Reduced aggression in mice lacking the serotonin transporter

Psychopharmacology

Volumn 161, Issue 2, 2002, Pages 160-167

  Holmes, Andrew ^a   Murphy, Dennis L ^a   Crawley, Jacqueline N ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Aggression; Knockout mouse; Locomotor activity; Resident intruder; RU24969; Serotonin transporter

Indexed keywords

5 METHOXY 3 (1,2,3,6 TETRAHYDRO 4 PYRIDYL) 1H INDOLE; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN TRANSPORTER;

AGGRESSION; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CIRCADIAN RHYTHM; CONTROLLED STUDY; DESENSITIZATION; EXPOSURE; GENE DELETION; KNOCKOUT MOUSE; LOCOMOTION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM;

AGGRESSION; ANIMALS; BEHAVIOR, ANIMAL; CARRIER PROTEINS; HOMING BEHAVIOR; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; REACTION TIME; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0036250544     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-002-1024-3     Document Type: Article

References (71)

1. Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice
2. 1B receptor gene by homologous recombination: In vitro and in vivo characterization
3. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide
4. Absence of 5-HT(1B) receptors is associated with impaired impulse control in male 5-HT(1B) knockout mice
5. CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence
6. 1B agonist
7. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA
8. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II
9. Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase
10. Central serotonin and impulsive aggression
11. Impulsive aggression and central serotonergic system function in humans: An example of a dimensional brain-behavior relationship
12. Influence of genetic knockout (KO) of the serotonin transporter (5-HTT) on kinetics of 5-HT clearance and 5-HT1B receptor regulation of 5-HT clearance in vivo
13. 1B receptors in knock-out mice lacking the 5-HT transporter
14. Specific anti-aggressive effects of fluprazine hydrochloride
15. Effects of para-chlorophenylalanine and 5-hydroxytryptophan on mouse killing behavior in killer rats
16. Manipulations of dietary tryptophan: Effects on mouse killing and brain serotonin in the rat
17. Modifications of the serotonergic system in mice lacking serotonin transporters: An in vivo electrophysiological study
18. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets
19. Intermale aggression and dark/light preference in ten inbred mouse strains
20. Serotonin transporter and seasonal variation in blood serotonin in families with obsessive-compulsive disorder
21. Allelic variation of human serotonin transporter gene expression
22. Application of experimental stressors in laboratory rodents
23. In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates
24. Abnormal emotional behaviors and age-related obesity in 5-HT transporter deficient mice
25. 5-Hydroxtryptophan receptors and effector coupling mechanisms in peripheral tissues
26. 1B agonists induce anorexia at a postsynaptic site
27. Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity
28. Impulsivity, aggression, and serotonin: A molecular psychobiological perspective
29. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
30. Reduction of 5-hydroxytryptamine (5-HT) (1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice
31. 1A) in 5-HT transporter knock-out mice: Gender and brain region differences
32. Aggression, suicidality, and serotonin
33. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels
34. Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample
35. Effects of serotonin transporter inactivation on extracellular 5-HT levels, in vivo microdialysis recovery and MDMA-induced release of serotonin and dopamine in mouse striatum
36. Drug effects on agonistic behavior
37. Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes
38. 1A receptor agonists
39. Aggressive behavioral phenotypes in mice
40. Inhibition of mouse killing behavior by serotonin-mimetic drugs: Effects of partial alterations of serotonin neurotransmission
41. Genetic perspective on the serotonin transporter
42. Molecular basis of aggression
43. Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase
44. 1 agonist RU24969 and effects on dopaminergic behaviour
45. Serotonergic modulation of social interactions in isolated male mice
46. Serotonin receptors and animal models of aggressive behavior
47. 1B receptors
48. 1C binding sites in rat frontal cortex
49. Barrel pattern formation requires serotonin uptake by thalamocortical endings, while vesicular monoamine release is necessary for development of supragranular layers
50. Effects of 5-HT receptor subtype-selective drugs on locomotor activity and motor habituation in the DHT adult rat model
51. 1B receptor activation mimics behavioral effects of presynaptic serotonin release
52. Suicidal behavior in depression: Relationship to platelet serotonin transporter
53. Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase A and 5-HT transporter knock-out mice
54. 2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice
55. The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice
56. 1B receptor
57. 5-HT receptor knockout mice: Pharmacological tools or models of psychiatric disorders
58. A comparative study of aggression related changes in brain serotonin in CBA, C57BL, and DBA mice
59. Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A
60. 1 receptors and offensive aggression in rats: A combined behavioural and autoradiographic study with eltoprazine
61. Molecular mechanisms of cocaine reward: Combined dopamine and serotonin transporter knockouts eliminate cocaine place preference
62. 1A receptor response in NCAM null mutant mice
63. 1 receptor agonist, RU24969, in the rat
64. Aggressive behavior induced by isolation
65. Aggressiveness by isolation and brain serotonin turnover changes in different strains of mice
66. p-Chlorophenylalanine-induced muricidal aggression in male and female laboratory rats
67. The concept of selectivity in 5-HT receptor research
68. Parachlorophenylalanine-induced serotonin depletion increases offensive but not defensive aggression in male rats
69. Habituation of aggressive-behavior in mice - A parametric study
70. Family-based association study of serotonin transporter promoter in suicidal adolescents: No association with suicidality but possible role in violence traits