Trans-activation of group II intron splicing by nuclear U5 snRNA

Nature

Volumn 386, Issue 6623, 1997, Pages 417-420

  Hetzer, Martin ^a   Wurzer, Gabriele ^a   Schweyen, Rudolf J ^a   Mueller, Manfred W ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

SMALL NUCLEAR RNA;

ARTICLE; INTRON; PRIORITY JOURNAL; RNA SEQUENCE; RNA SPLICING; RNA STRUCTURE; SPLICEOSOME; TRANSACTIVATION;

BINDING SITES; CELL NUCLEUS; INTRONS; NUCLEIC ACID CONFORMATION; RNA SPLICING; RNA, SMALL NUCLEAR; SACCHAROMYCES CEREVISIAE; SPLICEOSOMES;

EID: 0031003161     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/386417a0     Document Type: Article

References (24)

1. Jacquier, A. Self-splicing group II introns and nuclear pre-messenger RNA introns-how similar are they? Trends Biochem. Sci. 15, 351-354 (1990).
2. Sharp, P. A. Five easy pieces. Science 42, 663 (1991).
3. Weiner, A. M. mRNA splicing and autocatalytic introns: distant cousins or the products of chemical determinism? Cell 72, 161-164 (1993).
4. Wise, J. A. Guides to the heart of the spliceosome. Science 262, 1978-1979 (1993).
5. Newman, A. J. & Norman, C. U5 snRNA interacts with exon sequences at 5′ and 3′ splice-sites. Cell 68, 743-754 (1992).
6. Michel, F. & Ferat, J.-L. Structure and activities of group II introns. Annu. Rev. Biochem. 64, 435-461 (1994).
7. Padgett, R. A., Podar, M., Boulanger, S. C. & Perlman, P. S. The stereochemical course of group II intron self-splicing. Science 266, 1685-1688 (1994).
8. Moore, M. J. & Sharp, P. A. Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing. Nature 365, 364-368 (1993).
9. Peebles, C. L., Perlman, P. S., Mecklenburg, K. L., Petrillo, M. L. & Tabor, J. H. A self-splicing RNA excises an intorn lariat. Cell 44, 213-223 (1986).
10. Schmelzer, C. & Schweyen, R. J. A self-splicing of group II introns in vitro: mapping of the branch point and mutational inhibition of lariat formation. Cell 46, 557-565 (1986).
11. Van der Veen, R. et al. Excised group II introns in yeast mitochondria are lariats and can be formed by self-splicing in vitro. Cell 44, 225-234 (1986).
12. Moore, M. J., Query, C. C. & Sharp, P. A. in Teh RNA World (eds Gesteland, R. F. & Atkins, J. F.) 303-358 (Cold Spring Harbor Laboratory Press, NY, 1993).
13. Jacquier, A. & Michel, F. Multiple exon-binding sites in class II self-splicing introns. Cell 50, 17-29 (1987).
14. Harris-Kerr, C. L., Zhang, M. & Peebles, C. L. The phylogenatically predicted base-pairing interaction between α and α′ is required for group II splicing in vitro. Proc. Natl Acad. Sci. USA 90, 10658-10662 (1993).
15. O'Keefe, R. T., Norman, C. & Newman, A. J. The invariant U5 snRNA loop 1 sequence is dispensable for the first catalytic step of pre-mRNA splicing in yeast. Cell 86, 679-689 (1996).
16. Michel, F., Umesono, K. & Ozeki, H. Comparative and functional anatomy of group II catalytic introns - a rview. Gene 82, 5-30 (1989).
17. Madhani, H. D. & Guthrie, C. Dynamic RNA-RNA interactions in the spliceosome. Annu. Rev. Genet. 28, 1-26 (1994).
18. Sontheimer, E. J. & Steitz, J. A. The U5 and U6 small nuclear RNAs as active components of the spliceosome. Science 262, 1989-1996 (1993).
19. Mueller, M. W., Stocker, P., Hetzer, M. & Schweyen, R. J. The fate of the junction phosphate in alternating forward and reverse splicing reactions of group II intron RNA. J. Mol. Biol. 222, 145-154 (1991).
20. Mueller, M. W., Hetzer, M. & Schweyen, R. J. Group II intron RNA catalyzes progressive, site-specific, 3′ to 5′ nucleotide insertion: a model for RNA editing? Science 261, 1035-1038 (1993).
21. Michels, J. W. & Pyle, A. M. Conversion of a group II intron into a multiple-turnover ribozyme that selectively cleaves oligonucleotides: elucidation of reaction mechanism and structure/function relationships. Biochemistry 34, 2965-2977 (1995).
22. Bachl, J. & Schmelzer, C. Effects of deletions at structural domains of group II intron bI1 on self-splicing introns. L. Mol Biol. 212, 113-125 (1990).
23. Suchy, M. & Schmelzer, C. Restoration of the self-splicing activity of a defective group II intron by a small trans-acting RNA. J. Mol. Biol. 222, 179-187 (1991).
24. Frank, D. N., Roiha, H. & Guthrie, C. Architecture of the U5 small nuclear RNA. Mol. Cell. Biol 14, 2180-2190 (1994).