The intramolecular stem-loop structure of U6 snRNA can functionally replace the U6atac snRNA stem-loop

RNA

Volumn 7, Issue 1, 2001, Pages 94-105

  Shukla, Girish C ^a   Padgett, Richard A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Pre mRNA splicing; Spliceosomes; U12 dependent introns

Indexed keywords

RNA;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; GENE DELETION; GENE MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; RNA STRUCTURE; SPLICEOSOME; STRUCTURE ACTIVITY RELATION;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CHO CELLS; CRICETINAE; EXONS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA SPLICING; RNA, FUNGAL; RNA, SMALL NUCLEAR; SACCHAROMYCES CEREVISIAE; TRANSFECTION;

SACCHAROMYCETALES;

EID: 0035038510     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838201000218     Document Type: Article

References (36)

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2. A tertiary interaction that links active-site domains to the 5′ splice site of a group II intron
3. Spliceosomal RNA U6 is remarkably conserved from yeast to mammals
4. Evolutionary fates and origins of U12-type introns
5. Splicing of precursors to mRNAs by the spliceosome
6. Catalytic site components common to both splicing steps of a group II intron
7. The question remains: Is the spliceosome a ribozyme
8. Differential chemical probing of a group II self-splicing intron identifies bases involved in tertiary interactions and supports an alternative secondary structure model of domain V
9. Nucleoside phosphorothioates
10. Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicing in vitro
11. A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing
12. Messenger RNA splicing in yeast: Clues to why the spliceosome is a ribonucleoprotein
13. Requirement of U12 snRNA for the in vivo splicing of a minor class of eukaryotic nuclear pre-mRNA introns
14. Base pairing with U6atac snRNA is required for 5′ splice site activation of U12-dependent introns in vivo
15. U11 snRNA interacts in vivo with the 5′ splice site of U12-dependent (AU-AC) introns
16. Ribozyme catalysis from the major groove of group II intron domain 5
17. The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro
18. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome
19. Interactions of the yeast U6 RNA with the pre-mRNA branch site
20. RNA-RNA interactions in nuclear pre-mRNA splicing
21. RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2
22. A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoprotein particles
23. Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants
24. A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing
25. The human U6 snRNA intramolecular helix: Structural constraints and lack of sequence specificity
26. mRNA-type introns in U6 small nuclear RNA genes: Implications for the catalysis in pre-mRNA splicing
27. Highly diverged U4 and U6 small nuclear RNAs required for splicing rare AT-AC introns
28. A novel spliceosome containing U11, U12 and U5 snRNPs excises a minor class (AT-AC) intron in vitro
29. Pre-mRNA splicing: The discovery of a new spliceosome doubles the challenge
30. Conformational changes of U6 RNA during the spliceosome cycle: An intramolecular helix is essential both for initiating the U4-U6 interaction and for the first step of splicing
31. 9 years old
32. AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes
33. Metal ion coordination by U6 snRNA contributes to catalysis in the spliceosome
34. U6 snRNA function in nuclear pre-mRNA splicing: A phosphorothioate interference analysis of the U6 phosphate backbone
35. The growing world of small nuclear ribonucleoproteins
36. Prediction of RNA secondary structure by energy minimization