Alternative splicing of U12-dependent introns in vivo responds to purine-rich enhancers

RNA

Volumn 7, Issue 10, 2001, Pages 1378-1388

  Dietrich, Rosemary C ^a   Shukla, Girish C ^a   Fuller, John D ^a   Padgett, Richard A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Pre mRNA splicing; RNA binding proteins; SR proteins

Indexed keywords

MESSENGER RNA PRECURSOR; PURINE; RNA; RNA BINDING PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; ENHANCER REGION; EXON; GENE EXPRESSION; GENE SEQUENCE; HUMAN; INTRON; PRIORITY JOURNAL; REGULATORY MECHANISM; SEQUENCE ANALYSIS;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CHO CELLS; CRICETINAE; DNA PRIMERS; ENHANCER ELEMENTS (GENETICS); INTRONS; MOLECULAR SEQUENCE DATA; PURINES; RNA-BINDING PROTEINS;

EID: 0034762872     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Exon recognition in vertebrate splicing
2. Exonic splicing enhancers: Mechanism of action, diversity and role in human genetic diseases
3. EST comparison indicates 38% of human mRNAs contain possible alternative splice forms
4. Evolutionary fates and origins of U12-type introns
5. A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon
6. Identification of a new class of exonic splicing enhancers by in vivo selection
7. ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome
8. Terminal intron dinucleotide sequences do not distinguish between U2- and U12-dependent introns
9. Identification of exon sequences involved in splice site selection
10. A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro
11. Sorting out the complexity of SR protein functions
12. Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing
13. Requirement of U12 snRNA for the in vivo splicing of a minor class of eukaryotic nuclear pre-mRNA introns
14. Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway
15. Common themes in the function of transcription and splicing enhancers
16. The function of multisite splicing enhancers
17. A 32-nucleotide exon-splicing enhancer regulates usage of competing 5′ splice sites in a differential internal exon
18. Base pairing with U6atac snRNA is required for 5′ splice site activation of U12-dependent introns in vivo
19. U11 snRNA interacts in vivo with the 5′ splice site of U12-dependent (AU-AC) introns
20. The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites
21. Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells
22. Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins
23. SR proteins and splicing control
24. Inhibition of msl-2 splicing by sex-lethal reveals interaction between U2AF35 and the 3′ splice site AG
25. A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer
26. Exon definition may facilitate splice site selection in RNAs with multiple introns
27. Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively splicing premRNA
28. Alternative pre-mRNA splicing: The logic of combinatorial control
29. SR proteins promote the first specific recognition of pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex
30. SR proteins are sufficient for exon bridging across an intron
31. General splicing factors SF2/ASF promote alternative splicing by binding to an exonic splicing enhancer
32. Determinants of SR protein specificity
33. A novel spliceosome containing U11, U12 and U5 snRNPs excises a minor class (AT-AC) intron in vitro
34. Pre-mRNA splicing: The discovery of a new spliceosome doubles the challenge
35. Selection of novel exon recognition elements from a pool of random sequences
36. A splicing enhancer exhibits both constitutive and regulated activities
37. Regulation of pre-mRNA splicing
38. The role of exon sequences in splice site selection
39. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing
40. U1-mediated exon definition interactions between AT-AC and GT-AG introns
41. Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP
42. AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes
43. Functional recognition of the 3′ splice site AG by the splicing factor U2AF35
44. The cardiac troponin t alternative exon contains a novel purine-rich positive splicing element
45. Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements
46. Distinct functions of SR proteins in alternative pre-mRNA splicing
47. Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor
48. Both subunits of U2AF recognize the 3′ splice site in Caenorhabditis elegans
49. The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing