Prolonged exposure of microglia to lipopolysaccharide modifies the intracellular signaling pathways and selectively promotes prostaglandin E 2 synthesis

Journal of Neurochemistry

Volumn 87, Issue 5, 2003, Pages 1193-1203

  Ajmone Cat, M A ^a   Nicolini, A ^a   Minghetti, Luisa ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Brain macrophages; Cyclooxygenase; MAPkinase; Prostaglandin; Tolerance; Transcription factor

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E; PROSTAGLANDIN E2; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN MICROSOME; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME REPRESSION; IN VITRO STUDY; MICROGLIA; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; DOWN-REGULATION; INTRACELLULAR FLUID; ISOENZYMES; LIPOPOLYSACCHARIDES; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROSTAGLANDIN D2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

ANIMALIA;

EID: 0344011637     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02087.x     Document Type: Article

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