Altered regulation of the 5-HT system in the brain of MAO-A knock-out mice

European Journal of Neuroscience

Volumn 15, Issue 5, 2002, Pages 841-851

  Evrard, A ^a   Malagie I ^b   Laporte, A M ^a   Boni, C ^a   Hanoun, N ^a   Trillat, A C ^b   Seif, I ^c   De Maeyer, E ^c   Gardier, A ^b   Hamon, M ^a   Adrien, J ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c INSTITUT CURIE   (France)

Author keywords

5 HT1A; Monoamine oxidase; Serotonin; Serotonin transporter

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AUTORECEPTOR; CHLORAL HYDRATE; CITALOPRAM; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN; SEROTONIN 1A AGONIST;

ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG POTENCY; ELECTROPHYSIOLOGY; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HYPOTHERMIA; KNOCKOUT MOUSE; MALE; MICRODIALYSIS; MOLECULAR BIOLOGY; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SEROTONIN UPTAKE; SEROTONINERGIC SYSTEM; WILD TYPE;

ACTION POTENTIALS; ANIMALS; AUTORECEPTORS; BRAIN; CARRIER PROTEINS; CITALOPRAM; DOWN-REGULATION; EXTRACELLULAR SPACE; FEMALE; HYDROXYINDOLEACETIC ACID; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; MONOAMINE OXIDASE; NERVE TISSUE PROTEINS; NEURONS; RAPHE NUCLEI; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RNA, MESSENGER; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TRITIUM;

EID: 18744370711     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.01917.x     Document Type: Article

References (42)

1. Aghajanian, G.K., Graham, A.W. & Sheard, M.H. (1970) Serotonin-containing neurons in brain: Depression of firing by monoamine oxidase inhibitors. Science, 169, 1100-1102.
2. 1A receptor gene. J. Biol. Chem., 265, 5825-5832.
3. Baraban, J. & Aghajanian, G. (1980) Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoreceptor antagonists. Neuropharmacology, 19, 355-363.
4. Blier, P. & de Montigny, C. (1985) Serotoninergic but not noradrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors. Neuroscience, 16, 949-955.
5. Blier, P. & de Montigny, C. (1994) Current advances and trends in the treatment of depression. Trends Pharmacol. Sci., 15, 220-226.
6. Bou-Flores, C., Lajard, A.M., Monteau, R., De Maeyer, E., Seif, I., Lanoir, J. & Hilaire, G. (2000) Abnormal phrenic motoneuron activity and morphology in neonatal monoamine oxidase A-deficient transgenic mice: Possible role of a serotonin excess. J. Neurosci., 20, 4646-4656.
7. Brunner, H.G., Nelen, M., Breakefield, X.O., Ropers, H.H. & van Oost, B.A. (1993) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science, 262, 578-580.
8. Cases, O., Seif, I., Grimsby, J., Gaspar, P., Chen, K., Pournin, S., Muller, U., Aguet, M., Babinet, C., Shih, J.C. & De Maeyer, E. (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science, 268, 1763-1766.
9. Cases, O., Vitalis, T., Seif, I., De Maeyer, E., Sotelo, C. & Gaspar, P. (1996) Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: Role of a serotonin excess during the critical period. Neuron, 16, 297-307.
10. Chang, A.S., Chang, S.M., Starnes, D.M., Schroeter, S., Bauman, A.L. & Blakely, R.D. (1996) Cloning and expression of the mouse SERT. Brain Res. Mol. Brain Res., 43, 185-192.
11. 1B knockout mice. Eur. J. Neurosci., 11, 3823-3831.
12. 1B receptors in knockout mice lacking the 5-HT transporter. Eur. J. Neurosci., 12, 1-12.
13. 1A receptors in the rat brain. Eur. J. Pharmacol., 337, 297-308.
14. Fabre, V., Boutrel, B., Hanoun, N., Lanfumey, L., Fattaccini, C.-M., Demeneix, B., Adrien, J., Hamon, M. & Martres, M.P. (2000b) Homeostatic regulation of serotoninergic function by the serotonin transporter as revealed by nonviral gene transfer. J. Neurosci., 20, 5065- 5075.
15. Fabre, V., Mannoury La Cour, C., Rioux, A., Hanoun, N., Martres, M.P., Lesch, K.P., Hamon, M. & Lanfumey, L. (1998) Adaptations of the central serotonergic neurotransmission in mice lacking the 5-HT transporter (5-HTT). Eur. Neuropsychopharmacol., 8, 5188-5189.
16. 1A receptor antagonist. Behav. Brain Res., 73, 337-353.
17. Franklin, K.B. & Paxinos, G. (1996). The Mouse Brain in Stereotaxic Coordinates. Academic Press, Toronto/San Diego.
18. Fuller, R. (1994) Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci., 55, 163-167.
19. Gobbi, G., Murphy, D.L., Lesch, K.-P. & Blier, P. (2001) Modifications of the serotoninergic system in mice lacking serotonin transporter: An in vivo electrophysiological study. J. Pharmacol. Exp. Ther., 296, 987-995.
20. Goodwin, G.M., Souza, R.D. & Green, A.R. (1985) The pharmacology of the hypothermic response in mice to 8-hydroxy-2 (di-n-propylamino) tetralin (8-OH-DPAT). Neuropharmacology, 24, 1187-1194.
21. 1A receptor binding sites in rat brain membranes. Eur. J. Pharmacol. Mol. Pharmacol., 288, 173-186.
22. 1A agonists with potential anxiolytic properties. J. Pharmacol. Exp. Ther., 246, 745-752.
23. Hervas, I. & Artigas, F. (1998) Effect of fluoxetine on extracellular 5-hydroxytryptamine in rat brain. Role of 5-HT autoreceptors. Eur. J. Pharmacol., 358, 9-18.
24. Ikemoto, K., Kitahama, K., Seif, I., Maeda, T., De Maeyer, E. & Valatx, J.L. (1997) Monoamine oxidase B (MAOB)-containing structures in MAOA-deficient transgenic mice. Brain Res., 771, 121-132.
25. 1A receptors in rats treated chronically with a novel antidepressant, cericlamine. J. Pharmacol. Exp. Ther., 268, 1432-1443.
26. Lajard, A.M., Bou, C., Monteau, R. & Hilaire, G. (1999) Serotonin levels are abnormally elevated in the fetus of the monoamine oxidase-A-deficient transgenic mouse. Neurosci. Lett., 261, 41-44.
27. 1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology, 39, 110-122.
28. 1A binding sites in 5-HT transporter knockout mice. J. Pharmacol. Exp. Ther, 291, 999-1007.
29. Maudhuit, C., Hamon, M. & Adrien, J. (1996) Effects of chronic treatment with zimelidine and REM sleep deprivation on the regulation of raphe neuronal activity in a rat model of depression. Psychopharmacology, 124, 267-274.
30. 3H]-imipramine binding sites in rat cerebral cortex after prenatal exposure to antidepressants. Life Sci., 46, 1619-1626.
31. 1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neuron firing. Br. J. Pharmacol., 117, 750-756.
32. 1B receptor subtypes in rat brain. Eur. J. Pharmacol., 281, 229-239.
33. Pineyro, G. & Blier, P. (1999) Autoregulation of serotonin neurons: Role in antidepressant drug action. Pharmacol. Rev., 51, 533-591.
34. Salichon, N., Gaspar, P., Upton, A.L., Picaud, S., Hanoun, N., Hamon, M., De Maeyer, E.E., Murphy, D.L., Mossner, R., Lesch, K.P., Hen, R. & Seif, I. (2001) Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase A and 5-HT transporter knock-out mice. J. Neurosci., 21, 884-896.
35. 1A receptor antagonist on 5-hydroxytryptamine cell firing and release. Eur. J. Pharmacol., 320, 15-19.
36. Siebert, P. & Larrick, J. (1992) Competitive PCR. Nature, 359, 557-558.
37. 1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei. Eur. J. Neurosci., 2, 1144-1154.
38. 1B receptors: In vivo microdialysis studies. J. Neurochem., 69, 2019-2025.
39. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci., 6, 3474-3482.
40. Whitaker-Azmitia, P.M., Zhang, X. & Clarke, C. (1994) Effects of gestational exposure to monoamine oxidase inhibitors in rats: Preliminary behavioral and neurochemical studies. Neuropsychopharmacology, 11, 125-132.
41. 7 receptor. Br. J. Pharmacol., 396, 1-8.
42. Yeghiayan, S.K., Andersen, S.L. & Baldessarini, R.J. (1997) Lack of effect of chronic clorgyline or selegiline on dopamine and serotonin transporters in rat caudate-putamen or nucleus accumbens septi. Neurosci. Lett., 236, 147-150.