Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come

Annual Review of Genetics

Volumn 34, Issue , 2000, Pages 653-686

  Moore, K J ^a   Nagle, D L ^a  

^a Hypnion Inc   (United States)

Author keywords

Genetics; Mouse; Quantitative trait

Indexed keywords

ATHEROSCLEROSIS; DIABETES MELLITUS; GENE LOCATION; GENE LOCUS; MOLECULAR CLONING; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; QUANTITATIVE TRAIT; REVIEW;

ANIMALS; CHROMOSOME MAPPING; HUMANS; MICE; MODELS, ANIMAL; QUANTITATIVE TRAIT, HERITABLE;

MAMMALIA;

EID: 0034507639     PISSN: 00664197     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genet.34.1.653     Document Type: Review

References (128)

1. The decade of the mouse
2. Diabetes in identical twins. A study of 200 pairs
3. Mouse models of human disease. Part I: Techniques and resources for genetic analysis in mice
4. Mouse models of human disease. Part II: Recent progress and future directions
5. Construction of a genetic map in man using restriction fragment length polymorphism
6. Molecular characterization of the mouse agouti locus
7. The human obesity gene map: The 1997 update
8. Empirical threshold values for quantitative trait mapping
9. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
10. Positional cloning moves from perditional to traditional
11. Genome maps IV. Wall chart
12. A genetic linkage map of the mouse: Current applications and future prospects
13. Highdensity lipoprotein and plaque regression. The good cholesterol gets even better
14. Selective DNA pooling for determination of linkage between a molecular marker and a quantitative trait locus
15. Interval-specific congenic strains (ISCS): An experimental design for mapping a QTL into a 1-centimorgan interval
16. A simple method to calculate resolving power and confidence interval of QTL map location
17. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse
18. Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti
19. Permutation tests for multiple loci affecting a quantitative character
20. Statistical methods for mapping quantitative trait loci from a dense set of markers
21. Comparative maps: The mammalian jigsaw puzzle
22. Natural statins and stroke risk
23. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
24. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
25. Polygenic control of autoimmune diabetes in nonobese diabetic mice
26. Genetic analysis of NIDDM. The study of quantitative traits
27. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies
28. Analysis of the Mom1 modifer of intestinal neoplasia in mice
29. The recombinant congenic strains for analysis of multigenic traits: Genetic composition
30. The mouse mahogany locus encodes a transmembrane form of human attractin
31. Risk factors for coronary artery disease in families of young men with myocardial infarction
32. Mapping of obesity QTL in a cross between mouse lines divergently selected on fat content
33. The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL/KsJ and C57BL/6J strains
34. KK mouse
35. Genetic modification of hearing in tubby mice: Evidence for the existence of a major gene (moth1) which protects tubby mice from hearing loss
36. Recombinant inbred mouse strains: Models for disease study
37. Test of candidate gene - Quantitative trait locus association applied to fatness in mice
38. Methods of segregation analysis for animal breeding data: Parameter estimates
39. MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations
40. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps
41. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
42. A major effect QTL determined by multiple genes in epileptic, EL mice
43. The NOD mouse: A model for analyzing the interplay between heredity and environment in development of autoimmune disease
44. The polygenics of diabesity in mice
45. Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains
46. Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: Identification of a candidate segment of ancestral DNA by haplotype mapping
47. The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of Apc Min-induced intestinal neoplasia
48. Breeding of a non-obese, diabetic strain of mice
49. A Macintosh program for storage and analysis of experimental genetic mapping data
50. Overview of QTL mapping software and introduction to map manager QT
51. Theoretical and empirical issues for marker assisted breeding of congenic mouse strains
52. Current perspectives on statins
53. Atherosclerosis is the leading cause of death in the developed societies
54. The measurement of linkage
55. Umbrous: A case of dominance modification in mice
56. Hemorheologic changes in diabetes and their role in increased atherogenesis
57. Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model
58. Genetic susceptibility to death from coronary heart disease in a study of twins
59. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation
60. Genetic studies of the mouse mutations mahogany and mahoganoid
61. The recombinant congenic strains; a novel genetic tool applied to the study of colon tumor development in the mouse
62. Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death
63. The murine dilute suppressor gene dsu suppresses the coat-color phenotype of three pigment mutations that alter melanocyte morphology, d, ash and ln
64. Utilization of mouse models in the discovery of human disease genes
65. Polygenic control of susceptibility to murine systemic lupus erythematosus
66. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain Mamm
67. Functional dissection of systemic lupus erythematosus using congenic mouse strains
68. The laboratory mouse - A historical perspective
69. Quantitative trait loci analysis for the differences in susceptibility to atherosclerosis and diabetes between inbred mouse strains C57BL/6J and C57BLKS/J
70. Analysing complex genetic traits with chromosome substitution strains
71. The mahogany protein is a receptor involved in suppression of obesity
72. A diabetic strain of the mouse
73. Studies on a diabetic (KK) strain of the mouse
74. Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins
75. Breeding of mice strains for diabetes mellitus
76. Atherosclerosis and plasma and liver lipids in mine inbred strains of mice
77. Genetic-epidemiologic study of early-onset ischemic heart disease
78. Anchored reference loci for comparative genome mapping in mammals
79. Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice
80. Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice
81. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice
82. Genetics of responsiveness to high-fat and high-cholesterol diets in the mouse
83. Genetic analysis of the difference in diet-induces atherosclerosis between the inbred mouse strains SM/J and NZB/BINJ
84. Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1
85. Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3
86. Genetic dissection of obesity in polygenic animal models
87. Sever hypercholesterolemia and atherosclerosis in apoliprotein E-deficient mice created by homologus recombination in ES cells
88. Hereditary diabetes in the KK mouse: An overview
89. Genetic factors in the development of atheroma and in serum total cholesterol levels in inbred mice and their hybrids
90. The pathogenesis of atherosclerosis: A perspective for the 1990s
91. Mechanisms of disease: Atherosclerosis. An inflammatory disease
92. Conserved segment identification
93. Functional genomics in the mouse: Phenotyped-based mutagenesis screens
94. Major histocompatibility complex class I-deficient NOD-B2m null mice are diabetes and insulitis resistant
95. Genetic dissection of SLE pathogenesis: Adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells
96. Ath-3, a new gene for atherosclerosis in the mouse
97. Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice
98. y allele on quantitative regulation
99. Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice
100. Functional screening of an asthma QTL in YAC transgenic mice
101. Genetics of susceptibility to radiation-induced lymphomas, leukemias and lung tumors studied in recombinant congenic strains
102. High-resolution mapping of quantitative trait loci in outbred mice
103. Identification and expression cloning of a leptin receptor OB-R
104. Aetiology of non-insulin-dependent diabetes
105. PCR-amplification of simple sequence repeat variants from pooled DNA samples for rapidly mapping new mutations of the mouse
106. Gender-influenced obesity QTLs identified in a cross involving the KK type II diabetes-prone mouse strain
107. Location of polygenes
108. Aggregation of deaths from ischaemic heart disease among first and second degree relatives of 108 males and 42 females with myocardial infarction
109. A protective role of the environment in the development of type 1 diabetes
110. Genetic analysis of autoimmune type 1 diabetes mellitus in mice
111. Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus
112. LOD significance thresholds for QTL analysis in experimental populations of diploid species
113. Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice
114. Four new colon cancer susceptibility loci, Scc6 to Scc9 in the mouse
115. Speed congenics: Accelerated genome recovery using genetic markers
116. Speed congenics: A classic technique in the fast lane
117. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model
118. Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes
119. Genetic control of autoimmune diabetes in the NOD mouse
120. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: An approach for the genetic dissection of complex traits
121. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apoliprotien E
122. Positional cloning of the mouse obese gene and its human homologue