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Volumn 4, Issue 12, 2003, Pages 960-970

Splicing double: Insights from the second spliceosome

Author keywords

[No Author keywords available]

Indexed keywords

EVOLUTION; HUMAN; INTRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; RNA SPLICING; SPLICEOSOME;

EID: 0345169036     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm1259     Document Type: Review
Times cited : (331)

References (120)
  • 1
    • 0003604405 scopus 로고    scopus 로고
    • (eds Gesteland, R. F., Cech, T. R. & Atkins, J. F.) (Cold Spring Harbor Laboratory Press, New York)
    • Burge, C. B., Tuschl, T. & Sharp, P. A. in The RNA World 2nd edn (eds Gesteland, R. F., Cech, T. R. & Atkins, J. F.) 525-560 (Cold Spring Harbor Laboratory Press, New York, 1999).
    • (1999) The RNA World 2nd Edn. , pp. 525-560
    • Burge, C.B.1    Tuschl, T.2    Sharp, P.A.3
  • 2
    • 0030199215 scopus 로고    scopus 로고
    • RNA splicing: Unexpected spliceosome diversity
    • Kreivi, J. P. & Lamond, A. I. RNA splicing: unexpected spliceosome diversity. Curr. Biol. 6, 802-805 (1996).
    • (1996) Curr. Biol. , vol.6 , pp. 802-805
    • Kreivi, J.P.1    Lamond, A.I.2
  • 3
    • 0029878317 scopus 로고    scopus 로고
    • AT-AC introns: An ATtACk on dogma
    • Mount, S. M. AT-AC introns: an ATtACk on dogma. Science 271, 1690-1692 (1996).
    • (1996) Science , vol.271 , pp. 1690-1692
    • Mount, S.M.1
  • 4
    • 10144262703 scopus 로고    scopus 로고
    • A parallel spliceosome
    • Nilsen, T. W. A parallel spliceosome. Science 273, 1813 (1996).
    • (1996) Science , vol.273 , pp. 1813
    • Nilsen, T.W.1
  • 5
    • 0030995509 scopus 로고    scopus 로고
    • Pre-mRNA splicing: The discovery of a new spliceosome doubles the challenge
    • Tarn, W. Y. & Steitz, J. A. Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge. Trends Biochem. Sci. 22, 132-137 (1997).
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 132-137
    • Tarn, W.Y.1    Steitz, J.A.2
  • 6
    • 0032933429 scopus 로고    scopus 로고
    • AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes
    • Wu, Q. & Krainer, A. R. AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Mol. Cell. Biol. 19, 3225-3236 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3225-3236
    • Wu, Q.1    Krainer, A.R.2
  • 7
    • 0003604405 scopus 로고    scopus 로고
    • (eds Gesteland, R. F. & Atkins, J. F.) (Cold Spring Harbor Laboratory Press, New York)
    • Moore, M. J., Query, C. C. & Sharp, P. A. in The RNA World 1st edn (eds Gesteland, R. F. & Atkins, J. F.) 303-357 (Cold Spring Harbor Laboratory Press, New York, 1993).
    • (1993) The RNA World 1st Edn. , pp. 303-357
    • Moore, M.J.1    Query, C.C.2    Sharp, P.A.3
  • 8
    • 0004194908 scopus 로고    scopus 로고
    • (eds Simmons, R. W. & Grunberg-Menago, M.) (Cold Spring Harbor Laboratory Press, New York)
    • Nilsen, T. W. in RNA Structure and Function (eds Simmons, R. W. & Grunberg-Menago, M.) 279-307 (Cold Spring Harbor Laboratory Press, New York, 1998).
    • (1998) RNA Structure and Function , pp. 279-307
    • Nilsen, T.W.1
  • 9
    • 0032489021 scopus 로고    scopus 로고
    • Mechanical devices of the spliceosome: Motors, clocks, springs, and things
    • Staley, J. P. & Guthrie, C. Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell 92, 315-326 (1998).
    • (1998) Cell , vol.92 , pp. 315-326
    • Staley, J.P.1    Guthrie, C.2
  • 10
    • 0029933504 scopus 로고    scopus 로고
    • Initial splice-site recognition and pairing during pre-mRNA splicing
    • Reed, R. Initial splice-site recognition and pairing during pre-mRNA splicing. Curr. Opin. Genet. Dev. 6, 215-220 (1996).
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 215-220
    • Reed, R.1
  • 11
    • 0023659462 scopus 로고
    • Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes
    • Konarska, M. M. & Sharp, P. A. Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes. Cell 49, 763-774 (1987).
    • (1987) Cell , vol.49 , pp. 763-774
    • Konarska, M.M.1    Sharp, P.A.2
  • 12
    • 0027059033 scopus 로고
    • Site-specific cross-linking of mammalian U5 snRNP to the 5′ splice site before the first step of pre-mRNA splicing
    • Wyatt, J. R., Sontheimer, E. J. & Steitz, J. A. Site-specific cross-linking of mammalian U5 snRNP to the 5′ splice site before the first step of pre-mRNA splicing. Genes Dev. 6, 2542-2553 (1992).
    • (1992) Genes Dev. , vol.6 , pp. 2542-2553
    • Wyatt, J.R.1    Sontheimer, E.J.2    Steitz, J.A.3
  • 13
    • 0023672447 scopus 로고
    • Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein
    • Lamond, A. I., Konarska, M. M., Grabowski, P. J. & Sharp, P. A. Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein. Proc. Natl Acad. Sci. USA 85, 411-415 (1988).
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 411-415
    • Lamond, A.I.1    Konarska, M.M.2    Grabowski, P.J.3    Sharp, P.A.4
  • 14
    • 0026670431 scopus 로고
    • Interactions of small nuclear RNAs with precursor messenger RNA during in vitro splicing
    • Wassarman, D. A. & Steitz, J. A. Interactions of small nuclear RNAs with precursor messenger RNA during in vitro splicing. Science 257, 1918-1925 (1992).
    • (1992) Science , vol.257 , pp. 1918-1925
    • Wassarman, D.A.1    Steitz, J.A.2
  • 15
    • 0025821210 scopus 로고
    • Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing
    • Datta, B. & Weiner, A. M. Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing. Nature 352, 821-824 (1991).
    • (1991) Nature , vol.352 , pp. 821-824
    • Datta, B.1    Weiner, A.M.2
  • 16
    • 0025639012 scopus 로고
    • Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles
    • Hausner, T. P., Giglio, L. M. & Weiner, A. M. Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles. Genes Dev. 4, 2146-2156 (1990).
    • (1990) Genes Dev. , vol.4 , pp. 2146-2156
    • Hausner, T.P.1    Giglio, L.M.2    Weiner, A.M.3
  • 17
    • 0026486883 scopus 로고
    • A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome
    • Madhani, H. D. & Guthrie, C. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell 71, 803-817 (1992).
    • (1992) Cell , vol.71 , pp. 803-817
    • Madhani, H.D.1    Guthrie, C.2
  • 18
    • 0025742986 scopus 로고
    • Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA
    • Wu, J. A. & Manley, J. L. Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA. Nature 352, 818-821 (1991).
    • (1991) Nature , vol.352 , pp. 818-821
    • Wu, J.A.1    Manley, J.L.2
  • 19
    • 0025857390 scopus 로고
    • Mutations in yeast U5 snRNA alter the specificity of 5′ splice-site cleavage
    • Newman, A. & Norman, C. Mutations in yeast U5 snRNA alter the specificity of 5′ splice-site cleavage. Cell 65, 115-123 (1991).
    • (1991) Cell , vol.65 , pp. 115-123
    • Newman, A.1    Norman, C.2
  • 20
    • 0026605043 scopus 로고
    • U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites
    • Newman, A. J. & Norman, C. U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites. Cell 68, 743-754 (1992).
    • (1992) Cell , vol.68 , pp. 743-754
    • Newman, A.J.1    Norman, C.2
  • 21
    • 0027739853 scopus 로고
    • The U5 and U6 small nuclear RNAs as active site components of the spliceosome
    • Sontheimer, E. J. & Steitz, J. A. The U5 and U6 small nuclear RNAs as active site components of the spliceosome. Science 262, 1989-1996 (1993).
    • (1993) Science , vol.262 , pp. 1989-1996
    • Sontheimer, E.J.1    Steitz, J.A.2
  • 22
    • 0025836071 scopus 로고
    • A reappraisal of non-consensus mRNA splice sites
    • Jackson, I. J. A reappraisal of non-consensus mRNA splice sites. Nucleic Acids Res. 19, 3795-3798 (1991).
    • (1991) Nucleic Acids Res. , vol.19 , pp. 3795-3798
    • Jackson, I.J.1
  • 23
    • 0028366003 scopus 로고
    • Conserved sequences in a class of rare eukaryotic nuclear introns with non-consensus splice sites
    • Hall, S. L. & Padgett, R. A. Conserved sequences in a class of rare eukaryotic nuclear introns with non-consensus splice sites. J. Mol. Biol. 239, 357-365 (1994). The first proposal that a distinct spliceosome might excise a variant class of pre-mRNA introns, the splice-site sequences of which diverge from the established consensus. The participation of low-abundance snRNAs U11 and U12 was suggested on the basis of their complementarity to common sequences at the 5′ end and putative branch point of four of the new introns.
    • (1994) J. Mol. Biol. , vol.239 , pp. 357-365
    • Hall, S.L.1    Padgett, R.A.2
  • 24
    • 0024230675 scopus 로고
    • Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc.
    • Montzka, K. A. & Steitz, J. A. Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc. Proc. Natl Acad. Sci. USA 85, 8885-8889 (1988). The discovery of the low-abundance U11 and U12 snRNPs and their association to form the U11-U12 di-snRNP in extracts of human cells.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 8885-8889
    • Montzka, K.A.1    Steitz, J.A.2
  • 25
    • 0031306509 scopus 로고    scopus 로고
    • Terminal intron dinucleotide sequences do not distinguish between U2- and U12-dependent introns
    • Dietrich, R. C., Incorvaia, R. & Padgett, R. A. Terminal intron dinucleotide sequences do not distinguish between U2- and U12-dependent introns. Mol. Cell 1, 151-160 (1997). This study showed that the terminal dinucleotides of U12-type introns can be/Gr and AG/, as in the major-class introns, and that U12-type introns can instead be defined on the basis of longer consensus sequences at the 5′ end and the branch point.
    • (1997) Mol. Cell , vol.1 , pp. 151-160
    • Dietrich, R.C.1    Incorvaia, R.2    Padgett, R.A.3
  • 26
    • 0031456850 scopus 로고    scopus 로고
    • Classification of introns: U2-type or U12-type
    • Sharp, P. A. & Burge, C. B. Classification of introns: U2-type or U12-type. Cell 91, 875-879 (1997).
    • (1997) Cell , vol.91 , pp. 875-879
    • Sharp, P.A.1    Burge, C.B.2
  • 27
    • 12644306849 scopus 로고    scopus 로고
    • Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs
    • Wu, Q. & Krainer, A. R. Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs. RNA 3, 586-601 (1997).
    • (1997) RNA , vol.3 , pp. 586-601
    • Wu, Q.1    Krainer, A.R.2
  • 28
    • 0032247416 scopus 로고    scopus 로고
    • Evolutionary fates and origins of U12-type introns
    • Burge, C. B., Padgett, R. A. & Sharp, P. A. Evolutionary fates and origins of U12-type introns. Mol. Cell 2, 773-785 (1998). A genomic database analysis identified 56 different genes containing U12-type introns in various eukaryotic taxa and detected switching of AT-AC to GT-AG termini in U12-type introns, as well as conversion of U12-type to U2-type introns in homologous genes. A fission/fusion model for the evolutionary origin of the two different splicing systems was proposed.
    • (1998) Mol. Cell , vol.2 , pp. 773-785
    • Burge, C.B.1    Padgett, R.A.2    Sharp, P.A.3
  • 29
    • 0035476520 scopus 로고    scopus 로고
    • A computational scan for U12-dependent introns in the human genome sequence
    • Levine, A. & Durbin, R. A computational scan for U12-dependent introns in the human genome sequence. Nucleic Acids Res. 29, 4006-4013 (2001).
    • (2001) Nucleic Acids Res. , vol.29 , pp. 4006-4013
    • Levine, A.1    Durbin, R.2
  • 30
    • 0345524710 scopus 로고    scopus 로고
    • Thesis, Yale Univ.
    • Otake, L. R. Thesis, Yale Univ. (2001).
    • (2001)
    • Otake, L.R.1
  • 31
    • 0028895417 scopus 로고
    • Exon recognition in vertebrate splicing
    • Berget, S. M. Exon recognition in vertebrate splicing. J. Biol. Chem. 270, 2411-2414 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 2411-2414
    • Berget, S.M.1
  • 32
    • 0028288693 scopus 로고
    • Intron definition in splicing of small Drosophila introns
    • Talerico, M. & Berget, S. M. Intron definition in splicing of small Drosophila introns. Mol. Cell. Biol. 14, 3434-3445 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3434-3445
    • Talerico, M.1    Berget, S.M.2
  • 33
    • 0030575916 scopus 로고    scopus 로고
    • U1-mediated exon definition interactions between AT-AC and GT-AG introns
    • Wu, Q. & Krainer, A. R. U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science 274, 1005-1008 (1996). The first evidence that splicing of pre-mRNAs containing both U12-type and U2-type introns can be coordinated by exon-definition interactions.
    • (1996) Science , vol.274 , pp. 1005-1008
    • Wu, Q.1    Krainer, A.R.2
  • 34
    • 0029863992 scopus 로고    scopus 로고
    • A novel spliceosome containing U11, U12, and U5 snRNPs excises a minor class (AT-AC) intron in vitro
    • Tarn, W. Y. & Steitz, J. A. A novel spliceosome containing U11, U12, and U5 snRNPs excises a minor class (AT-AC) intron in vitro. Cell 84, 801-811 (1996). The first description of an in vitro system that could remove an AT-AC intron provided evidence for the predicted interaction of U12 with the branch site and for the additional participation of the U11 and U5, but not the U4 and U6 snRNPs.
    • (1996) Cell , vol.84 , pp. 801-811
    • Tarn, W.Y.1    Steitz, J.A.2
  • 35
    • 0036257216 scopus 로고    scopus 로고
    • Branchpoint selection in the splicing of U12-dependent introns in vitro
    • McConnell, T. S., Cho, S. J., Frilander, M. J. & Steitz, J. A. Branchpoint selection in the splicing of U12-dependent introns in vitro. RNA 8, 579-586 (2002).
    • (2002) RNA , vol.8 , pp. 579-586
    • McConnell, T.S.1    Cho, S.J.2    Frilander, M.J.3    Steitz, J.A.4
  • 36
    • 0030918785 scopus 로고    scopus 로고
    • Site-specific crosslinking of mammalian U11 and u6atac to the 5′ splice site of an AT-AC intron
    • Yu, Y. T. & Steitz, J. A. Site-specific crosslinking of mammalian U11 and u6atac to the 5′ splice site of an AT-AC intron. Proc. Natl Acad. Sci. USA 94, 6030-6035 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 6030-6035
    • Yu, Y.T.1    Steitz, J.A.2
  • 37
    • 0029763477 scopus 로고    scopus 로고
    • Highly diverged U4 and U6 small nuclear RNAs required for splicing rare AT-AC introns
    • Tarn, W. Y. & Steitz, J. A. Highly diverged U4 and U6 small nuclear RNAs required for splicing rare AT-AC introns. Science 273, 1824-1832 (1996). The identification and characterization of two new low-abundance snRNPs, U4atac and U6atac, allowed documentation of interactions between U6atac and U12 parallel to those previously proposed for U6 and U2 to occur in the spliceosomal active site and to juxtapose an intron's 5′ splice site and branch point for the first step of the splicing reaction.
    • (1996) Science , vol.273 , pp. 1824-1832
    • Tarn, W.Y.1    Steitz, J.A.2
  • 38
    • 0029989519 scopus 로고    scopus 로고
    • Requirement of U12 snRNA for in vivo splicing of a minor class of eukaryotic nuclear pre-mRNA introns
    • Hall, S. L. & Padgett, R. A. Requirement of U12 snRNA for in vivo splicing of a minor class of eukaryotic nuclear pre-mRNA introns. Science 271, 1716-1718 (1996). Mutations in the conserved branch-point sequence of an AT-AC intron were suppressed by compensatory mutations in U12, providing the first in vivo evidence for the U12-type splicing machinery.
    • (1996) Science , vol.271 , pp. 1716-1718
    • Hall, S.L.1    Padgett, R.A.2
  • 39
    • 0030941474 scopus 로고    scopus 로고
    • U11 snRNA interacts in vivo with the 5′ splice site of U12-dependent (AU-AC) pre-mRNA introns
    • Kolossova, I. & Padgett, R. A. U11 snRNA interacts in vivo with the 5′ splice site of U12-dependent (AU-AC) pre-mRNA introns. RNA 3, 227-233 (1997).
    • (1997) RNA , vol.3 , pp. 227-233
    • Kolossova, I.1    Padgett, R.A.2
  • 40
    • 0031745936 scopus 로고    scopus 로고
    • Base pairing with U6atac snRNA is required for 5′ splice site activation of U12-dependent introns in vivo
    • Incorvaia, R. & Padgett, R. A. Base pairing with U6atac snRNA is required for 5′ splice site activation of U12-dependent introns in vivo. RNA 4, 709-718 (1998).
    • (1998) RNA , vol.4 , pp. 709-718
    • Incorvaia, R.1    Padgett, R.A.2
  • 41
    • 0036184249 scopus 로고    scopus 로고
    • The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila
    • Otake, L. R., Scamborova, P., Hashimoto, C. & Steitz, J. A. The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila. Mol. Cell 9, 439-446 (2002). P-element-mediated disruptions of the single loci encoding U12 and U6atac in D. melanogaster caused lethality during the embryonic and third instar larval stages, respectively, and defects in the excision of U12-type introns from several transcripts.
    • (2002) Mol. Cell , vol.9 , pp. 439-446
    • Otake, L.R.1    Scamborova, P.2    Hashimoto, C.3    Steitz, J.A.4
  • 42
    • 0023782352 scopus 로고
    • Spliceosomal RNA U6 is remarkably conserved from yeast to mammals
    • Brow, D. A. & Guthrie, C. Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature 334, 213-218 (1988).
    • (1988) Nature , vol.334 , pp. 213-218
    • Brow, D.A.1    Guthrie, C.2
  • 43
    • 0037073946 scopus 로고    scopus 로고
    • Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome
    • Makarov, E. M. et al. Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science 298, 2205-2208 (2002).
    • (2002) Science , vol.298 , pp. 2205-2208
    • Makarov, E.M.1
  • 45
    • 0033046012 scopus 로고    scopus 로고
    • Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus 1p exhibits a dual substrate specificity for U2 snRNA and tRNA
    • Massenet, S. et al. Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA. Mol. Cell. Biol. 19, 2142-2154 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2142-2154
    • Massenet, S.1
  • 46
    • 0028970305 scopus 로고
    • Phylogenetic conservation of modified nucleotides in the terminal loop 1 of the spliceosomal U5 snRNA
    • Szkukalek, A., Myslinski, E., Mougin, A., Luhrmann, R. & Branlant, C. Phylogenetic conservation of modified nucleotides in the terminal loop 1 of the spliceosomal U5 snRNA. Biochimie 77, 16-21 (1995).
    • (1995) Biochimie , vol.77 , pp. 16-21
    • Szkukalek, A.1    Myslinski, E.2    Mougin, A.3    Luhrmann, R.4    Branlant, C.5
  • 47
    • 0032189145 scopus 로고    scopus 로고
    • Modifications of U2 snRNA are required for snRNP assembly and pre-mRNA splicing
    • Yu, Y. T., Shu, M. D. & Steitz, J. A. Modifications of U2 snRNA are required for snRNP assembly and pre-mRNA splicing. EMBO J. 17, 5783-5795 (1998).
    • (1998) EMBO J. , vol.17 , pp. 5783-5795
    • Yu, Y.T.1    Shu, M.D.2    Steitz, J.A.3
  • 48
    • 0032707206 scopus 로고    scopus 로고
    • A limited number of pseudouridine residues in the human atac spliceosomal UsnRNAs as compared to human major spliceosomal UsnRNAs
    • Massenet, S. & Branlant, C. A limited number of pseudouridine residues in the human atac spliceosomal UsnRNAs as compared to human major spliceosomal UsnRNAs. RNA 5, 1495-1503 (1999).
    • (1999) RNA , vol.5 , pp. 1495-1503
    • Massenet, S.1    Branlant, C.2
  • 50
    • 0035370526 scopus 로고    scopus 로고
    • Spliceosomal UsnRNP biogenesis, structure and function
    • Will, C. L. & Luhrmann, R. Spliceosomal UsnRNP biogenesis, structure and function. Curr Opin. Cell Biol. 13, 290-301 (2001).
    • (2001) Curr Opin. Cell Biol. , vol.13 , pp. 290-301
    • Will, C.L.1    Luhrmann, R.2
  • 51
    • 0038670209 scopus 로고    scopus 로고
    • Molecular architecture of the multiprotein splicing factor SF3b
    • Golas, M. M., Sander, B., Will, C. L., Luhrmann, R. & Stark, H. Molecular architecture of the multiprotein splicing factor SF3b. Science 300, 980-984 (2003).
    • (2003) Science , vol.300 , pp. 980-984
    • Golas, M.M.1    Sander, B.2    Will, C.L.3    Luhrmann, R.4    Stark, H.5
  • 52
    • 0029917043 scopus 로고    scopus 로고
    • Three recognition events at the branch-site adenine
    • Query, C. C., Strobel, S. A. & Sharp, P. A. Three recognition events at the branch-site adenine. EMBO J. 15, 1392-1402 (1996).
    • (1996) EMBO J. , vol.15 , pp. 1392-1402
    • Query, C.C.1    Strobel, S.A.2    Sharp, P.A.3
  • 53
    • 0035882161 scopus 로고    scopus 로고
    • A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site
    • Will, C. L. et al. A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. EMBO J. 20, 4536-4546 (2001).
    • (2001) EMBO J. , vol.20 , pp. 4536-4546
    • Will, C.L.1
  • 54
    • 0037634375 scopus 로고    scopus 로고
    • Identification of both shared and distinct proteins in the major and minor spliceosomes
    • Will, C. L., Schneider, C., Reed, R. & Luhrmann, R. Identification of both shared and distinct proteins in the major and minor spliceosomes. Science 284, 2003-2005 (1999). Analysis of 20 proteins associated with the U11-U12 di-snRNP showed that not only the U5 snRNP, but several protein components are shared by the major-class and minor-class spliceosomes.
    • (1999) Science , vol.284 , pp. 2003-2005
    • Will, C.L.1    Schneider, C.2    Reed, R.3    Luhrmann, R.4
  • 55
    • 0036240466 scopus 로고    scopus 로고
    • Human U4AJ6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions
    • Schneider, C., Will, C. L., Makarova, O. V., Makarov, E. M. & Luhrmann, R. Human U4AJ6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions. Mol. Cell. Biol. 22, 3219-3229 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 3219-3229
    • Schneider, C.1    Will, C.L.2    Makarova, O.V.3    Makarov, E.M.4    Luhrmann, R.5
  • 56
    • 0033229873 scopus 로고    scopus 로고
    • Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5′ stem-loop of U4 snRNA
    • Nottrott, S. et al. Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5′ stem-loop of U4 snRNA. EMBO J. 18, 6119-6133 (1999).
    • (1999) EMBO J. , vol.18 , pp. 6119-6133
    • Nottrott, S.1
  • 57
    • 0033028397 scopus 로고    scopus 로고
    • The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes
    • Luo, H. R., Moreau, G. A., Levin, N. & Moore, M. J. The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes. RNA 5, 893-908 (1999).
    • (1999) RNA , vol.5 , pp. 893-908
    • Luo, H.R.1    Moreau, G.A.2    Levin, N.3    Moore, M.J.4
  • 58
    • 0025810123 scopus 로고
    • Intron phylogeny: A new hypothesis
    • Cavalier-Smith, T. Intron phylogeny: a new hypothesis. Trends Genet. 7, 145-148 (1991).
    • (1991) Trends Genet. , vol.7 , pp. 145-148
    • Cavalier-Smith, T.1
  • 59
    • 0022552726 scopus 로고
    • The generality of self-splicing RNA: Relationship to nuclear mRNA splicing
    • Cech, T. R. The generality of self-splicing RNA: relationship to nuclear mRNA splicing. Cell 44, 207-210 (1986).
    • (1986) Cell , vol.44 , pp. 207-210
    • Cech, T.R.1
  • 60
    • 0024995219 scopus 로고
    • Self-splicing group II and nuclear pre-mRNA introns: How similar are they?
    • Jacquier, A. Self-splicing group II and nuclear pre-mRNA introns: how similar are they? Trends Biochem. Sci. 15, 351-354 (1990).
    • (1990) Trends Biochem. Sci. , vol.15 , pp. 351-354
    • Jacquier, A.1
  • 61
    • 0022131865 scopus 로고
    • On the origin of RNA splicing and introns
    • Sharp, P. A. On the origin of RNA splicing and introns. Cell 42, 397-400 (1985).
    • (1985) Cell , vol.42 , pp. 397-400
    • Sharp, P.A.1
  • 62
    • 0026261876 scopus 로고
    • Five easy pieces
    • Sharp, P. A. 'Five easy pieces'. Science 254, 663. (1991).
    • (1991) Science , vol.254 , pp. 663
    • Sharp, P.A.1
  • 63
    • 0035368207 scopus 로고    scopus 로고
    • The ins and outs of group II introns
    • Bonen, L. & Vogel, J. The ins and outs of group II introns. Trends Genet. 17, 322-331 (2001).
    • (2001) Trends Genet. , vol.17 , pp. 322-331
    • Bonen, L.1    Vogel, J.2
  • 64
    • 0036493198 scopus 로고    scopus 로고
    • Compilation and analysis of group II intron insertions in bacterial genomes: Evidence for retroelement behavior
    • Dai, L. & Zimmerly, S. Compilation and analysis of group II intron insertions in bacterial genomes: evidence for retroelement behavior. Nucleic Acids Res. 30, 1091-1102 (2002).
    • (2002) Nucleic Acids Res. , vol.30 , pp. 1091-1102
    • Dai, L.1    Zimmerly, S.2
  • 65
    • 0028631058 scopus 로고
    • Introns: Evolution and function
    • Mattick, J. S. Introns: evolution and function. Curr. Opin. Genet. Dev. 4, 823-831 (1994).
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 823-831
    • Mattick, J.S.1
  • 66
    • 0027394389 scopus 로고
    • mRNA splicing and autocatalytic introns: Distant cousins or the products of chemical determinism?
    • Weiner, A. M. mRNA splicing and autocatalytic introns: distant cousins or the products of chemical determinism? Cell 72, 161-164 (1993).
    • (1993) Cell , vol.72 , pp. 161-164
    • Weiner, A.M.1
  • 67
    • 0027364421 scopus 로고
    • Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing
    • Moore, M. J. & Sharp, P. A. Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing. Nature 365, 364-368 (1993).
    • (1993) Nature , vol.365 , pp. 364-368
    • Moore, M.J.1    Sharp, P.A.2
  • 68
    • 0028769660 scopus 로고
    • The stereochemical course of group II intron self-splicing
    • Padgett, R. A., Podar, M., Boulanger, S. C. & Perlman, P. S. The stereochemical course of group II intron self-splicing. Science 266, 1685-1688 (1994).
    • (1994) Science , vol.266 , pp. 1685-1688
    • Padgett, R.A.1    Podar, M.2    Boulanger, S.C.3    Perlman, P.S.4
  • 69
    • 0033166446 scopus 로고    scopus 로고
    • Metal ion catalysis during group II intron self-splicing: Parallels with the spliceosome
    • Sontheimer, E. J., Gordon, P. M. & Piccirilli, J. A. Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome. Genes Dev. 13, 1729-1741 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1729-1741
    • Sontheimer, E.J.1    Gordon, P.M.2    Piccirilli, J.A.3
  • 70
    • 0031003161 scopus 로고    scopus 로고
    • Trans-activation of group II intron splicing by nuclear U5 snRNA
    • Hetzer, M., Wurzer, G., Schweyen, R. J. & Mueller, M. W. Trans-activation of group II intron splicing by nuclear U5 snRNA. Nature 386, 417-420 (1997).
    • (1997) Nature , vol.386 , pp. 417-420
    • Hetzer, M.1    Wurzer, G.2    Schweyen, R.J.3    Mueller, M.W.4
  • 71
    • 0023663370 scopus 로고
    • Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA
    • Parker, R., Siliciano, P. G. & Guthrie, C. Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA. Cell 49, 229-239 (1987).
    • (1987) Cell , vol.49 , pp. 229-239
    • Parker, R.1    Siliciano, P.G.2    Guthrie, C.3
  • 72
    • 0022446227 scopus 로고
    • Self-splicing of group II introns in vitro: Mapping of the branch point and mutational inhibition of lariat formation
    • Schmelzer, C. & Schweyen, R. J. Self-splicing of group II introns in vitro: mapping of the branch point and mutational inhibition of lariat formation. Cell 46, 557-565 (1986).
    • (1986) Cell , vol.46 , pp. 557-565
    • Schmelzer, C.1    Schweyen, R.J.2
  • 73
    • 0029670279 scopus 로고    scopus 로고
    • Catalytic role of 2′-hydroxyl groups within a group II intron active site
    • Abramovitz, D. L., Fdedman, R. A. & Pyle, A. M. Catalytic role of 2′-hydroxyl groups within a group II intron active site. Science 271, 1410-1413 (1996).
    • (1996) Science , vol.271 , pp. 1410-1413
    • Abramovitz, D.L.1    Fdedman, R.A.2    Pyle, A.M.3
  • 74
    • 0024022167 scopus 로고
    • Group II intron domain 5 facilitates a trans-splicing reaction
    • Jarrell, K. A., Dietrich, R. C. & Perlman, P. S. Group II intron domain 5 facilitates a trans-splicing reaction. Mol. Cell. Biol. 8, 2361-2366 (1988).
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 2361-2366
    • Jarrell, K.A.1    Dietrich, R.C.2    Perlman, P.S.3
  • 75
    • 0031991610 scopus 로고    scopus 로고
    • Ribozyme catalysis from the major groove of group II intron domain 5
    • Konforti, B. B. et al. Ribozyme catalysis from the major groove of group II intron domain 5. Mol. Cell 1, 433-441 (1998).
    • (1998) Mol. Cell , vol.1 , pp. 433-441
    • Konforti, B.B.1
  • 77
    • 0029258858 scopus 로고
    • U6 snRNA function in nuclear pre-mRNA splicing: A phosphorothioate interference analysis of the U6 phosphate backbone
    • Yu, Y. T., Maroney, P. A., Darzynkiwicz, E. & Nilsen, T. W. U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone. RNA 1, 46-54 (1995).
    • (1995) RNA , vol.1 , pp. 46-54
    • Yu, Y.T.1    Maroney, P.A.2    Darzynkiwicz, E.3    Nilsen, T.W.4
  • 78
    • 0036285645 scopus 로고    scopus 로고
    • A catalytically active group II intron domain 5 can function in the U12-dependent spliceosome
    • Shukla, G. C. & Padgett, R. A. A catalytically active group II intron domain 5 can function in the U12-dependent spliceosome. Mol. Cell 9, 1145-1150 (2002). Evidence that the catalytic cores of the group-II self-splicing intron and the major- and minor-class spliceosomes are related was provided by functionally replacing a U6atac stem-loop with D5 of the group-II intron in an in vivo splicing assay.
    • (2002) Mol. Cell , vol.9 , pp. 1145-1150
    • Shukla, G.C.1    Padgett, R.A.2
  • 79
    • 0035038510 scopus 로고    scopus 로고
    • The intramolecular stem-loop structure of U6 snRNA can functionally replace the U6atac snRNA stem-loop
    • Shukla, G. C. & Padgett, R. A. The intramolecular stem-loop structure of U6 snRNA can functionally replace the U6atac snRNA stem-loop. RNA 7, 94-105 (2001).
    • (2001) RNA , vol.7 , pp. 94-105
    • Shukla, G.C.1    Padgett, R.A.2
  • 80
    • 0032943029 scopus 로고    scopus 로고
    • Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants
    • Shukla, G. C. & Padgett, R. A. Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants. RNA 5, 525-538 (1999).
    • (1999) RNA , vol.5 , pp. 525-538
    • Shukla, G.C.1    Padgett, R.A.2
  • 81
    • 0028917214 scopus 로고
    • A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing
    • Sun, J. S. & Manley, J. L. A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing. Genes Dev. 9, 843-854 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 843-854
    • Sun, J.S.1    Manley, J.L.2
  • 82
    • 0026654005 scopus 로고
    • Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicing in vitro
    • Fabrizio, P. & Abelson, J. Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicing in vitro. Nucleic Acids Res. 20, 3659-3664 (1992).
    • (1992) Nucleic Acids Res. , vol.20 , pp. 3659-3664
    • Fabrizio, P.1    Abelson, J.2
  • 83
    • 0028144641 scopus 로고
    • A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing
    • Fortner, D. M., Troy, R. G. & Brow, D. A. A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing. Genes Dev. 8, 221-233 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 221-233
    • Fortner, D.M.1    Troy, R.G.2    Brow, D.A.3
  • 84
    • 0028175201 scopus 로고
    • Randomization-selection analysis of snRNAs in vivo: Evidence for a tertiary interaction in the spliceosome
    • Madhani, H. D. & Guthrie, C. Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome. Genes Dev. 8, 1071-1086 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 1071-1086
    • Madhani, H.D.1    Guthrie, C.2
  • 85
    • 0026486884 scopus 로고
    • Mutational analysis of the yeast U2 snRNA suggests a structural similarity to the catalytic core of group I introns
    • McPheeters, D. S. & Abelson, J. Mutational analysis of the yeast U2 snRNA suggests a structural similarity to the catalytic core of group I introns. Cell 71, 819-831 (1992).
    • (1992) Cell , vol.71 , pp. 819-831
    • McPheeters, D.S.1    Abelson, J.2
  • 86
    • 0027220788 scopus 로고
    • Conformational changes of U6 RNA during the spliceosome cycle: An intramolecular helix is essential both for initiating the U4-U6 interaction and for the first step of splicing
    • Wolff, T. & Bindereif, A. Conformational changes of U6 RNA during the spliceosome cycle: an intramolecular helix is essential both for initiating the U4-U6 interaction and for the first step of splicing. Genes Dev. 7, 1377-1389 (1993).
    • (1993) Genes Dev. , vol.7 , pp. 1377-1389
    • Wolff, T.1    Bindereif, A.2
  • 87
    • 0027979539 scopus 로고
    • Splicing function of mammalian U6 small nuclear RNA: Conserved positions in central domain and helix I are essential during the first and second step of pre-mRNA splicing
    • Wolff, T., Menssen, R., Hammel, J. & Bindereif, A. Splicing function of mammalian U6 small nuclear RNA: conserved positions in central domain and helix I are essential during the first and second step of pre-mRNA splicing. Proc. Natl Acad. Sci. USA 91, 903-907 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 903-907
    • Wolff, T.1    Menssen, R.2    Hammel, J.3    Bindereif, A.4
  • 88
    • 0027408848 scopus 로고
    • Evidence for an essential non-Watson-Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron
    • Parker, R. & Siliciano, P. G. Evidence for an essential non-Watson-Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron. Nature 361, 660-662 (1993).
    • (1993) Nature , vol.361 , pp. 660-662
    • Parker, R.1    Siliciano, P.G.2
  • 89
    • 0026561544 scopus 로고
    • The low-abundance U11 and U12 small nuclear ribonucleoproteins (snRNPs) interact to form a two-snRNP complex
    • Wassarman, K. M. & Steitz, J. A. The low-abundance U11 and U12 small nuclear ribonucleoproteins (snRNPs) interact to form a two-snRNP complex. Mol. Cell. Biol. 12, 1276-1285 (1992).
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 1276-1285
    • Wassarman, K.M.1    Steitz, J.A.2
  • 90
    • 0033119176 scopus 로고    scopus 로고
    • Initial recognition of U12-dependent introns requires both U11/5′ splice-site and U12/branchpoint interactions
    • Fdlander, M. J. & Steitz, J. A. Initial recognition of U12-dependent introns requires both U11/5′ splice-site and U12/branchpoint interactions. Genes Dev. 13, 851-863 (1999). Strong cooperativity was documented for binding of the 5′ splice site and branch-point sequence by U11 and U12 snRNPs during pre-spliceosome formation on a U12-type intron, indicating greater rigidity in the intron recognition process for minor-versus major-class splicing.
    • (1999) Genes Dev. , vol.13 , pp. 851-863
    • Fdlander, M.J.1    Steitz, J.A.2
  • 91
    • 0023834880 scopus 로고
    • A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly
    • Ruskin, B., Zamore, P. D. & Green, M. R. A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Cell 52, 207-219 (1988).
    • (1988) Cell , vol.52 , pp. 207-219
    • Ruskin, B.1    Zamore, P.D.2    Green, M.R.3
  • 92
    • 0035104772 scopus 로고    scopus 로고
    • Dynamic exchanges of RNA interactions leading to catalytic core formation in the U12-dependent spliceosome
    • Frilander, M. J. & Steitz, J. A. Dynamic exchanges of RNA interactions leading to catalytic core formation in the U12-dependent spliceosome. Mol. Cell 7, 217-226 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 217-226
    • Frilander, M.J.1    Steitz, J.A.2
  • 93
    • 0032980192 scopus 로고    scopus 로고
    • Serine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing
    • Hertel, K. J. & Maniatis, T. Serine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing. Proc. Natl Acad. Sci. USA 96, 2651-2655 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 2651-2655
    • Hertel, K.J.1    Maniatis, T.2
  • 94
    • 0027923620 scopus 로고
    • Involvement of U6 snRNA in 5′ splice site selection
    • Kandels-Lewis, S. & Seraphin, B. Involvement of U6 snRNA in 5′ splice site selection. Science 262, 2035-2039 (1993).
    • (1993) Science , vol.262 , pp. 2035-2039
    • Kandels-Lewis, S.1    Seraphin, B.2
  • 95
    • 0033047503 scopus 로고    scopus 로고
    • Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome
    • Kuhn, A. N., Li, Z. & Brow, D. A. Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome. Mol. Cell 3, 65-75 (1999).
    • (1999) Mol. Cell , vol.3 , pp. 65-75
    • Kuhn, A.N.1    Li, Z.2    Brow, D.A.3
  • 96
    • 0027739852 scopus 로고
    • Mutations in U6 snRNA that alter splice site specificity: Implications for the active site
    • Lesser, C. F. & Guthrie, C. Mutations in U6 snRNA that alter splice site specificity: implications for the active site. Science 262, 1982-1988 (1993).
    • (1993) Science , vol.262 , pp. 1982-1988
    • Lesser, C.F.1    Guthrie, C.2
  • 97
    • 0033010430 scopus 로고    scopus 로고
    • An RNA switch at the 5′ splice site requires ATP and the DEAD box protein Prp28p
    • Staley, J. P. & Guthrie, C. An RNA switch at the 5′ splice site requires ATP and the DEAD box protein Prp28p. Mol. Cell 3, 55-64 (1999).
    • (1999) Mol. Cell , vol.3 , pp. 55-64
    • Staley, J.P.1    Guthrie, C.2
  • 98
    • 0027054380 scopus 로고
    • Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites
    • Stephens, R. M. & Schneider, T. D. Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites. J. Mol. Biol. 228, 1124-1136 (1992).
    • (1992) J. Mol. Biol. , vol.228 , pp. 1124-1136
    • Stephens, R.M.1    Schneider, T.D.2
  • 99
    • 0034743971 scopus 로고    scopus 로고
    • Role of the 3′ splice site in U12-dependent intron splicing
    • Dietrich, R. C., Peds, M. J., Seyboldt, A. S. & Padgett, R. A. Role of the 3′ splice site in U12-dependent intron splicing. Mol. Cell. Biol. 21, 1942-1952 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1942-1952
    • Dietrich, R.C.1    Peds, M.J.2    Seyboldt, A.S.3    Padgett, R.A.4
  • 100
    • 0025760145 scopus 로고
    • Control of alternative splicing by the differential binding of U1 small nuclear ribonucleoprotein particle
    • Kuo, H. C., Nasim, F. H. & Grabowski, P. J. Control of alternative splicing by the differential binding of U1 small nuclear ribonucleoprotein particle. Science 251, 1045-1050 (1991).
    • (1991) Science , vol.251 , pp. 1045-1050
    • Kuo, H.C.1    Nasim, F.H.2    Grabowski, P.J.3
  • 101
    • 0025098474 scopus 로고
    • Exon definition may facilitate splice site selection in RNAs with multiple exons
    • Robberson, B. L., Cote, G. J. & Berget, S. M. Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol. Cell. Biol. 10, 84-94 (1990).
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 84-94
    • Robberson, B.L.1    Cote, G.J.2    Berget, S.M.3
  • 102
    • 0031730213 scopus 로고    scopus 로고
    • Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP
    • Wu, Q. & Krainer, A. R. Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP. RNA 4, 1664-1673 (1998). Enhancer sequences located in exons were shown to stimulate splicing of U12-type introns, as they do for U2-type introns.
    • (1998) RNA , vol.4 , pp. 1664-1673
    • Wu, Q.1    Krainer, A.R.2
  • 103
    • 0034721644 scopus 로고    scopus 로고
    • Protein diversity from alternative splicing: A challenge for bioinformatics and post-genome biology
    • Black, D. L. Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology. Cell 103, 367370 (2000).
    • (2000) Cell , vol.103 , pp. 367370
    • Black, D.L.1
  • 104
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • Black, D. L. Mechanisms of alternative pre-messenger RNA splicing. Annu. Rev. Biochem. 72, 291-336 (2003).
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 291-336
    • Black, D.L.1
  • 105
    • 0034906754 scopus 로고    scopus 로고
    • Alternative RNA splicing in the nervous system
    • Grabowski, P. J. & Black, D. L. Alternative RNA splicing in the nervous system. Prog. Neurobiol. 65, 289-308 (2001).
    • (2001) Prog. Neurobiol. , vol.65 , pp. 289-308
    • Grabowski, P.J.1    Black, D.L.2
  • 106
    • 0034256020 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing: The logic of combinatorial control
    • Smith, C. W. & Valcarcel, J. Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem. Sci. 25, 381-388 (2000).
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 381-388
    • Smith, C.W.1    Valcarcel, J.2
  • 107
    • 0034762872 scopus 로고    scopus 로고
    • Alternative splicing of U12-dependent introns in vivo responds to purine-rich enhancers
    • Dietrich, R. C., Shukla, G. C., Fuller, J. D. & Padgett, R. A. Alternative splicing of U12-dependent introns in vivo responds to purine-rich enhancers. RNA 7, 1378-1388 (2001). By constructing artificial minigenes, the authors showed that U12-type introns can participate in alternative splicing and that the splicing pattern can be influenced by exonic enhancer elements.
    • (2001) RNA , vol.7 , pp. 1378-1388
    • Dietrich, R.C.1    Shukla, G.C.2    Fuller, J.D.3    Padgett, R.A.4
  • 108
    • 0035037737 scopus 로고    scopus 로고
    • Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway
    • Hastings, M. L. & Krainer, A. R. Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA 7, 471-82 (2001).
    • (2001) RNA , vol.7 , pp. 471-482
    • Hastings, M.L.1    Krainer, A.R.2
  • 109
    • 0034968747 scopus 로고    scopus 로고
    • A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA
    • Hastings, M. L., Wilson, C. M. & Munroe, S. H. A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA. RNA 7, 859-874 (2001).
    • (2001) RNA , vol.7 , pp. 859-874
    • Hastings, M.L.1    Wilson, C.M.2    Munroe, S.H.3
  • 110
    • 0036792889 scopus 로고    scopus 로고
    • A general role for splicing enhancers in exon definition
    • Lam, B. J. & Hertel, K. J. A general role for splicing enhancers in exon definition. RNA 8, 1233-1241 (2002).
    • (2002) RNA , vol.8 , pp. 1233-1241
    • Lam, B.J.1    Hertel, K.J.2
  • 111
    • 0036888952 scopus 로고    scopus 로고
    • The evolution of spliceosomal introns
    • Lynch, M. & Richardson, A. O. The evolution of spliceosomal introns. Curr. Opin. Genet. Dev. 12, 701-710 (2002). A theoretical framework for the phylogenetic and physical distribution of introns is presented, including the idea that the progenitor eukaryote had spliceosomal introns that diverged early on into two distinct classes.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 701-710
    • Lynch, M.1    Richardson, A.O.2
  • 112
    • 0032571082 scopus 로고    scopus 로고
    • A putative voltage-gated sodium channel α-subunit (PpSCN1) from the hydrozoan jellyfish, Polyorchis penicillatus: Structural comparisons and evolutionary considerations
    • Spafford, J. D., Spencer, A. N. & Gallin, W. J. A putative voltage-gated sodium channel α-subunit (PpSCN1) from the hydrozoan jellyfish, Polyorchis penicillatus: structural comparisons and evolutionary considerations. Biochem. Biophys. Res. Commun. 244, 772-780 (1998).
    • (1998) Biochem. Biophys. Res. Commun. , vol.244 , pp. 772-780
    • Spafford, J.D.1    Spencer, A.N.2    Gallin, W.J.3
  • 114
    • 0037099491 scopus 로고    scopus 로고
    • The splicing of U12-type introns can be a rate-limiting step in gene expression
    • Patel, A. A., McCarthy, M. & Steitz, J. A. The splicing of U12-type introns can be a rate-limiting step in gene expression. EMBO J. 21, 3804-3815 (2002). Data from a quantitative RT-PCR assay showed that U12-type introns are removed more slowly than neighbouring U2-type introns from pre-mRNAs in both human and Drosophila cells, and that minor-class introns thereby serve to lower the abundance of the RNA and protein products of a gene.
    • (2002) EMBO J. , vol.21 , pp. 3804-3815
    • Patel, A.A.1    McCarthy, M.2    Steitz, J.A.3
  • 115
    • 0036850385 scopus 로고    scopus 로고
    • Domains of human U4atac snRNA required for U12-dependent splicing in vivo
    • Shukla, G. C., Cole, A. J., Dietrich, R. C. & Padgett, R. A. Domains of human U4atac snRNA required for U12-dependent splicing in vivo. Nucleic Acids Res. 30, 4650-4657 (2002).
    • (2002) Nucleic Acids Res. , vol.30 , pp. 4650-4657
    • Shukla, G.C.1    Cole, A.J.2    Dietrich, R.C.3    Padgett, R.A.4
  • 116
    • 0034659241 scopus 로고    scopus 로고
    • RNA polymerase II and the integration of nuclear events
    • Hirose, Y. & Manley, J. L. RNA polymerase II and the integration of nuclear events. Genes Dev. 14, 1415-1429 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 1415-1429
    • Hirose, Y.1    Manley, J.L.2
  • 117
    • 0033153543 scopus 로고    scopus 로고
    • RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo
    • Misteli, T. & Spector, D. L. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol. Cell 3, 697-705 (1999).
    • (1999) Mol. Cell , vol.3 , pp. 697-705
    • Misteli, T.1    Spector, D.L.2
  • 118
    • 0034213044 scopus 로고    scopus 로고
    • Connecting transcription to messenger RNA processing
    • Proudfoot, N. Connecting transcription to messenger RNA processing. Trends Biochem. Sci. 25, 290-293 (2000).
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 290-293
    • Proudfoot, N.1
  • 119
    • 0003604405 scopus 로고    scopus 로고
    • (eds Gesteland, R. F. & Atkins, J. F.) (Cold Spring Harbor Laboratory Press, New York)
    • Baserga, S. J., & Steitz, J. A. in The RNA World 1st edn (eds Gesteland, R. F. & Atkins, J. F.) 359-381 (Cold Spring Harbor Laboratory Press, New York, 1993).
    • (1993) The RNA World 1st Edn. , pp. 359-381
    • Baserga, S.J.1    Steitz, J.A.2
  • 120
    • 0036213247 scopus 로고    scopus 로고
    • A revised model for U4atac/U6atac snRNA base pairing
    • Padgett, R. A. & Shukla, G. C. A revised model for U4atac/U6atac snRNA base pairing. RNA 8, 125-128 (2002).
    • (2002) RNA , vol.8 , pp. 125-128
    • Padgett, R.A.1    Shukla, G.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.