develop with sensory deficits
    • Ernfors, P., Lee, K.F. & Jaenisch, R. (1994) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368, 147-150.
    • (1994) Nature , vol.368 , pp. 147-150
    • Ernfors, P.1    Lee, K.F.2    Jaenisch, R.3
  • 35
  • 36
    • 0035449933 scopus 로고    scopus 로고
    • Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3
    • Espinosa, F., McMahon, A., Chan, E., Wang, S., Ho, C.S., Heintz, N. & Joho, R.H. (2001) Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3. J Neurosci 21, 6657-6665.
    • (2001) J Neurosci , vol.21 , pp. 6657-6665
    • Espinosa, F.1    McMahon, A.2    Chan, E.3    Wang, S.4    Ho, C.S.5    Heintz, N.6    Joho, R.H.7
  • 39
    • 0018764161 scopus 로고
    • Cumulative effects of irreversible MAO inhibitors in vivo
    • Felner, A.E. & Waldmeier, P.C. (1979) Cumulative effects of irreversible MAO inhibitors in vivo. Biochem Pharmacol 28, 995-1002.
    • (1979) Biochem Pharmacol , vol.28 , pp. 995-1002
    • Felner, A.E.1    Waldmeier, P.C.2
  • 40
    • 84971185409 scopus 로고
    • The correlations between relatives on the supposition of Mendelian inheritance
    • Fisher, R.A. (1918) The correlations between relatives on the supposition of Mendelian inheritance. Trans R Soc Edinburgh 52, 399-433.
    • (1918) Trans R Soc Edinburgh , vol.52 , pp. 399-433
    • Fisher, R.A.1
  • 41
    • 0030333453 scopus 로고    scopus 로고
    • Who's afraid of epistasis?
    • Frankel, W.N. & Schork, N.J. (1996) Who's afraid of epistasis? Nat Genet 14, 371-373.
    • (1996) Nat Genet , vol.14 , pp. 371-373
    • Frankel, W.N.1    Schork, N.J.2
  • 42
    • 0026518215 scopus 로고
    • Tackling a weighty problem
    • Friedman, J.M. & Leibel, R.L. (1992) Tackling a weighty problem. Cell 69, 217-220.
    • (1992) Cell , vol.69 , pp. 217-220
    • Friedman, J.M.1    Leibel, R.L.2
  • 43
    • 0034254643 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and trkB are essential for cAMP-mediated induction of the serotonergic neuronal phenotype
    • Galter, D. & Unsicker, K. (2000) Brain-derived neurotrophic factor and trkB are essential for cAMP-mediated induction of the serotonergic neuronal phenotype. J Neurosci Res 61, 295-301.
    • (2000) J Neurosci Res , vol.61 , pp. 295-301
    • Galter, D.1    Unsicker, K.2
  • 44
    • 0030071106 scopus 로고    scopus 로고
    • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    • Giros, B., Jaber, M., Jones, S.R., Wightman, R.M. & Caron, M.G. (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379, 606-612.
    • (1996) Nature , vol.379 , pp. 606-612
    • Giros, B.1    Jaber, M.2    Jones, S.R.3    Wightman, R.M.4    Caron, M.G.5
  • 45
    • 0035122950 scopus 로고    scopus 로고
    • Modifications of the serotoninergic system in mice lacking serotonin transporters. An in vivo eletrophysiological study
    • Gobbi, G., Murphy, D.L., Lesch, K.-P. & Blier, P. (2001) Modifications of the serotoninergic system in mice lacking serotonin transporters. An in vivo eletrophysiological study. J Pharmacol Exp Ther 296, 987-995.
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 987-995
    • Gobbi, G.1    Murphy, D.L.2    Lesch, K.-P.3    Blier, P.4
  • 47
    • 0036046157 scopus 로고    scopus 로고
    • Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders
    • Hahn, M.K. & Blakely, R.D. (2002) Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. Pharmacogenomics J 2, 217-235.
    • (2002) Pharmacogenomics J , vol.2 , pp. 217-235
    • Hahn, M.K.1    Blakely, R.D.2
  • 48
    • 0042165043 scopus 로고    scopus 로고
    • Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder
    • Hall, D., Dhilla, A., Charalambous, A., Gogos, J.A. & Karayiorgou, M. (2003a) Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Am J Hum Genet 73, 370-376.
    • (2003) Am J Hum Genet , vol.73 , pp. 370-376
    • Hall, D.1    Dhilla, A.2    Charalambous, A.3    Gogos, J.A.4    Karayiorgou, M.5
  • 49
    • 0041884826 scopus 로고    scopus 로고
    • Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice
    • Hall, F.S., Drgonova, J., Goeb, M. & Uhl, G.R. (2003b) Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice. Neuropsychopharmacology 28, 1485-1490.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1485-1490
    • Hall, F.S.1    Drgonova, J.2    Goeb, M.3    Uhl, G.R.4
  • 50
    • 0037110603 scopus 로고    scopus 로고
    • Cocaine mechanisms: Enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions
    • Hall, F.S., Li, X.F., Sora, I., Xu, F., Caron, M., Lesch, K.P., Murphy, D.L. & Uhl, G.R. (2002) Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience 115, 153-161.
    • (2002) Neuroscience , vol.115 , pp. 153-161
    • Hall, F.S.1    Li, X.F.2    Sora, I.3    Xu, F.4    Caron, M.5    Lesch, K.P.6    Murphy, D.L.7    Uhl, G.R.8
  • 51
    • 0037298936 scopus 로고    scopus 로고
    • Treatment of obesity: An update on anti-obesity medications
    • Halpern, A. & Mancini, M.C. (2003) Treatment of obesity: an update on anti-obesity medications. Obes Rev 4, 25-42.
    • (2003) Obes Rev , vol.4 , pp. 25-42
    • Halpern, A.1    Mancini, M.C.2
  • 54
    • 0042881041 scopus 로고    scopus 로고
    • Mathematical multi-locus approaches to localizing complex human trait genes
    • Hoh, J. & Ott, J. (2003) Mathematical multi-locus approaches to localizing complex human trait genes. Nat Rev Genet4, 701-709.
    • (2003) Nat Rev Genet , vol.4 , pp. 701-709
    • Hoh, J.1    Ott, J.2
  • 55
    • 0036250544 scopus 로고    scopus 로고
    • Reduced aggression in mice lacking the serotonin transporter
    • Holmes, A., Murphy, D.L. & Crawley, J.N. (2002a) Reduced aggression in mice lacking the serotonin transporter. Psychopharmacology (Berl) 161, 160-167.
    • (2002) Psychopharmacology (Berl) , vol.161 , pp. 160-167
    • Holmes, A.1    Murphy, D.L.2    Crawley, J.N.3
  • 56
    • 0036897940 scopus 로고    scopus 로고
    • Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter
    • Holmes, A., Yang, R.J., Murphy, D.L. & Crawley, J.N. (2002b) Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology 27, 914-923.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 914-923
    • Holmes, A.1    Yang, R.J.2    Murphy, D.L.3    Crawley, J.N.4
  • 57
    • 0034892846 scopus 로고    scopus 로고
    • Genomewide search for epistasis in a complex trait: Pentobarbital withdrawal convulsions in mice
    • Hood, H.M., Belknap, J.K., Crabbe, J.C. & Buck, K.J. (2001) Genomewide search for epistasis in a complex trait: pentobarbital withdrawal convulsions in mice. Behav Genet 31, 93-100.
    • (2001) Behav Genet , vol.31 , pp. 93-100
    • Hood, H.M.1    Belknap, J.K.2    Crabbe, J.C.3    Buck, K.J.4
  • 58
    • 0035168444 scopus 로고    scopus 로고
    • Twin studies of psychiatric illness: An update
    • Kendler, K.S. (2001) Twin studies of psychiatric illness: an update. Arch General Psychiatry 58, 1005-1014.
    • (2001) Arch General Psychiatry , vol.58 , pp. 1005-1014
    • Kendler, K.S.1
  • 59
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • Kernie, S.G., Liebl, D.J. & Parada, L.F. (2000) BDNF regulates eating behavior and locomotor activity in mice. Embo J 19, 1290-1300.
    • (2000) Embo J , vol.19 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.J.2    Parada, L.F.3
  • 60
    • 0042343721 scopus 로고    scopus 로고
    • A human serotonin transporter mutation causes constitutive activation of transport activity
    • Kilic, F., Murphy, D.L. & Rudnick, G. (2003) A human serotonin transporter mutation causes constitutive activation of transport activity. Mol Pharmacol 64, 440-446.
    • (2003) Mol Pharmacol , vol.64 , pp. 440-446
    • Kilic, F.1    Murphy, D.L.2    Rudnick, G.3
  • 61
    • 0037372019 scopus 로고    scopus 로고
    • Of mice and the fragile X syndrome
    • Kooy, R.F. (2003) of mice and the fragile X syndrome. Trends Genet 19, 148-154.
    • (2003) Trends Genet , vol.19 , pp. 148-154
    • Kooy, R.F.1
  • 62
    • 0028909534 scopus 로고
    • Anxiolytic-like effects of selective mineralocorticoid and glucocorticoid antagonists on fear-enhanced behavior in the elevated plus-maze
    • Korte, S.M., de Boer, S.F., de Kloet, E.R. & Bohus, B. (1995) Anxiolytic-like effects of selective mineralocorticoid and glucocorticoid antagonists on fear-enhanced behavior in the elevated plus-maze. Psychoneuroendocrinology 20, 385-394.
    • (1995) Psychoneuroendocrinology , vol.20 , pp. 385-394
    • Korte, S.M.1    De Boer, S.F.2    De Kloet, E.R.3    Bohus, B.4
  • 63
    • 77956849890 scopus 로고    scopus 로고
    • Genetic deficiencies of monoamine oxidase enzymes: A key to understanding the function of the enzymes in humans
    • Lenders, J.W., Brunner, H.G., Murphy, D.L. & Eisenhofer, G. (1998) Genetic deficiencies of monoamine oxidase enzymes: a key to understanding the function of the enzymes in humans. Adv Pharmacol 42, 297-301.
    • (1998) Adv Pharmacol , vol.42 , pp. 297-301
    • Lenders, J.W.1    Brunner, H.G.2    Murphy, D.L.3    Eisenhofer, G.4
  • 65
    • 0034331195 scopus 로고    scopus 로고
    • Reduction in the density and expression, but not G protein coupling of 5-HT1A receptors in 5-HT transporter knockout mice: Gender and brain region differences
    • Li, Q., Wichems, C., Heils, A., Lesch, K.-P. & Murphy, D.L. (2000) Reduction in the density and expression, but not G protein coupling of 5-HT1A receptors in 5-HT transporter knockout mice: gender and brain region differences. J Neurosci 20, 7888-7895.
    • (2000) J Neurosci , vol.20 , pp. 7888-7895
    • Li, Q.1    Wichems, C.2    Heils, A.3    Lesch, K.-P.4    Murphy, D.L.5
  • 66
    • 0032706095 scopus 로고    scopus 로고
    • Reduction of 5-hydroxytryptamine (5-HT) (1A)-mediated temperature and neuroendocrine responses and 5-HT (1A) binding sites in 5-HT transporter knockout mice
    • Li, Q., Wichems, C., Heils, A., Van De Kar, L.D., Lesch, K.P. & Murphy, D.L. (1999) Reduction of 5-hydroxytryptamine (5-HT) (1A)-mediated temperature and neuroendocrine responses and 5-HT (1A) binding sites in 5-HT transporter knockout mice. J Pharmacol Exp Ther 291, 999-1007.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 999-1007
    • Li, Q.1    Wichems, C.2    Heils, A.3    Van De Kar, L.D.4    Lesch, K.P.5    Murphy, D.L.6
  • 67
    • 0037343950 scopus 로고    scopus 로고
    • Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knock-out mice
    • Li, Q., Wichems, C., Ma, L., Van de Kar, L.D., Garcia, F. & Murphy, D.L. (2003) Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knock-out mice. J Neurochem 84, 1256-1265.
    • (2003) J Neurochem , vol.84 , pp. 1256-1265
    • Li, Q.1    Wichems, C.2    Ma, L.3    Van De Kar, L.D.4    Garcia, F.5    Murphy, D.L.6
  • 68
    • 0036890028 scopus 로고    scopus 로고
    • Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter
    • Liu, M.T., Rayport, S., Jiang, Y., Murphy, D.L. & Gershon, M.D. (2002) Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter. Am J Physiol Gastrointest Liver Physiol 283, G1398-G1411.
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283
    • Liu, M.T.1    Rayport, S.2    Jiang, Y.3    Murphy, D.L.4    Gershon, M.D.5
  • 69
    • 0028961745 scopus 로고
    • High resolution mapping of genetic factors affecting abdominal bristle number in Drosophila melanogaster
    • Long, A.D., Mullaney, S.L., Reid, L.A., Fry, J.D., Langley, C.H. & Mackay, T.F. (1995) High resolution mapping of genetic factors affecting abdominal bristle number in Drosophila melanogaster. Genetics 139, 1273-1291.
    • (1995) Genetics , vol.139 , pp. 1273-1291
    • Long, A.D.1    Mullaney, S.L.2    Reid, L.A.3    Fry, J.D.4    Langley, C.H.5    Mackay, T.F.6
  • 70
    • 0042861399 scopus 로고    scopus 로고
    • Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical 'barrel' map development
    • Lu, H.C., She, W.C., Plas, D.T., Neumann, P.E., Janz, R. & Crair, M.C. (2003) Adenylyl cyclase I regulates AMPA receptor trafficking during mouse cortical 'barrel' map development. Nat Neurosci 6, 939-947.
    • (2003) Nat Neurosci , vol.6 , pp. 939-947
    • Lu, H.C.1    She, W.C.2    Plas, D.T.3    Neumann, P.E.4    Janz, R.5    Crair, M.C.6
  • 71
    • 0033592920 scopus 로고    scopus 로고
    • Brain-derived neurotropic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
    • Lyons, W.E., Mamounas, L.A., Ricaurte, G.A., Coppola, V., Reid, S.W., Bora, S.H., Wihler, C., Koliatsos, V.E. & Tessarollo, L. (1999) Brain-derived neurotropic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. PNAS 96, 15239-15244.
    • (1999) PNAS , vol.96 , pp. 15239-15244
    • Lyons, W.E.1    Mamounas, L.A.2    Ricaurte, G.A.3    Coppola, V.4    Reid, S.W.5    Bora, S.H.6    Wihler, C.7    Koliatsos, V.E.8    Tessarollo, L.9
  • 72
    • 0034801530 scopus 로고    scopus 로고
    • Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression
    • MacQueen, G.M., Ramakrishnan, K., Croll, S.D., Siuciak, J.A., Yu, G., Young, L.T. & Fahnestock, M. (2001) Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression. Behav Neurosci 115, 1145-1153.
    • (2001) Behav Neurosci , vol.115 , pp. 1145-1153
    • MacQueen, G.M.1    Ramakrishnan, K.2    Croll, S.D.3    Siuciak, J.A.4    Yu, G.5    Young, L.T.6    Fahnestock, M.7
  • 74
    • 0029584365 scopus 로고
    • Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain
    • Mamounas, L.A., Blue, M.E., Siuciak, J.A. & Altar, C.A. (1995) Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J Neurosci 15, 7929-7939.
    • (1995) J Neurosci , vol.15 , pp. 7929-7939
    • Mamounas, L.A.1    Blue, M.E.2    Siuciak, J.A.3    Altar, C.A.4
  • 75
    • 0033937080 scopus 로고    scopus 로고
    • A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity
    • Manuck, S.B., Flory, J.D., Ferrell, R.E., Mann, J.J. & Muldoon, M.F. (2000) A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Res 95, 9-23.
    • (2000) Psychiatry Res , vol.95 , pp. 9-23
    • Manuck, S.B.1    Flory, J.D.2    Ferrell, R.E.3    Mann, J.J.4    Muldoon, M.F.5
  • 76
    • 0000758420 scopus 로고    scopus 로고
    • Effects of serotonin transporter inactivation on extracellular 5-HT levels in vivo microdialysis recovery and MDMA-induced release of serotonin and dopamine in mouse striatum
    • Mathews, T.A., Fedele, D.E., Unger, E.L., Lesch, K.-P., Murphy, D.L. & Andrews, A.M. (2000) Effects of serotonin transporter inactivation on extracellular 5-HT levels in vivo microdialysis recovery and MDMA-induced release of serotonin and dopamine in mouse striatum. Abstract, Society of Neuroscience 26, 624.3, 1666.
    • (2000) Abstract, Society of Neuroscience , vol.26 , pp. 6243
    • Mathews, T.A.1    Fedele, D.E.2    Unger, E.L.3    Lesch, K.-P.4    Murphy, D.L.5    Andrews, A.M.6
  • 78
    • 0031802343 scopus 로고    scopus 로고
    • Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder
    • McDougle, C.J., Epperson, C.N., Price, L.H. & Gelernter, J. (1998) Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Mol Psychiatry 3, 270-273.
    • (1998) Mol Psychiatry , vol.3 , pp. 270-273
    • McDougle, C.J.1    Epperson, C.N.2    Price, L.H.3    Gelernter, J.4
  • 79
    • 0025939413 scopus 로고
    • The Lurcher cerebellar mutant phenotype is not expressed on a staggerer mutant background
    • Messer, A., Eisenberg, B. & Plummer, J. (1991) The Lurcher cerebellar mutant phenotype is not expressed on a staggerer mutant background. J Neurosci 11, 2295-2302.
    • (1991) J Neurosci , vol.11 , pp. 2295-2302
    • Messer, A.1    Eisenberg, B.2    Plummer, J.3
  • 80
    • 0037045132 scopus 로고    scopus 로고
    • Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR
    • Mill, J., Asherson, P., Browes, C., D'Souza, U. & Craig, I. (2002) Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet 114, 975-979.
    • (2002) Am J Med Genet , vol.114 , pp. 975-979
    • Mill, J.1    Asherson, P.2    Browes, C.3    D'Souza, U.4    Craig, I.5
  • 81
    • 0035910939 scopus 로고    scopus 로고
    • Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: Relevance to cocaine sensitivity
    • Miller, G.M., Yatin, S.M., De La Garza, R.N., Goulet, M. & Madras, B.K. (2001) Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain Res Mol Brain Res 87, 124-143.
    • (2001) Brain Res Mol Brain Res , vol.87 , pp. 124-143
    • Miller, G.M.1    Yatin, S.M.2    De La Garza, R.N.3    Goulet, M.4    Madras, B.K.5
  • 82
    • 17144466384 scopus 로고    scopus 로고
    • Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice
    • Montanez, S., Owens, W.A., Gould, G.G., Murphy, D.L. & Daws, L.C. (2003) Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. J Neurochem 86, 210-219.
    • (2003) J Neurochem , vol.86 , pp. 210-219
    • Montanez, S.1    Owens, W.A.2    Gould, G.G.3    Murphy, D.L.4    Daws, L.C.5
  • 83
    • 0034507639 scopus 로고    scopus 로고
    • Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come
    • Moore, K.J. & Nagle, D.L. (2000) Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come. Annu Rev Genet 34, 653-686.
    • (2000) Annu Rev Genet , vol.34 , pp. 653-686
    • Moore, K.J.1    Nagle, D.L.2
  • 85
    • 0034606204 scopus 로고    scopus 로고
    • Search for bipolar disorder susceptibility loci: The applications of a modified genome scan concentrating on gene-rich regions
    • Murphy, V.E., Mynett-Johnson, L.A., Claffey, E., Bergin, P., McAuliffe, M., Kealey, C. & McKeon, P. (2000) Search for bipolar disorder susceptibility loci: the applications of a modified genome scan concentrating on gene-rich regions. Am J Med Genet 96, 728-732.
    • (2000) Am J Med Genet , vol.96 , pp. 728-732
    • Murphy, V.E.1    Mynett-Johnson, L.A.2    Claffey, E.3    Bergin, P.4    McAuliffe, M.5    Kealey, C.6    McKeon, P.7
  • 86
    • 0025138396 scopus 로고
    • Marked amine and amine metabolite changes in Norrie disease patients with an X-chromosomal deletion affecting monoamine oxidase
    • Murphy, D.L., Sims, K.B., Karoum, F., de la Chapelle, A., Norio, R., Sankila, E.M. & Breakefield, X.O. (1990) Marked amine and amine metabolite changes in Norrie disease patients with an X-chromosomal deletion affecting monoamine oxidase. J Neurochem 54, 242-247.
    • (1990) J Neurochem , vol.54 , pp. 242-247
    • Murphy, D.L.1    Sims, K.B.2    Karoum, F.3    De La Chapelle, A.4    Norio, R.5    Sankila, E.M.6    Breakefield, X.O.7
  • 87
    • 0033152508 scopus 로고    scopus 로고
    • Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission
    • Murphy, D.L., Wichems, C., Li, Q. & Heils, A. (1999) Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission. Trends Pharmacol Sci 20, 246-252.
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 246-252
    • Murphy, D.L.1    Wichems, C.2    Li, Q.3    Heils, A.4
  • 88
    • 0034606327 scopus 로고    scopus 로고
    • Multimarkerhaplo-types within the serotonin transporter gene suggest evidence of an association with bipolar disorder
    • Mynett-Johnson, L., Kealey, C., Claffey, E., Curtis, D., Bouchier-Hayes, L., Powell, C. & McKeon, P. (2000) Multimarkerhaplo-types within the serotonin transporter gene suggest evidence of an association with bipolar disorder. Am J Med Genet 96, 845-849.
    • (2000) Am J Med Genet , vol.96 , pp. 845-849
    • Mynett-Johnson, L.1    Kealey, C.2    Claffey, E.3    Curtis, D.4    Bouchier-Hayes, L.5    Powell, C.6    McKeon, P.7
  • 89
    • 0035287508 scopus 로고    scopus 로고
    • Modifier genes in mice and humans
    • Nadeau, J.H. (2001) Modifier genes in mice and humans. Nat Rev Genet 2, 165-174.
    • (2001) Nat Rev Genet , vol.2 , pp. 165-174
    • Nadeau, J.H.1
  • 91
    • 0035985245 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice
    • Nakagawa, T., Ono-Kishino, M., Sugaru, E., Yamanaka, M., Taiji, M. & Noguchi, H. (2002) Brain-derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice. Diabetes Metab Res Rev 18, 185-191.
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 185-191
    • Nakagawa, T.1    Ono-Kishino, M.2    Sugaru, E.3    Yamanaka, M.4    Taiji, M.5    Noguchi, H.6
  • 92
    • 0036724341 scopus 로고    scopus 로고
    • The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study
    • Neves-Pereira, M., Mundo, E., Muglia, P., King, N., Macciardi, F. & Kennedy, J.L. (2002) The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet 71, 651-655.
    • (2002) Am J Hum Genet , vol.71 , pp. 651-655
    • Neves-Pereira, M.1    Mundo, E.2    Muglia, P.3    King, N.4    Macciardi, F.5    Kennedy, J.L.6
  • 94
    • 0034084676 scopus 로고    scopus 로고
    • Selective genotyping with epistasis can be utilized for a major quantitative trait locus mapping in hypertension in rats
    • Ohno, Y., Tanase, H., Nabika, T., Otsuka, K., Sasaki, T., Suzawa, T., Morii, T., Yamori, Y. & Saruta, T. (2000) Selective genotyping with epistasis can be utilized for a major quantitative trait locus mapping in hypertension in rats. Genetics 155, 785-792.
    • (2000) Genetics , vol.155 , pp. 785-792
    • Ohno, Y.1    Tanase, H.2    Nabika, T.3    Otsuka, K.4    Sasaki, T.5    Suzawa, T.6    Morii, T.7    Yamori, Y.8    Saruta, T.9
  • 96
    • 0035977577 scopus 로고    scopus 로고
    • Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice
    • Pan, Y., Gembom, E., Peng, W., Lesch, K.P., Mossner, R. & Simantov, R. (2001) Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice. Brain Res Dev Brain Res 126, 125-129.
    • (2001) Brain Res Dev Brain Res , vol.126 , pp. 125-129
    • Pan, Y.1    Gembom, E.2    Peng, W.3    Lesch, K.P.4    Mossner, R.5    Simantov, R.6
  • 100
    • 0029896552 scopus 로고    scopus 로고
    • Waiting for a compensatory mutation: Phase zero of the shifting-balance process
    • Phillips, P.C. (1996) Waiting for a compensatory mutation: phase zero of the shifting-balance process. Genet Res 67, 271-283.
    • (1996) Genet Res , vol.67 , pp. 271-283
    • Phillips, P.C.1
  • 101
    • 0031716698 scopus 로고    scopus 로고
    • The population genetics of synthetic lethals
    • Phillips, P.C. & Johnson, N.A. (1998) The population genetics of synthetic lethals. Genetics 150, 449-458.
    • (1998) Genetics , vol.150 , pp. 449-458
    • Phillips, P.C.1    Johnson, N.A.2
  • 102
    • 0028340175 scopus 로고
    • The genetic basis of complex human behaviors
    • Plomin, R., Owen, M.J. & McGuffin, P. (1994) The genetic basis of complex human behaviors. Science 264, 1733-1739.
    • (1994) Science , vol.264 , pp. 1733-1739
    • Plomin, R.1    Owen, M.J.2    McGuffin, P.3
  • 103
    • 0033564051 scopus 로고    scopus 로고
    • Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice
    • Pozzo-Miller, L.D., Gottschalk, W., Zhang, L., Du McDermott, K.J., Gopalakrishnan, R., Oho, C., Sheng, Z.H. & Lu, B. (1999) Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. J Neurosci 19, 4972-4983.
    • (1999) J Neurosci , vol.19 , pp. 4972-4983
    • Pozzo-Miller, L.D.1    Gottschalk, W.2    Zhang, L.3    Du McDermott, K.J.4    Gopalakrishnan, R.5    Oho, C.6    Sheng, Z.H.7    Lu, B.8
  • 105
    • 0035059877 scopus 로고    scopus 로고
    • Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein
    • Ravary, A., Muzerelle, A., Darmon, M., Murphy, D.L., Moessner, R., Lesch, K.P. & Gaspar, P. (2001) Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. Eur J Neurosci 13, 1349-1362.
    • (2001) Eur J Neurosci , vol.13 , pp. 1349-1362
    • Ravary, A.1    Muzerelle, A.2    Darmon, M.3    Murphy, D.L.4    Moessner, R.5    Lesch, K.P.6    Gaspar, P.7
  • 106
    • 0028171014 scopus 로고
    • Effects of 5-HT on thalamocortical synaptic transmission in the developing rat
    • Rhoades, R.W., Bennett-Clarke, C.A., Shi, M.Y. & Mooney, R.D. (1994) Effects of 5-HT on thalamocortical synaptic transmission in the developing rat. J Neurophysiol 72, 2438-2450.
    • (1994) J Neurophysiol , vol.72 , pp. 2438-2450
    • Rhoades, R.W.1    Bennett-Clarke, C.A.2    Shi, M.Y.3    Mooney, R.D.4
  • 107
    • 0034792085 scopus 로고    scopus 로고
    • Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    • Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R., Lechan, R.M. & Jaenisch, R. (2001) Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15, 1748-1757.
    • (2001) Mol Endocrinol , vol.15 , pp. 1748-1757
    • Rios, M.1    Fan, G.2    Fekete, C.3    Kelly, J.4    Bates, B.5    Kuehn, R.6    Lechan, R.M.7    Jaenisch, R.8
  • 109
    • 0034500455 scopus 로고    scopus 로고
    • Generic models of obesity and energy balance in the mouse
    • Robinson, S.W., Dinulescu, D.M. & Cone, R.D. (2000) Generic models of obesity and energy balance in the mouse. Annu Rev Genet 34, 687-745.
    • (2000) Annu Rev Genet , vol.34 , pp. 687-745
    • Robinson, S.W.1    Dinulescu, D.M.2    Cone, R.D.3
  • 114
  • 116
    • 0029925352 scopus 로고    scopus 로고
    • BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration
    • Siuciak, J.A., Boylan, C., Fritsche, M., Altar, C.A. & Lindsay, R.M. (1996) BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration. Brain Res 710, 11-20.
    • (1996) Brain Res , vol.710 , pp. 11-20
    • Siuciak, J.A.1    Boylan, C.2    Fritsche, M.3    Altar, C.A.4    Lindsay, R.M.5
  • 118
    • 0035942241 scopus 로고    scopus 로고
    • Molecular mechanisms of cocaine reward: Combined dopamine and serotonin transporter knockouts eliminate cocaine place preference
    • Sora, I., Hall, F.S., Andrews, A.M., Itokawa, M., Li, X.-F., Wei, H.-B., Wichems, C., Lesch, K.-P., Murphy, D.L. & Uhl, G.R. (2001) Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. PNAS 98, 5300-5305.
    • (2001) PNAS , vol.98 , pp. 5300-5305
    • Sora, I.1    Hall, F.S.2    Andrews, A.M.3    Itokawa, M.4    Li, X.-F.5    Wei, H.-B.6    Wichems, C.7    Lesch, K.-P.8    Murphy, D.L.9    Uhl, G.R.10
  • 119
    • 0032560560 scopus 로고    scopus 로고
    • Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice
    • Sora, I., Wichems, C., Takahashi, N., Li, X.F., Zeng, Z., Revay, R., Lesch, K.P., Murphy, D.L. & Uhl, G.R. (1998) Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci U S A 95, 7699-7704.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7699-7704
    • Sora, I.1    Wichems, C.2    Takahashi, N.3    Li, X.F.4    Zeng, Z.5    Revay, R.6    Lesch, K.P.7    Murphy, D.L.8    Uhl, G.R.9
  • 120
    • 0029784930 scopus 로고    scopus 로고
    • The rate of compensatory evolution
    • Stephan, W. (1996) The rate of compensatory evolution. Genetics 144, 419-426.
    • (1996) Genetics , vol.144 , pp. 419-426
    • Stephan, W.1
  • 121
    • 0024549506 scopus 로고
    • A building block model for quantitative genetics
    • Tachida, H. & Cockerham, C.C. (1989) A building block model for quantitative genetics. Genetics 121, 839-844.
    • (1989) Genetics , vol.121 , pp. 839-844
    • Tachida, H.1    Cockerham, C.C.2
  • 122
    • 0030961962 scopus 로고    scopus 로고
    • Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease
    • Terauchi, Y., Iwamoto, K., Tamemoto, H., Komeda, K., Ishii, C., Kanazawa, Y., Asanuma, N., Aizawa, T., Akanuma, Y., Yasuda, K., Kodama, T., Tobe, K., Yazaki, Y. & Kadowaki, T. (1997) Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. J Clin Invest 99, 861-866.
    • (1997) J Clin Invest , vol.99 , pp. 861-866
    • Terauchi, Y.1    Iwamoto, K.2    Tamemoto, H.3    Komeda, K.4    Ishii, C.5    Kanazawa, Y.6    Asanuma, N.7    Aizawa, T.8    Akanuma, Y.9    Yasuda, K.10    Kodama, T.11    Tobe, K.12    Yazaki, Y.13    Kadowaki, T.14
  • 123
    • 85047700129 scopus 로고    scopus 로고
    • Cocaine, reward, movement and monoamine transporters
    • Uhl, G.R., Hall, F.S. & Sora, I. (2002) Cocaine, reward, movement and monoamine transporters. Mol Psychiatry 7, 21-26.
    • (2002) Mol Psychiatry , vol.7 , pp. 21-26
    • Uhl, G.R.1    Hall, F.S.2    Sora, I.3
  • 124
    • 0035209299 scopus 로고    scopus 로고
    • Polysubstance abuse-vulnerability genes: Genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms
    • Uhl, G.R., Liu, Q.R., Walther, D., Hess, J. & Naiman, D. (2001) Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am J Hum Genet 69, 1290-1300.
    • (2001) Am J Hum Genet , vol.69 , pp. 1290-1300
    • Uhl, G.R.1    Liu, Q.R.2    Walther, D.3    Hess, J.4    Naiman, D.5
  • 125
    • 0037198413 scopus 로고    scopus 로고
    • Lack of 5-HT (1 B) receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus
    • Upton, A.L., Ravary, A., Salichon, N., Moessner, R., Lesch, K.P., Hen, R., Self, I. & Gaspar, P. (2002) Lack of 5-HT (1 B) receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus. Neuroscience 111, 597-610.
    • (2002) Neuroscience , vol.111 , pp. 597-610
    • Upton, A.L.1    Ravary, A.2    Salichon, N.3    Moessner, R.4    Lesch, K.P.5    Hen, R.6    Self, I.7    Gaspar, P.8
  • 126
    • 0033566885 scopus 로고    scopus 로고
    • Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: Possible role of 5-HT uptake in retinal ganglion cells during development
    • Upton, A.L., Salichon, N., Lebrand, C., Ravary, A., Blakely, R., Seif, I. & Gaspar, P. (1999) Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development. J Neurosci 19, 7007-7024.
    • (1999) J Neurosci , vol.19 , pp. 7007-7024
    • Upton, A.L.1    Salichon, N.2    Lebrand, C.3    Ravary, A.4    Blakely, R.5    Seif, I.6    Gaspar, P.7
  • 128
    • 0031889318 scopus 로고    scopus 로고
    • Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: Determination of a sensitive developmental period
    • Vitalis, T., Cases, O., Callebert, J., Launay, J.M., Price, D.J., Seif, I. & Gaspar, P. (1998) Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: determination of a sensitive developmental period. J Comp Neurol 393, 169-184.
    • (1998) J Comp Neurol , vol.393 , pp. 169-184
    • Vitalis, T.1    Cases, O.2    Callebert, J.3    Launay, J.M.4    Price, D.J.5    Seif, I.6    Gaspar, P.7
  • 130
    • 0004254590 scopus 로고    scopus 로고
    • Genetic measurement of theory of epistatic effects
    • Wagner, G.P., Laubichler, M.D. & Bagheri-Chaichian, H. (1998) Genetic measurement of theory of epistatic effects. Genetica 102-103, 569-580.
    • (1998) Genetica , vol.102-103 , pp. 569-580
    • Wagner, G.P.1    Laubichler, M.D.2    Bagheri-Chaichian, H.3
  • 131
    • 0037379663 scopus 로고    scopus 로고
    • Modelling brain diseases in mice: The challenges of design and analysis
    • Watase, K. & Zoghbi, H.Y. (2003) Modelling brain diseases in mice: the challenges of design and analysis. Nat Rev Genet 4, 296-307.
    • (2003) Nat Rev Genet , vol.4 , pp. 296-307
    • Watase, K.1    Zoghbi, H.Y.2
  • 134
    • 0038355301 scopus 로고    scopus 로고
    • Essential conservation of D (1) mutant phenotype at the level of individual topographies of behaviour in mice lacking both D (1) and D (3) dopamine receptors
    • Wong, J.Y., Clifford, J.J., Massalas, J.S., Kinsella, A., Waddington, J.L. & Drago, J. (2003) Essential conservation of D (1) mutant phenotype at the level of individual topographies of behaviour in mice lacking both D (1) and D (3) dopamine receptors. Psychopharmacology (Berl) 167, 167-173.
    • (2003) Psychopharmacology (Berl) , vol.167 , pp. 167-173
    • Wong, J.Y.1    Clifford, J.J.2    Massalas, J.S.3    Kinsella, A.4    Waddington, J.L.5    Drago, J.6
  • 136
    • 0037189057 scopus 로고    scopus 로고
    • Serotonin uptake into dopamine neurons via dopamine transporters: A compensatory alternative
    • Zhou, F.C., Lesch, K.P. & Murphy, D.L. (2002) Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain Res 942, 109-119.
    • (2002) Brain Res , vol.942 , pp. 109-119
    • Zhou, F.C.1    Lesch, K.P.2    Murphy, D.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.