메뉴 건너뛰기




Volumn 27, Issue 5, 2003, Pages 557-565

Antiobesity and antidiabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance

Author keywords

Diabetic mice; Glucose tolerance; Leptin resistance; Neurotrophic factor; Obesity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; LEPTIN; INSULIN;

EID: 0038028204     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0802265     Document Type: Article
Times cited : (91)

References (43)
  • 1
    • 0035936764 scopus 로고    scopus 로고
    • Obesity and the regulation of energy balance
    • Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 2001; 104: 531-543.
    • (2001) Cell , vol.104 , pp. 531-543
    • Spiegelman, B.M.1    Flier, J.S.2
  • 6
    • 0032014836 scopus 로고    scopus 로고
    • A leptin missense mutation associated with hypogonadism and morbid obesity
    • Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998; 18: 213-215.
    • (1998) Nat Genet , vol.18 , pp. 213-215
    • Strobel, A.1    Issad, T.2    Camoin, L.3    Ozata, M.4    Strosberg, A.D.5
  • 12
    • 0029892470 scopus 로고    scopus 로고
    • Physiology of the neurotrophins
    • Lewin GR, Barde YA. Physiology of the neurotrophins. Annu Rev Neurosci 1996; 19: 289-317.
    • (1996) Annu Rev Neurosci , vol.19 , pp. 289-317
    • Lewin, G.R.1    Barde, Y.A.2
  • 15
    • 0033963228 scopus 로고    scopus 로고
    • Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice
    • Ono M, Itakura Y, Nonomura T, Nakagawa T, Nakayama C, Taiji M, Noguchi H. Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice. Metabolism 2000; 49: 129-133.
    • (2000) Metabolism , vol.49 , pp. 129-133
    • Ono, M.1    Itakura, Y.2    Nonomura, T.3    Nakagawa, T.4    Nakayama, C.5    Taiji, M.6    Noguchi, H.7
  • 18
    • 0028090302 scopus 로고
    • The trk family of neurotrophin receptors
    • Barbacid M. The trk family of neurotrophin receptors. J Neurobiol 1994; 25: 1386-1403.
    • (1994) J Neurobiol , vol.25 , pp. 1386-1403
    • Barbacid, M.1
  • 20
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • Kernie SG, Liebl D, Parada L. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 2000; 19: 1290-1300.
    • (2000) EMBO J , vol.19 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.2    Parada, L.3
  • 21
    • 0030279364 scopus 로고    scopus 로고
    • Genetics of obesity: Advances from rodent studies
    • Chagnon YC, Bouchard C. Genetics of obesity: advances from rodent studies. Trends Genet 1996; 12: 441-444.
    • (1996) Trends Genet , vol.12 , pp. 441-444
    • Chagnon, Y.C.1    Bouchard, C.2
  • 24
    • 0030669288 scopus 로고    scopus 로고
    • Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity
    • Widdowson PS, Upton R, Buckingham R, Arch J, Williams G. Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity. Diabetes 1997; 46: 1782-1785.
    • (1997) Diabetes , vol.46 , pp. 1782-1785
    • Widdowson, P.S.1    Upton, R.2    Buckingham, R.3    Arch, J.4    Williams, G.5
  • 25
    • 0034107525 scopus 로고    scopus 로고
    • Development of high fat diet-induced obesity and leptin resistance in C57B1/6J mice
    • Lin S, Thomas TC, Storlien LH, Huang XF. Development of high fat diet-induced obesity and leptin resistance in C57B1/6J mice. Int J Obes Relat Metab Disord 2000; 24: 639-646.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 639-646
    • Lin, S.1    Thomas, T.C.2    Storlien, L.H.3    Huang, X.F.4
  • 28
    • 0032768291 scopus 로고    scopus 로고
    • Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: Usefulness of leptin for the treatment of obesity-associated diabetes
    • Masuzaki H, Ogawa Y, Aizawa-Abe M, Hosoda K, Suga J, Ebihara K, Satoh N, Iwai H, Inoue G, Nishimura H, Yoshimasa Y, Nakao K. Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes. Diabetes 1999; 48: 1615-1622.
    • (1999) Diabetes , vol.48 , pp. 1615-1622
    • Masuzaki, H.1    Ogawa, Y.2    Aizawa-Abe, M.3    Hosoda, K.4    Suga, J.5    Ebihara, K.6    Satoh, N.7    Iwai, H.8    Inoue, G.9    Nishimura, H.10    Yoshimasa, Y.11    Nakao, K.12
  • 29
    • 0032547042 scopus 로고    scopus 로고
    • Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system
    • Satoh N, Ogawa Y, Katsuura G, Numata Y, Masuzaki H, Yoshimasa Y, Nakao K. Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci Lett 1998; 249: 107-110.
    • (1998) Neurosci Lett , vol.249 , pp. 107-110
    • Satoh, N.1    Ogawa, Y.2    Katsuura, G.3    Numata, Y.4    Masuzaki, H.5    Yoshimasa, Y.6    Nakao, K.7
  • 30
    • 0033931981 scopus 로고    scopus 로고
    • Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
    • El-Haschimi K, Pierroz DD, Hileman SM, Bjørbaek C, Flier JS. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 2000; 105: 1827-1832.
    • (2000) J Clin Invest , vol.105 , pp. 1827-1832
    • El-Haschimi, K.1    Pierroz, D.D.2    Hileman, S.M.3    Bjørbaek, C.4    Flier, J.S.5
  • 32
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjørbæk C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272: 32686-32695.
    • (1997) J Biol Chem , vol.272 , pp. 32686-32695
    • Bjørbæk, C.1    Uotani, S.2    Da Silva, B.3    Flier, J.S.4
  • 33
    • 0034457883 scopus 로고    scopus 로고
    • In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
    • Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 2000; 141: 2328-2339.
    • (2000) Endocrinology , vol.141 , pp. 2328-2339
    • Kim, Y.B.1    Uotani, S.2    Pierroz, D.D.3    Flier, J.S.4    Kahn, B.B.5
  • 34
    • 0027451877 scopus 로고
    • Signal transduction events mediated by the BDNF receptor gp145 TrkB in primary hippocampal pyramidal cell culture
    • Marsh HN, Scholz WK, Lamballe F, Klein R, Nanduri V, Barbacid M, Palfrey HC. Signal transduction events mediated by the BDNF receptor gp145 TrkB in primary hippocampal pyramidal cell culture. J Neurosci 1993; 13: 4281-4292.
    • (1993) J Neurosci , vol.13 , pp. 4281-4292
    • Marsh, H.N.1    Scholz, W.K.2    Lamballe, F.3    Klein, R.4    Nanduri, V.5    Barbacid, M.6    Palfrey, H.C.7
  • 35
    • 0029809187 scopus 로고    scopus 로고
    • N-Shc: A neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway
    • Nakamura T, Sanokawa R, Sasaki Y, Ayusawa D, Oishi M, Mori N. N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. Oncogene 1996; 13: 1111-1121.
    • (1996) Oncogene , vol.13 , pp. 1111-1121
    • Nakamura, T.1    Sanokawa, R.2    Sasaki, Y.3    Ayusawa, D.4    Oishi, M.5    Mori, N.6
  • 36
    • 0030856143 scopus 로고    scopus 로고
    • Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons
    • Yamada M, Ohnishi H, Sano S, Nakatani A, Ikeuchi T, Hatanaka H. Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons. J Biol Chem 1997; 272: 30334-30339.
    • (1997) J Biol Chem , vol.272 , pp. 30334-30339
    • Yamada, M.1    Ohnishi, H.2    Sano, S.3    Nakatani, A.4    Ikeuchi, T.5    Hatanaka, H.6
  • 41
    • 0029084805 scopus 로고
    • Interleukin-6 family of cytokines and gp130
    • Kishimoto T, Akira S, Narazaki M, Taga T. Interleukin-6 family of cytokines and gp130. Blood 1995; 86: 1243-1254.
    • (1995) Blood , vol.86 , pp. 1243-1254
    • Kishimoto, T.1    Akira, S.2    Narazaki, M.3    Taga, T.4
  • 42
    • 0029940555 scopus 로고    scopus 로고
    • The neurotrophins and CNTF: Two families of collaborative neurotrophic factors
    • Ip NY, Yancopoulos GD. The neurotrophins and CNTF: two families of collaborative neurotrophic factors. Annu Rev Neurosci 1996; 19: 491-515.
    • (1996) Annu Rev Neurosci , vol.19 , pp. 491-515
    • Ip, N.Y.1    Yancopoulos, G.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.