Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 114, Issue 8, 2002, Pages 975-979

  Mill, Jonathan ^a   Asherson, Philip ^a   Browes, Clare ^a   D'Souza, Ursula ^a   Craig, Ian ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Attention deficit hyperactivity disorder; Dopamine transporter gene (DAT1); Expression; Quantitative RT PCR; TaqMan; VNTR

Indexed keywords

COMPLEMENTARY DNA; DOPAMINE TRANSPORTER; GENOMIC DNA; CARRIER PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; SLC6A3 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ARTICLE; ATTENTION DEFICIT DISORDER; BRAIN; CLINICAL ARTICLE; DOPAMINERGIC SYSTEM; GENE EXPRESSION REGULATION; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HUMAN; HUMAN CELL; LYMPHOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VARIABLE NUMBER OF TANDEM REPEAT; GENETICS; PHYSIOLOGY;

3' UNTRANSLATED REGIONS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GENE EXPRESSION REGULATION; HUMANS; LYMPHOCYTES; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MINISATELLITE REPEATS; NERVE TISSUE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0037045132     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.10948     Document Type: Article

References (24)

1. Amenta F, Bronzetti E, Cantalamessa F, El-Assouad D, Felici L, Ricci A, Tayebati SK. 2001. Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes. J Neuroimmunol 117:133-142.
2. Barr CL, Xu C, Kroft J, Feng Y, Wigg K, Zai G, Tannock R, Schachar R, Malone M, Roberts W, Nothen MM, Grunhage F, Vandenbergh DJ, Uhi G, Sunohara G, King N, Kennedy JL. 2001. Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder. Biol Psychiatry 49:333-339.
3. Chen K, Chen SL, Mill J, Huang YS, Lin SK, Curran S, Purcell S, Sham P, Asherson P. The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample. Mol Psychiatry (in press).
4. Cook EH Jr, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE, Leventhal BL. 1995. Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet 56:993-998.
5. Curran S, Mill J, Tahir E, Kent L, Richards S, Gould A, Huckett L, Sharp J, Batten C, Fernando S, Ozbay F, Yazgan Y, Simonoff E, Thompson M, Taylor E, Asherson P. 2001. Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry 6:425-428.
6. Daly G, Hawi Z, Fitzgerald M, Gill M. 1999. Mapping susceptibility loci in attention deficit hyperactivity disorder: Preferential transmission of parental alleles at DAT1, DBH, and DRD5 to affected children. Mol Psychiatry 4:192-196.
7. Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Madras BK, Fischman AJ. 1999. Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet 354:2132-2133.
8. Dresel S, Krause J, Krause KH, LaFougere C, Brinkbaumer K, Kung HF, Hahn K, Tatsch K. 2000. Attention deficit hyperactivity disorder: Binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment. Eur J Nucl Med 27:1518-1524.
9. Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S. 2001. The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J 1:152-156.
10. Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M. 1997. Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry 2:311-313.
11. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. 1996. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612.
12. Heinz A, Goldman D, Jones DW, Palmour R, Hommer D, Gorey JG, Lee KS, Linnoila M, Weinberger DR. 2000. Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology 22:133-139.
13. Holmes J, Payton A, Barrett JH, Hever T, Fitzpatrick H, Trumper AL, Harrington R, McGuffin P, Owen M, Ollier W, Worthington J, Thapar A. 2000. A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficil: Hyperactivity disorder. Mol Psychiatry 5:523-530.
14. Jacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, Gelernter J. 2000. Prediction of dopamine transporter binding availability by genotype: A preliminary report. Am J Psychiatry 157:1700-1703.
15. Krause KH, Dresel SH, Krause J, Kung HF, Tatsch K. 2000. Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: Effects of methylphenidate as measured by single photon emission computed tomography. Neurosci Lett 285:107-110.
16. Madras BK, Miller GM, Fischman AJ. 2002. The dopamine transporter: Relevance to attention deficit hyperactivity disorder (ADHD). Behav Brain Res 130:57-63.
17. Martinez D, Gelernter J, Abi-Dargham A, van Dyck CH, Kegeles L, Innis RB, Laruelle M. 2001. The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans. Neuropsychopharmacology 24:553-560.
18. Michelhaugh SK, Fiskerstrand C, Lovejoy E, Bannon MJ, Quinn JP. 2001. The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons. J Neurochem 79:1033-1038.
19. Mignone F, Gissi C, Liuni S, Pesole G. 2002. Untranslated regions of mRNAs. Genome Biol 3: REVIEWS0004.
20. Miller GM, Madras BK. 2002. Polymorphisms in the 3′-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Mol Psychiatry 7:44-55.
21. Palmer CG, Bailey JN, Ramsey C, Cantwell D, Sinsheimer JS, Del'Homme M, McGough J, Woodward JA, Asarnow R, Asarnow J, Nelson S, Smalley SL. 1999. No evidence of linkage or linkage disequilibrium between DAT1 and attention deficit hyperactivity disorder in a large sample. Psychiatr Genet 9:157-160.
22. Todd RD, Jong YJ, Lobos EA, Reich W, Heath AC, Neuman RJ. 2001. No association of the dopamine transporter gene 3′ VNTR polymorphism with ADHD subtypes in a population sample of twins. Am J Med Genet 105:745-748.
23. Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL, Cleveland HH, Sanders ML, Gard JM, Stever C. 1998. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: Heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet 63:1767-1776.
24. Watanabe Y, Fujita M, Ito Y, Okada T, Kusuoka H, Nishimura T. 1997. Brain dopamine transporter in spontaneously hypertensive rats. J Nucl Med 38:470-474.