A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders

Molecular Psychiatry

Volumn 8, Issue 6, 2003, Pages 574-591

  Anguelova, M ^a   Benkelfat, C ^b   Turecki, Gustavo ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Bipolar disorder; Genetic association studies; Genetic polymorphisms; Major depressive disorder; Serotonin receptors; Serotonin transporter

Indexed keywords

CARRIER PROTEIN; MEMBRANE PROTEIN; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER;

BIPOLAR DISORDER; GENE DELETION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETICS; HUMAN; INTRON; MAJOR DEPRESSION; META ANALYSIS; MOOD DISORDER; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; VARIABLE NUMBER OF TANDEM REPEAT;

CARRIER PROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOOD DISORDERS; NERVE TISSUE PROTEINS; RECEPTORS, SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0041346384     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001328     Document Type: Review

References (74)

1. Murray CJL, Lepez AD. The global burden of disease. In: Murray CJL, Lopez AD (eds). The Global Burden of Disease and Injury. WHO: Genevea, 1998.
2. Merikangas K, Chakravarti A, Moldin S, Araj H, Blangero J, Burmeister M et al. Future of genetics of mood disorders research. Biol Psychiatry 2002; 52: 457
3. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996; 273: 1516-1517.
4. Collins FS, Guyer MS, Charkravarti A. Variations on a theme: cataloging human DNA sequence variation. Science 1997; 278: 1580-1581.
5. Duman RS. The neurochemistry of mood disorders: preclinical studies. In: Charney DS, Nestler EJ, Bunney BS (eds). Neurobiology of Mental Illness. Oxford University Press: New York, 1999, pp. 333-347.
6. Mulrow CD. The medical review article: state of the science. Ann Intern Med 1987; 106: 485-488.
7. Mulrow CD. Rationale for systematic reviews. BMJ 1994; 309: 597-599.
8. Olkin I. Statistical and theoretical considerations in meta-analysis. J Clin Epidemiol 1995; 48: 133-146.
9. Rosenthal R. Comparing and combining research results. In: Rosenthal R (ed). Meta-analytic procedures for social research. Sage Publications: Beverley Hills, CA, 1984, p. 63-111.
10. Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and transporter: II. Suicidal behavior. Mol Psychiatry, in press.
11. Fleiss J. Combining evidence from fourfold tables. In: Statistical Methods for Rates and Proportions. Wiley: New York, 1981, pp. 160-187.
12. Huang YY, Grailhe R, Arango V, Hen R, Mann JJ. Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue. Neuropsychopharmacology 1999; 21: 238-246.
13. Fehr C, Grintschuk N, Szegedi A, Anghelescu I, Klawe C, Singer P et al. The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. Psychiatry Res 2000; 97: 1-10.
14. Minov C, Baghai TC, Schule C, Zwanzger P, Schwarz MJ, Zill P et al. Serotonin-2A-receptor and -transporter polymorphisms: lack of association in patients with major depression. Neurosci Lett 2001; 303: 119-122.
15. Du L, Bakish D, Lapierre YD, Ravindran AV, Hrdina PD. Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am J Med Genet 2000; 96: 56-60.
16. Arias B, Gutierrez B, Pintor L, Gasto C, Fananas L. Variability in the 5-HT(2A) receptor gene is associated with seasonal pattern in major depression. Mol Psychiatry 2001; 6: 239-242.
17. Bondy B, Kuznik J, Baghai T, Schule C, Zwanzger P, Minov C et al. Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide. Am J Med Genet 2000; 96: 831-835.
18. Zhang HY, Ishigaki T, Tani K, Chen K, Shih JC, Miyasato K et al. Serotonin2A receptor gene polymorphism in mood disorders. Biol Psychiatry 1997; 41: 768-773.
19. Tsai SJ, Hang CJ, Hsu CC, Cheng CY, Liao WY, Song HL et al. Serotonin-2A receptor polymorphism (102T/C) in mood disorders. Psychiatry Res 1999; 87: 233-237.
20. Frisch A, Postilnick D, Rockah R, Michaelovsky E, Postilnick S, Birman E et al. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Mol Psychiatry 1999; 4: 389-392.
21. Enoch MA, Goldman D, Barnett R, Sher L, Mazzanti CM, Rosenthal NE. Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A. Mol Psychiatry 1999; 4: 89-92.
22. Bonnier B, Gorwood P, Hamon M, Sarfati Y, Boni C, Hardy B. Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk. Biol Psychiatry 2002; 51: 762-765.
23. Ohara K, Nagai M, Tsukamoto T, Tani K, Suzuki Y, Ohara K. 5-HT2A receptor gene promoter polymorphism -1438G/A and mood disorders. Neuroreport 1998; 9: 1139-1141.
24. Lerer B, Macciardi F, Segman RH, Adolfsson R, Blackwood D, Blairy S et al. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Mol Psychiatry 2001; 6: 579-585.
25. Arias B, Collier DA, Gasto C, Pintor L, Gutierrez B, Valles V et al. Genetic variation in the 5-HT5A receptor gene in patients with bipolar disorder and major depression. Neurosci Lett 2001; 303: 111-114.
26. Birkett JT, Arranz MJ, Munro J, Osbourn S, Kerwin RW, Collier DA. Association analysis of the 5-HT5A gene in depression, psychosis and antipsychotic response. Neuroreport 2000; 11: 2017-2020.
27. Hong CJ, Tsai SJ, Cheng CY, Liao WY, Song HL, Lai HC. Association analysis of the 5-HT(6) receptor polymorphism (C267T) in mood disorders. Am J Med Genet 1999; 88: 601-602.
28. Wu WH, Huo SJ, Cheng CY, Hong CJ, Tsai SJ. Association study of the 5-HT(6) receptor polymorphism (C267T) and symptomatology and antidepressant response in major depressive disorders. Neuropsychobiology 2001; 44: 172-175.
29. Golimbet VE, Alfimova MV, Manandyan KK, Mitushina NG, Abramova LI, Kaleda VG et al. 5HTR2A gene polymorphism and personality traits in patients with major psychoses. Eur Psychiatry 2002; 17: 24-28.
30. Serretti A, Lilli R, Lorenzi C, Lattuada E, Smeraldi E. Serotonin-2C and serotonin-1A receptor genes are not associated with psychotic symptomatology of mood disorders. Am J Med Genet 2000; 96: 161-166.
31. Serretti A, Lilli R, Lorenzi C, Smeraldi E. No association between serotonin-2A receptor gene polymorphism and psychotic symptomatology of mood disorders. Psychiatry Res 1999; 86: 203-209.
32. Liu HC, Hong CJ, Liu CY, Lin KN, Tsai SJ, Liu TY et al. Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease. Psychiatry Clin Neurosci 2001; 55: 427-429.
33. Ohara K, Nagai M, Tsukamoto T, Tani K, Suzuki Y, Ohara K. Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders. Biol Psychiatry 1998; 44: 550-554.
34. Collier DA, Stober G, Li T, Heils A, Catalano M, Di B et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1996; 1: 453-460.
35. Rees M, Norton N, Jones I, McCandless F, Scourfield J, Holmans P et al. Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). Mol Psychiatry 1997; 2: 398-402.
36. Kunugi H, Hattori M, Kato T, Tatsumi M, Sakai T, Sasaki T et al. Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry 1997; 2: 457-462.
37. Hoehe MR, Wendel B, Grunewald I, Chiaroni P, Levy N, Morris R et al. Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. Am J Med Genet 1998; 81: 1-3.
38. Furlong RA, Ho L, Walsh C, Rubinsztein JS, Jain S, Paykel ES et al. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet 1998; 81: 58-63.
39. Gutierrez B, Pintor L, Gasto C, Rosa A, Bertranpetit J, Vieta E et al. Variability in the serotonin transporter gene and increased risk for major depression with melancholia. Hum Genet 1998; 103: 319-322.
40. Bellivier F, Henry C, Szoke A, Schurhoff F, Nosten B, Feingold J et al. Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci Lett 1998; 255: 143-146.
41. Oliveira JR, Carvalho DR, Pontual D, Gallindo RM, Sougey EB, Gentil V et al. Analysis of the serotonin transporter polymorphism (5-HTTLPR) in Brazilian patients affected by dysthymia, major depression and bipolar disorder. Mol Psychiatry 2000; 5: 348-349.
42. Battersby S, Ogilvie AD, Smith CA, Blackwood DH, Muir WJ, Quinn JP et al. Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder. Psychiatr Genet 6: 177-181.
43. Liu W, Gu N, Feng G, Li S, Bai S, Zhang J et al. Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. Pharmacogenetics 1999; 9: 491-495.
44. Collier DA, Arranz MJ, Sham P, Battersby S, Vallada H, Gill P et al. The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. Neuroreport 1996; 7: 1675-1679.
45. Stober G, Heils A, Lesch KP. Serotonin transporter gene polymorphism and affective disorder. Lancet 1996; 347: 1340-1341.
46. Kunugi H, Tatsumi M, Sakai T, Hattori M, Nanko S. Serotonin transporter gene polymorphism and affective disorder. Lancet 1996; 347: 1340-1340.
47. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwim GM et al. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996; 347: 731-733.
48. Erdmann J, Shimron A, Cichon S, Albus M, Maier W, Lichtermann D et al. Systematic screening for mutations in the promoter and the coding region of the 5-HT1A gene. Am J Med Genet 1995; 60: 393-399.
49. Bruss M, Bonisch H, Buhlen M, Nothen MM, Propping P, Gothert M, Modified ligand binding to the naturally occurring Cys-124 variant of the human serotonin 5-HT1B receptor. Pharmacogenetics 1999; 9: 95-102.
50. Shimron A, Harms H, Erdmann J, Albus M, Maier W, Rietschel M et al. Systematic screening for mutations in the human serotonin 1F receptor gene in patients with bipolar affective disorder and schizophrenia. Am J Med Genet 1996; 67: 225-228.
51. Gutierrez B, Bertranpetit J, Collier D, Arranz MJ, Valles V, Guillamat R et al. Genetic variation of the 5-HT2A receptor gene and bipolar affective disorder. Hum Genet 1997; 100: 582-584.
52. Arranz MJ, Erdmann J, Kirov G, Rietschel M, Sodhi M, Albus M et al. 5-HT2A receptor and bipolar affective disorder: association studies in affected patients. Neurosci Lett 1997; 224: 95-98.
53. Massat I, Souery D, Lipp O, Blairy S, Papadimitriou G, Dikeos D et al. A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder. Am J Med Genet 2000; 96: 136-140.
54. Mahieu B, Souery D, Lipp O, Mendelbaum K, Verheyen G, De M et al. No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism. Psychiatry Res 1997; 70: 65-69.
55. Blairy S, Massat I, Staner L, Le B, Van G, Van B et al. 5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait. Am J Med Genet 2000; 96: 360-364.
56. Tut TG, Wang JL, Lim CC. Negative association between T102C polymorphism at the 5-HT2A receptor gene and bipolar affective disorders in Singaporean Chinese. J Affect Disord 2000; 58: 211-214.
57. Heiden A, Schussler P, Itzlinger U, Leisch F, Scharfetter J, Gebhardt C et al. Association studies of candidate genes in bipolar disorders. Neuropsychobiology 2000; 42 (Suppl 1): 18-21.
58. Chee IS, Lee SW, Kim JL, Wang SK, Shin YO, Shin SC et al. 5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder. Psychiatr Genet 2001; 11: 111-114.
59. Gutierrez B, Arias B, Papiol S, Rosa A, Fananas L. Association study between novel promoter variants at the 5-HT2C receptor gene and human patients with bipolar affective disorder. Neurosci Lett 2001; 309: 135-137.
60. Gutierrez B, Fananas L, Arranz MJ, Valles V, Guillamat R, Van O et al. Allelic association analysis of the 5-HT2C receptor gene in bipolar affective disorder. Neurosci Lett 1996; 212: 65-67.
61. Oruc L, Verheyen GR, Furac I, Jakovljeviç M, Iveziç S, Raeymaekers P et al. Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder. Am J Med Genet 1997; 74: 504-506.
62. Niesler B, Weiss B, Fischer C, Nothen MM, Propping P, Bondy B et al. Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients. Pharmacogenetics 2001; 11: 21-27.
63. Vogt IR, Shimron A, Neidt H, Erdmann J, Cichon S, Schulze TG et al. Investigation of the human serotonin 6 (5-HT6) receptor gene in bipolar affective disorder and schizophrenia. Am J Med Genet 2000; 96: 217-221.
64. Erdmann J, Nothen MM, Shimron A, Rietschel M, Albus M, Borrmann M et al. The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder. Mol Psychiatry 1996; 1: 392-397.
65. Rotondo A, Mazzanti C, Dell O, Rucci P, Sullivan P, Bouanani S et al. Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. Am J Psychiatry 2002; 159: 23-29.
66. Gutierrez B, Arranz MJ, Collier DA, Valles V, Guillamat R, Bertranpetit J et al. Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population. Biol Psychiatry 1998; 43: 843-847.
67. Ospina D, Duque C, Carvajal C, Ortiz B, Soto I, Pineda N et al. An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Columbia. Neurosci Lett 2000; 292: 199-202.
68. Saleem Q, Ganesh S, Vijaykumar M, Reddy YC, Brahmachari SK, Jain S. Association analysis of 5HT transporter gene in bipolar disorder in the Indian population. Am J Med Genet 2000; 96: 170-172.
69. Mendes de Oliveira JR, Otto PA, Vallada H, Lauriano V, Elkis H, Lafer B et al. Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia. Am J Med Genet 1998; 81: 225-227.
70. Bellivier F, Laplanche JL, Leboyer M, Feingold J, Bottos C, Allilaire JF et al. Serotonin transporter gene and manic depressive illness: an association study. Biol Psychiatry 1997; 41: 750-752.
71. Ho LW, Furlong RA, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC. Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder. Am J Med Genet 2000; 96: 36-42.
72. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet 2001; 29: 306-309.
73. Nakamura M, Ueno S, Sano A, Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 2000; 5: 32-38.
74. Sakai K, Nakamura M, Ueno S, Sano A, Sakai N, Shirai Y et al. The silencer activity of the novel human serotonin transporter linked polymorphic regions. Neurosci Lett 2002; 327: 13-16.