Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder

Molecular Psychiatry

Volumn 4, Issue 5, 1999, Pages 463-466

  Bengel, D ^a,b   Greenberg, B D ^a   Cora Locatelli G ^a   Altemus, M ^a   Heils, A ^a   Li, Q ^a   Murphy, D L ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Association study; Genetics; Obsessive compulsive disorder; Serotonin transporter

Indexed keywords

SEROTONIN TRANSPORTER;

ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; OBSESSION; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0032731373     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000550     Document Type: Article

References (28)

1. 1 Weissmann MM, Bland RC, Canino GJ, Greenwald S, Hwu HG, Lee CK et al. The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group. J Clin Psychiatry 1994; 55 Suppl: 5-10.
2. 2 Karno M, Golding JM, Sorenson SB, Burman MA. The epidemiology of obsessive-compulsive disorder in 5 US communities. Arch Gen Psychiatry 1998; 45: 1094-1099.
3. 3 Leckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C et al. Symptoms of obsessive-compulsive disorder. Am J Psychiatry 1997; 54: 911-917.
4. 4 Greenberg BD, Altemus M, Murphy DL. The role of neurotransmitters and neurohormones in obsessive-compulsive disorder. Int Rev Psychiatry 1997; 44: 946-951.
5. 5 Rasmussen SA. Genetic studies of obsessive-compulsive disorder. Ann Clin Psych 1993; 5: 241-248.
6. 6 Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF. A family study of obsessive-compulsive disorder. Am J Psychiatry 1995; 152: 76-84.
7. 7 Goodman WK, Price LH, Delgado PL, Palumbo J, Krystal JH, Nagy LM et al. Specificity for serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder. Arch Gen Psychiatry 1990; 47: 577-585.
8. 8 McDougle CJ, Epperson CN, Price LH, Gelernter J. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive-compulsive disorder. Mol Psychiatry 1998; 3: 270-273.
9. 9 Leonhard HL. New developments in the treatment of obsessive-compulsive disorder. J Clin Psychiatry 1997; 58 Suppl: 39-45.
10. 10 Altemus M, Murphy DL, Greenberg BD, Lesch KP. Intact coding region of the serotonin transporter gene in obsessive-compulsive disorder. Am J Med Genet 1996; 67: 409-411.
11. 11 Lesch KP, Gross J, Franzek E, Wolozin BL, Riederer P, Murphy DL. Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol Psychiatry 1995; 37: 215-223.
12. 12 Novelli E, Nobile M, Diaferia G, Sciuto G, Catalano M. A molecular investigation suggests no relationship between obsessive-compulsive disorder and the dopamine D2 receptor. Neuropsychobiology 1994; 29: 61-63.
13. 13 Esterling LE, Yoshikawa T, Turner G, Badner JA, Bengel D, Gershon ES et al. Serotonin transporter (5-HTT) gene and bipolar affective disorder. Am J Med Gen 1998; 81: 37-40.
14. 14 Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 2621-2624.
15. 15 Bengel D, Lesch KP, Heils A, Hamer DH, Murphy DL. A gene regulatory region polymorphism alters serotonin transporter expression and function in humans. Am J Hum Genet 1996; 59 Suppl: A53.
16. 16 Little KY, McLaughlin DP, Zhang L, Livermore CS, Dalack GW, Patrick M et al. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 1998; 155: 207-213.
17. 17 Greenberg BD, Tolliver TJ, Huang SJ, Li Q, Bengel D, Murphy DL. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 1999; 88: 83-87.
18. 18 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM III-R), 3rd edition, revised. American Psychiatric Press: Washington DC, 1987.
19. 19 Lesch KP, Bengel D, Heils A, Zabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
20. 20 Risch N, Merikangas K. The future of genetic studies of complex human disease. Science 1996; 273: 1516-1517.
21. 21 Plomin R, Owen MJ, McGuffin P. The genetics of complex human behaviors. Science 1994; 264: 1733-1739.
22. 22 Greenberg BD, McMahon FJ, Murphy DL. Serotonin transporter candidate gene studies in affective disorders and personality: promises and potential pitfalls. Mol Psychiatry 1998; 3: 186-189.
23. 23 Lesch KP, Heils A, Bengel D. Genetics of the 5-HT transporter. Allelic variation in functional expression affects anxiety-and depression-related personality traits and susceptibility to affective disorders. In: Wahlstrom J (ed). Genetics and Psychiatric Disorders. Wenner Grenn International Series, Vol 69. Pergamon Press: New York, 1998. pp 105-122.
24. 24 Karayiorgou M, Altemus M, Galke BL, Murphy DL, Gogos JA. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 1997; 94: 4572-4575.
25. 25 Billett EA, Richter MA, King N, Heils A, Lesch KP, Kennedy JL. Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene. Mol Psychiatry 1997; 2: 403-406.
26. 26 Rees M, Norton N, Jones I, McCandless F, Scourfield J, Holmans P et al. Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). Mol Psychiatry 1997; 2: 398-402.
27. 27 Collier DA, Stober G, Li T, Heils A, Catalano M, Di Bella D et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1996; 1: 453-460.
28. 2A promoter polymorphism -1438G/A, anorexia nervosa, and obsessive-compulsive disorder. The Lancet 1998; 351: 1785-1786.