Connecting transcription to messenger RNA processing

Trends in Biochemical Sciences

Volumn 25, Issue 6, 2000, Pages 290-293

  Proudfoot, Nick J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RNA POLYMERASE II;

CARBOXY TERMINAL SEQUENCE; CONFOCAL MICROSCOPY; ENZYME SUBUNIT; EXON; GENE; GENETIC TRANSCRIPTION; INTRON; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; REVIEW; RNA CAPPING; RNA PROCESSING; RNA SPLICING;

ANIMALS; DROSOPHILA; MODELS, BIOLOGICAL; RNA POLYMERASE II; RNA SPLICING; RNA, MESSENGER; TRANSCRIPTION, GENETIC; XENOPUS; YEASTS;

EID: 0034213044     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01591-7     Document Type: Review

References (41)

1. Proudfoot N.J. How RNA polymerase II terminates transcription in higher eukaryotes. Trends Biochem. Sci. 14:1989;105-110.
2. Groudine M.et al. Transcriptional regulation of hemoglobin switching in chicken embryos. Mol. Cell. Biol. 1:1981;281-288.
3. Falk-Pedersen E.et al. Transcriptional termination within the E1A gene of adenovirus induced by insertion of the mouse β-major terminator element. Cell. 40:1985;897-905.
4. Logan J.et al. A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse β-maj globin gene. Proc. Natl. Acad. Sci. U. S. A. 84:1987;8306-8310.
5. Whitelaw E., Proudfoot N.J. α-Thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3′ end processing in the human α globin gene. EMBO J. 5:1986;2915-2922.
6. Connelly S., Manley J.L. A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II. Genes Dev. 2:1988;440-452.
7. Dahmus M.E. Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem. 271:1996;19009-19012.
8. O'Brien T.et al. Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation. Nature. 370:1994;75-77.
9. Thompson C.M.et al. A multisubunit complex associated with the RNA polymerase II CTD and TAT-binding protein in yeast. Cell. 73:1993;1361-1375.
10. Myers L.C.et al. The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev. 12:1998;45-54.
11. Wittschieben B.O.et al. A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol. Cell. 4:1999;123-129.
12. Neugebauer K.M., Roth M.B. Transcription units as RNA processing units. Genes Dev. 11:1997;3279-3285.
13. Shuman S. Capping enzyme in eukaryotic mRNA synthesis. Prog. Nucleic Acid Res. Mol. Biol. 50:1995;101-129.
14. McCracken S.et al. 5′ capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II. Genes Dev. 11:1997;3306-3318.
15. Cho E.-J.et al. mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev. 11:1997;3319-3326.
16. Ho C.K., Shuman S. Distinct roles for CTD Ser-2 and Ser-5 phosphorylation in the recruitment and allosteric activation of mammalian mRNA capping enzyme. Mol. Cell. 3:1999;405-411.
17. Bentley D.L. Regulation of transcriptional elongation by RNA polymerase II. Curr. Opin. Genet. Dev. 5:1995;210-216.
18. Beyer A., Osheim Y. Splice site selection, rate of splicing and alternative splicing on nascent transcripts. Genes Dev. 2:1988;754-765.
19. Kim E.et al. Splicing factors associate with hyper-phosphorylated RNA polymerase II in the absence of pre-mRNA. J. Cell Biol. 136:1997;19-28.
20. Yuryev A.et al. The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine proteins. Proc. Natl. Acad. Sci. U. S. A. 93:1996;6975-6980.
21. Corden J.L., Patturajan M. CTD function linking transcription and splicing. Trends Biochem. Sci. 22:1997;413-416.
22. Manley J.L., Tacke R. SR proteins and splicing control. Genes Dev. 10:1996;1569-1579.
23. Hirose Y.et al. Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. Genes Dev. 13:1999;1234-1239.
24. Cramer P.et al. Functional association between promoter structure and transcript alternative splicing. Proc. Natl. Acad. Sci. U. S. A. 94:1997;11456-11460.
25. Cramer P.et al. Coupling of transcription with alternative splicing: RNA Pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. Mol. Cell. 4:1999;251-259.
26. Roberts G.R.et al. Co-transcriptional commitment to alternative splice site selection. Nucleic Acids Res. 26:1998;5568-5572.
27. Dantonel J.C.et al. Transcription factor TFIID recruits factor CPSF for formation of the 3′ end of mRNA. Nature. 389:1997;399-402.
28. McCracken S.et al. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature. 385:1997;357-361.
29. Hirose Y., Manley J.L. RNA polymerase II is an essential mRNA polyadenylation factor. Nature. 395:1998;93-96.
30. Birse C.E.et al. Coupling transcriptional termination to messenger RNA maturation in yeast. Science. 280:1998;298-301.
31. Osheim Y.et al. EM visualization of transcription by RNA polymerase II through a poly(A) signal: downstream termination requires a poly(A) signal but not transcript cleavage. Mol. Cell. 3:1999;379-387.
32. Dye M.J., Proudfoot N.J. Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase II. Mol. Cell. 3:1999;371-378.
33. Baurén G.et al. Transcriptional termination in the Balbiana ring1 gene is closely coupled to 3′-end formation and excision of the 3′ terminal intron. Genes Dev. 12:1998;2759-2769.
34. Niwa M.et al. Are vertebrate exons scanned during splice site selection? Nature. 360:1992;277-280.
35. Iborra F.J.et al. Active RNA polymerases are localized within discrete transcription `factories' in human nuclei. J. Cell Sci. 109:1996;1427-1479.
36. Gall J. Spliceosomes and snurposomes. Science. 252:1999;1499-1500.
37. Misteli T.et al. The dynamics of a pre-mRNA splicing factor in living cells. Nature. 387:1997;523-527.
38. Misteli T., Spector D.L. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol. Cell. 3:1999;697-707.
39. Bentley D. Coupling RNA polymerase II transcription with pre-mRNA processing. Curr. Opin. Cell Biol. 11:1999;347-351.
40. Minvielle-Sebastia L., Keller W. mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription. Curr. Opin. Cell Biol. 11:1999;352-357.
41. Hirose Y., Manley J.L. RNA polymerase II and the integration of nuclear events. Genes Dev. 2000;. (in press).